Project name: 27d2451c73f5ff

Chain sequence(s)	A: DQGPNVCALQQILGTKKKYFSTCKNWYKKSICGQKTTVLYECCPGYMRMEGMKGCPAVLPIDHVYGTLGIVGATTTQRYSDASKLREEIEGKGSFTYFAPSNEAWDNLDSDIRRGLESNVNVELLNALHSHMINKRMLTKDLKNGMIIPSMYNNLGLFINHYPNGVVTVNCARIIHGNQIATNGVVHVIDRVLTQIGTSIQDFIEAEDDLSSFRAAAITSDILEALGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSESIMGGAVFETLEGNTIEIGCDGDSITVNGIKMVNKKDIVTNNGVIHLIDQVLIPDSAKQVIELAGKQQTTFTDLVAQLGLASALRPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKVGLNELYNGQILETIGGKQLRVFVYRTAVCIENSCMEKGSKQGRNGAIHIFREIIKPAEKSLHEKLKQDKRFSTFLSLLEAADLKELLTQPGDWTLFVPTNDAFKGMTSEEKEILIRDKNALQNIILYHLTPGVFIGKGFEPGVTNILKTTQGSKIFLKEVNDTLLVNELKSKESDIMTTNGVIHVVDKLLYPA
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.7538
• Maximal score value: 2.5581
• Average score: -0.9523
• Total score value: -565.6757

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
38	D	A	-2.6368
39	Q	A	-2.6737
40	G	A	-1.9587
41	P	A	-1.4843
42	N	A	-1.1729
43	V	A	0.0000
44	C	A	0.0000
45	A	A	0.0000
46	L	A	0.5814
47	Q	A	0.0000
48	Q	A	-0.8109
49	I	A	0.0000
50	L	A	-0.7640
51	G	A	-1.0419
52	T	A	-1.6630
53	K	A	-2.3554
54	K	A	0.0000
55	K	A	-0.8353
56	Y	A	-0.0624
57	F	A	0.5303
58	S	A	-0.1228
59	T	A	-0.6863
60	C	A	-1.1514
61	K	A	-2.0159
62	N	A	-1.4956
63	W	A	-0.1461
64	Y	A	-0.5228
65	K	A	-1.4539
66	K	A	-2.4275
67	S	A	-2.1089
68	I	A	0.0000
69	C	A	0.0000
70	G	A	-2.0345
71	Q	A	-2.3529
72	K	A	-2.4856
73	T	A	-1.2129
74	T	A	-0.0086
75	V	A	0.6114
76	L	A	1.0803
77	Y	A	-0.2804
78	E	A	-1.7253
79	C	A	-0.9708
80	C	A	0.0000
81	P	A	0.4294
82	G	A	1.6226
83	Y	A	1.0533
84	M	A	0.4331
85	R	A	-1.8846
86	M	A	-1.1778
87	E	A	-2.2297
88	G	A	-1.5379
89	M	A	-1.2833
90	K	A	-2.6333
91	G	A	0.0000
92	C	A	0.0000
93	P	A	-0.2092
94	A	A	0.9939
95	V	A	2.5581
96	L	A	2.4585
97	P	A	1.4489
98	I	A	1.9104
99	D	A	0.0431
100	H	A	-0.9141
101	V	A	0.0000
102	Y	A	-1.3776
103	G	A	-0.2976
104	T	A	0.0000
105	L	A	0.0000
106	G	A	-0.2203
107	I	A	0.8243
108	V	A	0.3231
109	G	A	-0.1786
110	A	A	0.0000
111	T	A	-0.7759
112	T	A	-1.5129
113	T	A	0.0000
114	Q	A	-1.6025
115	R	A	-2.5171
116	Y	A	0.0000
117	S	A	0.0000
118	D	A	-2.5056
119	A	A	-1.7238
120	S	A	0.0000
121	K	A	-3.1856
122	L	A	0.0000
123	R	A	-3.4941
124	E	A	-3.7538
125	E	A	-2.9963
126	I	A	0.0000
127	E	A	-2.7359
128	G	A	-2.4984
129	K	A	-2.6206
130	G	A	-2.2369
131	S	A	-2.0216
132	F	A	0.0000
133	T	A	0.0000
134	Y	A	0.0000
135	F	A	0.0000
136	A	A	0.0000
137	P	A	0.0000
138	S	A	-1.3924
139	N	A	-2.1775
140	E	A	-3.3354
141	A	A	0.0000
142	W	A	0.0000
143	D	A	-3.4976
144	N	A	-3.1157
145	L	A	-1.9649
146	D	A	-2.4661
147	S	A	-2.2858
148	D	A	-2.2642
149	I	A	-0.3762
150	R	A	-1.9019
151	R	A	-2.7791
152	G	A	-1.7680
153	L	A	-1.3727
154	E	A	-1.9413
155	S	A	-1.4131
156	N	A	-1.5640
157	V	A	-1.0436
158	N	A	-1.4191
159	V	A	-0.2804
160	E	A	-1.5268
161	L	A	0.0000
162	L	A	-0.5995
163	N	A	-0.5628
164	A	A	-0.2652
165	L	A	0.0000
166	H	A	-0.5422
167	S	A	-0.4128
168	H	A	0.0000
169	M	A	0.0000
170	I	A	0.0000
171	N	A	-2.2549
172	K	A	-2.6296
173	R	A	-1.9223
174	M	A	-1.2942
175	L	A	-1.0052
176	T	A	-1.3655
177	K	A	-2.5160
178	D	A	-1.9583
179	L	A	0.0000
180	K	A	-2.6581
181	N	A	-2.2619
182	G	A	-0.9843
183	M	A	0.2011
184	I	A	1.7651
185	I	A	0.0000
186	P	A	-0.2988
187	S	A	0.0000
188	M	A	-0.8793
189	Y	A	-0.7608
190	N	A	-1.6520
191	N	A	-1.6440
192	L	A	-0.4989
193	G	A	0.0231
194	L	A	0.0000
195	F	A	0.5743
196	I	A	0.0000
197	N	A	0.0000
198	H	A	-1.9082
199	Y	A	-1.0908
200	P	A	-1.0556
201	N	A	-1.3724
202	G	A	-1.2727
203	V	A	0.0000
204	V	A	0.0000
205	T	A	0.0000
206	V	A	0.0000
207	N	A	0.0137
208	C	A	0.0000
209	A	A	0.0000
210	R	A	0.0000
211	I	A	0.1156
212	I	A	0.2327
213	H	A	-0.0962
214	G	A	-0.3605
215	N	A	-0.7104
216	Q	A	0.2735
217	I	A	0.7561
218	A	A	0.0000
219	T	A	-0.1988
220	N	A	0.0000
221	G	A	0.0000
222	V	A	0.0000
223	V	A	0.0000
224	H	A	0.0000
225	V	A	0.0000
226	I	A	0.0000
227	D	A	-0.9916
228	R	A	-1.2141
229	V	A	-0.6148
230	L	A	-0.1225
231	T	A	-0.4597
232	Q	A	-1.1056
233	I	A	-0.4005
234	G	A	-0.6620
235	T	A	-0.8119
236	S	A	0.0000
237	I	A	0.0000
238	Q	A	-2.0244
239	D	A	-2.0542
240	F	A	-1.4115
241	I	A	0.0000
242	E	A	-3.0062
243	A	A	-2.1853
244	E	A	-2.8227
245	D	A	-3.4173
246	D	A	-3.4929
247	L	A	0.0000
248	S	A	-1.9084
249	S	A	-1.0471
250	F	A	0.0000
251	R	A	-0.7515
252	A	A	0.1950
253	A	A	0.0000
254	A	A	0.0000
255	I	A	1.0893
256	T	A	-0.0510
257	S	A	0.0000
258	D	A	-1.7225
259	I	A	-1.0900
260	L	A	0.0000
261	E	A	-2.3335
262	A	A	-2.0353
263	L	A	0.0000
264	G	A	-2.4992
265	R	A	-3.4627
266	D	A	-3.1565
267	G	A	-2.2855
268	H	A	-2.0127
269	F	A	-1.0456
270	T	A	0.0000
271	L	A	0.0000
272	F	A	0.0000
273	A	A	0.0000
274	P	A	0.0000
275	T	A	-2.1933
276	N	A	-2.9747
277	E	A	-3.6639
278	A	A	0.0000
279	F	A	0.0000
280	E	A	-3.6544
281	K	A	-3.5123
282	L	A	-1.9533
283	P	A	-1.8755
284	R	A	-2.8858
285	G	A	-2.1440
286	V	A	-1.6972
287	L	A	-1.9838
288	E	A	-3.0520
289	R	A	-3.2859
290	I	A	0.0000
291	M	A	-1.5661
292	G	A	-1.8550
293	D	A	-1.7018
294	K	A	-1.6834
295	V	A	0.4618
296	A	A	0.0000
297	S	A	0.0000
298	E	A	-1.0968
299	A	A	-0.6486
300	L	A	0.0000
301	M	A	0.0000
302	K	A	-0.9705
303	Y	A	0.0000
304	H	A	0.0000
305	I	A	0.0000
306	L	A	0.0000
307	N	A	-1.6279
308	T	A	-1.0893
309	L	A	-0.6120
310	Q	A	0.0000
311	C	A	0.0000
312	S	A	0.0000
313	E	A	0.0000
314	S	A	0.0000
315	I	A	0.0000
316	M	A	-0.6093
317	G	A	-0.7586
318	G	A	-0.9926
319	A	A	0.0952
320	V	A	0.5633
321	F	A	-0.3432
322	E	A	-2.0161
323	T	A	0.0000
324	L	A	-0.9505
325	E	A	-1.2659
326	G	A	-1.4541
327	N	A	-1.6099
328	T	A	-1.2554
329	I	A	0.0000
330	E	A	-1.6077
331	I	A	0.0000
332	G	A	-1.2031
333	C	A	-1.6968
334	D	A	-2.7923
335	G	A	-2.3217
336	D	A	-2.6092
337	S	A	-2.1216
338	I	A	0.0000
339	T	A	-1.6225
340	V	A	0.0000
341	N	A	-1.4477
342	G	A	-1.3903
343	I	A	-0.8253
344	K	A	-2.2652
345	M	A	0.0000
346	V	A	-1.5615
347	N	A	-2.4359
348	K	A	-2.3209
349	K	A	-1.5156
350	D	A	-0.6303
351	I	A	-0.1112
352	V	A	-0.0803
353	T	A	0.0000
354	N	A	-1.7284
355	N	A	0.0000
356	G	A	0.0000
357	V	A	0.0000
358	I	A	0.0000
359	H	A	0.0000
360	L	A	-1.2058
361	I	A	0.0000
362	D	A	-2.4200
363	Q	A	-1.8159
364	V	A	-0.8764
365	L	A	0.0000
366	I	A	0.1017
367	P	A	0.0000
368	D	A	-1.6980
369	S	A	-1.0862
370	A	A	0.0000
371	K	A	-1.4096
372	Q	A	-1.6851
373	V	A	0.0000
374	I	A	-0.3937
375	E	A	-1.1656
376	L	A	0.0000
377	A	A	-1.0118
378	G	A	-1.5113
379	K	A	-2.4202
380	Q	A	-2.3572
381	Q	A	0.0000
382	T	A	-1.5435
383	T	A	-1.3630
384	F	A	0.0000
385	T	A	-1.4618
386	D	A	-2.0646
387	L	A	0.0000
388	V	A	0.0000
389	A	A	-1.2483
390	Q	A	-1.9409
391	L	A	-1.4375
392	G	A	-0.8507
393	L	A	0.0000
394	A	A	-0.7326
395	S	A	-0.6596
396	A	A	-0.7958
397	L	A	0.0000
398	R	A	-2.7534
399	P	A	-2.4872
400	D	A	-2.8115
401	G	A	-2.5447
402	E	A	-2.6806
403	Y	A	0.0000
404	T	A	0.0000
405	L	A	0.0000
406	L	A	0.0000
407	A	A	0.0000
408	P	A	0.0000
409	V	A	-1.7315
410	N	A	-1.7836
411	N	A	-1.9196
412	A	A	0.0000
413	F	A	0.0000
414	S	A	-1.6900
415	D	A	-2.4084
416	D	A	-2.4219
417	T	A	-1.3343
418	L	A	-0.7049
419	S	A	-1.3198
420	M	A	-1.2279
421	D	A	-2.0105
422	Q	A	-2.2182
423	R	A	-2.0299
424	L	A	-0.0956
425	L	A	0.0000
426	K	A	-0.9060
427	L	A	0.9403
428	I	A	0.0000
429	L	A	0.0000
430	Q	A	0.1146
431	N	A	-0.9569
432	H	A	0.0000
433	I	A	0.0000
434	L	A	0.0000
435	K	A	-1.8549
436	V	A	-0.1540
437	K	A	-0.9337
438	V	A	0.0000
439	G	A	0.0000
440	L	A	-0.6363
441	N	A	-1.6063
442	E	A	-1.8904
443	L	A	-0.3394
444	Y	A	0.3997
445	N	A	-0.4993
446	G	A	-0.7889
447	Q	A	-0.1519
448	I	A	-0.0782
449	L	A	0.0000
450	E	A	-2.5286
451	T	A	0.0000
452	I	A	-0.7936
453	G	A	-1.0161
454	G	A	-1.7852
455	K	A	-2.5068
456	Q	A	-2.3993
457	L	A	0.0000
458	R	A	-1.0541
459	V	A	0.0000
460	F	A	0.0000
461	V	A	0.0927
462	Y	A	-0.6630
463	R	A	-1.9053
464	T	A	-1.2018
465	A	A	-0.8487
466	V	A	0.0836
467	C	A	0.0000
468	I	A	0.0000
469	E	A	0.0000
470	N	A	-0.8981
471	S	A	0.0000
472	C	A	0.0000
473	M	A	0.0000
474	E	A	-2.9593
475	K	A	-2.8100
476	G	A	-1.7591
477	S	A	-1.3891
478	K	A	-1.5664
479	Q	A	-1.8921
480	G	A	0.0000
481	R	A	-1.4854
482	N	A	0.0000
483	G	A	0.0000
484	A	A	0.0000
485	I	A	0.0000
486	H	A	0.0000
487	I	A	0.0000
488	F	A	0.0000
489	R	A	-2.0354
490	E	A	-2.0850
491	I	A	0.0000
492	I	A	0.0000
493	K	A	-1.8190
494	P	A	-1.8094
495	A	A	-1.5934
496	E	A	-2.4721
497	K	A	-2.0764
498	S	A	-1.3831
499	L	A	0.0000
500	H	A	-1.9420
501	E	A	-2.3179
502	K	A	-2.0234
503	L	A	0.0000
504	K	A	-3.3559
505	Q	A	-3.2105
506	D	A	-2.9987
507	K	A	-3.4368
508	R	A	-3.4937
509	F	A	0.0000
510	S	A	-1.7767
511	T	A	-1.1046
512	F	A	0.0000
513	L	A	-1.0302
514	S	A	-0.8090
515	L	A	-0.3737
516	L	A	0.0000
517	E	A	-1.8901
518	A	A	-1.2725
519	A	A	-1.7407
520	D	A	-2.6612
521	L	A	-1.8183
522	K	A	-2.5354
523	E	A	-2.9226
524	L	A	-1.8324
525	L	A	0.0000
526	T	A	-1.7247
527	Q	A	-2.1275
528	P	A	-1.4157
529	G	A	-1.3542
530	D	A	-2.0430
531	W	A	-0.7582
532	T	A	0.0000
533	L	A	0.0000
534	F	A	0.0000
535	V	A	0.0000
536	P	A	0.0000
537	T	A	0.0000
538	N	A	-2.8332
539	D	A	-3.5198
540	A	A	-2.7667
541	F	A	0.0000
542	K	A	-3.2068
543	G	A	-2.1222
544	M	A	-1.8708
545	T	A	-2.2048
546	S	A	-2.2381
547	E	A	-2.8261
548	E	A	-2.4179
549	K	A	-2.1211
550	E	A	-2.2591
551	I	A	-0.4955
552	L	A	-1.0007
553	I	A	-0.9491
554	R	A	-2.2765
555	D	A	-2.5700
556	K	A	-3.0263
557	N	A	-2.8292
558	A	A	-1.7474
559	L	A	-1.3682
560	Q	A	-2.1121
561	N	A	-1.1669
562	I	A	-0.1121
563	I	A	0.0000
564	L	A	-0.2541
565	Y	A	0.0000
566	H	A	0.0000
567	L	A	0.0000
568	T	A	0.0000
569	P	A	-0.8703
570	G	A	-0.7714
571	V	A	0.0000
572	F	A	0.0086
573	I	A	0.0000
574	G	A	0.0000
575	K	A	-1.2809
576	G	A	0.0000
577	F	A	0.0000
578	E	A	-1.9660
579	P	A	-1.3776
580	G	A	-0.2877
581	V	A	1.0875
582	T	A	0.7239
583	N	A	0.0000
584	I	A	1.3664
585	L	A	0.0000
586	K	A	-1.9474
587	T	A	0.0000
588	T	A	-0.8746
589	Q	A	-1.1776
590	G	A	-1.2918
591	S	A	-1.3648
592	K	A	-1.6917
593	I	A	0.0000
594	F	A	0.6726
595	L	A	0.0000
596	K	A	-0.6836
597	E	A	-1.3990
598	V	A	-1.3851
599	N	A	-2.1290
600	D	A	-2.5154
601	T	A	-2.1592
602	L	A	0.0000
603	L	A	-1.5140
604	V	A	0.0000
605	N	A	-0.9688
606	E	A	-2.1590
607	L	A	-2.1670
608	K	A	-3.0415
609	S	A	0.0000
610	K	A	-3.1069
611	E	A	-2.6282
612	S	A	-1.5818
613	D	A	-0.4702
614	I	A	-0.0244
615	M	A	-0.3788
616	T	A	0.0000
617	T	A	-1.4992
618	N	A	0.0000
619	G	A	0.0000
620	V	A	0.0000
621	I	A	0.0000
622	H	A	0.0000
623	V	A	0.0000
624	V	A	0.0000
625	D	A	-3.3832
626	K	A	-2.8452
627	L	A	-0.7285
628	L	A	0.0000
629	Y	A	1.0795
630	P	A	0.1633
631	A	A	0.1965