Project name: leptin

Chain sequence(s)	A: IQKVQDDTKTLIKTIVTRINDILDFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLPEASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5188
• Maximal score value: 1.9191
• Average score: -0.617
• Total score value: -80.2079

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
3	I	A	0.8285
4	Q	A	-1.4949
5	K	A	-2.4744
6	V	A	-1.1561
7	Q	A	-1.9217
8	D	A	-2.7703
9	D	A	-2.7656
10	T	A	0.0000
11	K	A	-2.3597
12	T	A	-1.7538
13	L	A	-1.4064
14	I	A	0.0000
15	K	A	-2.1041
16	T	A	-1.2848
17	I	A	0.0000
18	V	A	-1.3184
19	T	A	-1.5268
20	R	A	-1.7839
21	I	A	0.0000
22	N	A	-1.7703
23	D	A	-1.7518
24	I	A	0.3503
39	L	A	0.7586
40	D	A	-0.4657
41	F	A	1.2868
42	I	A	0.7371
43	P	A	-0.0842
44	G	A	-0.4208
45	L	A	0.0000
46	H	A	-0.8855
47	P	A	-0.4545
48	I	A	0.6364
49	L	A	1.4431
50	T	A	0.4196
51	L	A	0.0000
52	S	A	-0.6491
53	K	A	-0.6559
54	M	A	0.0000
55	D	A	0.0000
56	Q	A	-1.0897
57	T	A	0.0000
58	L	A	0.0000
59	A	A	-0.9258
60	V	A	0.0000
61	Y	A	0.0000
62	Q	A	-0.7683
63	Q	A	-0.7267
64	I	A	0.0000
65	L	A	0.0000
66	T	A	-0.2100
67	S	A	-0.4947
68	M	A	0.0000
69	P	A	-0.6246
70	S	A	-1.0935
71	R	A	-1.6180
72	N	A	-1.1193
73	V	A	0.0000
74	I	A	-0.0721
75	Q	A	-1.1289
76	I	A	0.0000
77	S	A	-1.1862
78	N	A	-2.1780
79	D	A	-2.0546
80	L	A	0.0000
81	E	A	-3.5188
82	N	A	-3.2086
83	L	A	0.0000
84	R	A	-2.2138
85	D	A	-2.6895
86	L	A	-1.3254
87	L	A	0.0000
88	H	A	-0.3122
89	V	A	0.9816
90	L	A	0.0000
91	A	A	0.0000
92	F	A	1.9191
93	S	A	1.1642
94	K	A	0.2112
95	S	A	0.1439
96	C	A	-0.1286
97	H	A	-0.8514
98	L	A	-0.7517
99	P	A	-1.4619
100	E	A	-2.1651
101	A	A	-1.3110
102	S	A	-1.0945
103	G	A	-1.1564
104	L	A	-1.0132
105	E	A	-2.0185
106	T	A	-1.3659
107	L	A	-1.0879
108	D	A	-2.0584
109	S	A	-1.2337
110	L	A	0.0000
111	G	A	-1.4299
112	G	A	-1.2469
113	V	A	-0.4507
114	L	A	0.0000
115	E	A	-1.8891
116	A	A	-0.7644
117	S	A	-0.5346
118	G	A	-0.3248
119	Y	A	0.4211
120	S	A	-0.2633
121	T	A	-0.7357
122	E	A	-0.8014
123	V	A	0.5383
124	V	A	0.0000
125	A	A	0.0000
126	L	A	0.0000
127	S	A	-0.1528
128	R	A	-0.3115
129	L	A	0.0000
130	Q	A	-1.1301
131	G	A	-0.5913
132	S	A	0.0000
133	L	A	0.0000
134	Q	A	-1.3985
135	D	A	-0.5884
136	M	A	0.0000
137	L	A	-0.5564
138	W	A	0.3799
139	Q	A	0.4483
140	L	A	0.0000
141	D	A	-0.9870
142	L	A	0.8214
143	S	A	0.0627
144	P	A	0.1987
145	G	A	-0.0371
146	C	A	-0.2492