| Chain sequence(s) |
A: AFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPEL C: GPWRSLTFYPAWLTVSEGANATFTCSLSNWSEDLMLNWNRLSPSNQTEKQAAFSNGLSQPVQDARFQIIQLPNRHDFHMNILDTRRNDSGIYLCGAISLHPKAKIEESPGAELVVTER B: RSLTFYPAWLTVSEGANATFTCSLSNWSEDLMLNWNRLSPSNQTEKQAAFSNGLSQPVQDARFQIIQLPNRHDFHMNILDTRRNDSGIYLCGAISLHPKAKIEESPGAELVVTERI |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 18 | A | A | -1.0075 | |
| 19 | F | A | 0.0000 | |
| 20 | T | A | -0.4494 | |
| 21 | V | A | 0.0000 | |
| 22 | T | A | -1.0026 | |
| 23 | V | A | -1.0196 | |
| 24 | P | A | -1.2519 | |
| 25 | K | A | -1.7416 | |
| 26 | D | A | -1.3056 | |
| 27 | L | A | 0.2684 | |
| 28 | Y | A | 0.4510 | |
| 29 | V | A | 1.0471 | |
| 30 | V | A | -0.1395 | |
| 31 | E | A | -1.4851 | |
| 32 | Y | A | -1.1613 | |
| 33 | G | A | -1.8228 | |
| 34 | S | A | -1.9206 | |
| 35 | N | A | -2.2627 | |
| 36 | M | A | 0.0000 | |
| 37 | T | A | -0.7389 | |
| 38 | I | A | 0.0000 | |
| 39 | E | A | -1.2828 | |
| 40 | C | A | 0.0000 | |
| 41 | K | A | -1.1548 | |
| 42 | F | A | 0.0000 | |
| 43 | P | A | -0.3491 | |
| 44 | V | A | -0.5235 | |
| 45 | E | A | -1.5462 | |
| 46 | K | A | -2.0862 | |
| 47 | Q | A | -1.3958 | |
| 48 | L | A | -0.4643 | |
| 49 | D | A | -0.5850 | |
| 50 | L | A | -0.2646 | |
| 51 | A | A | -0.3446 | |
| 52 | A | A | -0.0869 | |
| 53 | L | A | 0.0000 | |
| 54 | I | A | 0.0000 | |
| 55 | V | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | W | A | 0.0000 | |
| 58 | E | A | 0.0000 | |
| 59 | M | A | 0.0000 | |
| 60 | E | A | -2.7764 | |
| 61 | D | A | -3.3132 | |
| 62 | K | A | -2.5353 | |
| 63 | N | A | -1.5442 | |
| 64 | I | A | 0.0000 | |
| 65 | I | A | 0.0000 | |
| 66 | Q | A | 0.0000 | |
| 67 | F | A | 0.0000 | |
| 68 | V | A | -0.8776 | |
| 69 | H | A | -1.4408 | |
| 70 | G | A | -1.5353 | |
| 71 | E | A | -2.3101 | |
| 72 | E | A | -1.8760 | |
| 73 | D | A | -1.0152 | |
| 74 | L | A | -0.5375 | |
| 75 | K | A | -1.2261 | |
| 76 | V | A | -0.5705 | |
| 77 | Q | A | -1.0316 | |
| 78 | H | A | -1.5333 | |
| 79 | S | A | -1.4233 | |
| 80 | S | A | -1.3707 | |
| 81 | Y | A | 0.0000 | |
| 82 | R | A | -2.8055 | |
| 83 | Q | A | -2.6142 | |
| 84 | R | A | -2.4046 | |
| 85 | A | A | 0.0000 | |
| 86 | R | A | -2.6216 | |
| 87 | L | A | 0.0000 | |
| 88 | L | A | -1.3467 | |
| 89 | K | A | -2.3456 | |
| 90 | D | A | -2.1513 | |
| 91 | Q | A | -1.3040 | |
| 92 | L | A | 0.0000 | |
| 93 | S | A | -0.5627 | |
| 94 | L | A | 0.5148 | |
| 95 | G | A | 0.0000 | |
| 96 | N | A | -0.6830 | |
| 97 | A | A | 0.0000 | |
| 98 | A | A | 0.0000 | |
| 99 | L | A | 0.0000 | |
| 100 | Q | A | -1.3324 | |
| 101 | I | A | 0.0000 | |
| 102 | T | A | -2.1642 | |
| 103 | D | A | -2.6864 | |
| 104 | V | A | 0.0000 | |
| 105 | K | A | -2.3694 | |
| 106 | L | A | 0.0000 | |
| 107 | Q | A | -2.0945 | |
| 108 | D | A | 0.0000 | |
| 109 | A | A | -0.4951 | |
| 110 | G | A | -0.3819 | |
| 111 | V | A | 0.4561 | |
| 112 | Y | A | 0.0000 | |
| 113 | R | A | -0.4986 | |
| 114 | C | A | 0.0000 | |
| 115 | M | A | 0.0000 | |
| 116 | I | A | 0.0000 | |
| 117 | S | A | 0.0000 | |
| 118 | Y | A | 0.0000 | |
| 119 | G | A | -0.6641 | |
| 120 | G | A | -0.5365 | |
| 121 | A | A | 0.0000 | |
| 122 | D | A | 0.0000 | |
| 123 | Y | A | 0.0000 | |
| 124 | K | A | 0.0000 | |
| 125 | R | A | -0.4508 | |
| 126 | I | A | 0.0000 | |
| 127 | T | A | 0.0382 | |
| 128 | V | A | 0.0000 | |
| 129 | K | A | -1.0529 | |
| 130 | V | A | 0.0000 | |
| 131 | N | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | P | A | -1.1158 | |
| 134 | Y | A | 0.0000 | |
| 135 | N | A | -2.4422 | |
| 136 | K | A | -2.7971 | |
| 137 | I | A | -2.1051 | |
| 138 | N | A | -2.6331 | |
| 139 | Q | A | -2.4972 | |
| 140 | R | A | -2.1922 | |
| 141 | I | A | -0.0493 | |
| 142 | L | A | 0.7412 | |
| 143 | V | A | 1.7677 | |
| 144 | V | A | 0.8642 | |
| 145 | D | A | 0.2636 | |
| 146 | P | A | 0.9435 | |
| 147 | V | A | 1.4234 | |
| 148 | T | A | 0.3313 | |
| 149 | S | A | 0.0178 | |
| 150 | E | A | -0.8510 | |
| 151 | H | A | -0.3586 | |
| 152 | E | A | -0.7201 | |
| 153 | L | A | 0.0000 | |
| 154 | T | A | -1.5594 | |
| 155 | C | A | 0.0000 | |
| 156 | Q | A | -1.5925 | |
| 157 | A | A | 0.0000 | |
| 158 | E | A | -1.6966 | |
| 159 | G | A | 0.0000 | |
| 160 | Y | A | -0.5832 | |
| 161 | P | A | -0.9630 | |
| 162 | K | A | -2.0789 | |
| 163 | A | A | 0.0000 | |
| 164 | E | A | -2.5472 | |
| 165 | V | A | -1.3123 | |
| 166 | I | A | -0.2318 | |
| 167 | W | A | 0.0000 | |
| 168 | T | A | 0.0000 | |
| 169 | S | A | -0.9335 | |
| 170 | S | A | -1.3800 | |
| 171 | D | A | -2.3373 | |
| 172 | H | A | -1.9675 | |
| 173 | Q | A | -1.2246 | |
| 174 | V | A | 0.9213 | |
| 175 | L | A | 0.3700 | |
| 176 | S | A | -0.3657 | |
| 177 | G | A | -1.1583 | |
| 178 | K | A | -2.2558 | |
| 179 | T | A | -1.3305 | |
| 180 | T | A | -0.7829 | |
| 181 | T | A | -0.9452 | |
| 182 | T | A | -1.2858 | |
| 183 | N | A | -2.7677 | |
| 184 | S | A | 0.0000 | |
| 185 | K | A | -3.7929 | |
| 186 | R | A | -3.8154 | |
| 187 | E | A | -3.8460 | |
| 188 | E | A | -4.2999 | |
| 189 | K | A | -3.5401 | |
| 190 | L | A | 0.0000 | |
| 191 | F | A | -1.6114 | |
| 192 | N | A | -1.3766 | |
| 193 | V | A | 0.0000 | |
| 194 | T | A | -1.0178 | |
| 195 | S | A | 0.0000 | |
| 196 | T | A | -1.4726 | |
| 197 | L | A | 0.0000 | |
| 198 | R | A | -2.0304 | |
| 199 | I | A | -1.1430 | |
| 200 | N | A | -1.4518 | |
| 201 | T | A | -1.0376 | |
| 202 | T | A | -0.9983 | |
| 203 | T | A | -1.0160 | |
| 204 | N | A | -1.5717 | |
| 205 | E | A | -0.7236 | |
| 206 | I | A | -0.1524 | |
| 207 | F | A | 0.0000 | |
| 208 | Y | A | 0.0058 | |
| 209 | C | A | 0.0000 | |
| 210 | T | A | -0.8255 | |
| 211 | F | A | 0.0000 | |
| 212 | R | A | -2.3865 | |
| 213 | R | A | 0.0000 | |
| 214 | L | A | -1.0523 | |
| 215 | D | A | -1.8890 | |
| 216 | P | A | -1.4704 | |
| 217 | E | A | -2.3215 | |
| 218 | E | A | -1.8878 | |
| 219 | N | A | -2.0219 | |
| 220 | H | A | -1.4646 | |
| 221 | T | A | -1.0024 | |
| 222 | A | A | -1.2311 | |
| 223 | E | A | -0.8722 | |
| 224 | L | A | 0.0000 | |
| 225 | V | A | 0.1928 | |
| 226 | I | A | 0.0000 | |
| 227 | P | A | -0.8229 | |
| 228 | E | A | -1.3525 | |
| 229 | L | A | 0.5858 | |
| 33 | R | B | -2.1040 | |
| 34 | S | B | -1.4866 | |
| 35 | L | B | 0.0000 | |
| 36 | T | B | -0.0373 | |
| 37 | F | B | 0.0000 | |
| 38 | Y | B | 1.1641 | |
| 39 | P | B | 0.9272 | |
| 40 | A | B | 0.8758 | |
| 41 | W | B | 1.3368 | |
| 42 | L | B | 0.9478 | |
| 43 | T | B | 0.4586 | |
| 44 | V | B | -0.8501 | |
| 45 | S | B | -1.6923 | |
| 46 | E | B | -3.0126 | |
| 47 | G | B | -2.4637 | |
| 48 | A | B | -1.6807 | |
| 49 | N | B | -2.0753 | |
| 50 | A | B | 0.0000 | |
| 51 | T | B | -0.2379 | |
| 52 | F | B | 0.0000 | |
| 53 | T | B | 0.2181 | |
| 54 | C | B | 0.0000 | |
| 55 | S | B | -0.6598 | |
| 56 | L | B | 0.0000 | |
| 57 | S | B | -1.4816 | |
| 58 | N | B | -2.1188 | |
| 59 | W | B | -2.0720 | |
| 60 | S | B | -2.0192 | |
| 61 | E | B | -3.2363 | |
| 62 | D | B | -3.0217 | |
| 63 | L | B | 0.0000 | |
| 64 | M | B | -0.8287 | |
| 65 | L | B | 0.0000 | |
| 66 | N | B | 0.0000 | |
| 67 | W | B | 0.0000 | |
| 68 | N | B | 0.0000 | |
| 69 | R | B | -1.1015 | |
| 70 | L | B | -0.8992 | |
| 71 | S | B | -0.9895 | |
| 72 | P | B | -0.7327 | |
| 73 | S | B | -0.9730 | |
| 74 | N | B | -1.7284 | |
| 75 | Q | B | 0.0000 | |
| 76 | T | B | 0.0000 | |
| 77 | E | B | -1.7983 | |
| 78 | K | B | 0.0000 | |
| 79 | Q | B | -1.0466 | |
| 80 | A | B | 0.0000 | |
| 81 | A | B | -0.1557 | |
| 82 | F | B | 0.0000 | |
| 83 | S | B | -1.4471 | |
| 84 | N | B | -2.4158 | |
| 85 | G | B | -1.3983 | |
| 86 | L | B | -0.6915 | |
| 87 | S | B | -0.2853 | |
| 88 | Q | B | -0.8301 | |
| 89 | P | B | -0.7829 | |
| 90 | V | B | -0.8555 | |
| 91 | Q | B | -1.4750 | |
| 92 | D | B | -1.2589 | |
| 93 | A | B | -0.7160 | |
| 94 | R | B | -1.0552 | |
| 95 | F | B | 0.0000 | |
| 96 | Q | B | -0.3496 | |
| 97 | I | B | 0.0000 | |
| 98 | I | B | 0.3432 | |
| 99 | Q | B | -0.8631 | |
| 100 | L | B | -1.1088 | |
| 101 | P | B | -1.4705 | |
| 102 | N | B | -2.4126 | |
| 103 | R | B | -3.0503 | |
| 104 | H | B | -2.1675 | |
| 105 | D | B | -1.4814 | |
| 106 | F | B | 0.0000 | |
| 107 | H | B | -0.0774 | |
| 108 | M | B | 0.0000 | |
| 109 | N | B | -0.5992 | |
| 110 | I | B | 0.0000 | |
| 111 | L | B | -1.4410 | |
| 112 | D | B | -2.6913 | |
| 113 | T | B | 0.0000 | |
| 114 | R | B | -4.0389 | |
| 115 | R | B | -3.8813 | |
| 116 | N | B | -2.7057 | |
| 117 | D | B | 0.0000 | |
| 118 | S | B | -1.2494 | |
| 119 | G | B | -0.4346 | |
| 120 | I | B | -0.0017 | |
| 121 | Y | B | 0.0000 | |
| 122 | L | B | 0.0000 | |
| 123 | C | B | 0.0000 | |
| 124 | G | B | 0.0000 | |
| 125 | A | B | 0.0000 | |
| 126 | I | B | 0.0000 | |
| 127 | S | B | 0.0000 | |
| 128 | L | B | -0.9277 | |
| 129 | H | B | -1.6007 | |
| 130 | P | B | -1.0595 | |
| 131 | K | B | -0.9161 | |
| 132 | A | B | 0.0000 | |
| 133 | K | B | -1.5970 | |
| 134 | I | B | 0.0000 | |
| 135 | E | B | -1.6207 | |
| 136 | E | B | -0.9270 | |
| 137 | S | B | 0.0000 | |
| 138 | P | B | -0.2741 | |
| 139 | G | B | -0.1602 | |
| 140 | A | B | 0.0000 | |
| 141 | E | B | 0.1539 | |
| 142 | L | B | 0.0000 | |
| 143 | V | B | -0.1409 | |
| 144 | V | B | 0.0000 | |
| 145 | T | B | -1.7174 | |
| 146 | E | B | -2.8774 | |
| 147 | R | B | -2.3749 | |
| 148 | I | B | 0.5621 | |
| 30 | G | C | -0.5398 | |
| 31 | P | C | -0.0592 | |
| 32 | W | C | 0.4513 | |
| 33 | R | C | -0.4774 | |
| 34 | S | C | -0.9491 | |
| 35 | L | C | 0.0000 | |
| 36 | T | C | -0.2115 | |
| 37 | F | C | 0.0000 | |
| 38 | Y | C | 1.1508 | |
| 39 | P | C | 0.9353 | |
| 40 | A | C | 0.9188 | |
| 41 | W | C | 1.4647 | |
| 42 | L | C | 0.9827 | |
| 43 | T | C | 0.3818 | |
| 44 | V | C | -1.2622 | |
| 45 | S | C | -2.3995 | |
| 46 | E | C | -3.8485 | |
| 47 | G | C | -2.9645 | |
| 48 | A | C | -1.9556 | |
| 49 | N | C | -2.0365 | |
| 50 | A | C | 0.0000 | |
| 51 | T | C | -0.2199 | |
| 52 | F | C | 0.0000 | |
| 53 | T | C | 0.2339 | |
| 54 | C | C | 0.0000 | |
| 55 | S | C | -0.4958 | |
| 56 | L | C | 0.0000 | |
| 57 | S | C | -0.6316 | |
| 58 | N | C | -1.0101 | |
| 59 | W | C | -1.4272 | |
| 60 | S | C | -1.5101 | |
| 61 | E | C | -2.4600 | |
| 62 | D | C | -2.3052 | |
| 63 | L | C | 0.0000 | |
| 64 | M | C | -0.0361 | |
| 65 | L | C | 0.0000 | |
| 66 | N | C | 0.0000 | |
| 67 | W | C | 0.0000 | |
| 68 | N | C | 0.0000 | |
| 69 | R | C | -0.9522 | |
| 70 | L | C | -0.4633 | |
| 71 | S | C | -1.0728 | |
| 72 | P | C | -0.8566 | |
| 73 | S | C | -1.2609 | |
| 74 | N | C | -2.1366 | |
| 75 | Q | C | -2.4409 | |
| 76 | T | C | -2.0665 | |
| 77 | E | C | -2.6315 | |
| 78 | K | C | -1.9426 | |
| 79 | Q | C | -1.2233 | |
| 80 | A | C | 0.0000 | |
| 81 | A | C | -0.0112 | |
| 82 | F | C | 0.0000 | |
| 83 | S | C | -1.1974 | |
| 84 | N | C | -1.9994 | |
| 85 | G | C | -1.1465 | |
| 86 | L | C | -0.4063 | |
| 87 | S | C | -0.0358 | |
| 88 | Q | C | -0.2534 | |
| 89 | P | C | -0.3029 | |
| 90 | V | C | -0.0698 | |
| 91 | Q | C | -1.0566 | |
| 92 | D | C | -0.8920 | |
| 93 | A | C | -0.3750 | |
| 94 | R | C | -0.8896 | |
| 95 | F | C | 0.0000 | |
| 96 | Q | C | -0.1403 | |
| 97 | I | C | 0.0000 | |
| 98 | I | C | 0.8317 | |
| 99 | Q | C | -0.5137 | |
| 100 | L | C | -0.9390 | |
| 101 | P | C | -1.5775 | |
| 102 | N | C | -2.3816 | |
| 103 | R | C | -2.5279 | |
| 104 | H | C | -1.9577 | |
| 105 | D | C | -1.2522 | |
| 106 | F | C | 0.0000 | |
| 107 | H | C | 0.0507 | |
| 108 | M | C | 0.0000 | |
| 109 | N | C | -0.4656 | |
| 110 | I | C | 0.0000 | |
| 111 | L | C | -1.1692 | |
| 112 | D | C | -2.7119 | |
| 113 | T | C | 0.0000 | |
| 114 | R | C | -4.1031 | |
| 115 | R | C | -3.8917 | |
| 116 | N | C | -2.8083 | |
| 117 | D | C | 0.0000 | |
| 118 | S | C | -1.1396 | |
| 119 | G | C | -0.2009 | |
| 120 | I | C | 0.8303 | |
| 121 | Y | C | 0.0000 | |
| 122 | L | C | -0.2132 | |
| 123 | C | C | 0.0000 | |
| 124 | G | C | 0.0000 | |
| 125 | A | C | 0.0000 | |
| 126 | I | C | -0.1998 | |
| 127 | S | C | -0.5357 | |
| 128 | L | C | 0.0959 | |
| 129 | H | C | -1.4673 | |
| 130 | P | C | -1.3474 | |
| 131 | K | C | -2.0478 | |
| 132 | A | C | -0.8708 | |
| 133 | K | C | -1.5092 | |
| 134 | I | C | 0.2129 | |
| 135 | E | C | -1.8203 | |
| 136 | E | C | -2.3492 | |
| 137 | S | C | 0.0000 | |
| 138 | P | C | -0.7203 | |
| 139 | G | C | -0.0633 | |
| 140 | A | C | 0.0000 | |
| 141 | E | C | 0.5588 | |
| 142 | L | C | 0.0000 | |
| 143 | V | C | -0.1224 | |
| 144 | V | C | 0.0000 | |
| 145 | T | C | -2.4000 | |
| 146 | E | C | -3.6350 | |
| 147 | R | C | -3.0647 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine