Project name: 5d7z

Chain sequence(s)	A: VDWHKHDSKRMLHAVYRVGDLDRTIKYYTECFGMKLLRKRDVPDEKYTNAFLGFGPENTNNFAVELTYNYGVDDKYDIGTGFGHFAIANDDVYKLAENIKSKGGKITREPGPVKGGSTVIAFAQDPDGYMFELIQRADTPEPLCQVMLRVGDLERSIKFYEKALGMKLLRKKDVPDYKYTIAMLGYADEDKTTVLELTYNYGVTEYSKGNAYAQVAIGTNDVYKSAEAVDLATKELGGKILRQPGPLPGINTKIASFVDPDGWKVVLVDNTDFLKELHLEHHH
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.7088
• Maximal score value: 0.4812
• Average score: -1.0588
• Total score value: -297.5334

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
15	V	A	0.4812
16	D	A	-0.9629
17	W	A	-1.3332
18	H	A	-1.7885
19	K	A	-2.3837
20	H	A	-2.1684
21	D	A	-2.0958
22	S	A	-1.3615
23	K	A	-1.1512
24	R	A	-0.7561
25	M	A	0.0000
26	L	A	0.0000
27	H	A	0.0000
28	A	A	0.0000
29	V	A	0.0000
30	Y	A	0.0000
31	R	A	-1.1988
32	V	A	0.0000
33	G	A	-2.5273
34	D	A	-3.0139
35	L	A	0.0000
36	D	A	-3.4639
37	R	A	-3.7075
38	T	A	0.0000
39	I	A	0.0000
40	K	A	-3.5934
41	Y	A	-2.5192
42	Y	A	0.0000
43	T	A	-1.9500
44	E	A	-3.0644
45	C	A	0.0000
46	F	A	0.0000
47	G	A	-1.4619
48	M	A	0.0000
49	K	A	-1.8488
50	L	A	-0.8167
51	L	A	0.0000
52	R	A	0.0000
53	K	A	-2.2466
54	R	A	-2.1679
55	D	A	-2.9287
56	V	A	-2.3242
57	P	A	-2.6530
58	D	A	-3.3766
59	E	A	-3.6168
60	K	A	-3.2042
61	Y	A	-1.7293
62	T	A	-1.5348
63	N	A	0.0000
64	A	A	0.0000
65	F	A	0.0000
66	L	A	0.0000
67	G	A	0.0000
68	F	A	-0.1181
69	G	A	-0.4219
70	P	A	-0.6966
71	E	A	0.0000
72	N	A	-1.1597
73	T	A	-0.7416
74	N	A	-0.5333
75	F	A	0.0000
76	A	A	0.0000
77	V	A	0.0000
78	E	A	0.0000
79	L	A	0.0000
80	T	A	-0.3808
81	Y	A	-0.9064
82	N	A	-1.0964
83	Y	A	-0.6953
84	G	A	-0.8866
85	V	A	-0.8222
86	D	A	-2.6689
87	K	A	-3.1017
88	Y	A	-2.1355
89	D	A	-2.5191
90	I	A	-1.3339
91	G	A	-1.0943
92	T	A	-0.7726
93	G	A	0.0000
94	F	A	0.0000
95	G	A	0.0000
96	H	A	0.0000
97	F	A	0.0000
98	A	A	0.0000
99	I	A	0.0000
100	A	A	0.0000
101	N	A	-2.0718
102	D	A	-2.9944
103	D	A	-1.8354
104	V	A	0.0000
105	Y	A	-1.2128
106	K	A	-2.6101
107	L	A	0.0000
108	A	A	0.0000
109	E	A	-3.5002
110	N	A	-2.9293
111	I	A	0.0000
112	K	A	-3.5844
113	S	A	-2.7572
114	K	A	-3.2499
115	G	A	-2.2533
116	G	A	-2.4250
117	K	A	-2.2257
118	I	A	-1.6337
119	T	A	-0.8919
120	R	A	-1.4319
121	E	A	-2.0406
122	P	A	-1.1427
123	G	A	-0.6465
124	P	A	-0.8235
125	V	A	-0.7687
126	K	A	-1.7697
127	G	A	-1.4391
128	G	A	-1.1969
129	S	A	-0.7832
130	T	A	-0.4866
131	V	A	-0.5455
132	I	A	0.0000
133	A	A	0.0000
134	F	A	-0.4485
135	A	A	0.0000
136	Q	A	-0.6252
137	D	A	0.0000
138	P	A	-0.9985
139	D	A	-1.6383
140	G	A	-0.6280
141	Y	A	0.0000
142	M	A	0.0844
143	F	A	0.0000
144	E	A	-0.0608
145	L	A	0.0000
146	I	A	-0.5513
147	Q	A	-1.4842
148	R	A	-2.2982
149	A	A	-2.0808
150	D	A	-2.9629
151	T	A	-2.3631
152	P	A	-1.4434
153	E	A	0.0000
154	P	A	-0.9519
155	L	A	0.0000
156	C	A	-0.5975
157	Q	A	0.0000
158	V	A	0.0000
159	M	A	0.0000
160	L	A	0.0000
161	R	A	-0.7173
162	V	A	0.0000
163	G	A	0.0000
164	D	A	-2.0348
165	L	A	0.0000
166	E	A	-2.8428
167	R	A	-2.8345
168	S	A	0.0000
169	I	A	0.0000
170	K	A	-2.9663
171	F	A	0.0000
172	Y	A	0.0000
173	E	A	-2.4874
174	K	A	-2.2223
175	A	A	0.0000
176	L	A	0.0000
177	G	A	-1.7169
178	M	A	0.0000
179	K	A	-2.3251
180	L	A	-1.4247
181	L	A	-1.3733
182	R	A	-2.3922
183	K	A	-2.9907
184	K	A	-2.9977
185	D	A	-2.9235
186	V	A	-1.6767
187	P	A	-1.8387
188	D	A	-1.9315
189	Y	A	-0.7631
190	K	A	-1.8569
191	Y	A	-1.0962
192	T	A	0.0000
193	I	A	-1.2571
194	A	A	0.0000
195	M	A	0.0000
196	L	A	0.0000
197	G	A	0.0000
198	Y	A	-0.8107
199	A	A	-1.7145
200	D	A	-3.2271
201	E	A	-2.8526
202	D	A	-3.7088
203	K	A	-3.5104
204	T	A	-1.9510
205	T	A	0.0000
206	V	A	0.0000
207	L	A	0.0000
208	E	A	0.0000
209	L	A	0.0000
210	T	A	0.0000
211	Y	A	-0.6383
212	N	A	-0.5487
213	Y	A	-0.2821
214	G	A	-0.5826
215	V	A	-0.1729
216	T	A	-0.9814
217	E	A	-2.0085
218	Y	A	-1.0612
219	S	A	-1.2218
220	K	A	-1.4849
221	G	A	-1.5235
222	N	A	-1.8115
223	A	A	0.0000
224	Y	A	0.0000
225	A	A	-0.5594
226	Q	A	-0.3573
227	V	A	0.0000
228	A	A	0.0000
229	I	A	0.0000
230	G	A	0.0000
231	T	A	0.0000
232	N	A	-2.0114
233	D	A	-1.3225
234	V	A	0.0000
235	Y	A	-0.8584
236	K	A	-1.7922
237	S	A	0.0000
238	A	A	0.0000
239	E	A	-2.1616
240	A	A	0.0000
241	V	A	0.0000
242	D	A	-2.7839
243	L	A	-0.9015
244	A	A	0.0000
245	T	A	-2.4219
246	K	A	-2.8506
247	E	A	-2.9445
248	L	A	0.0000
249	G	A	-1.8159
250	G	A	-1.7438
251	K	A	-2.0227
252	I	A	-1.3241
253	L	A	-0.1958
254	R	A	-1.5576
255	Q	A	-1.6448
256	P	A	-1.1060
257	G	A	-0.8545
258	P	A	-0.8267
259	L	A	-0.2384
260	P	A	-0.3920
261	G	A	-0.1433
262	I	A	0.4277
263	N	A	-0.8826
264	T	A	0.0000
265	K	A	-0.8221
266	I	A	-0.7589
267	A	A	0.0000
268	S	A	0.0000
269	F	A	0.0000
270	V	A	-0.5620
271	D	A	0.0000
272	P	A	-1.0353
273	D	A	-1.2539
274	G	A	-0.9791
275	W	A	0.0000
276	K	A	-0.6764
277	V	A	0.0000
278	V	A	0.0000
279	L	A	0.0000
280	V	A	0.0000
281	D	A	-1.1443
282	N	A	-1.3130
283	T	A	-1.0640
284	D	A	-1.4295
285	F	A	0.0000
286	L	A	-1.0920
287	K	A	-1.8555
288	E	A	-1.3424
289	L	A	0.0000
290	H	A	-2.4227
291	L	A	-1.7001
292	E	A	-2.5564
293	H	A	-2.3160
294	H	A	-2.3070
295	H	A	-2.0038