Project name: 244112f9b481160

Chain sequence(s)	A: HKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAAL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.7768
• Maximal score value: 1.0622
• Average score: -1.261
• Total score value: -732.6288

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
3	H	A	-2.3707
4	K	A	-3.1830
5	S	A	0.0000
6	E	A	-2.0564
7	V	A	0.0000
8	A	A	0.0000
9	H	A	-2.3838
10	R	A	-1.9441
11	F	A	0.0000
12	K	A	-3.1393
13	D	A	-2.8334
14	L	A	-2.0480
15	G	A	-2.4936
16	E	A	-3.2477
17	E	A	-2.8548
18	N	A	-1.8980
19	F	A	0.0000
20	K	A	-2.0144
21	A	A	0.0000
22	L	A	-0.3252
23	V	A	-0.0462
24	L	A	0.0000
25	I	A	0.0000
26	A	A	0.2575
27	F	A	0.0000
28	A	A	0.0000
29	Q	A	0.0000
30	Y	A	0.0000
31	L	A	0.0000
32	Q	A	0.0000
33	Q	A	-1.3553
34	C	A	0.0000
35	P	A	-1.4305
36	F	A	-1.6696
37	E	A	-2.8286
38	D	A	-2.7579
39	H	A	0.0000
40	V	A	-2.0753
41	K	A	-3.1425
42	L	A	-2.2775
43	V	A	0.0000
44	N	A	-3.0566
45	E	A	-3.3414
46	V	A	-1.9888
47	T	A	0.0000
48	E	A	-2.9297
49	F	A	-1.8449
50	A	A	0.0000
51	K	A	-2.3171
52	T	A	-1.6622
53	C	A	0.0000
54	V	A	-1.2233
55	A	A	-1.0246
56	D	A	-2.3409
57	E	A	-3.0247
58	S	A	-2.3721
59	A	A	-2.1881
60	E	A	-3.2136
61	N	A	-3.0397
62	C	A	0.0000
63	D	A	-3.7768
64	K	A	-2.5182
65	S	A	-1.2624
66	L	A	-0.3920
67	H	A	-0.3781
68	T	A	-0.7005
69	L	A	-0.6595
70	F	A	-0.0111
71	G	A	0.0000
72	D	A	-0.6987
73	K	A	-0.7770
74	L	A	0.0000
75	C	A	-0.4659
76	T	A	-0.1630
77	V	A	-0.3249
78	A	A	-0.4291
79	T	A	-1.1166
80	L	A	0.0000
81	R	A	-3.3723
82	E	A	-2.9498
83	T	A	-1.8881
84	Y	A	-1.9429
85	G	A	-2.6990
86	E	A	-3.0656
87	M	A	0.0000
88	A	A	-2.3154
89	D	A	-2.8023
90	C	A	0.0000
91	C	A	-1.5906
92	A	A	-1.4195
93	K	A	-2.7562
94	Q	A	-2.3743
95	E	A	-2.0025
96	P	A	-2.0013
97	E	A	-2.7855
98	R	A	0.0000
99	N	A	-1.9469
100	E	A	-2.9380
101	C	A	-2.3053
102	F	A	0.0000
103	L	A	-1.8112
104	Q	A	-2.1812
105	H	A	-2.0485
106	K	A	-1.8507
107	D	A	-2.8694
108	D	A	-2.4822
109	N	A	-2.4817
110	P	A	-2.1687
111	N	A	-2.1274
112	L	A	-1.1310
113	P	A	-0.8509
114	R	A	-1.3393
115	L	A	0.5593
116	V	A	0.9176
117	R	A	-0.6455
118	P	A	-0.7617
119	E	A	-1.8298
120	V	A	0.0000
121	D	A	-1.5814
122	V	A	0.1790
123	M	A	0.0000
124	C	A	0.0000
125	T	A	-1.0325
126	A	A	-1.3910
127	F	A	0.0000
128	H	A	-2.6810
129	D	A	-3.2803
130	N	A	-3.2915
131	E	A	-3.4333
132	E	A	-3.2367
133	T	A	-1.9322
134	F	A	0.0000
135	L	A	-1.3552
136	K	A	-1.2574
137	K	A	-1.0391
138	Y	A	0.1666
139	L	A	0.0000
140	Y	A	0.0000
141	E	A	0.0000
142	I	A	0.1589
143	A	A	0.0000
144	R	A	-0.7941
145	R	A	-1.3078
146	H	A	-0.8224
147	P	A	0.0000
148	Y	A	-0.5510
149	F	A	0.0000
150	Y	A	0.2450
151	A	A	0.0000
152	P	A	-0.0943
153	E	A	-0.2542
154	L	A	0.0000
155	L	A	0.0000
156	F	A	-0.5004
157	F	A	0.0000
158	A	A	-0.7535
159	K	A	-1.3847
160	R	A	-1.6168
161	Y	A	-1.2523
162	K	A	-1.6804
163	A	A	-1.3490
164	A	A	0.0000
165	F	A	0.0000
166	T	A	-1.7302
167	E	A	-2.2741
168	C	A	0.0000
169	C	A	0.0000
170	Q	A	-2.0938
171	A	A	-1.5513
172	A	A	-1.1471
173	D	A	-2.0524
174	K	A	-1.8424
175	A	A	-1.0501
176	A	A	-0.4718
177	C	A	-0.7891
178	L	A	0.0000
179	L	A	-0.1959
180	P	A	-0.8274
181	K	A	-1.4408
182	L	A	0.0000
183	D	A	-2.0925
184	E	A	-3.2270
185	L	A	0.0000
186	R	A	-2.8175
187	D	A	-3.1544
188	E	A	-2.9458
189	G	A	-2.3508
190	K	A	-2.8062
191	A	A	-1.7704
192	S	A	-1.4068
193	S	A	0.0000
194	A	A	-1.3206
195	K	A	-1.2341
196	Q	A	-0.9592
197	R	A	-1.2627
198	L	A	-0.9595
199	K	A	-1.1250
200	C	A	-1.1386
201	A	A	-1.0936
202	S	A	-1.1006
203	L	A	-1.6224
204	Q	A	-2.0278
205	K	A	-2.0981
206	F	A	-0.9836
207	G	A	-1.9380
208	E	A	-3.0914
209	R	A	-2.7145
210	A	A	-1.3568
211	F	A	-1.2966
212	K	A	-1.7561
213	A	A	-1.1682
214	W	A	-0.4694
215	A	A	0.0000
216	V	A	0.0000
217	A	A	0.0000
218	R	A	-0.7315
219	L	A	0.0000
220	S	A	0.0000
221	Q	A	0.0000
222	R	A	-1.8803
223	F	A	0.0000
224	P	A	0.0000
225	K	A	-2.5172
226	A	A	0.0000
227	E	A	-2.2883
228	F	A	-0.8749
229	A	A	-0.8480
230	E	A	-1.2993
231	V	A	0.0000
232	S	A	-0.9685
233	K	A	-1.8183
234	L	A	0.0000
235	V	A	0.0000
236	T	A	-1.6626
237	D	A	-2.0431
238	L	A	-1.1826
239	T	A	-1.6747
240	K	A	-2.0834
241	V	A	0.0000
242	H	A	-1.0754
243	T	A	-1.4648
244	E	A	-1.4731
245	C	A	-0.8451
246	C	A	-0.9409
247	H	A	-1.5340
248	G	A	-1.0518
249	D	A	-0.8979
250	L	A	-0.1981
251	L	A	-0.4123
252	E	A	-1.5672
253	C	A	0.0000
254	A	A	-0.9973
255	D	A	-1.7626
256	D	A	-2.0061
257	R	A	-1.8751
258	A	A	-1.6093
259	D	A	-2.6352
260	L	A	-1.7038
261	A	A	0.0000
262	K	A	-2.3645
263	Y	A	-1.5283
264	I	A	0.0000
265	C	A	-2.1956
266	E	A	-2.6193
267	N	A	-2.1431
268	Q	A	-2.4626
269	D	A	-2.9076
270	S	A	-2.1007
271	I	A	0.0000
272	S	A	0.0000
273	S	A	-2.2026
274	K	A	-2.6904
275	L	A	0.0000
276	K	A	-3.5850
277	E	A	-3.5401
278	C	A	0.0000
279	C	A	-2.7949
280	E	A	-3.2015
281	K	A	-2.4083
282	P	A	-1.1050
283	L	A	-0.4691
284	L	A	-0.3572
285	E	A	-1.0556
286	K	A	-1.3658
287	S	A	-1.0243
288	H	A	-0.8852
289	C	A	-1.3519
290	I	A	-1.3431
291	A	A	-1.0957
292	E	A	-2.3059
293	V	A	0.0000
294	E	A	-2.8590
295	N	A	-2.2853
296	D	A	0.0000
297	E	A	-2.5270
298	M	A	-1.5223
299	P	A	-1.3234
300	A	A	-1.1932
301	D	A	-1.6928
302	L	A	-0.7766
303	P	A	-0.8014
304	S	A	-0.6925
305	L	A	-0.6322
306	A	A	-0.8545
307	A	A	-1.6934
308	D	A	-2.6075
309	F	A	0.0000
310	V	A	-1.9563
311	E	A	-3.1039
312	S	A	-2.6576
313	K	A	-3.4212
314	D	A	-3.4118
315	V	A	0.0000
316	C	A	-2.3428
317	K	A	-3.4882
318	N	A	-2.9958
319	Y	A	0.0000
320	A	A	-2.3993
321	E	A	-2.8487
322	A	A	-1.8320
323	K	A	-2.5032
324	D	A	-1.8906
325	V	A	0.3096
326	F	A	-0.3892
327	L	A	0.0000
328	G	A	-0.0076
329	M	A	0.4084
330	F	A	0.0000
331	L	A	0.0000
332	Y	A	0.0000
333	E	A	-0.2255
334	Y	A	0.0000
335	A	A	0.0000
336	R	A	-1.1057
337	R	A	-0.6806
338	H	A	-0.6776
339	P	A	-1.1630
340	D	A	-1.4616
341	Y	A	-0.5570
342	S	A	0.0000
343	V	A	0.0000
344	V	A	-0.0088
345	L	A	0.0000
346	L	A	0.0000
347	L	A	0.0000
348	R	A	-0.6587
349	L	A	0.0000
350	A	A	-0.7975
351	K	A	-1.5294
352	T	A	-0.9151
353	Y	A	0.0000
354	E	A	-1.9753
355	T	A	-1.6188
356	T	A	-1.6873
357	L	A	0.0000
358	E	A	-2.8042
359	K	A	-2.5070
360	C	A	0.0000
361	C	A	-1.2396
362	A	A	-0.8930
363	A	A	-1.0780
364	A	A	-0.9518
365	D	A	-2.2040
366	P	A	-1.8924
367	H	A	-2.5429
368	E	A	-2.6855
369	C	A	-1.4014
370	Y	A	0.0000
371	A	A	-1.8022
372	K	A	-2.6483
373	V	A	0.0000
374	F	A	-1.4087
375	D	A	-3.0511
376	E	A	-2.6063
377	F	A	0.0000
378	K	A	-2.7454
379	P	A	-1.9486
380	L	A	-1.2370
381	V	A	-1.4134
382	E	A	-2.2194
383	E	A	-1.8219
384	P	A	0.0000
385	Q	A	-2.1106
386	N	A	-2.4792
387	L	A	-1.5233
388	I	A	-1.8949
389	K	A	-2.8563
390	Q	A	-2.5765
391	N	A	-2.0308
392	C	A	0.0000
393	E	A	-3.2286
394	L	A	-2.2795
395	F	A	-2.1983
396	E	A	-3.1302
397	Q	A	-2.4876
398	L	A	-1.5073
399	G	A	-1.5703
400	E	A	-1.8826
401	Y	A	-1.3417
402	K	A	-1.8072
403	F	A	0.0000
404	Q	A	0.0000
405	N	A	-0.9405
406	A	A	-0.7574
407	L	A	-0.4465
408	L	A	0.0000
409	V	A	0.0000
410	R	A	-1.2142
411	Y	A	-0.4964
412	T	A	0.0000
413	K	A	-1.0990
414	K	A	-0.9631
415	V	A	0.0000
416	P	A	0.0000
417	Q	A	-0.1788
418	V	A	0.0000
419	S	A	-0.2728
420	T	A	0.0000
421	P	A	-0.5373
422	T	A	-0.5613
423	L	A	0.0000
424	V	A	0.0000
425	E	A	-1.2131
426	V	A	0.0000
427	S	A	0.0000
428	R	A	-0.7905
429	N	A	-0.6607
430	L	A	-0.2696
431	G	A	0.0000
432	K	A	-1.1423
433	V	A	-0.6630
434	G	A	-1.3938
435	S	A	-1.7440
436	K	A	-2.0491
437	C	A	0.0000
438	C	A	-2.4996
439	K	A	-2.8710
440	H	A	-2.3077
441	P	A	-2.0679
442	E	A	-2.9499
443	A	A	-1.8547
444	K	A	-2.3132
445	R	A	-2.2501
446	M	A	-0.9634
447	P	A	-0.7018
448	C	A	-0.7949
449	A	A	-0.4139
450	E	A	-0.3931
451	D	A	-0.6768
452	Y	A	-0.1340
453	L	A	0.1629
454	S	A	-0.1631
455	V	A	-0.4057
456	V	A	-0.0117
457	L	A	0.0000
458	N	A	0.0321
459	Q	A	-0.1495
460	L	A	0.0000
461	C	A	0.0000
462	V	A	0.2608
463	L	A	-0.2613
464	H	A	0.0000
465	E	A	-2.0251
466	K	A	-2.0839
467	T	A	-1.0451
468	P	A	-0.9584
469	V	A	-0.0702
470	S	A	0.0000
471	D	A	-2.2756
472	R	A	-1.6914
473	V	A	0.0000
474	T	A	-2.0776
475	K	A	-2.7047
476	C	A	0.0000
477	C	A	0.0000
478	T	A	-1.7052
479	E	A	-1.8809
480	S	A	-1.0201
481	L	A	-0.1873
482	V	A	0.0000
483	N	A	-1.0628
484	R	A	-1.0760
485	R	A	-0.5441
486	P	A	-0.4099
487	C	A	-0.5833
488	F	A	-0.4721
489	S	A	-0.2876
490	A	A	-0.2188
491	L	A	-0.5368
492	E	A	-1.6098
493	V	A	-0.6213
494	D	A	-0.8511
495	E	A	-1.8042
496	T	A	-0.3168
497	Y	A	0.3525
498	V	A	1.0622
499	P	A	-0.1981
500	K	A	-1.0528
501	E	A	-1.8665
502	F	A	-1.2288
503	N	A	-1.5480
504	A	A	-1.3090
505	E	A	-1.8657
506	T	A	-0.9151
507	F	A	-0.5190
508	T	A	-0.9459
509	F	A	-1.0680
510	H	A	-1.8061
511	A	A	-1.9431
512	D	A	-2.2501
513	I	A	0.0000
514	C	A	-1.4233
515	T	A	-0.9440
516	L	A	-1.6357
517	S	A	-2.1727
518	E	A	-3.3189
519	K	A	-3.4875
520	E	A	-3.2847
521	R	A	-2.9404
522	Q	A	-2.2456
523	I	A	-1.5060
524	K	A	-1.5774
525	K	A	-0.9609
526	Q	A	0.0000
527	T	A	-0.5282
528	A	A	-0.2464
529	L	A	0.0000
530	V	A	0.0000
531	E	A	-0.3770
532	L	A	-0.0487
533	V	A	0.0000
534	K	A	0.0000
535	H	A	-1.0202
536	K	A	-1.1495
537	P	A	-1.0956
538	K	A	-2.1761
539	A	A	0.0000
540	T	A	-2.2797
541	K	A	-3.4033
542	E	A	-3.3082
543	Q	A	-2.2405
544	L	A	0.0000
545	K	A	-3.3115
546	A	A	-2.4014
547	V	A	-1.7727
548	M	A	-1.7977
549	D	A	-2.7912
550	D	A	-2.5489
551	F	A	-1.6351
552	A	A	-1.7925
553	A	A	-1.9981
554	F	A	0.0000
555	V	A	0.0000
556	E	A	-3.0264
557	K	A	-3.2769
558	C	A	0.0000
559	C	A	-2.9981
560	K	A	-3.4919
561	A	A	-3.2491
562	D	A	-3.1374
563	D	A	-3.4987
564	K	A	-3.5000
565	E	A	-2.7991
566	T	A	-2.0108
567	C	A	-2.7914
568	F	A	0.0000
569	A	A	-2.3295
570	E	A	-3.3187
571	E	A	-3.1554
572	G	A	-2.4357
573	K	A	-3.1859
574	K	A	-3.0834
575	L	A	-1.7385
576	V	A	-0.8251
577	A	A	-1.0523
578	A	A	-0.8075
579	S	A	-0.5138
580	Q	A	-0.6358
581	A	A	-0.1279
582	A	A	-0.0295
583	L	A	-0.2665