Project name: 2a72d1177b9562a

Chain sequence(s)	A: MERRRITSAARREYVSEGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQELKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDEKEVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.3209
• Maximal score value: 1.9977
• Average score: -1.0653
• Total score value: -460.2254

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-0.3843
2	E	A	-2.0066
3	R	A	-2.0891
4	R	A	-2.9592
5	R	A	-2.6020
6	I	A	-1.6705
7	T	A	-1.2413
8	S	A	-1.6179
9	A	A	-1.3409
10	A	A	-1.5308
11	R	A	-2.7521
12	R	A	-2.6666
13	E	A	-1.7971
14	Y	A	-0.5212
15	V	A	0.4889
16	S	A	-0.6428
17	E	A	-1.6799
18	G	A	-1.4879
19	E	A	-1.0107
20	M	A	-0.8422
21	M	A	0.0627
22	V	A	0.0000
23	G	A	-0.2097
24	G	A	0.0000
25	L	A	-0.2071
26	A	A	-0.7731
27	P	A	0.0000
28	G	A	-1.0366
29	R	A	-2.2315
30	R	A	-1.4532
31	L	A	-0.6531
32	G	A	-0.7661
33	P	A	0.0000
34	G	A	-0.3628
35	T	A	0.0000
36	R	A	0.0000
37	L	A	0.0000
38	S	A	-0.1458
39	L	A	0.0000
40	A	A	0.0000
41	R	A	-0.4313
42	M	A	0.2052
43	P	A	0.0834
44	P	A	0.0000
45	P	A	0.0000
46	L	A	-0.3496
47	P	A	0.0000
48	T	A	0.0000
49	R	A	-2.4219
50	V	A	-2.0739
51	D	A	-2.3109
52	F	A	-0.5734
53	S	A	0.2261
54	L	A	1.1861
55	A	A	0.0000
56	G	A	0.2617
57	A	A	0.5073
58	L	A	0.0000
59	N	A	0.0000
60	A	A	-1.0330
61	G	A	-1.0116
62	F	A	0.0000
63	K	A	-2.4428
64	E	A	-3.1759
65	T	A	-2.6075
66	R	A	-2.9766
67	A	A	-2.2163
68	S	A	-2.2507
69	E	A	-2.9821
70	R	A	-1.8481
71	A	A	-1.2727
72	E	A	-1.0691
73	M	A	-0.8217
74	M	A	0.0000
75	E	A	-1.8499
76	L	A	-1.2583
77	N	A	-1.6084
78	D	A	-1.9376
79	R	A	-2.2369
80	F	A	-0.8705
81	A	A	-0.8418
82	S	A	-1.3481
83	Y	A	-1.0941
84	I	A	-0.4298
85	E	A	-1.2267
86	K	A	-1.6104
87	V	A	-0.6087
88	R	A	-0.8150
89	F	A	0.5586
90	L	A	-0.5242
91	E	A	-1.3540
92	Q	A	-1.4032
93	Q	A	-1.5253
94	N	A	-1.8496
95	K	A	-2.5594
96	A	A	-1.8289
97	L	A	0.0000
98	A	A	-2.4832
99	A	A	-2.0004
100	E	A	-2.9606
101	L	A	0.0000
102	N	A	-2.8579
103	Q	A	-2.9981
104	L	A	-2.6081
105	R	A	-3.1853
106	A	A	-2.0806
107	K	A	-2.0983
108	E	A	-1.6257
109	P	A	-0.8902
110	T	A	-0.2712
111	K	A	-0.5624
112	L	A	0.8186
113	A	A	0.0681
114	D	A	-0.6884
115	V	A	0.8659
116	Y	A	-0.0197
117	Q	A	-1.0555
118	A	A	-0.9670
119	E	A	-1.2544
120	L	A	-1.2893
121	R	A	-2.3386
122	E	A	-2.5189
123	L	A	0.0000
124	R	A	0.0000
125	L	A	-1.4851
126	R	A	-2.4626
127	L	A	0.0000
128	D	A	-1.9806
129	Q	A	-2.1386
130	L	A	-1.7041
131	T	A	0.0000
132	A	A	-1.5978
133	N	A	-1.9642
134	S	A	-1.0286
135	A	A	-0.7844
136	R	A	-1.9395
137	L	A	-1.1337
138	E	A	-1.1645
139	V	A	-0.2330
140	E	A	-1.5831
141	R	A	-2.0790
142	D	A	-2.7590
143	N	A	-2.7634
144	L	A	-2.0459
145	A	A	-1.8796
146	Q	A	-2.5704
147	D	A	-2.2610
148	L	A	-1.2364
149	A	A	-1.3525
150	T	A	-1.1960
151	V	A	-1.0413
152	R	A	-1.6925
153	Q	A	-1.8009
154	K	A	-1.9126
155	L	A	0.0000
156	Q	A	-1.5470
157	D	A	-1.3522
158	E	A	0.0000
159	T	A	-0.7995
160	N	A	-0.8485
161	L	A	0.5734
162	R	A	0.3690
163	L	A	1.0511
164	E	A	0.1013
165	A	A	-0.3356
166	E	A	-1.3270
167	N	A	-1.4167
168	N	A	-0.5664
169	L	A	0.0000
170	A	A	-0.9509
171	A	A	-0.3131
172	Y	A	-0.0711
173	R	A	-1.4804
174	Q	A	-2.0992
175	E	A	-1.9057
176	A	A	-1.8439
177	D	A	-2.6223
178	E	A	-2.3238
179	A	A	-1.4069
180	T	A	-0.7509
181	L	A	-0.0758
182	A	A	-1.5316
183	R	A	-1.8966
184	L	A	-1.2656
185	D	A	-2.7631
186	L	A	0.0000
187	E	A	-2.5888
188	R	A	-3.1227
189	K	A	-2.2765
190	I	A	0.0000
191	E	A	-2.2508
192	S	A	-1.1971
193	L	A	0.0000
194	E	A	0.0000
195	E	A	-0.5609
196	E	A	0.0000
197	I	A	0.0000
198	R	A	0.0000
199	F	A	0.0000
200	L	A	-0.5839
201	R	A	-1.5400
202	K	A	-2.1757
203	I	A	-1.8092
204	H	A	-2.1692
205	E	A	-2.5701
206	E	A	-2.4620
207	E	A	-1.4122
208	V	A	0.0000
209	R	A	0.0000
210	E	A	0.0000
211	L	A	-0.1166
212	Q	A	-0.2148
213	E	A	-0.1498
214	Q	A	0.0000
215	L	A	0.3490
216	A	A	0.0136
217	R	A	-0.6657
218	Q	A	-1.4465
219	Q	A	-0.6648
220	V	A	0.4551
221	H	A	-0.4840
222	V	A	0.0000
223	E	A	-2.3070
224	L	A	-0.4686
225	D	A	-1.3006
226	V	A	-1.2630
227	A	A	-0.8893
228	K	A	-0.7747
229	P	A	-0.2541
230	D	A	0.0000
231	L	A	0.0000
232	T	A	-0.3321
233	A	A	-0.2377
234	A	A	-0.2374
235	L	A	0.3404
236	K	A	-1.5549
237	E	A	-1.6292
238	I	A	-1.0648
239	R	A	-2.0975
240	T	A	-1.0385
241	Q	A	-0.5776
242	Y	A	0.7998
243	E	A	0.0615
244	A	A	-0.0670
245	M	A	0.2775
246	A	A	0.0000
247	S	A	-0.8653
248	S	A	-0.6949
249	N	A	0.0000
250	M	A	-1.2818
251	H	A	-2.3406
252	E	A	-2.6483
253	A	A	0.0000
254	E	A	-3.1028
255	E	A	-2.8431
256	W	A	-1.7995
257	Y	A	-1.2944
258	R	A	-2.1686
259	S	A	0.0000
260	K	A	0.0000
261	F	A	0.6118
262	A	A	-0.1689
263	D	A	-0.6749
264	L	A	0.2137
265	T	A	-0.1098
266	D	A	-1.0352
267	A	A	0.0000
268	A	A	-0.8707
269	A	A	-1.0402
270	R	A	-1.6155
271	N	A	-1.5827
272	A	A	-0.8907
273	E	A	-1.1021
274	L	A	0.9869
275	L	A	0.8180
276	R	A	-1.7861
277	Q	A	-1.7803
278	A	A	-1.2238
279	K	A	-2.3145
280	H	A	-2.6424
281	E	A	-3.0883
282	A	A	-2.4163
283	N	A	0.0000
284	D	A	-2.8501
285	Y	A	-1.6478
286	R	A	-1.5995
287	R	A	-0.9716
288	Q	A	0.0000
289	L	A	0.0000
290	Q	A	-0.8021
291	S	A	-0.3893
292	L	A	0.0000
293	T	A	-0.8117
294	C	A	-1.2088
295	D	A	-0.4670
296	L	A	0.0000
297	E	A	-1.4349
298	S	A	0.0000
299	L	A	0.0000
300	R	A	-1.5193
301	G	A	-1.3906
302	T	A	0.0000
303	N	A	-1.0462
304	E	A	-1.0640
305	S	A	-1.1569
306	L	A	-1.3476
307	E	A	-2.0881
308	R	A	-2.9844
309	Q	A	-2.8838
310	M	A	-2.7525
311	R	A	-4.3209
312	E	A	-4.2545
313	Q	A	-3.1252
314	E	A	-3.3980
315	E	A	-3.7217
316	R	A	-2.8240
317	H	A	-1.8337
318	V	A	-0.2871
319	R	A	-1.7714
320	E	A	-1.2278
321	A	A	-0.5247
322	A	A	-0.7910
323	S	A	-1.1318
324	Y	A	0.0000
325	Q	A	-1.6250
326	E	A	-1.9413
327	A	A	0.0000
328	L	A	0.0000
329	A	A	-2.1520
330	R	A	-2.2599
331	L	A	0.0000
332	E	A	-3.1980
333	E	A	-3.2006
334	E	A	0.0000
335	G	A	-1.8776
336	Q	A	-1.8884
337	E	A	-1.7548
338	L	A	-0.2288
339	K	A	-1.4388
340	D	A	-1.7981
341	E	A	-2.0195
342	M	A	-1.4592
343	A	A	-1.6166
344	R	A	-2.4594
345	H	A	-1.9847
346	L	A	0.0000
347	Q	A	-2.2353
348	E	A	-2.8783
349	Y	A	0.0000
350	Q	A	0.0000
351	D	A	-2.6515
352	L	A	-1.0969
353	L	A	-1.0680
354	N	A	-1.6081
355	V	A	-0.2635
356	K	A	-0.8175
357	L	A	-0.4430
358	A	A	0.0920
359	L	A	0.1752
360	D	A	0.0348
361	I	A	0.0709
362	E	A	-0.4148
363	I	A	0.2996
364	A	A	0.0000
365	T	A	0.0000
366	Y	A	-0.2731
367	R	A	-0.3689
368	K	A	-0.5849
369	L	A	0.0000
370	L	A	0.0000
371	E	A	-1.0339
372	G	A	0.0000
373	E	A	-1.3409
374	E	A	-1.2900
375	N	A	-1.2578
376	R	A	-1.0564
377	I	A	-0.0165
378	T	A	0.7274
379	I	A	1.0158
380	P	A	0.7687
381	V	A	1.2408
382	Q	A	0.3098
383	T	A	1.0538
384	F	A	1.9977
385	S	A	0.0000
386	N	A	-0.4346
387	L	A	-1.3763
388	Q	A	-0.6882
389	I	A	0.3538
390	R	A	-1.3146
391	E	A	-2.0693
392	T	A	-1.0564
393	S	A	-0.6908
394	L	A	-0.6236
395	D	A	-2.6137
396	E	A	-3.2446
397	K	A	-3.1356
398	E	A	-2.4700
399	V	A	-0.3057
400	S	A	-1.2376
401	E	A	-1.2800
402	G	A	-1.2078
403	H	A	-1.4457
404	L	A	-1.5958
405	K	A	-2.2505
406	R	A	-1.7802
407	N	A	-1.5085
408	I	A	-0.0830
409	V	A	0.9595
410	V	A	0.1078
411	K	A	-0.3433
412	T	A	-0.2931
413	V	A	-0.3651
414	E	A	-0.7640
415	M	A	-0.9328
416	R	A	-0.4082
417	D	A	0.0000
418	G	A	0.0000
419	E	A	-1.2876
420	V	A	-0.9527
421	I	A	-1.1096
422	K	A	-2.3562
423	E	A	-2.1045
424	S	A	-1.7770
425	K	A	-2.8189
426	Q	A	-3.1992
427	E	A	-3.4719
428	H	A	-2.5244
429	K	A	-2.8253
430	D	A	-1.9691
431	V	A	0.0376
432	M	A	0.6270