| Chain sequence(s) |
A: DNQFYSVEVGDSTFTVLKRYQQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMMKKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCCPEFMKKLQPTVRNNYVENRPKKYAGLTFPKLFPDSLFPNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN B: VVRPGSLDLP |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 45 | D | A | -3.0259 | |
| 46 | N | A | -2.7509 | |
| 47 | Q | A | -2.5719 | |
| 48 | F | A | -1.6442 | |
| 49 | Y | A | -0.8442 | |
| 50 | S | A | -0.6135 | |
| 51 | V | A | -1.0639 | |
| 52 | E | A | -2.4322 | |
| 53 | V | A | 0.0000 | |
| 54 | G | A | -2.0256 | |
| 55 | D | A | -2.4098 | |
| 56 | S | A | -1.5071 | |
| 57 | T | A | -1.2427 | |
| 58 | F | A | 0.0000 | |
| 59 | T | A | -0.6725 | |
| 60 | V | A | 0.0000 | |
| 61 | L | A | -1.1797 | |
| 62 | K | A | -1.8580 | |
| 63 | R | A | -0.6699 | |
| 64 | Y | A | 0.0000 | |
| 65 | Q | A | -1.6237 | |
| 66 | N | A | -1.8542 | |
| 67 | L | A | -1.5057 | |
| 68 | K | A | -2.0878 | |
| 69 | P | A | -0.8018 | |
| 70 | I | A | 0.2490 | |
| 71 | G | A | 0.3424 | |
| 72 | S | A | 0.1830 | |
| 73 | G | A | 0.0854 | |
| 74 | A | A | -0.2094 | |
| 75 | Q | A | -0.4139 | |
| 76 | G | A | 0.0000 | |
| 77 | I | A | 0.1342 | |
| 78 | V | A | 0.0000 | |
| 79 | C | A | 0.0000 | |
| 80 | A | A | -0.7080 | |
| 81 | A | A | 0.0000 | |
| 82 | Y | A | -0.8944 | |
| 83 | D | A | 0.0000 | |
| 84 | A | A | -0.1327 | |
| 85 | V | A | 1.5010 | |
| 86 | L | A | 0.7722 | |
| 87 | D | A | -1.1545 | |
| 88 | R | A | -1.0895 | |
| 89 | N | A | -1.4606 | |
| 90 | V | A | 0.0000 | |
| 91 | A | A | 0.0000 | |
| 92 | I | A | 0.0000 | |
| 93 | K | A | 0.0000 | |
| 94 | K | A | -0.4479 | |
| 95 | L | A | 0.0000 | |
| 96 | S | A | -1.3314 | |
| 97 | R | A | -2.5599 | |
| 98 | P | A | 0.0000 | |
| 99 | F | A | -1.8768 | |
| 100 | Q | A | -2.1570 | |
| 101 | N | A | -1.9357 | |
| 102 | Q | A | -1.9711 | |
| 103 | T | A | -1.2749 | |
| 104 | H | A | -1.5035 | |
| 105 | A | A | 0.0000 | |
| 106 | K | A | -1.6090 | |
| 107 | R | A | -1.0857 | |
| 108 | A | A | 0.0000 | |
| 109 | Y | A | -0.3912 | |
| 110 | R | A | -0.5506 | |
| 111 | E | A | 0.0000 | |
| 112 | L | A | 0.0000 | |
| 113 | V | A | -0.7057 | |
| 114 | L | A | 0.0000 | |
| 115 | M | A | -0.6895 | |
| 116 | K | A | -1.4451 | |
| 117 | C | A | 0.0000 | |
| 118 | V | A | 0.0000 | |
| 119 | N | A | -2.0838 | |
| 120 | H | A | -1.6398 | |
| 121 | K | A | -2.0714 | |
| 122 | N | A | 0.0000 | |
| 123 | I | A | 0.0000 | |
| 124 | I | A | 0.0000 | |
| 125 | S | A | -0.4915 | |
| 126 | L | A | 0.2818 | |
| 127 | L | A | 0.7408 | |
| 128 | N | A | 0.2386 | |
| 129 | V | A | 0.2190 | |
| 130 | F | A | 0.0000 | |
| 131 | T | A | 0.0000 | |
| 132 | P | A | -1.3216 | |
| 133 | Q | A | -2.2385 | |
| 134 | K | A | -2.5678 | |
| 135 | T | A | -1.9925 | |
| 136 | L | A | -2.2432 | |
| 137 | E | A | -3.2725 | |
| 138 | E | A | -3.3027 | |
| 139 | F | A | 0.0000 | |
| 140 | Q | A | -1.9732 | |
| 141 | D | A | -1.2907 | |
| 142 | V | A | 0.0000 | |
| 143 | Y | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | M | A | 0.0000 | |
| 147 | E | A | 0.0000 | |
| 148 | L | A | -0.4643 | |
| 149 | M | A | -0.9850 | |
| 150 | D | A | -2.0454 | |
| 151 | A | A | -1.0170 | |
| 152 | N | A | -0.3443 | |
| 153 | L | A | 0.0000 | |
| 154 | C | A | -0.0549 | |
| 155 | Q | A | -0.8374 | |
| 156 | V | A | 0.0000 | |
| 157 | I | A | 0.0000 | |
| 158 | Q | A | -1.9886 | |
| 159 | M | A | -1.6961 | |
| 160 | E | A | -2.3826 | |
| 161 | L | A | -1.6651 | |
| 162 | D | A | -1.6550 | |
| 163 | H | A | 0.0000 | |
| 164 | E | A | -1.0771 | |
| 165 | R | A | -1.4428 | |
| 166 | M | A | 0.0000 | |
| 167 | S | A | 0.0000 | |
| 168 | Y | A | 0.0000 | |
| 169 | L | A | 0.0000 | |
| 170 | L | A | 0.0000 | |
| 171 | Y | A | 0.0000 | |
| 172 | Q | A | 0.0000 | |
| 173 | M | A | 0.0000 | |
| 174 | L | A | 0.0000 | |
| 175 | C | A | 0.0000 | |
| 176 | G | A | 0.0000 | |
| 177 | I | A | 0.0000 | |
| 178 | K | A | -1.1247 | |
| 179 | H | A | 0.0000 | |
| 180 | L | A | 0.0000 | |
| 181 | H | A | -0.5099 | |
| 182 | S | A | -0.4763 | |
| 183 | A | A | 0.0000 | |
| 184 | G | A | -0.6073 | |
| 185 | I | A | 0.0000 | |
| 186 | I | A | -0.3528 | |
| 187 | H | A | 0.0000 | |
| 188 | R | A | -0.7039 | |
| 189 | D | A | 0.0000 | |
| 190 | L | A | 0.0000 | |
| 191 | K | A | 0.0000 | |
| 192 | P | A | 0.0000 | |
| 193 | S | A | 0.0000 | |
| 194 | N | A | 0.0000 | |
| 195 | I | A | 0.0000 | |
| 196 | V | A | -0.3684 | |
| 197 | V | A | 0.0000 | |
| 198 | K | A | -1.9037 | |
| 199 | S | A | -1.9398 | |
| 200 | D | A | -2.1898 | |
| 201 | C | A | 0.0000 | |
| 202 | T | A | -1.0056 | |
| 203 | L | A | 0.0000 | |
| 204 | K | A | -0.6200 | |
| 205 | I | A | 0.0000 | |
| 206 | L | A | 0.0000 | |
| 207 | D | A | -0.1995 | |
| 208 | F | A | 0.0000 | |
| 209 | G | A | -0.2762 | |
| 210 | L | A | -0.5617 | |
| 211 | A | A | -0.7445 | |
| 212 | R | A | -1.3367 | |
| 213 | T | A | -0.4108 | |
| 214 | A | A | -0.3211 | |
| 215 | G | A | 0.0000 | |
| 216 | T | A | 0.0000 | |
| 217 | S | A | 0.8863 | |
| 218 | F | A | 1.8211 | |
| 219 | M | A | 0.0000 | |
| 220 | M | A | 1.0668 | |
| 221 | T | A | 0.8257 | |
| 222 | P | A | 0.7089 | |
| 223 | Y | A | 1.9590 | |
| 224 | V | A | 1.4412 | |
| 225 | V | A | 1.0480 | |
| 226 | T | A | 0.0000 | |
| 227 | R | A | -0.3220 | |
| 228 | Y | A | -0.1032 | |
| 229 | Y | A | 0.0000 | |
| 230 | R | A | -0.3811 | |
| 231 | A | A | 0.0000 | |
| 232 | P | A | 0.0000 | |
| 233 | E | A | 0.0000 | |
| 234 | V | A | -0.0520 | |
| 235 | I | A | 0.4774 | |
| 236 | L | A | 0.0000 | |
| 237 | G | A | -0.3771 | |
| 238 | M | A | -0.4800 | |
| 239 | G | A | -0.3169 | |
| 240 | Y | A | -0.4519 | |
| 241 | K | A | -1.8554 | |
| 242 | E | A | -2.1034 | |
| 243 | N | A | -1.3744 | |
| 244 | V | A | 0.0000 | |
| 245 | D | A | 0.0000 | |
| 246 | I | A | 0.0000 | |
| 247 | W | A | 0.0000 | |
| 248 | S | A | 0.0000 | |
| 249 | V | A | 0.0000 | |
| 250 | G | A | 0.0000 | |
| 251 | C | A | 0.0000 | |
| 252 | I | A | 0.0000 | |
| 253 | M | A | 0.0000 | |
| 254 | G | A | 0.0000 | |
| 255 | E | A | 0.0000 | |
| 256 | M | A | 0.0000 | |
| 257 | V | A | 0.0000 | |
| 258 | R | A | -1.4569 | |
| 259 | H | A | -1.8026 | |
| 260 | K | A | -1.9488 | |
| 261 | I | A | -0.3919 | |
| 262 | L | A | 0.0000 | |
| 263 | F | A | 0.0000 | |
| 264 | P | A | -0.7627 | |
| 265 | G | A | 0.0000 | |
| 266 | R | A | -1.8227 | |
| 267 | D | A | -0.6227 | |
| 268 | Y | A | 0.7907 | |
| 269 | I | A | 1.6488 | |
| 270 | D | A | -0.0408 | |
| 271 | Q | A | 0.0000 | |
| 272 | W | A | 0.0000 | |
| 273 | N | A | -0.3816 | |
| 274 | K | A | -0.9505 | |
| 275 | V | A | 0.0000 | |
| 276 | I | A | 0.0000 | |
| 277 | E | A | -1.6702 | |
| 278 | Q | A | -0.8177 | |
| 279 | L | A | -0.0562 | |
| 280 | G | A | 0.0000 | |
| 281 | T | A | -0.9428 | |
| 282 | P | A | 0.0000 | |
| 283 | C | A | -0.6798 | |
| 284 | P | A | -1.8716 | |
| 285 | E | A | -2.7722 | |
| 286 | F | A | 0.0000 | |
| 287 | M | A | 0.0000 | |
| 288 | K | A | -3.7955 | |
| 289 | K | A | -3.2271 | |
| 290 | L | A | 0.0000 | |
| 291 | Q | A | -2.3060 | |
| 292 | P | A | -1.7065 | |
| 293 | T | A | -1.0813 | |
| 294 | V | A | -1.1914 | |
| 295 | R | A | -2.7332 | |
| 296 | N | A | -2.7359 | |
| 297 | Y | A | -1.4568 | |
| 298 | V | A | 0.0000 | |
| 299 | E | A | -3.2068 | |
| 300 | N | A | -2.8621 | |
| 301 | R | A | -2.2814 | |
| 302 | P | A | -1.9512 | |
| 303 | K | A | -2.4027 | |
| 304 | Y | A | -1.0110 | |
| 305 | A | A | -0.3802 | |
| 306 | G | A | -0.4728 | |
| 307 | L | A | -0.0610 | |
| 308 | T | A | -0.3053 | |
| 309 | F | A | -0.4871 | |
| 310 | P | A | -1.2912 | |
| 311 | K | A | -1.8012 | |
| 312 | L | A | 0.0000 | |
| 313 | F | A | 0.0000 | |
| 314 | P | A | -1.3798 | |
| 315 | D | A | -1.9922 | |
| 316 | S | A | -0.7998 | |
| 317 | L | A | -0.5430 | |
| 318 | F | A | 0.0000 | |
| 319 | P | A | -1.4717 | |
| 325 | N | A | -1.9849 | |
| 326 | K | A | -2.0466 | |
| 327 | L | A | -0.1133 | |
| 328 | K | A | -1.3028 | |
| 329 | A | A | 0.0000 | |
| 330 | S | A | -0.9165 | |
| 331 | Q | A | -0.7637 | |
| 332 | A | A | 0.0000 | |
| 333 | R | A | -0.8425 | |
| 334 | D | A | -1.1400 | |
| 335 | L | A | 0.0000 | |
| 336 | L | A | 0.0000 | |
| 337 | S | A | -0.6312 | |
| 338 | K | A | -1.4134 | |
| 339 | M | A | 0.0000 | |
| 340 | L | A | 0.0000 | |
| 341 | V | A | -0.2651 | |
| 342 | I | A | 0.0000 | |
| 343 | D | A | 0.0000 | |
| 344 | P | A | 0.0000 | |
| 345 | A | A | -0.8774 | |
| 346 | K | A | -1.7167 | |
| 347 | R | A | 0.0000 | |
| 348 | I | A | -1.1036 | |
| 349 | S | A | -1.6649 | |
| 350 | V | A | 0.0000 | |
| 351 | D | A | -2.2261 | |
| 352 | D | A | -2.8663 | |
| 353 | A | A | 0.0000 | |
| 354 | L | A | 0.0000 | |
| 355 | Q | A | -2.1044 | |
| 356 | H | A | 0.0000 | |
| 357 | P | A | -0.6692 | |
| 358 | Y | A | 0.0000 | |
| 359 | I | A | 0.0000 | |
| 360 | N | A | -0.5181 | |
| 361 | V | A | 1.1049 | |
| 362 | W | A | 0.0000 | |
| 363 | Y | A | 0.2082 | |
| 364 | D | A | -0.6647 | |
| 365 | P | A | -0.9860 | |
| 366 | A | A | -0.7958 | |
| 367 | E | A | 0.0000 | |
| 368 | V | A | 0.0000 | |
| 369 | E | A | -2.1256 | |
| 370 | A | A | -1.4843 | |
| 371 | P | A | -1.0110 | |
| 372 | P | A | -0.9865 | |
| 373 | P | A | -0.9021 | |
| 374 | Q | A | -0.8229 | |
| 375 | I | A | 0.5115 | |
| 376 | Y | A | 0.0000 | |
| 377 | D | A | -2.6112 | |
| 378 | K | A | -3.6163 | |
| 379 | Q | A | -3.6518 | |
| 380 | L | A | -3.2651 | |
| 381 | D | A | -3.5327 | |
| 382 | E | A | -3.9558 | |
| 383 | R | A | -4.0238 | |
| 384 | E | A | -3.3503 | |
| 385 | H | A | -2.0854 | |
| 386 | T | A | -1.5497 | |
| 387 | I | A | -1.7653 | |
| 388 | E | A | -2.6679 | |
| 389 | E | A | -2.4117 | |
| 390 | W | A | 0.0000 | |
| 391 | K | A | -2.0315 | |
| 392 | E | A | -2.1861 | |
| 393 | L | A | -1.3044 | |
| 394 | I | A | 0.0000 | |
| 395 | Y | A | -1.2062 | |
| 396 | K | A | -2.0139 | |
| 397 | E | A | -1.4895 | |
| 398 | V | A | 0.0000 | |
| 399 | M | A | -0.5246 | |
| 400 | N | A | -1.4182 | |
| 341 | V | B | 2.6312 | |
| 342 | V | B | 2.1651 | |
| 343 | R | B | 0.3672 | |
| 344 | P | B | -0.4896 | |
| 345 | G | B | -1.0204 | |
| 346 | S | B | -1.5674 | |
| 347 | L | B | 0.0000 | |
| 348 | D | B | -2.1960 | |
| 349 | L | B | -1.3484 | |
| 350 | P | B | -0.7916 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine