Project name: 2593f75256f35ed
Status: done
submitted: 2018-12-15 23:05:21, status changed: 2018-12-15 23:18:08
Settings
|
Chain sequence(s)
|
B: KRLSVNYVKGILQPTDTCDIWDKIWNFQAKPDDLLISTYPKAGTTWTQEIVELIQNEGDVEKSKRAPTHQRFPFLEMKIPSLGSGLEQAHAMPSPRILKTHLPFHLLPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAPGTWEEYFETFLAGKVCWGSWHEHVKGWWEAKDKHRILYLFYEDMKKNPKHEIQKLAEFIGKKLDDKVLDKIVHYTSFDVMKQNPMANYSSIPAEIMDHSISPFMRKGAVGDWKKHFTVAQNERFDEDYKKKMTDTRRLTFHFQF
|
| Distance of aggregation |
10 Å |
| Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-4.3724
-
Maximal score value
-
1.0302
-
Average score
-
-1.0028
-
Total score value
-
-288.8208
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
| residue index |
residue name |
chain |
Aggrescan3D score |
|
| 15 |
K |
B |
-2.3769 |
|
| 16 |
R |
B |
-1.7845 |
|
| 17 |
L |
B |
-0.9111 |
|
| 18 |
S |
B |
-0.7398 |
|
| 19 |
V |
B |
0.1245 |
|
| 20 |
N |
B |
-0.0642 |
|
| 21 |
Y |
B |
0.5205 |
|
| 22 |
V |
B |
-0.5601 |
|
| 23 |
K |
B |
-1.6918 |
|
| 24 |
G |
B |
-0.8373 |
|
| 25 |
I |
B |
0.0000 |
|
| 26 |
L |
B |
0.1093 |
|
| 27 |
Q |
B |
0.0000 |
|
| 28 |
P |
B |
-0.1041 |
|
| 29 |
T |
B |
-0.7238 |
|
| 30 |
D |
B |
-1.6080 |
|
| 31 |
T |
B |
-0.7788 |
|
| 32 |
C |
B |
-0.5976 |
|
| 33 |
D |
B |
-2.0975 |
|
| 34 |
I |
B |
-1.5192 |
|
| 35 |
W |
B |
0.0000 |
|
| 36 |
D |
B |
-3.0103 |
|
| 37 |
K |
B |
-3.1276 |
|
| 38 |
I |
B |
0.0000 |
|
| 39 |
W |
B |
-1.5003 |
|
| 40 |
N |
B |
-2.5014 |
|
| 41 |
F |
B |
0.0000 |
|
| 42 |
Q |
B |
-2.1808 |
|
| 43 |
A |
B |
0.0000 |
|
| 44 |
K |
B |
-2.6909 |
|
| 45 |
P |
B |
-2.6079 |
|
| 46 |
D |
B |
-2.7054 |
|
| 47 |
D |
B |
0.0000 |
|
| 48 |
L |
B |
0.0000 |
|
| 49 |
L |
B |
0.0000 |
|
| 50 |
I |
B |
0.0000 |
|
| 51 |
S |
B |
0.0000 |
|
| 52 |
T |
B |
0.0000 |
|
| 53 |
Y |
B |
0.0000 |
|
| 54 |
P |
B |
0.0000 |
|
| 55 |
K |
B |
-0.1733 |
|
| 56 |
A |
B |
0.0000 |
|
| 57 |
G |
B |
-0.0922 |
|
| 58 |
T |
B |
0.0000 |
|
| 59 |
T |
B |
0.0046 |
|
| 60 |
W |
B |
0.1517 |
|
| 61 |
T |
B |
0.0000 |
|
| 62 |
Q |
B |
0.0000 |
|
| 63 |
E |
B |
0.0000 |
|
| 64 |
I |
B |
0.0000 |
|
| 65 |
V |
B |
0.0000 |
|
| 66 |
E |
B |
0.0000 |
|
| 67 |
L |
B |
0.0000 |
|
| 68 |
I |
B |
0.0000 |
|
| 69 |
Q |
B |
-1.1881 |
|
| 70 |
N |
B |
-1.9764 |
|
| 71 |
E |
B |
-2.6809 |
|
| 72 |
G |
B |
0.0000 |
|
| 73 |
D |
B |
-2.6331 |
|
| 74 |
V |
B |
-2.1710 |
|
| 75 |
E |
B |
-3.2503 |
|
| 76 |
K |
B |
-3.0893 |
|
| 77 |
S |
B |
0.0000 |
|
| 78 |
K |
B |
-2.6147 |
|
| 79 |
R |
B |
-2.6207 |
|
| 80 |
A |
B |
-1.3892 |
|
| 81 |
P |
B |
-0.9002 |
|
| 82 |
T |
B |
0.0000 |
|
| 83 |
H |
B |
-0.5730 |
|
| 84 |
Q |
B |
-1.1494 |
|
| 85 |
R |
B |
0.0000 |
|
| 86 |
F |
B |
0.0000 |
|
| 87 |
P |
B |
0.0000 |
|
| 88 |
F |
B |
-0.1377 |
|
| 89 |
L |
B |
0.0000 |
|
| 90 |
E |
B |
0.0000 |
|
| 91 |
M |
B |
-0.2670 |
|
| 92 |
K |
B |
-0.8584 |
|
| 93 |
I |
B |
0.0000 |
|
| 94 |
P |
B |
-0.6151 |
|
| 95 |
S |
B |
-0.5956 |
|
| 96 |
L |
B |
-0.3181 |
|
| 97 |
G |
B |
-0.9155 |
|
| 98 |
S |
B |
-1.1111 |
|
| 99 |
G |
B |
0.0000 |
|
| 100 |
L |
B |
0.0000 |
|
| 101 |
E |
B |
-2.3321 |
|
| 102 |
Q |
B |
-1.5778 |
|
| 103 |
A |
B |
0.0000 |
|
| 104 |
H |
B |
-1.8510 |
|
| 105 |
A |
B |
-0.9632 |
|
| 106 |
M |
B |
-0.7081 |
|
| 107 |
P |
B |
-0.4541 |
|
| 108 |
S |
B |
-0.9936 |
|
| 109 |
P |
B |
-1.1303 |
|
| 110 |
R |
B |
0.0000 |
|
| 111 |
I |
B |
0.0000 |
|
| 112 |
L |
B |
0.0000 |
|
| 113 |
K |
B |
0.0000 |
|
| 114 |
T |
B |
0.0000 |
|
| 115 |
H |
B |
0.0000 |
|
| 116 |
L |
B |
0.0000 |
|
| 117 |
P |
B |
0.0000 |
|
| 118 |
F |
B |
-0.6655 |
|
| 119 |
H |
B |
-0.8918 |
|
| 120 |
L |
B |
0.0000 |
|
| 121 |
L |
B |
0.0000 |
|
| 122 |
P |
B |
0.0000 |
|
| 123 |
P |
B |
-1.1631 |
|
| 124 |
S |
B |
-1.8469 |
|
| 125 |
L |
B |
0.0000 |
|
| 126 |
L |
B |
-1.8995 |
|
| 127 |
E |
B |
-2.7520 |
|
| 128 |
K |
B |
-3.1723 |
|
| 129 |
N |
B |
-3.1085 |
|
| 130 |
C |
B |
0.0000 |
|
| 131 |
K |
B |
-1.3285 |
|
| 132 |
I |
B |
0.0000 |
|
| 133 |
I |
B |
0.0000 |
|
| 134 |
Y |
B |
0.0000 |
|
| 135 |
V |
B |
0.0000 |
|
| 136 |
A |
B |
0.0000 |
|
| 137 |
R |
B |
0.0000 |
|
| 138 |
N |
B |
0.0000 |
|
| 139 |
P |
B |
0.0000 |
|
| 140 |
K |
B |
0.0000 |
|
| 141 |
D |
B |
0.0000 |
|
| 142 |
N |
B |
0.0000 |
|
| 143 |
M |
B |
0.0000 |
|
| 144 |
V |
B |
0.0000 |
|
| 145 |
S |
B |
-0.2327 |
|
| 146 |
Y |
B |
0.0000 |
|
| 147 |
Y |
B |
-0.1860 |
|
| 148 |
H |
B |
-0.2889 |
|
| 149 |
F |
B |
-0.2250 |
|
| 150 |
Q |
B |
0.0000 |
|
| 151 |
R |
B |
-1.0595 |
|
| 152 |
M |
B |
0.0000 |
|
| 153 |
N |
B |
0.0000 |
|
| 154 |
K |
B |
-1.5484 |
|
| 155 |
A |
B |
0.0000 |
|
| 156 |
L |
B |
0.0000 |
|
| 157 |
P |
B |
-0.3730 |
|
| 158 |
A |
B |
-0.5201 |
|
| 159 |
P |
B |
-0.9766 |
|
| 160 |
G |
B |
-1.4009 |
|
| 161 |
T |
B |
-1.5433 |
|
| 162 |
W |
B |
-1.7325 |
|
| 163 |
E |
B |
-3.1781 |
|
| 164 |
E |
B |
-3.3899 |
|
| 165 |
Y |
B |
0.0000 |
|
| 166 |
F |
B |
0.0000 |
|
| 167 |
E |
B |
-3.2063 |
|
| 168 |
T |
B |
-2.2008 |
|
| 169 |
F |
B |
0.0000 |
|
| 170 |
L |
B |
0.0000 |
|
| 171 |
A |
B |
-1.0725 |
|
| 172 |
G |
B |
-1.3055 |
|
| 173 |
K |
B |
-1.9381 |
|
| 174 |
V |
B |
0.0000 |
|
| 175 |
C |
B |
0.0000 |
|
| 176 |
W |
B |
0.0000 |
|
| 177 |
G |
B |
0.0000 |
|
| 178 |
S |
B |
-0.8828 |
|
| 179 |
W |
B |
0.0000 |
|
| 180 |
H |
B |
0.0000 |
|
| 181 |
E |
B |
-1.6152 |
|
| 182 |
H |
B |
0.0000 |
|
| 183 |
V |
B |
0.0000 |
|
| 184 |
K |
B |
-1.7856 |
|
| 185 |
G |
B |
-1.4045 |
|
| 186 |
W |
B |
0.0000 |
|
| 187 |
W |
B |
-1.6185 |
|
| 188 |
E |
B |
-2.9911 |
|
| 189 |
A |
B |
0.0000 |
|
| 190 |
K |
B |
-2.6281 |
|
| 191 |
D |
B |
-3.5647 |
|
| 192 |
K |
B |
-3.3849 |
|
| 193 |
H |
B |
-2.9845 |
|
| 194 |
R |
B |
-2.3798 |
|
| 195 |
I |
B |
-1.2365 |
|
| 196 |
L |
B |
-0.1538 |
|
| 197 |
Y |
B |
0.0901 |
|
| 198 |
L |
B |
0.0000 |
|
| 199 |
F |
B |
0.0000 |
|
| 200 |
Y |
B |
0.0000 |
|
| 201 |
E |
B |
0.0000 |
|
| 202 |
D |
B |
-2.8679 |
|
| 203 |
M |
B |
0.0000 |
|
| 204 |
K |
B |
-2.2788 |
|
| 205 |
K |
B |
-3.2061 |
|
| 206 |
N |
B |
-2.9936 |
|
| 207 |
P |
B |
-2.6242 |
|
| 208 |
K |
B |
-2.9573 |
|
| 209 |
H |
B |
-2.5959 |
|
| 210 |
E |
B |
0.0000 |
|
| 211 |
I |
B |
0.0000 |
|
| 212 |
Q |
B |
-2.9635 |
|
| 213 |
K |
B |
-2.3468 |
|
| 214 |
L |
B |
0.0000 |
|
| 215 |
A |
B |
0.0000 |
|
| 216 |
E |
B |
-2.7433 |
|
| 217 |
F |
B |
-1.1491 |
|
| 218 |
I |
B |
0.0000 |
|
| 219 |
G |
B |
-1.5152 |
|
| 220 |
K |
B |
-2.4095 |
|
| 221 |
K |
B |
-3.1694 |
|
| 222 |
L |
B |
-3.2456 |
|
| 223 |
D |
B |
-3.9746 |
|
| 224 |
D |
B |
-4.2404 |
|
| 225 |
K |
B |
-3.7023 |
|
| 226 |
V |
B |
-3.1486 |
|
| 227 |
L |
B |
0.0000 |
|
| 228 |
D |
B |
-3.5262 |
|
| 229 |
K |
B |
-2.4484 |
|
| 230 |
I |
B |
0.0000 |
|
| 231 |
V |
B |
-1.4649 |
|
| 232 |
H |
B |
-1.2783 |
|
| 233 |
Y |
B |
-0.3254 |
|
| 234 |
T |
B |
0.0000 |
|
| 235 |
S |
B |
-0.6429 |
|
| 236 |
F |
B |
-1.3105 |
|
| 237 |
D |
B |
-2.3479 |
|
| 238 |
V |
B |
-1.2938 |
|
| 239 |
M |
B |
0.0000 |
|
| 240 |
K |
B |
-2.4886 |
|
| 241 |
Q |
B |
-2.1815 |
|
| 242 |
N |
B |
-1.4149 |
|
| 243 |
P |
B |
-0.9974 |
|
| 244 |
M |
B |
-0.9816 |
|
| 245 |
A |
B |
0.0000 |
|
| 246 |
N |
B |
-0.8446 |
|
| 247 |
Y |
B |
0.0000 |
|
| 248 |
S |
B |
-0.7219 |
|
| 249 |
S |
B |
-0.3188 |
|
| 250 |
I |
B |
0.0000 |
|
| 251 |
P |
B |
-0.7712 |
|
| 252 |
A |
B |
-1.1526 |
|
| 253 |
E |
B |
-2.3399 |
|
| 254 |
I |
B |
0.0000 |
|
| 255 |
M |
B |
0.0000 |
|
| 256 |
D |
B |
-1.0345 |
|
| 257 |
H |
B |
-0.5103 |
|
| 258 |
S |
B |
-0.1340 |
|
| 259 |
I |
B |
0.1941 |
|
| 260 |
S |
B |
-0.2300 |
|
| 261 |
P |
B |
-0.6459 |
|
| 262 |
F |
B |
-0.4189 |
|
| 263 |
M |
B |
-1.1682 |
|
| 264 |
R |
B |
-1.1980 |
|
| 265 |
K |
B |
-1.7440 |
|
| 266 |
G |
B |
-1.0998 |
|
| 267 |
A |
B |
-0.4347 |
|
| 268 |
V |
B |
-0.4517 |
|
| 269 |
G |
B |
-0.5176 |
|
| 270 |
D |
B |
0.0000 |
|
| 271 |
W |
B |
0.0000 |
|
| 272 |
K |
B |
-2.2264 |
|
| 273 |
K |
B |
-2.6410 |
|
| 274 |
H |
B |
-1.6203 |
|
| 275 |
F |
B |
0.0000 |
|
| 276 |
T |
B |
-0.5642 |
|
| 277 |
V |
B |
0.6343 |
|
| 278 |
A |
B |
-0.4379 |
|
| 279 |
Q |
B |
-1.5213 |
|
| 280 |
N |
B |
-1.8912 |
|
| 281 |
E |
B |
-3.1385 |
|
| 282 |
R |
B |
-3.6201 |
|
| 283 |
F |
B |
0.0000 |
|
| 284 |
D |
B |
-3.6352 |
|
| 285 |
E |
B |
-4.3724 |
|
| 286 |
D |
B |
-3.2184 |
|
| 287 |
Y |
B |
-2.8184 |
|
| 288 |
K |
B |
-3.7064 |
|
| 289 |
K |
B |
-3.5761 |
|
| 290 |
K |
B |
-2.7877 |
|
| 291 |
M |
B |
0.0000 |
|
| 292 |
T |
B |
-2.2456 |
|
| 293 |
D |
B |
-2.7420 |
|
| 294 |
T |
B |
-1.9591 |
|
| 295 |
R |
B |
-1.9867 |
|
| 296 |
L |
B |
0.0000 |
|
| 297 |
T |
B |
-0.4346 |
|
| 298 |
F |
B |
1.0302 |
|
| 299 |
H |
B |
-0.2477 |
|
| 300 |
F |
B |
0.0000 |
|
| 301 |
Q |
B |
-0.4353 |
|
| 302 |
F |
B |
0.6034 |
|
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine