Project name: 1f52cdafeb72bff

Chain sequence(s)	A: KVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFTLN
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.7177
• Maximal score value: 1.0344
• Average score: -0.7928
• Total score value: -391.6285

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
75	K	A	-2.7556
76	V	A	-2.6980
77	R	A	-3.0476
78	W	A	-2.3362
79	P	A	-1.9532
80	D	A	-2.7187
81	F	A	0.0000
82	N	A	-2.3872
83	Q	A	-2.2639
84	E	A	-2.6815
85	A	A	-1.4979
86	Y	A	0.0000
87	V	A	0.0000
88	G	A	-1.0743
89	G	A	-0.6787
90	T	A	-0.2231
91	M	A	0.0147
92	V	A	-1.0299
93	R	A	-2.2020
94	S	A	-1.7210
95	G	A	-1.8349
96	Q	A	-2.4745
97	D	A	-2.6504
98	P	A	-1.4852
99	Y	A	-0.9565
100	A	A	-1.3125
101	R	A	-1.7837
102	N	A	0.0000
103	K	A	-1.7076
104	F	A	0.0000
105	N	A	-1.0483
106	Q	A	0.0000
107	V	A	-0.3289
108	E	A	-1.3072
109	S	A	0.0000
110	D	A	-1.1822
111	K	A	-2.0276
112	L	A	-1.5379
113	R	A	-2.4821
114	M	A	-1.3513
115	D	A	-1.0574
116	R	A	-0.7967
117	A	A	-0.4340
118	I	A	-0.4810
119	P	A	-1.1213
120	D	A	-2.5019
121	T	A	-1.5278
122	R	A	-2.2465
123	H	A	-2.2851
124	D	A	-3.4370
125	Q	A	-3.1204
126	C	A	0.0000
127	Q	A	-3.5709
128	R	A	-3.6293
129	K	A	-2.8507
130	Q	A	-1.9941
131	W	A	-0.6542
132	R	A	-0.7755
133	V	A	0.4462
134	D	A	-1.1356
135	L	A	0.0000
136	P	A	-0.8943
137	A	A	-1.2783
138	T	A	0.0000
139	S	A	0.0000
140	V	A	0.0000
141	V	A	0.0000
142	I	A	0.0000
143	T	A	-0.2342
144	F	A	0.0000
145	H	A	-0.4569
146	N	A	-1.0089
147	E	A	0.0000
148	A	A	0.0000
149	R	A	0.0000
150	S	A	0.0000
151	A	A	0.0000
152	L	A	0.0000
153	L	A	0.0000
154	R	A	0.0000
155	T	A	0.0000
156	V	A	0.0000
157	V	A	0.0000
158	S	A	0.0000
159	V	A	0.0000
160	L	A	-0.9360
161	K	A	-1.5668
162	K	A	-1.4435
163	S	A	0.0000
164	P	A	-0.7939
165	P	A	-1.2484
166	H	A	-1.4171
167	L	A	0.0000
168	I	A	0.0000
169	K	A	-2.0870
170	E	A	0.0000
171	I	A	0.0000
172	I	A	0.0000
173	L	A	0.0000
174	V	A	0.0000
175	D	A	0.0000
176	D	A	0.0000
177	Y	A	-0.9812
178	S	A	0.0000
179	N	A	-1.8013
180	D	A	-1.9311
181	P	A	-1.4684
182	E	A	-1.7635
183	D	A	0.0000
184	G	A	0.0000
185	A	A	-0.7263
186	L	A	-0.3482
187	L	A	0.0000
188	G	A	-1.2479
189	K	A	-2.5169
190	I	A	0.0000
191	E	A	-2.0488
192	K	A	-1.8638
193	V	A	0.0000
194	R	A	-0.7802
195	V	A	-0.0834
196	L	A	-0.2297
197	R	A	-0.9990
198	N	A	0.0000
199	D	A	-2.7085
200	R	A	-2.7655
201	R	A	-1.5905
202	E	A	-1.3582
203	G	A	0.0000
204	L	A	-0.1142
205	M	A	0.0000
206	R	A	-0.5331
207	S	A	0.0000
208	R	A	0.0000
209	V	A	-1.0120
210	R	A	-1.5089
211	G	A	0.0000
212	A	A	0.0000
213	D	A	-2.4213
214	A	A	-1.3302
215	A	A	0.0000
216	Q	A	-2.0045
217	A	A	0.0000
218	K	A	-1.2968
219	V	A	0.0000
220	L	A	0.0000
221	T	A	0.0000
222	F	A	0.0000
223	L	A	0.0000
224	D	A	-0.5386
225	S	A	0.0000
226	H	A	0.0000
227	C	A	0.0000
228	E	A	0.0000
229	C	A	0.0000
230	N	A	0.0000
231	E	A	-2.5077
232	H	A	-1.6521
233	W	A	0.0000
234	L	A	0.0000
235	E	A	0.0000
236	P	A	-0.5687
237	L	A	0.0000
238	L	A	0.0000
239	E	A	-1.1640
240	R	A	-1.4482
241	V	A	0.0000
242	A	A	-2.0167
243	E	A	-2.7771
244	D	A	-2.4800
245	R	A	-2.4277
246	T	A	-1.3475
247	R	A	-1.5017
248	V	A	0.0000
249	V	A	0.0000
250	S	A	0.0000
251	P	A	0.0000
252	I	A	0.0000
253	I	A	0.0000
254	D	A	0.0000
255	V	A	0.7141
256	I	A	0.0000
257	N	A	-1.2784
258	M	A	-1.4274
259	D	A	-2.0327
260	N	A	-2.4501
261	F	A	0.0000
262	Q	A	-1.5061
263	Y	A	0.0000
264	V	A	0.6054
265	G	A	-0.0400
266	A	A	0.1359
267	S	A	0.0097
268	A	A	-0.3564
269	D	A	-0.4026
270	L	A	0.0629
271	K	A	-0.4400
272	G	A	0.0000
273	G	A	0.0000
274	F	A	0.0000
275	D	A	-1.3208
276	W	A	0.0000
277	N	A	-0.2956
278	L	A	0.0000
279	V	A	0.3714
280	F	A	-0.0852
281	K	A	-0.8950
282	W	A	-0.1545
283	D	A	-0.1572
284	Y	A	0.7274
285	M	A	0.0000
286	T	A	-1.1316
287	P	A	-1.8120
288	E	A	-3.0550
289	Q	A	-2.3355
290	R	A	-2.7271
291	R	A	-3.6141
292	S	A	-2.6105
293	R	A	-2.4656
294	Q	A	-2.5480
295	G	A	-1.7167
296	N	A	-1.4199
297	P	A	-1.7320
298	V	A	0.0000
299	A	A	-0.6961
300	P	A	-0.5755
301	I	A	0.0000
302	K	A	-1.5464
303	T	A	0.0000
304	P	A	0.0000
305	M	A	0.0000
306	I	A	0.0000
307	A	A	-0.1451
308	G	A	0.0000
309	G	A	-0.2499
310	L	A	0.0000
311	F	A	0.0000
312	V	A	0.0000
313	M	A	0.0000
314	D	A	0.0000
315	K	A	-0.8173
316	F	A	0.4400
317	Y	A	0.0000
318	F	A	0.0000
319	E	A	-1.4594
320	E	A	-1.7817
321	L	A	0.0000
322	G	A	0.0000
323	K	A	-1.1658
324	Y	A	0.0000
325	D	A	0.0000
326	M	A	0.3680
327	M	A	0.3485
328	M	A	0.0000
329	D	A	-0.2026
330	V	A	0.0000
331	W	A	0.4228
332	G	A	0.0000
333	G	A	0.0000
334	E	A	0.0000
335	N	A	0.0348
336	L	A	0.0000
337	E	A	0.0000
338	I	A	0.0000
339	S	A	0.0000
340	F	A	0.0000
341	R	A	0.0000
342	V	A	0.0000
343	W	A	0.0000
344	Q	A	0.0000
345	C	A	-0.7300
346	G	A	-0.5692
347	G	A	0.0000
348	S	A	-0.7310
349	L	A	0.0000
350	E	A	0.0000
351	I	A	0.0000
352	I	A	0.0000
353	P	A	0.0000
354	C	A	0.0000
355	S	A	0.0000
356	R	A	0.0000
357	V	A	0.0000
358	G	A	0.0000
359	H	A	0.1787
360	V	A	0.0000
361	F	A	-0.1019
362	R	A	-1.6738
363	K	A	-2.4935
364	Q	A	-2.3179
365	H	A	-1.4752
366	P	A	-1.1657
367	Y	A	-0.4344
368	T	A	-0.1347
369	F	A	-0.2234
370	P	A	-0.5488
371	G	A	-0.7612
372	G	A	-0.6336
373	S	A	-0.4204
374	G	A	-0.6143
375	T	A	-0.6241
376	V	A	0.0000
377	F	A	0.1298
378	A	A	0.0000
379	R	A	-0.6567
380	N	A	0.0000
381	T	A	0.0000
382	R	A	-0.5863
383	R	A	0.0000
384	A	A	0.0000
385	A	A	0.0000
386	E	A	-0.7746
387	V	A	0.0000
388	W	A	0.0000
389	M	A	0.0000
390	D	A	-1.9156
391	E	A	-2.5862
392	Y	A	-1.3425
393	K	A	-1.4653
394	N	A	-1.7879
395	F	A	-0.9238
396	Y	A	0.0000
397	Y	A	-0.7754
398	A	A	-0.6672
399	A	A	-0.1671
400	V	A	-0.1246
401	P	A	-0.6784
402	S	A	-0.9711
403	A	A	0.0000
404	R	A	-2.1909
405	N	A	-2.0181
406	V	A	-1.1409
407	P	A	-0.9557
408	Y	A	-0.7332
409	G	A	-1.1003
410	N	A	-1.6692
411	I	A	-1.3238
412	Q	A	-2.0632
413	S	A	-1.7178
414	R	A	-1.6746
415	L	A	-1.8869
416	E	A	-3.1750
417	L	A	0.0000
418	R	A	-2.3033
419	K	A	-3.2948
420	K	A	-2.9848
421	L	A	-1.9192
422	S	A	-1.7123
423	C	A	-1.1723
424	K	A	-1.3661
425	P	A	-1.3009
426	F	A	0.0000
427	K	A	-2.6819
428	W	A	-1.7858
429	Y	A	0.0000
430	L	A	0.0000
431	E	A	-2.9172
432	N	A	-2.3823
433	V	A	-1.4476
434	Y	A	0.0000
435	P	A	-1.8515
436	E	A	-1.5204
437	L	A	-1.2957
438	R	A	-1.7530
439	V	A	-0.2692
440	P	A	-1.1390
441	D	A	-2.7284
442	H	A	-2.6229
443	Q	A	-2.7851
444	D	A	-2.3383
445	I	A	-0.3882
446	A	A	0.3695
447	F	A	0.6920
448	G	A	0.0000
449	A	A	-0.5369
450	L	A	0.0000
451	Q	A	-0.9504
452	Q	A	0.0000
453	G	A	-0.9658
454	T	A	-0.8716
455	N	A	-0.9276
456	C	A	0.0000
457	L	A	0.0000
458	D	A	0.0000
459	T	A	0.0000
460	L	A	0.7498
461	G	A	-0.1135
462	H	A	0.1207
463	F	A	0.9929
464	A	A	-0.3115
465	D	A	-1.4353
466	G	A	-0.4467
467	V	A	-0.0878
468	V	A	0.0000
469	G	A	0.0000
470	V	A	0.4622
471	Y	A	0.4492
472	E	A	-1.5696
473	C	A	-1.3212
474	H	A	-1.6075
475	N	A	-2.1244
476	A	A	-1.2746
477	G	A	-1.3008
478	G	A	-1.2113
479	N	A	-0.8657
480	Q	A	0.0000
481	E	A	-0.7657
482	W	A	0.0000
483	A	A	0.0000
484	L	A	-0.5222
485	T	A	-1.4294
486	K	A	-2.6543
487	E	A	-3.7177
488	K	A	-2.6026
489	S	A	-1.8835
490	V	A	0.0000
491	K	A	-0.6021
492	H	A	-0.3569
493	M	A	-0.4240
494	D	A	-1.4282
495	L	A	0.0000
496	C	A	0.0000
497	L	A	0.0000
498	T	A	0.0000
499	V	A	0.0000
500	V	A	-0.6917
501	D	A	-1.9824
502	R	A	-2.5037
503	A	A	-1.2078
504	P	A	-0.8946
505	G	A	-0.7307
506	S	A	-0.7892
507	L	A	-0.2074
508	I	A	0.0000
509	K	A	-0.6341
510	L	A	0.0000
511	Q	A	-0.7261
512	G	A	-0.9533
513	C	A	-1.4567
514	R	A	-2.7500
515	E	A	-3.4560
516	N	A	-2.8517
517	D	A	0.0000
518	S	A	-1.4617
519	R	A	-1.4350
520	Q	A	0.0000
521	K	A	-1.4920
522	W	A	0.0000
523	E	A	-1.0228
524	Q	A	-1.9082
525	I	A	-1.8833
526	E	A	-2.6682
527	G	A	-2.2012
528	N	A	-2.6466
529	S	A	-2.1372
530	K	A	-1.7076
531	L	A	0.0000
532	R	A	-1.1443
533	H	A	0.0000
534	V	A	-0.5072
535	G	A	-0.7189
536	S	A	-0.9186
537	N	A	-1.3140
538	L	A	0.0000
539	C	A	0.0000
540	L	A	0.0000
541	D	A	0.0000
542	S	A	-0.8008
543	R	A	-1.6191
544	T	A	-1.3732
545	A	A	-1.1043
546	K	A	-2.1031
547	S	A	-1.3560
548	G	A	-0.9090
549	G	A	0.0000
550	L	A	0.0000
551	S	A	0.0000
552	V	A	0.0000
553	E	A	-0.4686
554	V	A	0.3333
555	C	A	0.0260
556	G	A	0.0640
557	P	A	0.1083
558	A	A	0.2969
559	L	A	0.9565
560	S	A	-0.0820
561	Q	A	0.0000
562	Q	A	-1.0778
563	W	A	0.0000
564	K	A	-1.6245
565	F	A	-0.2470
566	T	A	0.3051
567	L	A	1.0344
568	N	A	-0.6001