Project name: 6cr1:H

Chain sequence(s)	H: EVQLVESGGGLVQPGRRSLRRLSCAASGFTFDDYAMHWVRQAPGKGLEWVSAITWNSGHIDYADSVEGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCAKVSYLSTASSLDYYWGQGTLVTVSSASTKGPTVKILQSICDGGGHFPPTIQLLCLVSGYTPGTIQITWLEDGQVMDVDLSTASTTQEGELASTQSELTLSQKHWLSDRTYTCQVTYQGHTFEDSTKKCA
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.1624
• Maximal score value: 1.9783
• Average score: -0.7299
• Total score value: -164.2182

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.1758
2	V	H	-1.2927
3	Q	H	-1.2307
4	L	H	0.0000
5	V	H	1.2440
6	E	H	0.0000
7	S	H	-0.2103
8	G	H	-0.9492
9	G	H	-0.6446
10	G	H	-0.4821
11	L	H	-0.0302
12	V	H	-0.9201
13	Q	H	-1.8793
14	P	H	-2.1487
15	G	H	-2.1182
16	R	H	-2.7365
17	S	H	-1.9908
18	L	H	-1.3459
19	R	H	-1.8791
20	L	H	0.0000
21	S	H	-0.3252
22	C	H	0.0000
23	A	H	-0.0677
24	A	H	0.0000
25	S	H	-1.0926
26	G	H	-1.3057
27	F	H	-0.8184
28	T	H	-0.8292
29	F	H	0.0000
30	D	H	-2.2787
31	D	H	-1.1399
32	Y	H	-0.0112
33	A	H	0.0000
34	M	H	0.0000
35	H	H	0.0729
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.5776
40	A	H	-1.2002
41	P	H	-1.2827
42	G	H	-1.4085
43	K	H	-2.0529
44	G	H	-0.9015
45	L	H	0.5537
46	E	H	-0.1970
47	W	H	0.3726
48	V	H	0.0000
49	S	H	0.0000
50	A	H	-0.3382
51	I	H	0.0000
52	T	H	0.0000
53	W	H	-0.9877
54	N	H	-1.9819
55	S	H	-1.0540
56	G	H	-1.0921
57	H	H	-1.2618
58	I	H	-0.3445
59	D	H	-1.8452
60	Y	H	-1.5290
61	A	H	-1.7204
62	D	H	-2.6840
63	S	H	-1.7530
64	V	H	0.0000
65	E	H	-2.9942
66	G	H	-1.8319
67	R	H	-1.5155
68	F	H	0.0000
69	T	H	-0.8632
70	I	H	0.0000
71	S	H	-0.3139
72	R	H	-1.1538
73	D	H	-1.7247
74	N	H	-2.0580
75	A	H	-1.4835
76	K	H	-2.4265
77	N	H	-2.0461
78	S	H	0.0000
79	L	H	0.0000
80	Y	H	-0.4946
81	L	H	0.0000
82	Q	H	-1.0623
83	M	H	0.0000
84	N	H	-1.8030
85	S	H	-1.7093
86	L	H	0.0000
87	R	H	-2.5829
88	A	H	-1.7426
89	E	H	-2.2605
90	D	H	0.0000
91	T	H	-0.8171
92	A	H	0.0000
93	V	H	0.0368
94	Y	H	0.0000
95	Y	H	0.3773
96	C	H	0.0000
97	A	H	0.0000
98	K	H	0.0000
99	V	H	0.0000
100	S	H	0.6035
101	Y	H	1.7418
102	L	H	1.9783
103	S	H	0.9781
104	T	H	0.4508
105	A	H	0.3978
106	S	H	0.3538
107	S	H	-0.1695
108	L	H	-0.0229
109	D	H	-0.7183
110	Y	H	-0.0720
111	W	H	0.3754
112	G	H	0.0000
113	Q	H	-0.4540
114	G	H	-0.2185
115	T	H	0.0000
116	L	H	0.0000
117	V	H	0.0000
118	T	H	0.0000
119	V	H	0.0000
120	S	H	-0.8352
121	S	H	-0.5064
122	A	H	-0.3258
123	S	H	-0.6545
124	T	H	-1.1243
125	K	H	-1.9077
126	G	H	-1.1971
127	P	H	-0.7617
128	T	H	-0.7612
129	V	H	-1.0861
130	K	H	-1.5023
131	I	H	-0.5578
132	L	H	0.5687
133	Q	H	0.0828
134	S	H	0.5782
135	I	H	1.3550
136	C	H	-0.3427
137	D	H	-1.9898
138	G	H	-1.5850
139	G	H	-1.7209
140	G	H	-1.4948
141	H	H	-1.5291
142	F	H	-0.4025
143	P	H	-0.3698
144	P	H	-0.4186
145	T	H	-0.5210
146	I	H	0.0000
147	Q	H	-0.3091
148	L	H	0.0000
149	L	H	-0.2752
150	C	H	0.0000
151	L	H	-0.4663
152	V	H	0.0000
153	S	H	-0.5823
154	G	H	-0.8787
155	Y	H	0.0000
156	T	H	-1.1260
157	P	H	-1.3333
158	G	H	-0.5384
159	T	H	-0.1754
160	I	H	0.1408
161	Q	H	-0.0565
162	I	H	0.0093
163	T	H	0.0132
164	W	H	0.0000
165	L	H	0.0000
166	E	H	-1.5277
167	D	H	-2.4040
168	G	H	-1.4737
169	Q	H	-1.2530
170	V	H	0.6335
171	M	H	0.0000
172	D	H	-1.1353
173	V	H	0.1935
174	D	H	-1.3031
175	L	H	-0.5388
176	S	H	-0.4731
177	T	H	-0.4313
178	A	H	-0.4874
179	S	H	-0.6620
180	T	H	-0.7097
181	T	H	-1.3476
182	Q	H	-2.6395
183	E	H	-3.1624
184	G	H	-2.5744
185	E	H	-2.7577
186	L	H	-2.0367
187	A	H	0.0000
188	S	H	-0.9548
189	T	H	0.0000
190	Q	H	-1.1854
191	S	H	0.0000
192	E	H	-0.7626
193	L	H	0.0000
194	T	H	-0.4305
195	L	H	0.0000
196	S	H	-0.7469
197	Q	H	-0.8888
198	K	H	-1.7150
199	H	H	-1.3502
200	W	H	0.0000
201	L	H	-0.4729
202	S	H	-1.5461
203	D	H	-2.9071
204	R	H	-2.9272
205	T	H	-2.4463
206	Y	H	0.0000
207	T	H	-1.3616
208	C	H	0.0000
209	Q	H	-0.7628
210	V	H	0.0000
211	T	H	-0.5902
212	Y	H	0.0000
213	Q	H	-0.7865
214	G	H	-0.7785
215	H	H	-1.0609
216	T	H	-0.8520
217	F	H	-0.6400
218	E	H	-2.0414
219	D	H	-1.7239
220	S	H	-1.5428
221	T	H	-1.5012
222	K	H	-2.6001
223	K	H	-1.5034
224	C	H	-0.1781
225	A	H	-0.1661