| Chain sequence(s) |
A: QVQLQESGPGLVKPSETLSLTCTVSGGSISSGYWNWIRQPPGKGLEWIGTISYSGDTYYNPSLKSRVAISVDTSKNQFSLKLSSVTAADTAVYYCARYGSYVFDYWGDGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES B: DIVMTQTPLSLSVTPGQPASISCRSSQSLLHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHGPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Q | A | -1.6580 | |
| 2 | V | A | 0.0000 | |
| 3 | Q | A | -2.1865 | |
| 4 | L | A | 0.0000 | |
| 5 | Q | A | -2.0948 | |
| 6 | E | A | -1.3762 | |
| 7 | S | A | -0.8760 | |
| 8 | G | A | -0.6598 | |
| 9 | P | A | -0.6448 | |
| 10 | G | A | -0.5232 | |
| 11 | L | A | -0.4961 | |
| 12 | V | A | 0.0000 | |
| 13 | K | A | -2.1549 | |
| 14 | P | A | -1.4476 | |
| 15 | S | A | -1.2312 | |
| 16 | E | A | -1.5752 | |
| 17 | T | A | -1.2503 | |
| 18 | L | A | 0.0000 | |
| 19 | S | A | -0.9582 | |
| 20 | L | A | 0.0000 | |
| 21 | T | A | -0.7578 | |
| 22 | C | A | 0.0000 | |
| 23 | T | A | -1.1883 | |
| 24 | V | A | 0.0000 | |
| 25 | S | A | -1.3047 | |
| 26 | G | A | -1.3492 | |
| 27 | G | A | -1.1562 | |
| 28 | S | A | -0.8557 | |
| 29 | I | A | 0.0000 | |
| 30 | S | A | -0.2074 | |
| 31 | S | A | 0.0136 | |
| 32 | G | A | 0.1241 | |
| 33 | Y | A | 0.1715 | |
| 34 | W | A | 0.0000 | |
| 35 | N | A | 0.0000 | |
| 36 | W | A | 0.0000 | |
| 37 | I | A | 0.0000 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.8128 | |
| 40 | P | A | -0.9910 | |
| 41 | P | A | -1.1109 | |
| 42 | G | A | -1.4999 | |
| 43 | K | A | -2.3722 | |
| 44 | G | A | -1.5331 | |
| 45 | L | A | 0.0000 | |
| 46 | E | A | -0.6541 | |
| 47 | W | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | G | A | 0.0000 | |
| 50 | T | A | 0.0000 | |
| 51 | I | A | 0.0000 | |
| 52 | S | A | 0.0411 | |
| 53 | Y | A | 0.5840 | |
| 54 | S | A | -0.4387 | |
| 55 | G | A | -0.9454 | |
| 56 | D | A | -1.5440 | |
| 57 | T | A | -0.3120 | |
| 58 | Y | A | 0.5960 | |
| 59 | Y | A | 0.3524 | |
| 60 | N | A | 0.0000 | |
| 61 | P | A | -1.0350 | |
| 62 | S | A | -1.1157 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0117 | |
| 65 | S | A | -1.2629 | |
| 66 | R | A | -1.3823 | |
| 67 | V | A | 0.0000 | |
| 68 | A | A | -0.5354 | |
| 69 | I | A | 0.0000 | |
| 70 | S | A | -0.6333 | |
| 71 | V | A | -0.2995 | |
| 72 | D | A | -1.1918 | |
| 73 | T | A | -1.1498 | |
| 74 | S | A | -1.3404 | |
| 75 | K | A | -2.1419 | |
| 76 | N | A | -1.4591 | |
| 77 | Q | A | -1.2857 | |
| 78 | F | A | 0.0000 | |
| 79 | S | A | -0.5548 | |
| 80 | L | A | 0.0000 | |
| 81 | K | A | -1.6872 | |
| 82 | L | A | 0.0000 | |
| 83 | S | A | -1.0219 | |
| 84 | S | A | -0.9036 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | -0.5509 | |
| 87 | A | A | -0.2070 | |
| 88 | A | A | 0.0287 | |
| 89 | D | A | 0.0000 | |
| 90 | T | A | 0.0316 | |
| 91 | A | A | 0.0000 | |
| 92 | V | A | 0.0174 | |
| 93 | Y | A | 0.0000 | |
| 94 | Y | A | 0.0000 | |
| 95 | C | A | 0.0000 | |
| 96 | A | A | 0.0000 | |
| 97 | R | A | -0.6544 | |
| 98 | Y | A | -0.0559 | |
| 99 | G | A | -0.0764 | |
| 100 | S | A | -0.0749 | |
| 101 | Y | A | 0.2761 | |
| 102 | V | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | D | A | -0.4145 | |
| 105 | Y | A | -0.8370 | |
| 106 | W | A | 0.0000 | |
| 107 | G | A | 0.0000 | |
| 108 | D | A | -2.5178 | |
| 109 | G | A | -1.3861 | |
| 110 | T | A | -0.7393 | |
| 111 | T | A | -0.3181 | |
| 112 | V | A | 0.0000 | |
| 113 | T | A | -0.2909 | |
| 114 | V | A | 0.0000 | |
| 115 | S | A | -0.8333 | |
| 116 | S | A | -0.9407 | |
| 117 | A | A | -0.5494 | |
| 118 | S | A | -0.6645 | |
| 119 | T | A | -0.7517 | |
| 120 | K | A | -1.1944 | |
| 121 | G | A | -1.3196 | |
| 122 | P | A | -0.6114 | |
| 123 | S | A | -0.4670 | |
| 124 | V | A | 0.0000 | |
| 125 | F | A | 0.0000 | |
| 126 | P | A | -1.3370 | |
| 127 | L | A | 0.0000 | |
| 128 | A | A | -0.8977 | |
| 129 | P | A | 0.0000 | |
| 130 | C | A | -0.4551 | |
| 131 | S | A | -0.5373 | |
| 132 | R | A | -0.8873 | |
| 133 | S | A | 0.0000 | |
| 134 | T | A | -0.8854 | |
| 135 | S | A | -1.3575 | |
| 136 | E | A | -2.0794 | |
| 137 | S | A | -1.3121 | |
| 138 | T | A | -0.9406 | |
| 139 | A | A | 0.0000 | |
| 140 | A | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | G | A | 0.0000 | |
| 143 | C | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | K | A | -0.2739 | |
| 147 | D | A | -0.3624 | |
| 148 | Y | A | 0.0000 | |
| 149 | F | A | 0.0000 | |
| 150 | P | A | 0.0000 | |
| 151 | E | A | -0.5199 | |
| 152 | P | A | -0.6740 | |
| 153 | V | A | -0.6100 | |
| 154 | T | A | -0.5248 | |
| 155 | V | A | -0.3210 | |
| 156 | S | A | -0.4520 | |
| 157 | W | A | 0.0000 | |
| 158 | N | A | -1.0249 | |
| 159 | S | A | -0.7674 | |
| 160 | G | A | -0.5950 | |
| 161 | A | A | -0.2865 | |
| 162 | L | A | -0.1396 | |
| 163 | T | A | -0.2480 | |
| 164 | S | A | -0.2734 | |
| 165 | G | A | -0.3903 | |
| 166 | V | A | 0.0720 | |
| 167 | H | A | -0.2426 | |
| 168 | T | A | 0.0005 | |
| 169 | F | A | 0.0000 | |
| 170 | P | A | -0.2968 | |
| 171 | A | A | 0.3190 | |
| 172 | V | A | 0.7164 | |
| 173 | L | A | 1.4077 | |
| 174 | Q | A | 0.3825 | |
| 175 | S | A | 0.0057 | |
| 176 | S | A | -0.1568 | |
| 177 | G | A | 0.1305 | |
| 178 | L | A | 0.2383 | |
| 179 | Y | A | 0.5273 | |
| 180 | S | A | 0.0000 | |
| 181 | L | A | 0.0000 | |
| 182 | S | A | 0.0000 | |
| 183 | S | A | 0.0000 | |
| 184 | V | A | 0.0000 | |
| 185 | V | A | 0.0000 | |
| 186 | T | A | -0.1878 | |
| 187 | V | A | 0.0000 | |
| 188 | P | A | -0.6408 | |
| 189 | S | A | -0.6896 | |
| 190 | S | A | -0.5503 | |
| 191 | S | A | -0.6636 | |
| 192 | L | A | -0.8239 | |
| 193 | G | A | -1.1740 | |
| 194 | T | A | -0.9002 | |
| 195 | K | A | -1.6329 | |
| 196 | T | A | -1.4990 | |
| 197 | Y | A | 0.0000 | |
| 198 | T | A | 0.0000 | |
| 199 | C | A | 0.0000 | |
| 200 | N | A | -1.7246 | |
| 201 | V | A | 0.0000 | |
| 202 | D | A | -1.8044 | |
| 203 | H | A | 0.0000 | |
| 204 | K | A | -2.6930 | |
| 205 | P | A | -1.6491 | |
| 206 | S | A | -1.8332 | |
| 207 | N | A | -2.5182 | |
| 208 | T | A | -2.0491 | |
| 209 | K | A | -2.6472 | |
| 210 | V | A | -1.9994 | |
| 211 | D | A | -2.9284 | |
| 212 | K | A | -2.6990 | |
| 213 | R | A | -3.1141 | |
| 214 | V | A | 0.0000 | |
| 215 | E | A | -2.6255 | |
| 216 | S | A | -1.1034 | |
| 217 | D | B | -1.5631 | |
| 218 | I | B | -0.4672 | |
| 219 | V | B | 0.7436 | |
| 220 | M | B | 0.0000 | |
| 221 | T | B | -0.4993 | |
| 222 | Q | B | 0.0000 | |
| 223 | T | B | -0.3812 | |
| 224 | P | B | -0.2757 | |
| 225 | L | B | 0.0100 | |
| 226 | S | B | -0.5939 | |
| 227 | L | B | 0.0000 | |
| 228 | S | B | -1.0698 | |
| 229 | V | B | 0.0000 | |
| 230 | T | B | -1.6656 | |
| 231 | P | B | -2.0230 | |
| 232 | G | B | -1.9074 | |
| 233 | Q | B | -2.3110 | |
| 234 | P | B | -2.1049 | |
| 235 | A | B | -1.2879 | |
| 236 | S | B | -0.7924 | |
| 237 | I | B | 0.0000 | |
| 238 | S | B | -0.8881 | |
| 239 | C | B | 0.0000 | |
| 240 | R | B | -2.1252 | |
| 241 | S | B | 0.0000 | |
| 242 | S | B | -0.8613 | |
| 243 | Q | B | -1.3850 | |
| 244 | S | B | -0.7274 | |
| 245 | L | B | 0.0000 | |
| 246 | L | B | 0.5125 | |
| 247 | H | B | -0.6210 | |
| 248 | S | B | -0.9424 | |
| 249 | N | B | -1.6512 | |
| 250 | G | B | -1.1447 | |
| 251 | N | B | -0.9821 | |
| 252 | T | B | -0.2799 | |
| 253 | Y | B | 0.0000 | |
| 254 | L | B | 0.0000 | |
| 255 | H | B | 0.0000 | |
| 256 | W | B | 0.0000 | |
| 257 | Y | B | 0.0000 | |
| 258 | L | B | 0.0000 | |
| 259 | Q | B | -1.1215 | |
| 260 | K | B | -1.7384 | |
| 261 | P | B | -1.4209 | |
| 262 | G | B | -1.6998 | |
| 263 | Q | B | -2.1645 | |
| 264 | S | B | 0.0000 | |
| 265 | P | B | 0.0000 | |
| 266 | Q | B | -1.2759 | |
| 267 | L | B | 0.0000 | |
| 268 | L | B | 0.0000 | |
| 269 | I | B | 0.0000 | |
| 270 | Y | B | -0.4912 | |
| 271 | K | B | -0.9074 | |
| 272 | V | B | 0.0000 | |
| 273 | S | B | -0.9351 | |
| 274 | N | B | -1.2317 | |
| 275 | R | B | -1.7313 | |
| 276 | F | B | -0.6523 | |
| 277 | S | B | -0.5797 | |
| 278 | G | B | -0.8099 | |
| 279 | V | B | -0.8897 | |
| 280 | P | B | -1.2695 | |
| 281 | D | B | -2.2243 | |
| 282 | R | B | -2.0437 | |
| 283 | F | B | 0.0000 | |
| 284 | S | B | -1.3079 | |
| 285 | G | B | 0.0000 | |
| 286 | S | B | -0.7760 | |
| 287 | G | B | -0.9696 | |
| 288 | S | B | -0.6463 | |
| 289 | G | B | -0.6194 | |
| 290 | T | B | -1.3667 | |
| 291 | D | B | -1.9924 | |
| 292 | F | B | 0.0000 | |
| 293 | T | B | -0.9899 | |
| 294 | L | B | 0.0000 | |
| 295 | K | B | -1.5634 | |
| 296 | I | B | 0.0000 | |
| 297 | S | B | -2.2800 | |
| 298 | R | B | -3.0466 | |
| 299 | V | B | 0.0000 | |
| 300 | E | B | -2.6280 | |
| 301 | A | B | -2.2938 | |
| 302 | E | B | -2.4094 | |
| 303 | D | B | 0.0000 | |
| 304 | V | B | 0.0000 | |
| 305 | G | B | 0.0000 | |
| 306 | V | B | -0.7566 | |
| 307 | Y | B | 0.0000 | |
| 308 | Y | B | 0.0000 | |
| 309 | C | B | 0.0000 | |
| 310 | S | B | 0.0000 | |
| 311 | Q | B | 0.0000 | |
| 312 | S | B | 0.0000 | |
| 313 | T | B | 0.0000 | |
| 314 | H | B | -0.9300 | |
| 315 | G | B | -0.8298 | |
| 316 | P | B | 0.0000 | |
| 317 | W | B | 0.0000 | |
| 318 | T | B | -0.1722 | |
| 319 | F | B | 0.1294 | |
| 320 | G | B | 0.0000 | |
| 321 | Q | B | -1.2647 | |
| 322 | G | B | 0.0000 | |
| 323 | T | B | 0.0000 | |
| 324 | K | B | -1.8247 | |
| 325 | V | B | 0.0000 | |
| 326 | E | B | -1.7214 | |
| 327 | I | B | 0.0000 | |
| 328 | K | B | -1.4972 | |
| 329 | R | B | -1.0024 | |
| 330 | T | B | -0.0408 | |
| 331 | V | B | 0.3197 | |
| 332 | A | B | -0.0918 | |
| 333 | A | B | -0.1705 | |
| 334 | P | B | 0.0000 | |
| 335 | S | B | -0.1347 | |
| 336 | V | B | -0.1565 | |
| 337 | F | B | 0.0000 | |
| 338 | I | B | 0.0000 | |
| 339 | F | B | 0.0000 | |
| 340 | P | B | -0.6926 | |
| 341 | P | B | 0.0000 | |
| 342 | S | B | -1.5167 | |
| 343 | D | B | -2.9667 | |
| 344 | E | B | -2.7950 | |
| 345 | Q | B | 0.0000 | |
| 346 | L | B | -2.1076 | |
| 347 | K | B | -2.6911 | |
| 348 | S | B | -1.7146 | |
| 349 | G | B | -1.0486 | |
| 350 | T | B | -1.0624 | |
| 351 | A | B | 0.0000 | |
| 352 | S | B | 0.0000 | |
| 353 | V | B | 0.0000 | |
| 354 | V | B | 0.0000 | |
| 355 | C | B | 0.0000 | |
| 356 | L | B | 0.0000 | |
| 357 | L | B | 0.0000 | |
| 358 | N | B | 0.0000 | |
| 359 | N | B | -1.0857 | |
| 360 | F | B | 0.0000 | |
| 361 | Y | B | 0.0000 | |
| 362 | P | B | -1.7977 | |
| 363 | R | B | -3.1874 | |
| 364 | E | B | -3.3054 | |
| 365 | A | B | -2.4318 | |
| 366 | K | B | -2.6310 | |
| 367 | V | B | -1.3335 | |
| 368 | Q | B | -1.1878 | |
| 369 | W | B | 0.0000 | |
| 370 | K | B | -0.9298 | |
| 371 | V | B | 0.0000 | |
| 372 | D | B | -2.1352 | |
| 373 | N | B | -1.6670 | |
| 374 | A | B | -0.3922 | |
| 375 | L | B | 0.5735 | |
| 376 | Q | B | -0.3407 | |
| 377 | S | B | -0.5748 | |
| 378 | G | B | -0.9153 | |
| 379 | N | B | -0.8398 | |
| 380 | S | B | -1.1133 | |
| 381 | Q | B | -1.1835 | |
| 382 | E | B | -1.4082 | |
| 383 | S | B | -0.6157 | |
| 384 | V | B | -0.7179 | |
| 385 | T | B | -1.2761 | |
| 386 | E | B | -2.3532 | |
| 387 | Q | B | 0.0000 | |
| 388 | D | B | -2.2504 | |
| 389 | S | B | -2.4158 | |
| 390 | K | B | -2.7270 | |
| 391 | D | B | -1.9804 | |
| 392 | S | B | 0.0000 | |
| 393 | T | B | 0.0000 | |
| 394 | Y | B | 0.0000 | |
| 395 | S | B | 0.0000 | |
| 396 | L | B | 0.0000 | |
| 397 | S | B | 0.0000 | |
| 398 | S | B | 0.0000 | |
| 399 | T | B | -0.5314 | |
| 400 | L | B | 0.0000 | |
| 401 | T | B | -0.4549 | |
| 402 | L | B | -0.8014 | |
| 403 | S | B | -1.3691 | |
| 404 | K | B | -2.1328 | |
| 405 | A | B | -2.1324 | |
| 406 | D | B | -2.9971 | |
| 407 | Y | B | 0.0000 | |
| 408 | E | B | -3.7195 | |
| 409 | K | B | -3.8235 | |
| 410 | H | B | -3.2919 | |
| 411 | K | B | -3.3923 | |
| 412 | V | B | -2.1207 | |
| 413 | Y | B | 0.0000 | |
| 414 | A | B | -0.9383 | |
| 415 | C | B | 0.0000 | |
| 416 | E | B | -1.0274 | |
| 417 | V | B | 0.0000 | |
| 418 | T | B | -1.3265 | |
| 419 | H | B | -1.6207 | |
| 420 | Q | B | -1.8244 | |
| 421 | G | B | -0.5214 | |
| 422 | L | B | -0.3096 | |
| 423 | S | B | -0.4519 | |
| 424 | S | B | -0.4410 | |
| 425 | P | B | -0.5533 | |
| 426 | V | B | 0.1224 | |
| 427 | T | B | -0.4632 | |
| 428 | K | B | -0.7352 | |
| 429 | S | B | -0.9918 | |
| 430 | F | B | 0.0000 | |
| 431 | N | B | -2.4974 | |
| 432 | R | B | -2.8676 | |
| 433 | G | B | -2.2664 | |
| 434 | E | B | -2.2214 | |
| 435 | C | B | -0.7093 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine