| Chain sequence(s) |
A: PVDRSLLKLKMVQVVFRHGARSPLKPLPLEEQVEWNPQLLEVPPQTQFDYTVTNLAGGPKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQRAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAMDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQVPRGCPDGLCPLDMFLNAMSVYTLSPEKYHALCSQT |
| Distance of aggregation | 5 Å |
| Dynamic mode | No |
| Mutated residues | IA325V |
| Energy difference between WT (input) and mutated protein (by FoldX) | 0.435207 kcal/mol
Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 42 | P | A | -0.0632 | |
| 43 | V | A | 0.6772 | |
| 44 | D | A | -1.9006 | |
| 45 | R | A | -2.0997 | |
| 46 | S | A | -0.4466 | |
| 47 | L | A | 0.4234 | |
| 48 | L | A | 0.0000 | |
| 49 | K | A | -1.6678 | |
| 50 | L | A | -0.2912 | |
| 51 | K | A | -0.8092 | |
| 52 | M | A | 0.0000 | |
| 53 | V | A | 0.0000 | |
| 54 | Q | A | 0.0000 | |
| 55 | V | A | 0.0000 | |
| 56 | V | A | 0.0000 | |
| 57 | F | A | 0.0000 | |
| 58 | R | A | 0.0000 | |
| 59 | H | A | 0.0000 | |
| 60 | G | A | 0.0000 | |
| 61 | A | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | S | A | 0.0000 | |
| 64 | P | A | 0.0000 | |
| 65 | L | A | 0.2625 | |
| 66 | K | A | -0.8210 | |
| 67 | P | A | -0.2313 | |
| 68 | L | A | 0.0000 | |
| 69 | P | A | -0.0445 | |
| 70 | L | A | -0.1656 | |
| 71 | E | A | -2.1217 | |
| 72 | E | A | -2.2399 | |
| 73 | Q | A | -0.7526 | |
| 74 | V | A | -0.1147 | |
| 75 | E | A | -1.2234 | |
| 76 | W | A | 0.0000 | |
| 77 | N | A | -0.5543 | |
| 78 | P | A | -0.4333 | |
| 79 | Q | A | -1.1844 | |
| 80 | L | A | 0.1016 | |
| 81 | L | A | 0.3656 | |
| 82 | E | A | -1.4563 | |
| 83 | V | A | 0.9916 | |
| 84 | P | A | 0.1675 | |
| 85 | P | A | -0.3797 | |
| 86 | Q | A | -0.6981 | |
| 87 | T | A | 0.0000 | |
| 88 | Q | A | -1.1983 | |
| 89 | F | A | 0.0000 | |
| 90 | D | A | -1.7415 | |
| 91 | Y | A | -0.0854 | |
| 92 | T | A | 0.0098 | |
| 93 | V | A | 0.1596 | |
| 94 | T | A | -0.2465 | |
| 95 | N | A | -0.1336 | |
| 96 | L | A | 0.5162 | |
| 97 | A | A | 0.0554 | |
| 98 | G | A | -0.4039 | |
| 99 | G | A | -0.4094 | |
| 100 | P | A | -0.6128 | |
| 101 | K | A | -1.7525 | |
| 102 | P | A | -0.0908 | |
| 103 | Y | A | 1.3066 | |
| 104 | S | A | 0.1963 | |
| 105 | P | A | -0.0695 | |
| 106 | Y | A | 0.2512 | |
| 107 | D | A | -0.3129 | |
| 108 | S | A | -0.3384 | |
| 109 | Q | A | -1.0663 | |
| 110 | Y | A | 0.0000 | |
| 111 | H | A | -0.9025 | |
| 112 | E | A | -1.9260 | |
| 113 | T | A | -0.3566 | |
| 114 | T | A | 0.0246 | |
| 115 | L | A | 0.0000 | |
| 116 | K | A | -1.7274 | |
| 117 | G | A | -0.9332 | |
| 118 | G | A | -0.5218 | |
| 119 | M | A | 0.0000 | |
| 120 | F | A | 0.7670 | |
| 121 | A | A | 0.0000 | |
| 122 | G | A | 0.0000 | |
| 123 | Q | A | -0.1262 | |
| 124 | L | A | 0.0000 | |
| 125 | T | A | 0.0000 | |
| 126 | K | A | -0.7839 | |
| 127 | V | A | 0.2945 | |
| 128 | G | A | 0.0000 | |
| 129 | M | A | 0.0000 | |
| 130 | Q | A | -0.7766 | |
| 131 | Q | A | -0.5086 | |
| 132 | M | A | 0.0000 | |
| 133 | F | A | 0.1479 | |
| 134 | A | A | -0.0078 | |
| 135 | L | A | 0.0000 | |
| 136 | G | A | 0.0000 | |
| 137 | E | A | -0.9929 | |
| 138 | R | A | -0.6865 | |
| 139 | L | A | 0.0000 | |
| 140 | R | A | -0.5499 | |
| 141 | K | A | -1.6867 | |
| 142 | N | A | -0.8240 | |
| 143 | Y | A | 0.0000 | |
| 144 | V | A | -0.1810 | |
| 145 | E | A | -2.2489 | |
| 146 | D | A | -1.9521 | |
| 147 | I | A | 0.5116 | |
| 148 | P | A | -0.0894 | |
| 149 | F | A | 0.0000 | |
| 150 | L | A | 0.0000 | |
| 151 | S | A | -0.0934 | |
| 152 | P | A | -0.2473 | |
| 153 | T | A | -0.1167 | |
| 154 | F | A | 0.0000 | |
| 155 | N | A | -0.2405 | |
| 156 | P | A | -0.3418 | |
| 157 | Q | A | -1.2510 | |
| 158 | E | A | -0.4758 | |
| 159 | V | A | 0.0000 | |
| 160 | F | A | 0.3118 | |
| 161 | I | A | 0.0000 | |
| 162 | R | A | 0.0000 | |
| 163 | S | A | 0.0000 | |
| 164 | T | A | 0.0000 | |
| 165 | N | A | -0.1234 | |
| 166 | I | A | 0.0000 | |
| 167 | F | A | 1.3132 | |
| 168 | R | A | 0.0000 | |
| 169 | N | A | 0.0000 | |
| 170 | L | A | 0.0000 | |
| 171 | E | A | -0.2030 | |
| 172 | S | A | 0.0000 | |
| 173 | T | A | 0.0000 | |
| 174 | R | A | 0.0000 | |
| 175 | C | A | 0.0000 | |
| 176 | L | A | 0.0000 | |
| 177 | L | A | 0.0000 | |
| 178 | A | A | 0.0000 | |
| 179 | G | A | 0.0000 | |
| 180 | L | A | 0.0000 | |
| 181 | F | A | 0.0000 | |
| 182 | Q | A | -0.5243 | |
| 183 | C | A | 0.0473 | |
| 184 | Q | A | -0.6942 | |
| 185 | K | A | -1.2467 | |
| 186 | E | A | -1.9836 | |
| 187 | G | A | -0.4689 | |
| 188 | P | A | -0.2708 | |
| 189 | I | A | 0.0000 | |
| 190 | I | A | 0.6232 | |
| 191 | I | A | 0.0000 | |
| 192 | H | A | -0.1510 | |
| 193 | T | A | 0.0000 | |
| 194 | D | A | -0.6207 | |
| 195 | E | A | -1.8705 | |
| 196 | A | A | -0.6528 | |
| 197 | D | A | -1.8224 | |
| 198 | S | A | -0.5174 | |
| 199 | E | A | 0.0000 | |
| 200 | V | A | 0.2745 | |
| 201 | L | A | 0.0000 | |
| 202 | Y | A | 0.1336 | |
| 203 | P | A | 0.0000 | |
| 204 | N | A | 0.0000 | |
| 205 | Y | A | -0.0181 | |
| 206 | Q | A | -1.1700 | |
| 207 | S | A | -0.2740 | |
| 208 | C | A | 0.0000 | |
| 209 | W | A | 0.4210 | |
| 210 | S | A | 0.0000 | |
| 211 | L | A | 0.0000 | |
| 212 | R | A | -1.0277 | |
| 213 | Q | A | -1.5027 | |
| 214 | R | A | -1.0735 | |
| 215 | T | A | 0.0000 | |
| 216 | R | A | -1.9300 | |
| 217 | G | A | -0.8772 | |
| 218 | R | A | -0.7508 | |
| 219 | R | A | -1.8200 | |
| 220 | Q | A | -1.4845 | |
| 221 | T | A | -0.2467 | |
| 222 | A | A | 0.0000 | |
| 223 | S | A | 0.2110 | |
| 224 | L | A | 1.4972 | |
| 225 | Q | A | 0.0313 | |
| 226 | P | A | -0.3073 | |
| 227 | G | A | -0.1282 | |
| 228 | I | A | 0.0000 | |
| 229 | S | A | -0.3075 | |
| 230 | E | A | -1.4193 | |
| 231 | D | A | -0.5647 | |
| 232 | L | A | -0.1991 | |
| 233 | K | A | -1.8105 | |
| 234 | K | A | -1.1018 | |
| 235 | V | A | 0.0000 | |
| 236 | K | A | -0.5025 | |
| 237 | D | A | -2.1630 | |
| 238 | R | A | -2.1754 | |
| 239 | M | A | 0.0000 | |
| 240 | G | A | -0.4663 | |
| 241 | I | A | 0.0000 | |
| 242 | D | A | -1.8285 | |
| 243 | S | A | -0.5804 | |
| 244 | S | A | -0.4081 | |
| 245 | D | A | -1.2087 | |
| 246 | K | A | -1.8587 | |
| 247 | V | A | 0.0000 | |
| 248 | D | A | -0.5541 | |
| 249 | F | A | 0.0000 | |
| 250 | F | A | 0.7655 | |
| 251 | I | A | 0.6042 | |
| 252 | L | A | 0.0000 | |
| 253 | L | A | 0.0000 | |
| 254 | D | A | -0.2484 | |
| 255 | N | A | 0.0000 | |
| 256 | V | A | 0.0000 | |
| 257 | A | A | 0.0192 | |
| 258 | A | A | 0.0000 | |
| 259 | E | A | 0.0000 | |
| 260 | Q | A | -0.7354 | |
| 261 | A | A | -0.1106 | |
| 262 | H | A | -0.3305 | |
| 263 | N | A | -1.3058 | |
| 264 | L | A | -0.0159 | |
| 265 | P | A | -0.2125 | |
| 266 | S | A | -0.0587 | |
| 267 | C | A | 0.0518 | |
| 268 | P | A | -0.2027 | |
| 269 | M | A | -0.0532 | |
| 270 | L | A | 0.0000 | |
| 271 | K | A | -1.9192 | |
| 272 | R | A | -2.0734 | |
| 273 | F | A | -0.1034 | |
| 274 | A | A | -0.2818 | |
| 275 | R | A | -1.8190 | |
| 276 | M | A | -0.2399 | |
| 277 | I | A | 0.0000 | |
| 278 | E | A | -0.4825 | |
| 279 | Q | A | -0.4032 | |
| 280 | R | A | -0.3654 | |
| 281 | A | A | 0.0000 | |
| 282 | V | A | 0.0000 | |
| 283 | D | A | -0.3211 | |
| 284 | T | A | 0.0000 | |
| 285 | S | A | 0.0119 | |
| 286 | L | A | 0.2739 | |
| 287 | Y | A | 0.4409 | |
| 288 | I | A | 0.2800 | |
| 289 | L | A | 0.0000 | |
| 290 | P | A | -0.3254 | |
| 291 | K | A | -2.0407 | |
| 292 | E | A | -2.1640 | |
| 293 | D | A | -0.7438 | |
| 294 | R | A | -1.5245 | |
| 295 | E | A | -1.6643 | |
| 296 | S | A | 0.0000 | |
| 297 | L | A | 0.0000 | |
| 298 | Q | A | -0.3306 | |
| 299 | M | A | 0.0000 | |
| 300 | A | A | 0.0000 | |
| 301 | V | A | 0.0000 | |
| 302 | G | A | 0.0000 | |
| 303 | P | A | 0.0000 | |
| 304 | F | A | 0.0000 | |
| 305 | L | A | 0.0000 | |
| 306 | H | A | -0.1660 | |
| 307 | I | A | 0.3252 | |
| 308 | L | A | 0.0000 | |
| 309 | E | A | -0.3675 | |
| 310 | S | A | -0.0646 | |
| 311 | N | A | 0.0000 | |
| 312 | L | A | 0.0000 | |
| 313 | L | A | 0.4820 | |
| 314 | K | A | -0.5615 | |
| 315 | A | A | -0.0108 | |
| 316 | M | A | 0.2244 | |
| 317 | D | A | -1.7258 | |
| 318 | S | A | -0.5351 | |
| 319 | A | A | 0.0061 | |
| 320 | T | A | -0.0564 | |
| 321 | A | A | -0.2263 | |
| 322 | P | A | -0.5810 | |
| 323 | D | A | -2.1460 | |
| 324 | K | A | -1.9345 | |
| 325 | V | A | 0.1157 | mutated: IA325V |
| 326 | R | A | -0.5343 | |
| 327 | K | A | -0.8221 | |
| 328 | L | A | 0.0000 | |
| 329 | Y | A | 0.0000 | |
| 330 | L | A | 0.0000 | |
| 331 | Y | A | 0.0000 | |
| 332 | A | A | 0.0000 | |
| 333 | A | A | 0.0000 | |
| 334 | H | A | 0.0000 | |
| 335 | D | A | -0.0615 | |
| 336 | V | A | 1.0452 | |
| 337 | T | A | 0.0000 | |
| 338 | F | A | 0.0000 | |
| 339 | I | A | 0.0000 | |
| 340 | P | A | 0.0000 | |
| 341 | L | A | 0.0000 | |
| 342 | L | A | 0.0000 | |
| 343 | M | A | 0.0000 | |
| 344 | T | A | 0.0000 | |
| 345 | L | A | 0.0000 | |
| 346 | G | A | -0.4708 | |
| 347 | I | A | 0.0000 | |
| 348 | F | A | 0.1075 | |
| 349 | D | A | -0.9775 | |
| 350 | H | A | -0.8641 | |
| 351 | K | A | -1.5543 | |
| 352 | W | A | -0.1186 | |
| 353 | P | A | 0.0000 | |
| 354 | P | A | -0.0513 | |
| 355 | F | A | 0.2068 | |
| 356 | A | A | 0.0483 | |
| 357 | V | A | 0.0000 | |
| 358 | D | A | 0.0000 | |
| 359 | L | A | 0.0000 | |
| 360 | T | A | 0.0000 | |
| 361 | M | A | 0.0000 | |
| 362 | E | A | 0.0000 | |
| 363 | L | A | 0.0000 | |
| 364 | Y | A | 0.0000 | |
| 365 | Q | A | -0.1608 | |
| 366 | H | A | -0.1991 | |
| 367 | L | A | 0.2428 | |
| 368 | E | A | -1.7303 | |
| 369 | S | A | -0.7539 | |
| 370 | K | A | -2.0636 | |
| 371 | E | A | -2.1004 | |
| 372 | W | A | -0.1936 | |
| 373 | F | A | 0.0000 | |
| 374 | V | A | 0.0000 | |
| 375 | Q | A | -0.1179 | |
| 376 | L | A | 0.0000 | |
| 377 | Y | A | -0.0597 | |
| 378 | Y | A | 0.0000 | |
| 379 | H | A | -0.6895 | |
| 380 | G | A | -0.8534 | |
| 381 | K | A | -2.1115 | |
| 382 | E | A | -2.1362 | |
| 383 | Q | A | -0.1668 | |
| 384 | V | A | 1.7349 | |
| 385 | P | A | 0.0000 | |
| 386 | R | A | -0.9256 | |
| 387 | G | A | -0.5994 | |
| 388 | C | A | -0.0619 | |
| 389 | P | A | -0.5746 | |
| 390 | D | A | -1.8494 | |
| 391 | G | A | -0.1629 | |
| 392 | L | A | 0.1730 | |
| 393 | C | A | 0.0000 | |
| 394 | P | A | -0.0566 | |
| 395 | L | A | 0.0000 | |
| 396 | D | A | -1.7072 | |
| 397 | M | A | 0.1240 | |
| 398 | F | A | 0.0000 | |
| 399 | L | A | 0.0338 | |
| 400 | N | A | -1.2222 | |
| 401 | A | A | -0.2278 | |
| 402 | M | A | 0.0000 | |
| 403 | S | A | -0.0912 | |
| 404 | V | A | 0.4840 | |
| 405 | Y | A | 0.0000 | |
| 406 | T | A | -0.0302 | |
| 407 | L | A | 0.0000 | |
| 408 | S | A | -0.1119 | |
| 409 | P | A | -0.5004 | |
| 410 | E | A | -2.1399 | |
| 411 | K | A | -1.9299 | |
| 412 | Y | A | 0.0000 | |
| 413 | H | A | -0.9793 | |
| 414 | A | A | -0.0409 | |
| 415 | L | A | 0.4843 | |
| 416 | C | A | 0.2385 | |
| 417 | S | A | -0.3461 | |
| 418 | Q | A | -1.2392 | |
| 419 | T | A | -0.2918 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine