| Chain sequence(s) |
A: SLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDTGVEHVTFFIYNKIVD C: FSKLREQLGPVTQEFWDNLEKETEGLRQEMS B: SLPFGWLIVGVALLAVFQSASKIITLKKRWQLALSKGVHFVCNLLLLFVTVYSHLLLVAAGLEAPFLYLYALVYFLQSINFVRIIMRLWLCWKCRSKNPLLYDANYFLCWHTNCYDYCIPYNSVTSSIVITSGDGEHDYQIGGYTEKWESGVKDCVVLHSYFTSDYYQLYSTQLSTDTGVEHVTFFIYNKIVD D: FSKLREQLGPVTQEFWDNLEKETEGLRQEMS |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 40 | S | A | 0.0740 | |
| 41 | L | A | 0.8214 | |
| 42 | P | A | 0.4547 | |
| 43 | F | A | 0.9615 | |
| 44 | G | A | 0.6108 | |
| 45 | W | A | 1.4375 | |
| 46 | L | A | 0.0000 | |
| 47 | I | A | 0.0000 | |
| 48 | V | A | 0.9784 | |
| 49 | G | A | 0.0000 | |
| 50 | V | A | 0.0000 | |
| 51 | A | A | 0.0000 | |
| 52 | L | A | 0.8809 | |
| 53 | L | A | 0.0000 | |
| 54 | A | A | 0.0000 | |
| 55 | V | A | 1.0439 | |
| 56 | F | A | 0.9599 | |
| 57 | Q | A | 0.0000 | |
| 58 | S | A | 0.0000 | |
| 59 | A | A | 0.5899 | |
| 60 | S | A | 0.0651 | |
| 61 | K | A | -0.1480 | |
| 62 | I | A | 0.4943 | |
| 63 | I | A | 0.3952 | |
| 64 | T | A | -0.2597 | |
| 65 | L | A | -0.7288 | |
| 66 | K | A | -2.0285 | |
| 67 | K | A | -2.7779 | |
| 68 | R | A | -2.1786 | |
| 69 | W | A | -1.3825 | |
| 70 | Q | A | 0.0000 | |
| 71 | L | A | 0.0000 | |
| 72 | A | A | -0.5126 | |
| 73 | L | A | 0.4327 | |
| 74 | S | A | 0.0000 | |
| 75 | K | A | -0.0694 | |
| 76 | G | A | 0.4115 | |
| 77 | V | A | 0.0000 | |
| 78 | H | A | 0.7183 | |
| 79 | F | A | 2.1684 | |
| 80 | V | A | 1.7972 | |
| 81 | C | A | 0.0000 | |
| 82 | N | A | 0.0000 | |
| 83 | L | A | 1.9117 | |
| 84 | L | A | 1.5792 | |
| 85 | L | A | 0.0000 | |
| 86 | L | A | 1.3094 | |
| 87 | F | A | 1.4115 | |
| 88 | V | A | 0.0000 | |
| 89 | T | A | 0.0000 | |
| 90 | V | A | 1.4925 | |
| 91 | Y | A | 1.5453 | |
| 92 | S | A | 0.0000 | |
| 93 | H | A | 1.4212 | |
| 94 | L | A | 1.7713 | |
| 95 | L | A | 0.0000 | |
| 96 | L | A | 0.0000 | |
| 97 | V | A | 1.9147 | |
| 98 | A | A | 1.1342 | |
| 99 | A | A | 0.8561 | |
| 100 | G | A | 0.8539 | |
| 101 | L | A | 1.6044 | |
| 102 | E | A | 1.2674 | |
| 103 | A | A | 0.9634 | |
| 104 | P | A | 0.6746 | |
| 105 | F | A | 1.5167 | |
| 106 | L | A | 1.8936 | |
| 107 | Y | A | 2.0739 | |
| 108 | L | A | 1.8307 | |
| 109 | Y | A | 0.0000 | |
| 110 | A | A | 1.8359 | |
| 111 | L | A | 1.9319 | |
| 112 | V | A | 0.0000 | |
| 113 | Y | A | 2.0570 | |
| 114 | F | A | 2.7213 | |
| 115 | L | A | 1.9588 | |
| 116 | Q | A | 0.0000 | |
| 117 | S | A | 1.7799 | |
| 118 | I | A | 2.1053 | |
| 119 | N | A | 0.0000 | |
| 120 | F | A | 2.4703 | |
| 121 | V | A | 2.3098 | |
| 122 | R | A | 1.4076 | |
| 123 | I | A | 2.2088 | |
| 124 | I | A | 2.8467 | |
| 125 | M | A | 0.0000 | |
| 126 | R | A | 1.1291 | |
| 127 | L | A | 1.8184 | |
| 128 | W | A | 1.4579 | |
| 129 | L | A | 0.0000 | |
| 130 | C | A | 0.1142 | |
| 131 | W | A | 0.4511 | |
| 132 | K | A | -0.0549 | |
| 133 | C | A | 0.0000 | |
| 134 | R | A | -1.9399 | |
| 135 | S | A | -1.4201 | |
| 136 | K | A | -1.6072 | |
| 137 | N | A | 0.0000 | |
| 138 | P | A | 0.0000 | |
| 139 | L | A | -0.2550 | |
| 140 | L | A | 0.0000 | |
| 141 | Y | A | -0.9668 | |
| 142 | D | A | -1.6658 | |
| 143 | A | A | -0.9369 | |
| 144 | N | A | -0.6310 | |
| 145 | Y | A | -0.0747 | |
| 146 | F | A | 0.0000 | |
| 147 | L | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | W | A | 0.0000 | |
| 150 | H | A | -1.2403 | |
| 151 | T | A | -1.0523 | |
| 152 | N | A | -1.1798 | |
| 153 | C | A | -0.1751 | |
| 154 | Y | A | -0.6424 | |
| 155 | D | A | -1.3002 | |
| 156 | Y | A | 0.0000 | |
| 157 | C | A | 0.0000 | |
| 158 | I | A | 0.0000 | |
| 159 | P | A | 0.0000 | |
| 160 | Y | A | 0.0000 | |
| 161 | N | A | -0.3134 | |
| 162 | S | A | 0.0804 | |
| 163 | V | A | 0.6492 | |
| 164 | T | A | 0.1518 | |
| 165 | S | A | -0.2184 | |
| 166 | S | A | 0.0000 | |
| 167 | I | A | 0.0000 | |
| 168 | V | A | 0.2496 | |
| 169 | I | A | 0.0000 | |
| 170 | T | A | 0.0000 | |
| 171 | S | A | 0.0000 | |
| 172 | G | A | -2.1393 | |
| 173 | D | A | -3.0475 | |
| 174 | G | A | -2.2254 | |
| 181 | E | A | -2.7320 | |
| 182 | H | A | -2.5889 | |
| 183 | D | A | -1.7926 | |
| 184 | Y | A | 0.0000 | |
| 185 | Q | A | 0.0000 | |
| 186 | I | A | 0.0000 | |
| 187 | G | A | 0.0117 | |
| 188 | G | A | 0.0000 | |
| 189 | Y | A | 0.0867 | |
| 190 | T | A | -0.4229 | |
| 191 | E | A | 0.0000 | |
| 192 | K | A | -1.5932 | |
| 193 | W | A | -1.4274 | |
| 194 | E | A | -1.3088 | |
| 195 | S | A | -0.9251 | |
| 196 | G | A | -0.7834 | |
| 197 | V | A | -0.6893 | |
| 198 | K | A | -1.7072 | |
| 199 | D | A | -1.9192 | |
| 200 | C | A | -0.5677 | |
| 201 | V | A | 0.0000 | |
| 202 | V | A | 0.0000 | |
| 203 | L | A | 0.0000 | |
| 204 | H | A | 0.0000 | |
| 205 | S | A | 0.2812 | |
| 206 | Y | A | 0.1734 | |
| 207 | F | A | 0.1246 | |
| 208 | T | A | 0.1287 | |
| 209 | S | A | 0.3052 | |
| 210 | D | A | 0.6958 | |
| 211 | Y | A | 1.3611 | |
| 212 | Y | A | 0.0000 | |
| 213 | Q | A | -0.3194 | |
| 214 | L | A | -0.1774 | |
| 215 | Y | A | 0.4954 | |
| 216 | S | A | 0.2091 | |
| 217 | T | A | 0.1287 | |
| 218 | Q | A | 0.0000 | |
| 219 | L | A | -0.2120 | |
| 220 | S | A | -1.2598 | |
| 221 | T | A | -1.0818 | |
| 222 | D | A | -1.8295 | |
| 223 | T | A | 0.0000 | |
| 224 | G | A | -1.2149 | |
| 225 | V | A | 0.0000 | |
| 226 | E | A | -2.5717 | |
| 227 | H | A | -2.4394 | |
| 228 | V | A | 0.0000 | |
| 229 | T | A | -0.6280 | |
| 230 | F | A | 0.0000 | |
| 231 | F | A | 0.3483 | |
| 232 | I | A | 0.0000 | |
| 233 | Y | A | 0.0000 | |
| 234 | N | A | 0.0611 | |
| 235 | K | A | 0.5519 | |
| 236 | I | A | 1.2838 | |
| 237 | V | A | 1.3100 | |
| 238 | D | A | -0.7631 | |
| 40 | S | B | 0.0769 | |
| 41 | L | B | 0.8293 | |
| 42 | P | B | 0.6656 | |
| 43 | F | B | 1.3157 | |
| 44 | G | B | 0.9296 | |
| 45 | W | B | 1.6840 | |
| 46 | L | B | 0.0000 | |
| 47 | I | B | 0.0000 | |
| 48 | V | B | 1.4027 | |
| 49 | G | B | 0.0000 | |
| 50 | V | B | 0.0000 | |
| 51 | A | B | 0.0000 | |
| 52 | L | B | 0.9942 | |
| 53 | L | B | 0.0000 | |
| 54 | A | B | 0.0000 | |
| 55 | V | B | 1.0226 | |
| 56 | F | B | 0.9040 | |
| 57 | Q | B | 0.0000 | |
| 58 | S | B | 0.0000 | |
| 59 | A | B | 0.6234 | |
| 60 | S | B | 0.1843 | |
| 61 | K | B | -0.0033 | |
| 62 | I | B | 0.5758 | |
| 63 | I | B | 0.4382 | |
| 64 | T | B | -0.1230 | |
| 65 | L | B | -0.5186 | |
| 66 | K | B | -1.8252 | |
| 67 | K | B | -2.2299 | |
| 68 | R | B | -2.1247 | |
| 69 | W | B | -1.2343 | |
| 70 | Q | B | 0.0000 | |
| 71 | L | B | 0.0000 | |
| 72 | A | B | -0.4063 | |
| 73 | L | B | 0.3490 | |
| 74 | S | B | 0.0000 | |
| 75 | K | B | -0.0048 | |
| 76 | G | B | 0.3240 | |
| 77 | V | B | 0.0000 | |
| 78 | H | B | 0.5939 | |
| 79 | F | B | 1.6807 | |
| 80 | V | B | 1.7527 | |
| 81 | C | B | 0.0000 | |
| 82 | N | B | 1.3606 | |
| 83 | L | B | 2.3590 | |
| 84 | L | B | 1.8308 | |
| 85 | L | B | 0.0000 | |
| 86 | L | B | 1.5615 | |
| 87 | F | B | 1.7133 | |
| 88 | V | B | 0.0000 | |
| 89 | T | B | 0.0000 | |
| 90 | V | B | 1.4629 | |
| 91 | Y | B | 0.0000 | |
| 92 | S | B | 0.0000 | |
| 93 | H | B | 1.4334 | |
| 94 | L | B | 1.8120 | |
| 95 | L | B | 0.0000 | |
| 96 | L | B | 0.0000 | |
| 97 | V | B | 1.9982 | |
| 98 | A | B | 1.1421 | |
| 99 | A | B | 0.8716 | |
| 100 | G | B | 0.8580 | |
| 101 | L | B | 1.6066 | |
| 102 | E | B | 1.3076 | |
| 103 | A | B | 0.9772 | |
| 104 | P | B | 0.7073 | |
| 105 | F | B | 1.3185 | |
| 106 | L | B | 1.9917 | |
| 107 | Y | B | 2.0626 | |
| 108 | L | B | 1.7669 | |
| 109 | Y | B | 0.0000 | |
| 110 | A | B | 1.8602 | |
| 111 | L | B | 2.0558 | |
| 112 | V | B | 0.0000 | |
| 113 | Y | B | 2.0486 | |
| 114 | F | B | 2.7279 | |
| 115 | L | B | 1.9191 | |
| 116 | Q | B | 0.0000 | |
| 117 | S | B | 1.6753 | |
| 118 | I | B | 1.9456 | |
| 119 | N | B | 0.0000 | |
| 120 | F | B | 2.1113 | |
| 121 | V | B | 1.9746 | |
| 122 | R | B | 1.2130 | |
| 123 | I | B | 1.8644 | |
| 124 | I | B | 2.5215 | |
| 125 | M | B | 0.0000 | |
| 126 | R | B | 1.0506 | |
| 127 | L | B | 1.8734 | |
| 128 | W | B | 1.5953 | |
| 129 | L | B | 0.0000 | |
| 130 | C | B | 0.1995 | |
| 131 | W | B | 0.6176 | |
| 132 | K | B | 0.0000 | |
| 133 | C | B | 0.0000 | |
| 134 | R | B | -1.8807 | |
| 135 | S | B | -1.3767 | |
| 136 | K | B | -1.6311 | |
| 137 | N | B | 0.0000 | |
| 138 | P | B | 0.0000 | |
| 139 | L | B | -0.3014 | |
| 140 | L | B | 0.0000 | |
| 141 | Y | B | -0.9783 | |
| 142 | D | B | -1.6952 | |
| 143 | A | B | -0.9973 | |
| 144 | N | B | -0.6712 | |
| 145 | Y | B | 0.0000 | |
| 146 | F | B | 0.0000 | |
| 147 | L | B | 0.0000 | |
| 148 | C | B | 0.0000 | |
| 149 | W | B | 0.0000 | |
| 150 | H | B | -1.1258 | |
| 151 | T | B | -1.0242 | |
| 152 | N | B | -1.1642 | |
| 153 | C | B | -0.1805 | |
| 154 | Y | B | -0.6352 | |
| 155 | D | B | -1.2045 | |
| 156 | Y | B | 0.0000 | |
| 157 | C | B | 0.0000 | |
| 158 | I | B | 0.0000 | |
| 159 | P | B | 0.0000 | |
| 160 | Y | B | 0.0000 | |
| 161 | N | B | -0.3857 | |
| 162 | S | B | 0.0562 | |
| 163 | V | B | 0.6856 | |
| 164 | T | B | 0.1858 | |
| 165 | S | B | -0.2060 | |
| 166 | S | B | 0.0000 | |
| 167 | I | B | 0.0000 | |
| 168 | V | B | 0.2498 | |
| 169 | I | B | 0.0000 | |
| 170 | T | B | 0.0000 | |
| 171 | S | B | 0.0000 | |
| 172 | G | B | -2.1933 | |
| 173 | D | B | -3.0315 | |
| 174 | G | B | -2.2375 | |
| 181 | E | B | -2.8497 | |
| 182 | H | B | -2.8009 | |
| 183 | D | B | -2.0827 | |
| 184 | Y | B | 0.0000 | |
| 185 | Q | B | 0.0000 | |
| 186 | I | B | 0.0000 | |
| 187 | G | B | 0.0240 | |
| 188 | G | B | 0.0000 | |
| 189 | Y | B | 0.0942 | |
| 190 | T | B | -0.3774 | |
| 191 | E | B | 0.0000 | |
| 192 | K | B | -2.3093 | |
| 193 | W | B | -1.8183 | |
| 194 | E | B | -1.7949 | |
| 195 | S | B | -1.1412 | |
| 196 | G | B | -0.8558 | |
| 197 | V | B | -0.7313 | |
| 198 | K | B | -1.7584 | |
| 199 | D | B | -1.9452 | |
| 200 | C | B | -0.6136 | |
| 201 | V | B | 0.0000 | |
| 202 | V | B | 0.0000 | |
| 203 | L | B | 0.0000 | |
| 204 | H | B | 0.0000 | |
| 205 | S | B | 0.2318 | |
| 206 | Y | B | 0.1709 | |
| 207 | F | B | 0.0409 | |
| 208 | T | B | 0.0875 | |
| 209 | S | B | 0.2792 | |
| 210 | D | B | 0.5173 | |
| 211 | Y | B | 1.1144 | |
| 212 | Y | B | 0.0000 | |
| 213 | Q | B | -0.3598 | |
| 214 | L | B | -0.1681 | |
| 215 | Y | B | 0.5898 | |
| 216 | S | B | 0.2466 | |
| 217 | T | B | 0.1643 | |
| 218 | Q | B | 0.0000 | |
| 219 | L | B | -0.1175 | |
| 220 | S | B | -1.1861 | |
| 221 | T | B | -1.0122 | |
| 222 | D | B | -1.7286 | |
| 223 | T | B | 0.0000 | |
| 224 | G | B | -1.2025 | |
| 225 | V | B | 0.0000 | |
| 226 | E | B | -2.5558 | |
| 227 | H | B | -2.4225 | |
| 228 | V | B | 0.0000 | |
| 229 | T | B | -0.5906 | |
| 230 | F | B | 0.0000 | |
| 231 | F | B | 0.3681 | |
| 232 | I | B | 0.0000 | |
| 233 | Y | B | 0.0000 | |
| 234 | N | B | 0.0570 | |
| 235 | K | B | 0.5204 | |
| 236 | I | B | 1.0790 | |
| 237 | V | B | 1.2188 | |
| 238 | D | B | -0.7041 | |
| 25 | F | C | 1.1702 | |
| 26 | S | C | -0.4535 | |
| 27 | K | C | -1.7075 | |
| 28 | L | C | -0.3047 | |
| 29 | R | C | -0.8996 | |
| 30 | E | C | -2.2927 | |
| 31 | Q | C | -1.6499 | |
| 32 | L | C | -0.6937 | |
| 33 | G | C | -0.9121 | |
| 34 | P | C | -0.9907 | |
| 35 | V | C | -0.2276 | |
| 36 | T | C | -0.4950 | |
| 37 | Q | C | -1.6456 | |
| 38 | E | C | -1.9722 | |
| 39 | F | C | -0.1643 | |
| 40 | W | C | -1.3272 | |
| 41 | D | C | -2.5039 | |
| 42 | N | C | -3.0567 | |
| 43 | L | C | -2.2056 | |
| 44 | E | C | -3.0471 | |
| 45 | K | C | -3.8720 | |
| 46 | E | C | -3.5487 | |
| 47 | T | C | -2.7324 | |
| 48 | E | C | -3.5247 | |
| 49 | G | C | -2.0499 | |
| 50 | L | C | -0.5709 | |
| 51 | R | C | -1.5147 | |
| 52 | Q | C | -2.1005 | |
| 53 | E | C | -1.8468 | |
| 54 | M | C | -0.1200 | |
| 55 | S | C | -0.6310 | |
| 25 | F | D | 1.0324 | |
| 26 | S | D | -0.5778 | |
| 27 | K | D | -1.6914 | |
| 28 | L | D | -0.3634 | |
| 29 | R | D | -1.0182 | |
| 30 | E | D | -2.1309 | |
| 31 | Q | D | -1.3471 | |
| 32 | L | D | -0.3571 | |
| 33 | G | D | -0.6532 | |
| 34 | P | D | -0.6276 | |
| 35 | V | D | 0.5494 | |
| 36 | T | D | -0.0784 | |
| 37 | Q | D | -1.3336 | |
| 38 | E | D | -1.5359 | |
| 39 | F | D | 0.3052 | |
| 40 | W | D | -0.6895 | |
| 41 | D | D | -1.9797 | |
| 42 | N | D | -2.4895 | |
| 43 | L | D | -1.7672 | |
| 44 | E | D | -2.6169 | |
| 45 | K | D | -3.5414 | |
| 46 | E | D | -3.3598 | |
| 47 | T | D | -2.4947 | |
| 48 | E | D | -3.3818 | |
| 49 | G | D | -2.0100 | |
| 50 | L | D | -0.5206 | |
| 51 | R | D | -1.4018 | |
| 52 | Q | D | -2.0960 | |
| 53 | E | D | -1.8430 | |
| 54 | M | D | -0.1194 | |
| 55 | S | D | -0.6399 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine