Project name: SR1 monomer

Chain sequence(s)	A: IISALLEAEPPPLYSNHDPNQPPSEAYLMTSLTNLADRELVHVINWAKQIPGYTDLSLNDQVHLLESSWLEILIIGLVWRSMQHRGEKLVFAPDLIMDRDDSKAAGISEICDHILAIASKFAELNLTKEEYVCLKALVLVNSSSKRLESHDQIQKLQDDLTDALADAVAKSHPSEPRRLAKLLMLLSHVRHISSKGIEHLFDVKSEGTVPLYDLLLEMLDA
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.0557
• Maximal score value: 1.0555
• Average score: -1.0429
• Total score value: -230.4743

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	I	A	0.8457
3	I	A	0.1566
4	S	A	-0.1084
5	A	A	-0.3290
6	L	A	0.0000
7	L	A	-0.7463
8	E	A	-1.7796
9	A	A	-1.6804
10	E	A	-1.2976
11	P	A	-0.7589
12	P	A	-0.3798
13	P	A	-0.1658
14	L	A	0.1091
15	Y	A	0.4990
16	S	A	-0.5132
17	N	A	-1.7186
18	H	A	-2.0888
19	D	A	-2.6354
20	P	A	-2.1591
21	N	A	-2.4740
22	Q	A	-2.4410
23	P	A	-1.4436
24	P	A	-1.3875
25	S	A	-1.4143
26	E	A	-1.8206
27	A	A	-0.9604
28	Y	A	-0.9082
29	L	A	0.0000
30	M	A	0.0000
31	T	A	-0.2506
32	S	A	0.0000
33	L	A	-0.0578
34	T	A	0.0000
35	N	A	-0.4676
36	L	A	0.0000
37	A	A	-0.0555
38	D	A	-0.3488
39	R	A	-0.2461
40	E	A	-0.2153
41	L	A	0.0000
42	V	A	0.7730
43	H	A	-0.2668
44	V	A	0.0000
45	I	A	-0.0021
46	N	A	-1.3876
47	W	A	0.0000
48	A	A	0.0000
49	K	A	-1.9764
50	Q	A	-2.1705
51	I	A	0.0000
52	P	A	-0.7898
53	G	A	-1.2732
54	Y	A	0.0000
55	T	A	-1.2288
56	D	A	-1.8390
57	L	A	0.0000
58	S	A	-0.2599
59	L	A	0.6371
60	N	A	-0.5630
61	D	A	0.0000
62	Q	A	0.0000
63	V	A	0.1121
64	H	A	-0.8845
65	L	A	0.0000
66	L	A	0.0000
67	E	A	-1.1297
68	S	A	-0.6523
69	S	A	0.0000
70	W	A	0.0000
71	L	A	0.0086
72	E	A	0.0000
73	I	A	0.0000
74	L	A	0.2187
75	I	A	0.0000
76	I	A	0.0000
77	G	A	0.0000
78	L	A	0.0000
79	V	A	0.0000
80	W	A	-0.5729
81	R	A	-0.7887
82	S	A	0.0000
83	M	A	-2.0398
84	Q	A	-2.1785
85	H	A	-2.5775
86	R	A	-3.3911
87	G	A	-2.8406
88	E	A	-3.5684
89	K	A	-2.6802
90	L	A	0.0000
91	V	A	0.0000
92	F	A	0.4547
93	A	A	0.0000
94	P	A	-0.2046
95	D	A	-0.8553
96	L	A	0.0917
97	I	A	0.5080
98	M	A	0.0000
99	D	A	-2.6776
100	R	A	-3.4889
101	D	A	-3.6301
102	D	A	-3.0173
103	S	A	0.0000
104	K	A	-3.3449
105	A	A	-2.0681
106	A	A	-1.5620
107	G	A	-1.4867
108	I	A	0.0000
109	S	A	-2.4514
110	E	A	-2.6947
111	I	A	0.0000
112	C	A	0.0000
113	D	A	-2.2039
114	H	A	-1.3579
115	I	A	0.0000
116	L	A	0.0000
117	A	A	-1.1366
118	I	A	0.0000
119	A	A	0.0000
120	S	A	-2.3124
121	K	A	-1.8453
122	F	A	0.0000
123	A	A	0.0000
124	E	A	-2.6346
125	L	A	-1.6227
126	N	A	-2.0124
127	L	A	0.0000
128	T	A	-1.2976
129	K	A	-1.9006
130	E	A	-1.2719
131	E	A	0.0000
132	Y	A	0.0000
133	V	A	0.0000
134	C	A	0.0000
135	L	A	0.0000
136	K	A	0.0000
137	A	A	0.0000
138	L	A	0.0000
139	V	A	0.0000
140	L	A	0.0000
141	V	A	0.0000
142	N	A	-1.8077
143	S	A	-1.0929
144	S	A	-1.4154
145	S	A	-1.8105
146	K	A	-3.1809
147	R	A	-2.5378
148	L	A	-0.8994
149	E	A	-2.5381
150	S	A	-2.6228
151	H	A	-3.2926
152	D	A	-3.7366
153	Q	A	-3.2273
154	I	A	0.0000
155	Q	A	-4.0349
156	K	A	-3.9034
157	L	A	-2.8669
158	Q	A	-3.2183
159	D	A	-4.0557
160	D	A	-3.6741
161	L	A	0.0000
162	T	A	-2.4876
163	D	A	-3.3999
164	A	A	0.0000
165	L	A	0.0000
166	A	A	-2.1127
167	D	A	-2.8044
168	A	A	-1.9513
169	V	A	0.0000
170	A	A	-2.1085
171	K	A	-2.6052
172	S	A	-1.7845
173	H	A	-2.0970
174	P	A	-1.5852
175	S	A	-1.2123
176	E	A	-1.7642
177	P	A	-1.7530
178	R	A	-2.5018
179	R	A	-1.4775
180	L	A	-0.6835
181	A	A	-0.5333
182	K	A	-0.8451
183	L	A	0.0000
184	L	A	0.7658
185	M	A	0.6507
186	L	A	0.0000
187	L	A	-0.2303
188	S	A	-0.7157
189	H	A	-1.0846
190	V	A	0.0000
191	R	A	-2.2037
192	H	A	-2.1209
193	I	A	0.0000
194	S	A	-1.4101
195	S	A	-1.7403
196	K	A	-2.2145
197	G	A	-1.4683
198	I	A	-0.9862
199	E	A	-2.1751
200	H	A	-1.5705
201	L	A	0.0000
202	F	A	-0.9587
203	D	A	-2.4552
204	V	A	0.0000
205	K	A	-1.6457
206	S	A	-1.9039
207	E	A	-2.6593
208	G	A	-1.5849
209	T	A	-1.2859
210	V	A	-0.3764
211	P	A	0.3984
212	L	A	1.0555
213	Y	A	-0.1314
214	D	A	-1.5771
215	L	A	-1.0510
216	L	A	0.0000
217	L	A	-1.2774
218	E	A	-2.7489
219	M	A	0.0000
220	L	A	0.0000
221	D	A	-2.1411
222	A	A	-1.4286