Project name: >AAR13230.1

Chain sequence(s)	A: VTDLHIVNSFIQPDGFNRSGVLAEGIFPGPLITGNKGDSFQINVIDELTNGTMLLSTSIHWHGLFQKTTNWADGPAFVNQCPIAANDSFLYNFNVPDQAGTFWYHSHLSTQYCDGLRGPLVVYDPQDPYVDLYDVDDDSTVITLADWYHVPAPQAGAVPTSDATLINGLGRSVNGPADAPFAVVNVVQGSRYRFRLVSISCDPNFLFSIDGHTFTVIEADGVNHEPIVADSIQIFAAQRYSFILTANQTADNYWIRANPNNGHTGFAGGINSAILRYSGAPVADPVTTQTSANLLQETSLVPRENPGAPGNATANGVNVDLNLVLSFVGGRFEINGVSFVPPTVPVLLQILSGATTAAELLPSGSVYTLPLNSVIQLSFNTVAVAAVGGPHPFHLHGHTFDVVRSAGSTEYNYINPPRRDVVSTGAATDNVTIRFTTDNAGPWFLHCHIDWHLEAGFAIVFAEDAPDVAAVNPVPDAWNQLCPTYDALTP
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.3594
• Maximal score value: 1.9477
• Average score: -0.117
• Total score value: -57.3255

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
23	V	A	1.7244
24	T	A	0.0985
25	D	A	-1.1110
26	L	A	0.0000
27	H	A	-0.5489
28	I	A	0.0000
29	V	A	0.2654
30	N	A	-0.1315
31	S	A	0.2167
32	F	A	1.9477
33	I	A	0.3292
34	Q	A	-1.1833
35	P	A	0.0000
36	D	A	0.0000
37	G	A	-0.0472
38	F	A	0.9968
39	N	A	-1.1699
40	R	A	0.0000
41	S	A	0.2267
42	G	A	0.0000
43	V	A	0.0000
44	L	A	0.0000
45	A	A	0.0000
46	E	A	-0.9552
47	G	A	-0.3163
48	I	A	1.6078
49	F	A	0.5524
50	P	A	0.0002
51	G	A	0.0000
52	P	A	0.0067
53	L	A	0.3279
54	I	A	0.0000
55	T	A	-0.0673
56	G	A	-0.2382
57	N	A	-0.8582
58	K	A	-0.8712
59	G	A	-0.7792
60	D	A	-1.1074
61	S	A	-0.5764
62	F	A	0.0000
63	Q	A	-0.2588
64	I	A	0.0000
65	N	A	-0.3342
66	V	A	0.0000
67	I	A	0.2391
68	D	A	0.0000
69	E	A	-1.4315
70	L	A	0.0000
71	T	A	-0.1460
72	N	A	-0.5079
73	G	A	-0.4753
74	T	A	-0.1157
75	M	A	0.0000
76	L	A	0.6704
77	L	A	0.7679
78	S	A	0.0000
79	T	A	0.0000
80	S	A	0.0000
81	I	A	0.0000
82	H	A	0.0000
83	W	A	0.0000
84	H	A	0.0000
85	G	A	-0.0476
86	L	A	0.0000
87	F	A	0.3460
88	Q	A	0.0000
89	K	A	-1.0844
90	T	A	-0.2480
91	T	A	-0.0171
92	N	A	0.0000
93	W	A	0.0000
94	A	A	0.0000
95	D	A	0.0000
96	G	A	0.0000
97	P	A	0.0000
98	A	A	0.0000
99	F	A	0.2518
100	V	A	0.0000
101	N	A	0.0000
102	Q	A	0.0000
103	C	A	0.0000
104	P	A	0.0000
105	I	A	0.0000
106	A	A	0.0000
107	A	A	-0.2202
108	N	A	-1.4577
109	D	A	-1.2808
110	S	A	-0.2324
111	F	A	0.0000
112	L	A	0.5990
113	Y	A	0.0000
114	N	A	-0.7811
115	F	A	0.0000
116	N	A	-1.3035
117	V	A	0.0000
118	P	A	-0.6598
119	D	A	-1.8611
120	Q	A	-0.4571
121	A	A	-0.0163
122	G	A	0.0000
123	T	A	0.0000
124	F	A	0.0000
125	W	A	0.0000
126	Y	A	0.0000
127	H	A	0.0000
128	S	A	0.0000
129	H	A	0.0000
130	L	A	0.0000
131	S	A	-0.1232
132	T	A	0.0000
133	Q	A	0.0000
134	Y	A	0.0000
135	C	A	0.0000
136	D	A	0.0000
137	G	A	0.0000
138	L	A	0.0000
139	R	A	0.0000
140	G	A	0.0000
141	P	A	0.0000
142	L	A	0.0000
143	V	A	0.0000
144	V	A	0.0000
145	Y	A	0.1091
146	D	A	-0.2914
147	P	A	-0.5234
148	Q	A	-1.2753
149	D	A	-0.4002
150	P	A	-0.1066
151	Y	A	0.0000
152	V	A	1.4511
153	D	A	-1.3834
154	L	A	0.1692
155	Y	A	-0.1743
156	D	A	-1.6966
157	V	A	-0.0055
158	D	A	-0.4953
159	D	A	-1.4551
160	D	A	-2.0188
161	S	A	-0.5366
162	T	A	0.0000
163	V	A	0.0000
164	I	A	0.0000
165	T	A	0.0000
166	L	A	0.0000
167	A	A	0.0000
168	D	A	0.0000
169	W	A	0.0000
170	Y	A	0.0000
171	H	A	0.0271
172	V	A	1.0696
173	P	A	0.1608
174	A	A	0.0000
175	P	A	-0.4726
176	Q	A	-1.2413
177	A	A	-0.2846
178	G	A	-0.4550
179	A	A	0.2712
180	V	A	1.6368
181	P	A	0.2020
182	T	A	-0.0808
183	S	A	-0.1285
184	D	A	-0.4914
185	A	A	0.0000
186	T	A	0.0000
187	L	A	0.0000
188	I	A	0.0000
189	N	A	-0.4780
190	G	A	0.0000
191	L	A	0.3381
192	G	A	0.0000
193	R	A	-0.2812
194	S	A	0.0000
195	V	A	1.5488
196	N	A	-1.0434
197	G	A	-0.6958
198	P	A	-0.2951
199	A	A	-0.3715
200	D	A	-1.7911
201	A	A	0.0000
202	P	A	-0.2549
203	F	A	0.0000
204	A	A	0.0000
205	V	A	0.8774
206	V	A	0.0000
207	N	A	-1.2966
208	V	A	0.0000
209	V	A	1.5549
210	Q	A	-0.9602
211	G	A	-0.6906
212	S	A	-0.2290
213	R	A	-0.5540
214	Y	A	0.0000
215	R	A	0.0000
216	F	A	0.0000
217	R	A	0.0000
218	L	A	0.0000
219	V	A	0.0000
220	S	A	0.0000
221	I	A	0.0000
222	S	A	0.0000
223	C	A	0.0000
224	D	A	-0.2536
225	P	A	0.0000
226	N	A	0.0000
227	F	A	0.0000
228	L	A	0.2936
229	F	A	0.0000
230	S	A	-0.0355
231	I	A	0.0000
232	D	A	0.0000
233	G	A	-0.4663
234	H	A	0.0000
235	T	A	-0.1110
236	F	A	0.0000
237	T	A	0.2469
238	V	A	0.0000
239	I	A	0.0000
240	E	A	0.0000
241	A	A	0.0000
242	D	A	0.0000
243	G	A	-0.0654
244	V	A	0.0941
245	N	A	-0.5115
246	H	A	0.0000
247	E	A	-1.7095
248	P	A	-0.3193
249	I	A	0.6400
250	V	A	1.8328
251	A	A	0.0000
252	D	A	-0.3462
253	S	A	0.0000
254	I	A	0.0000
255	Q	A	-0.3641
256	I	A	0.0000
257	F	A	0.0000
258	A	A	0.0000
259	A	A	0.0000
260	Q	A	0.0000
261	R	A	0.0000
262	Y	A	0.0000
263	S	A	0.0000
264	F	A	0.0000
265	I	A	0.0000
266	L	A	0.0000
267	T	A	-0.1216
268	A	A	0.0000
269	N	A	-1.4276
270	Q	A	-1.0910
271	T	A	-0.2152
272	A	A	-0.1442
273	D	A	-0.9789
274	N	A	0.0000
275	Y	A	0.0000
276	W	A	0.1297
277	I	A	0.0000
278	R	A	0.0000
279	A	A	0.0000
280	N	A	-0.3572
281	P	A	0.0000
282	N	A	-1.2808
283	N	A	-1.3780
284	G	A	-0.5610
285	H	A	-0.4960
286	T	A	-0.1781
287	G	A	-0.0855
288	F	A	0.4495
289	A	A	0.0579
290	G	A	-0.4557
291	G	A	0.0000
292	I	A	0.0000
293	N	A	0.0000
294	S	A	0.0000
295	A	A	0.0000
296	I	A	0.0000
297	L	A	0.0000
298	R	A	-0.3585
299	Y	A	0.0000
300	S	A	-0.2983
301	G	A	-0.5008
302	A	A	-0.1039
303	P	A	0.0695
304	V	A	1.7370
305	A	A	0.3821
306	D	A	0.0000
307	P	A	-0.1829
308	V	A	0.3315
309	T	A	-0.0113
310	T	A	-0.2987
311	Q	A	-1.2228
312	T	A	-0.3028
313	S	A	-0.0796
314	A	A	-0.1851
315	N	A	-1.1139
316	L	A	0.5835
317	L	A	0.0000
318	Q	A	-1.2349
319	E	A	-0.4228
320	T	A	-0.0953
321	S	A	-0.2145
322	L	A	0.0000
323	V	A	0.1906
324	P	A	0.0000
325	R	A	-2.3594
326	E	A	-2.3454
327	N	A	-1.3392
328	P	A	-0.2615
329	G	A	-0.0417
330	A	A	-0.0438
331	P	A	-0.0925
332	G	A	-0.5736
333	N	A	-1.3332
334	A	A	-0.1858
335	T	A	-0.0498
336	A	A	-0.1816
337	N	A	-1.2758
338	G	A	-0.4177
339	V	A	-0.0263
340	N	A	-1.1579
341	V	A	-0.0682
342	D	A	-1.2054
343	L	A	-0.2225
344	N	A	-0.9931
345	L	A	0.0000
346	V	A	1.3279
347	L	A	0.0000
348	S	A	0.0201
349	F	A	0.9834
350	V	A	1.8107
351	G	A	-0.2328
352	G	A	-0.6694
353	R	A	-0.7193
354	F	A	0.0000
355	E	A	-0.3616
356	I	A	0.0000
357	N	A	-0.5978
358	G	A	-0.5181
359	V	A	0.2285
360	S	A	-0.0304
361	F	A	0.0000
362	V	A	1.7322
363	P	A	0.0887
364	P	A	0.0000
365	T	A	0.1272
366	V	A	1.0564
367	P	A	0.0000
368	V	A	0.0000
369	L	A	0.0000
370	L	A	0.2247
371	Q	A	-0.0801
372	I	A	0.0000
373	L	A	0.3649
374	S	A	-0.2257
375	G	A	-0.5044
376	A	A	-0.0898
377	T	A	-0.0763
378	T	A	-0.0481
379	A	A	0.0123
380	A	A	-0.2679
381	E	A	-1.8094
382	L	A	0.0000
383	L	A	1.2527
384	P	A	0.0000
385	S	A	-0.1450
386	G	A	-0.4363
387	S	A	0.0000
388	V	A	0.0000
389	Y	A	0.2238
390	T	A	0.0030
391	L	A	0.0000
392	P	A	-0.0036
393	L	A	0.5608
394	N	A	-1.1275
395	S	A	0.0000
396	V	A	0.2563
397	I	A	0.0000
398	Q	A	-0.2644
399	L	A	0.0000
400	S	A	-0.1372
401	F	A	0.0000
402	N	A	-0.5296
403	T	A	0.0000
404	V	A	0.4475
405	A	A	0.4370
406	V	A	1.7835
407	A	A	0.3409
408	A	A	0.0000
409	V	A	1.3109
410	G	A	-0.2621
411	G	A	-0.3554
412	P	A	-0.1202
413	H	A	0.0000
414	P	A	0.0000
415	F	A	0.0000
416	H	A	0.0000
417	L	A	0.0000
418	H	A	0.0000
419	G	A	0.0000
420	H	A	0.0000
421	T	A	-0.0161
422	F	A	0.0000
423	D	A	0.0000
424	V	A	0.0000
425	V	A	0.0000
426	R	A	-0.2111
427	S	A	0.0000
428	A	A	-0.0682
429	G	A	-0.4673
430	S	A	-0.1186
431	T	A	-0.3704
432	E	A	-1.5122
433	Y	A	0.3751
434	N	A	-0.0468
435	Y	A	0.4926
436	I	A	1.9411
437	N	A	-0.0547
438	P	A	0.0000
439	P	A	0.0000
440	R	A	-0.4961
441	R	A	0.0000
442	D	A	0.0000
443	V	A	0.0000
444	V	A	0.0000
445	S	A	0.0000
446	T	A	0.0000
447	G	A	0.0000
448	A	A	0.0640
449	A	A	0.0888
450	T	A	-0.0984
451	D	A	-0.2355
452	N	A	-0.3318
453	V	A	0.0000
454	T	A	0.0000
455	I	A	0.0000
456	R	A	0.0000
457	F	A	0.0000
458	T	A	-0.0013
459	T	A	0.0000
460	D	A	-1.7894
461	N	A	0.0000
462	A	A	0.0000
463	G	A	0.0000
464	P	A	0.0000
465	W	A	0.0000
466	F	A	0.0000
467	L	A	0.0000
468	H	A	0.0000
469	C	A	0.0000
470	H	A	0.0000
471	I	A	0.0000
472	D	A	0.0000
473	W	A	0.0000
474	H	A	0.0000
475	L	A	-0.0613
476	E	A	-1.2453
477	A	A	-0.2933
478	G	A	0.0000
479	F	A	0.0000
480	A	A	0.0000
481	I	A	0.0000
482	V	A	0.0000
483	F	A	0.0000
484	A	A	0.0000
485	E	A	0.0000
486	D	A	0.0000
487	A	A	0.0000
488	P	A	-0.4188
489	D	A	-0.9640
490	V	A	0.0000
491	A	A	0.0656
492	A	A	0.1968
493	V	A	0.7120
494	N	A	0.0000
495	P	A	-0.1408
496	V	A	0.5594
497	P	A	-0.2802
498	D	A	-1.7977
499	A	A	-0.4252
500	W	A	0.0000
501	N	A	-1.1444
502	Q	A	-1.3646
503	L	A	0.0000
504	C	A	0.0000
505	P	A	-0.2601
506	T	A	-0.0137
507	Y	A	0.0082
508	D	A	-1.7184
509	A	A	-0.0781
510	L	A	1.0123
511	T	A	0.0723
512	P	A	-0.2676