Project name: 1fe25c6f5a34c83

Chain sequence(s)	A: PLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.2684
• Maximal score value: 1.5072
• Average score: -0.7287
• Total score value: -145.7389

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
92	P	A	0.5393
93	L	A	1.5072
94	S	A	0.0000
95	S	A	0.1872
96	S	A	0.2670
97	V	A	0.6091
98	P	A	-0.1107
99	S	A	-0.8351
100	Q	A	-1.4411
101	K	A	-2.0546
102	T	A	-1.2315
103	Y	A	-0.6349
104	Q	A	-1.3614
105	G	A	-0.4572
106	S	A	-0.5423
107	Y	A	-0.7464
108	G	A	-1.1234
109	F	A	0.0000
110	R	A	-1.1244
111	L	A	-0.2869
112	G	A	-0.0207
113	F	A	0.2417
114	L	A	0.2433
115	H	A	-0.7093
116	S	A	-0.4290
117	G	A	-0.8853
118	T	A	-1.2080
119	A	A	-1.2348
120	K	A	-2.3296
121	S	A	-1.0723
122	V	A	-0.4541
123	T	A	-0.3007
124	C	A	0.0000
125	T	A	0.0000
126	Y	A	-0.1331
127	S	A	0.0000
128	P	A	-0.4669
129	A	A	-0.0414
130	L	A	-0.0740
131	N	A	-0.6366
132	K	A	0.0000
133	M	A	0.0000
134	F	A	0.0000
135	C	A	0.0000
136	Q	A	-0.3179
137	L	A	-0.0860
138	A	A	-0.4813
139	K	A	-0.9354
140	T	A	-0.6925
141	C	A	0.0000
142	P	A	-0.1729
143	V	A	0.0000
144	Q	A	-0.3350
145	L	A	0.0000
146	W	A	-0.7413
147	V	A	-1.1524
148	D	A	-2.1021
149	S	A	-0.9787
150	T	A	-0.7563
151	P	A	0.0000
152	P	A	-0.7335
153	P	A	-0.9978
154	G	A	-1.1352
155	T	A	0.0000
156	R	A	-1.2785
157	V	A	0.0000
158	R	A	-0.6051
159	A	A	0.0000
160	M	A	0.0834
161	A	A	0.0000
162	I	A	0.0000
163	Y	A	0.0000
164	K	A	-1.8084
165	Q	A	-2.0465
166	S	A	-1.4775
167	Q	A	-1.8643
168	H	A	-1.2898
169	M	A	-0.6537
170	T	A	0.0022
171	E	A	0.1045
172	V	A	0.0000
173	V	A	0.0000
174	R	A	-0.9542
175	R	A	0.0000
176	C	A	0.0000
177	P	A	-1.2217
178	H	A	-1.6811
179	H	A	-1.7570
180	E	A	-2.2788
181	R	A	-2.5505
182	C	A	-1.1587
183	S	A	-1.5009
184	D	A	-1.8329
185	S	A	-1.6366
186	D	A	-1.9883
187	G	A	-0.9100
188	L	A	0.0495
189	A	A	0.0000
190	P	A	-0.5852
191	P	A	-1.3106
192	Q	A	-1.3376
193	H	A	0.0000
194	L	A	0.0000
195	I	A	0.0000
196	R	A	0.0000
197	V	A	0.0000
198	E	A	-1.1681
199	G	A	-0.9428
200	N	A	-0.7960
201	L	A	0.1837
202	R	A	-1.5921
203	V	A	0.0000
204	E	A	-1.7582
205	Y	A	-0.8504
206	L	A	-1.1184
207	D	A	-2.1621
208	D	A	-2.2878
209	R	A	-2.8209
210	N	A	-2.2738
211	T	A	-0.7059
212	F	A	-0.0483
213	R	A	0.0000
214	H	A	-0.7771
215	S	A	0.0000
216	V	A	0.0000
217	V	A	0.0000
218	V	A	0.0000
219	P	A	-1.6480
220	Y	A	0.0000
221	E	A	-2.4098
222	P	A	-1.5420
223	P	A	-1.5803
224	E	A	-1.7638
225	V	A	0.3055
226	G	A	-0.6033
227	S	A	-1.2869
228	D	A	-2.1485
229	C	A	0.0000
230	T	A	0.0000
231	T	A	-0.7960
232	I	A	0.0000
233	H	A	-0.9520
234	Y	A	0.0000
235	N	A	-0.5679
236	Y	A	0.0000
237	M	A	0.0000
238	C	A	0.0000
239	N	A	-0.5918
240	S	A	0.0000
241	S	A	-1.2821
242	C	A	-0.5650
243	M	A	0.0926
244	G	A	-0.3970
245	G	A	0.0000
246	M	A	0.0000
247	N	A	-1.5990
248	R	A	-2.4284
249	R	A	-1.9306
250	P	A	-1.4573
251	I	A	0.0000
252	L	A	0.0000
253	T	A	0.0000
254	I	A	0.0000
255	I	A	0.0000
256	T	A	-0.4100
257	L	A	0.0000
258	E	A	0.0000
259	D	A	-1.1502
260	S	A	-1.0761
261	S	A	-0.9927
262	G	A	-1.1379
263	N	A	-1.3376
264	L	A	-0.1360
265	L	A	-0.1305
266	G	A	0.0000
267	R	A	-0.8263
268	N	A	-0.9060
269	S	A	-0.6724
270	F	A	0.0000
271	E	A	-0.6096
272	V	A	0.0000
273	R	A	-1.0031
274	V	A	0.0000
275	C	A	0.0000
276	A	A	-0.3602
277	C	A	-0.8342
278	P	A	0.0000
279	G	A	0.0000
280	R	A	-2.3066
281	D	A	0.0000
282	R	A	-1.9110
283	R	A	-2.6545
284	T	A	-1.9011
285	E	A	-2.0229
286	E	A	-2.1061
287	E	A	-3.2684
288	N	A	-2.9189
289	L	A	-1.3898
290	R	A	-2.9619
291	K	A	-2.9876