Project name: 3EXG pyruvate dehydrogenase E1 beta chain B

Chain sequence(s)	B: LQVTVRDAINQGMDEELERDEKVFLLGEEVAQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAIDQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNSEDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVVSHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFGVGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.7528
• Maximal score value: 1.8962
• Average score: -0.4453
• Total score value: -146.5129

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	L	B	0.3869
2	Q	B	-1.0919
3	V	B	0.0000
4	T	B	-0.9772
5	V	B	0.0000
6	R	B	-1.3516
7	D	B	-1.7500
8	A	B	0.0000
9	I	B	0.0000
10	N	B	-1.4032
11	Q	B	-1.4022
12	G	B	0.0000
13	M	B	0.0000
14	D	B	-1.6693
15	E	B	0.0000
16	E	B	0.0000
17	L	B	0.0000
18	E	B	-3.4945
19	R	B	-3.7528
20	D	B	-3.2216
21	E	B	-3.4726
22	K	B	-2.7715
23	V	B	0.0000
24	F	B	0.0000
25	L	B	0.0000
26	L	B	0.0000
27	G	B	0.0000
28	E	B	-0.1025
29	E	B	-0.4964
30	V	B	0.0000
31	A	B	0.0000
32	Q	B	-1.5613
33	Y	B	-0.0968
34	D	B	-1.4119
35	G	B	0.0000
36	A	B	-0.2652
37	Y	B	-0.5036
38	K	B	-1.4189
39	V	B	0.0000
40	S	B	0.0000
41	R	B	-2.8331
42	G	B	-2.2596
43	L	B	0.0000
44	W	B	-2.2426
45	K	B	-3.2141
46	K	B	-2.8584
47	Y	B	-2.2656
48	G	B	-2.3565
49	D	B	-3.0597
50	K	B	-2.4158
51	R	B	0.0000
52	I	B	0.0000
53	I	B	-0.7442
54	D	B	-0.5452
55	T	B	0.0361
56	P	B	0.4641
57	I	B	1.7356
58	S	B	0.6426
59	E	B	0.0000
60	M	B	0.1190
61	G	B	0.4145
62	F	B	0.0000
63	A	B	0.0000
64	G	B	0.5322
65	I	B	1.8962
66	A	B	0.0000
67	V	B	0.0000
68	G	B	0.7482
69	A	B	0.5712
70	A	B	0.0000
71	M	B	0.6638
72	A	B	0.2776
73	G	B	-0.0079
74	L	B	-0.2204
75	R	B	-0.9618
76	P	B	0.0000
77	I	B	0.0000
78	C	B	0.0000
79	E	B	0.0000
80	F	B	0.0000
81	M	B	0.3617
82	T	B	0.0613
83	F	B	0.0000
84	N	B	-0.2478
85	F	B	0.4726
86	S	B	0.0000
87	M	B	-0.0471
88	Q	B	-1.0094
89	A	B	0.0000
90	I	B	-0.8036
91	D	B	-2.0341
92	Q	B	-1.1623
93	V	B	0.0000
94	I	B	-1.0144
95	N	B	-1.6433
96	S	B	-1.0026
97	A	B	0.0000
98	A	B	0.0000
99	K	B	-0.2052
100	T	B	0.5631
101	Y	B	1.2676
102	Y	B	1.7563
103	M	B	1.6269
104	S	B	1.1344
105	G	B	0.7357
106	G	B	0.9391
107	L	B	1.6013
108	Q	B	0.8697
109	P	B	0.0372
110	V	B	0.0000
111	P	B	-0.8008
112	I	B	0.0000
113	V	B	0.0000
114	F	B	0.0000
115	R	B	0.0000
116	G	B	0.0000
117	P	B	0.0000
118	N	B	0.0000
119	G	B	-0.2538
120	A	B	-0.0877
121	S	B	0.0181
122	A	B	-0.0618
123	G	B	0.2218
124	V	B	0.6908
125	A	B	0.2025
126	A	B	-0.2960
127	Q	B	-1.3037
128	H	B	-0.8396
129	S	B	0.0000
130	Q	B	-0.5463
131	C	B	0.0768
132	F	B	0.0000
133	A	B	0.0000
134	A	B	0.2283
135	W	B	0.8188
136	Y	B	0.0000
137	G	B	-0.5453
138	H	B	-0.8945
139	C	B	0.0000
140	P	B	-0.6276
141	G	B	-0.3688
142	L	B	0.0000
143	K	B	-0.7909
144	V	B	0.0000
145	V	B	0.0000
146	S	B	0.0000
147	P	B	0.0000
148	W	B	0.0000
149	N	B	0.0000
150	S	B	0.0000
151	E	B	-0.9324
152	D	B	0.0000
153	A	B	0.0000
154	K	B	0.0000
155	G	B	0.0000
156	L	B	0.0000
157	I	B	0.0000
158	K	B	0.0000
159	S	B	0.0000
160	A	B	0.0000
161	I	B	0.0000
162	R	B	-1.0124
163	D	B	-1.3113
164	N	B	-1.7827
165	N	B	-1.2021
166	P	B	0.0000
167	V	B	0.0000
168	V	B	0.0000
169	V	B	0.0000
170	L	B	0.0000
171	E	B	0.0000
172	N	B	-0.4327
173	E	B	-0.4659
174	L	B	0.0364
175	M	B	0.0000
176	Y	B	0.0000
177	G	B	-0.4038
178	V	B	0.0544
179	P	B	-0.5701
180	F	B	-0.7903
181	E	B	-1.8328
182	F	B	0.0000
183	P	B	-1.2903
184	P	B	-1.3553
185	E	B	-2.6641
186	A	B	0.0000
187	Q	B	-1.9059
188	S	B	-2.3333
189	K	B	-3.1430
190	D	B	-2.7063
191	F	B	-1.4419
192	L	B	-0.0389
193	I	B	0.0000
194	P	B	-0.3797
195	I	B	-0.4681
196	G	B	-1.0691
197	K	B	-2.2561
198	A	B	0.0000
199	K	B	-1.4459
200	I	B	-0.5725
201	E	B	-0.8721
202	R	B	-1.1093
203	Q	B	-1.5109
204	G	B	0.0000
205	T	B	-1.2114
206	H	B	-1.2903
207	I	B	0.0000
208	T	B	0.0000
209	V	B	0.0000
210	V	B	0.0000
211	S	B	0.0000
212	H	B	0.0000
213	S	B	0.0000
214	R	B	-0.7314
215	P	B	0.0000
216	V	B	0.0000
217	G	B	-0.6413
218	H	B	-1.1446
219	C	B	0.0000
220	L	B	-0.4321
221	E	B	-1.2909
222	A	B	0.0000
223	A	B	0.0000
224	A	B	-0.5990
225	V	B	-0.1349
226	L	B	0.0000
227	S	B	-1.6560
228	K	B	-2.4735
229	E	B	-2.7698
230	G	B	-2.0628
231	V	B	0.0000
232	E	B	-1.7343
233	C	B	0.0000
234	E	B	0.0000
235	V	B	0.0000
236	I	B	0.0000
237	N	B	0.0000
238	M	B	0.0000
239	R	B	0.0000
240	T	B	0.0000
241	I	B	-0.4653
242	R	B	-0.8648
243	P	B	-0.8989
244	M	B	-0.9671
245	D	B	-1.4954
246	M	B	-1.2882
247	E	B	-2.1229
248	T	B	-1.3018
249	I	B	0.0000
250	E	B	-0.7935
251	A	B	-0.7455
252	S	B	0.0000
253	V	B	0.0000
254	M	B	-0.3386
255	K	B	-1.2169
256	T	B	0.0000
257	N	B	-1.0921
258	H	B	-0.7886
259	L	B	0.0000
260	V	B	0.0000
261	T	B	0.0000
262	V	B	0.0000
263	E	B	0.0000
264	G	B	-0.0504
265	G	B	0.0000
266	W	B	-0.1017
267	P	B	-0.6752
268	Q	B	-0.4907
269	F	B	1.1389
270	G	B	0.0000
271	V	B	0.0000
272	G	B	0.0000
273	A	B	-0.7487
274	E	B	-1.3689
275	I	B	0.0000
276	C	B	-0.8240
277	A	B	-0.9729
278	R	B	-1.4192
279	I	B	0.0000
280	M	B	-0.4411
281	E	B	-1.5756
282	G	B	-1.1478
283	P	B	-0.5259
284	A	B	0.0000
285	F	B	0.6323
286	N	B	-0.2809
287	F	B	0.1012
288	L	B	-0.4067
289	D	B	-1.6257
290	A	B	-1.0060
291	P	B	-0.2566
292	A	B	-0.2297
293	V	B	-0.5651
294	R	B	-1.5442
295	V	B	0.0000
296	T	B	-0.9101
297	G	B	0.0000
298	A	B	-0.6440
299	D	B	-1.3495
300	V	B	0.2008
301	P	B	-0.1720
302	M	B	0.0000
303	P	B	0.6959
304	Y	B	1.3993
305	A	B	0.6875
306	K	B	-0.5770
307	I	B	1.1615
308	L	B	1.1112
309	E	B	0.0000
310	D	B	-1.3092
311	N	B	-1.4379
312	S	B	0.0000
313	I	B	-0.7353
314	P	B	0.0000
315	Q	B	-2.1409
316	V	B	-1.1134
317	K	B	-1.6003
318	D	B	-0.8800
319	I	B	0.0000
320	I	B	-0.0532
321	F	B	0.9854
322	A	B	-0.4679
323	I	B	0.0000
324	K	B	-0.4500
325	K	B	-1.2852
326	T	B	0.0000
327	L	B	-0.8836
328	N	B	-1.0035
329	I	B	1.0179