Project name: 2ca7ff3ef013fc2

Chain sequence(s)	A: GQETSYIEDNSNQNGAISLIFSLKEEVGALAKVLRLFEENDINLTHIESRPSRLNKDEYEFFTYLDKRTKPVLGSIIKSLRNDIGATVHELSRDKEKNTVPWFPRTIQELDRFANQILDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYTEEEKQTWGTVFRTLKALYKTHACYEHNHIFPLLEKYCGFREDNIPQLEDVSQFLQTCTGFRLRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQFSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKEGDSIKAYGAGLLSSFGELQYCLSDKPKLLPLELEKTACQEYSVTEFQPLYYVAESFSDAKEKVRTFAATIPRPFSVRYDPYTQRVEVLDNT
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.3512
• Maximal score value: 1.6247
• Average score: -0.899
• Total score value: -362.2999

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
19	G	A	-1.7971
20	Q	A	-2.5412
21	E	A	-2.4003
22	T	A	-1.5548
23	S	A	-0.6857
24	Y	A	-1.0033
25	I	A	-0.9440
26	E	A	-2.5712
27	D	A	-2.0338
28	N	A	-2.3352
29	S	A	-2.1781
30	N	A	-2.4714
31	Q	A	-2.3607
32	N	A	-1.9368
33	G	A	0.0000
34	A	A	0.0000
35	I	A	0.0000
36	S	A	0.0000
37	L	A	0.0000
38	I	A	0.0000
39	F	A	0.0000
40	S	A	-1.0302
41	L	A	0.0000
42	K	A	-3.6895
43	E	A	-3.7421
44	E	A	-2.5833
45	V	A	0.2184
46	G	A	-0.5479
47	A	A	-1.2596
48	L	A	-0.6970
49	A	A	-0.7788
50	K	A	-1.7064
51	V	A	0.0000
52	L	A	-1.4812
53	R	A	-3.0535
54	L	A	-2.2733
55	F	A	0.0000
56	E	A	-4.1470
57	E	A	-3.9110
58	N	A	-2.9640
59	D	A	-3.2058
60	I	A	0.0000
61	N	A	-2.1731
62	L	A	-1.2366
63	T	A	-0.5193
64	H	A	-0.3205
65	I	A	0.0000
66	E	A	-0.4699
67	S	A	-0.8158
68	R	A	-1.7652
69	P	A	-2.0282
70	S	A	-1.8710
71	R	A	-1.2297
72	L	A	-0.1539
73	N	A	-2.4236
74	K	A	-3.4697
75	D	A	-4.2109
76	E	A	-3.6019
77	Y	A	-2.1073
78	E	A	-1.0711
79	F	A	0.0000
80	F	A	0.0000
81	T	A	0.0000
82	Y	A	0.1633
83	L	A	0.0000
84	D	A	0.0000
85	K	A	-2.0773
86	R	A	-2.4601
87	T	A	-1.7491
88	K	A	-1.6424
89	P	A	-0.9960
90	V	A	-0.6977
91	L	A	0.0000
92	G	A	-0.8102
93	S	A	-1.1018
94	I	A	0.0000
95	I	A	0.0000
96	K	A	-3.1551
97	S	A	-2.5128
98	L	A	0.0000
99	R	A	-3.5656
100	N	A	-3.5134
101	D	A	-3.1396
102	I	A	-1.8091
103	G	A	-1.9843
104	A	A	-1.5454
105	T	A	-0.7302
106	V	A	0.0000
107	H	A	-0.4642
108	E	A	-0.6879
109	L	A	0.0000
110	S	A	0.0000
111	R	A	0.0000
112	D	A	-2.4347
113	K	A	-2.4451
114	E	A	-2.6100
115	K	A	-2.9515
116	N	A	-2.4544
117	T	A	-1.8111
118	V	A	-1.0580
119	P	A	0.0000
120	W	A	0.0000
121	F	A	0.0000
122	P	A	0.0000
123	R	A	0.0000
124	T	A	0.0000
125	I	A	0.0000
126	Q	A	-1.8516
127	E	A	0.0000
128	L	A	0.0000
129	D	A	-1.6553
130	R	A	-1.2926
131	F	A	0.0000
132	A	A	0.0000
133	N	A	-0.4982
134	Q	A	-0.3273
135	I	A	1.2818
136	L	A	1.6247
143	D	A	-2.5549
144	A	A	-1.9697
145	D	A	-2.6186
146	H	A	-2.1291
147	P	A	-1.4854
148	G	A	-1.5330
149	F	A	-1.8950
150	K	A	-2.2485
151	D	A	-1.1243
152	P	A	-0.5486
153	V	A	0.7771
154	Y	A	-0.7586
155	R	A	-2.0875
156	A	A	-1.1826
157	R	A	-1.2250
158	R	A	-1.9466
159	K	A	-2.7652
160	Q	A	-1.9714
161	F	A	0.0000
162	A	A	-1.2269
163	D	A	-1.4629
164	I	A	-1.0887
165	A	A	0.0000
166	Y	A	-0.8162
167	N	A	-1.5960
168	Y	A	0.0000
169	R	A	-2.3420
170	H	A	-1.7700
171	G	A	-1.5359
172	Q	A	-1.6487
173	P	A	-1.5496
174	I	A	0.0000
175	P	A	-1.2403
176	R	A	-2.4994
177	V	A	0.0000
178	E	A	-2.4564
179	Y	A	-2.0439
180	T	A	-2.2461
181	E	A	-3.7309
182	E	A	-3.4719
183	E	A	-2.7854
184	K	A	-3.5712
185	Q	A	-3.4270
186	T	A	0.0000
187	W	A	0.0000
188	G	A	0.0000
189	T	A	-1.3924
190	V	A	0.0000
191	F	A	0.0000
192	R	A	-2.8389
193	T	A	-1.1192
194	L	A	0.0000
195	K	A	-1.9627
196	A	A	-1.0070
197	L	A	-0.8992
198	Y	A	0.0000
199	K	A	-1.8211
200	T	A	-0.9055
201	H	A	-0.5068
202	A	A	0.0000
203	C	A	0.0000
204	Y	A	0.2997
205	E	A	-0.4488
206	H	A	0.0000
207	N	A	-0.9206
208	H	A	-0.9522
209	I	A	0.0000
210	F	A	0.0000
211	P	A	-0.5529
212	L	A	0.0087
213	L	A	0.0000
214	E	A	-1.3296
215	K	A	-1.3006
216	Y	A	0.4311
217	C	A	0.0000
218	G	A	-1.4043
219	F	A	0.0000
220	R	A	-3.8915
221	E	A	-4.3512
222	D	A	-4.2028
223	N	A	-2.9511
224	I	A	0.0000
225	P	A	0.0000
226	Q	A	-1.3088
227	L	A	0.0000
228	E	A	-1.5390
229	D	A	-1.3401
230	V	A	0.0000
231	S	A	0.0000
232	Q	A	-1.9051
233	F	A	-0.7249
234	L	A	0.0000
235	Q	A	-1.7667
236	T	A	-0.9192
237	C	A	-0.8946
238	T	A	0.0000
239	G	A	-1.3906
240	F	A	0.0000
241	R	A	-1.0013
242	L	A	0.0000
243	R	A	0.0000
244	P	A	0.0000
245	V	A	0.0000
246	A	A	0.0000
247	G	A	0.6011
248	L	A	1.0693
249	L	A	0.0000
250	S	A	0.0000
251	S	A	0.0000
252	R	A	0.0000
253	D	A	-0.5285
254	F	A	0.2962
255	L	A	0.0000
256	G	A	0.0000
257	G	A	0.0000
258	L	A	0.0000
259	A	A	0.0000
260	F	A	0.0000
261	R	A	-0.7788
262	V	A	0.0000
263	F	A	0.0000
264	H	A	0.0000
265	C	A	0.0000
266	T	A	0.0000
267	Q	A	0.0000
268	Y	A	0.0000
269	I	A	0.0000
270	R	A	0.0000
271	H	A	-1.0570
272	G	A	-1.5012
273	S	A	-0.8457
274	K	A	-0.9417
275	P	A	-0.3021
276	M	A	0.9360
277	Y	A	0.2574
278	T	A	-0.0635
279	P	A	-0.7519
280	E	A	-0.4497
281	P	A	-0.2276
282	D	A	0.0000
283	I	A	0.0000
284	C	A	0.0000
285	H	A	-0.2095
286	E	A	0.0000
287	L	A	0.0000
288	L	A	0.0000
289	G	A	0.0000
290	H	A	0.0000
291	V	A	0.0000
292	P	A	0.0000
293	L	A	0.0000
294	F	A	0.0000
295	S	A	0.0000
296	D	A	-1.3877
297	R	A	-2.1933
298	S	A	-1.4213
299	F	A	0.0000
300	A	A	0.0000
301	Q	A	-1.1962
302	F	A	0.0000
303	S	A	0.0000
304	Q	A	0.0000
305	E	A	0.0000
306	I	A	0.0000
307	G	A	0.0000
308	L	A	-0.2833
309	A	A	0.0000
310	S	A	0.0000
311	L	A	0.0000
312	G	A	0.0000
313	A	A	0.0000
314	P	A	-1.3431
315	D	A	-2.4943
316	E	A	-2.8050
317	Y	A	-1.5941
318	I	A	0.0000
319	E	A	-2.2511
320	K	A	-1.6032
321	L	A	0.0000
322	A	A	0.0000
323	T	A	0.0000
324	I	A	0.0000
325	Y	A	0.0000
326	W	A	0.0000
327	F	A	0.0000
328	T	A	0.0000
329	V	A	0.0000
330	E	A	-0.1061
331	F	A	0.2245
332	G	A	0.0000
333	L	A	0.0000
334	C	A	0.0000
335	K	A	-2.8120
336	E	A	-2.2308
337	G	A	-2.3510
338	D	A	-2.5012
339	S	A	-1.6435
340	I	A	-1.0732
341	K	A	-0.3750
342	A	A	0.0000
343	Y	A	0.0000
344	G	A	0.0000
345	A	A	0.0000
346	G	A	0.0000
347	L	A	0.0000
348	L	A	0.0000
349	S	A	0.0000
350	S	A	0.2475
351	F	A	0.2419
352	G	A	-0.1015
353	E	A	0.0000
354	L	A	0.0000
355	Q	A	-0.8336
356	Y	A	0.0000
357	C	A	0.0000
358	L	A	-0.5966
359	S	A	-1.8263
360	D	A	-2.8009
361	K	A	-2.8073
362	P	A	-1.8198
363	K	A	-2.0536
364	L	A	-0.4885
365	L	A	-0.0765
366	P	A	-0.7183
367	L	A	0.0000
368	E	A	-1.7437
369	L	A	0.0000
370	E	A	-2.3057
371	K	A	-1.6208
372	T	A	0.0000
373	A	A	0.0000
374	C	A	-0.6045
375	Q	A	-1.0815
376	E	A	-1.9852
377	Y	A	0.0000
378	S	A	-1.3907
379	V	A	-0.5518
380	T	A	-0.8880
381	E	A	-1.2422
382	F	A	-0.1853
383	Q	A	0.0000
384	P	A	-0.7948
385	L	A	-0.6770
386	Y	A	0.0000
387	Y	A	0.0000
388	V	A	0.0000
389	A	A	0.0000
390	E	A	-2.6251
391	S	A	-1.6907
392	F	A	0.0000
393	S	A	-1.7076
394	D	A	-2.2353
395	A	A	0.0000
396	K	A	-2.2208
397	E	A	-3.1727
398	K	A	-2.7014
399	V	A	0.0000
400	R	A	-2.8412
401	T	A	-1.6901
402	F	A	0.0000
403	A	A	0.0000
404	A	A	-0.6959
405	T	A	-0.3424
406	I	A	0.0000
407	P	A	-0.4786
408	R	A	-0.7910
409	P	A	-0.9630
410	F	A	0.0000
411	S	A	-1.0663
412	V	A	-0.5554
413	R	A	-0.7843
414	Y	A	0.0000
415	D	A	0.0000
416	P	A	-0.0512
417	Y	A	0.9764
418	T	A	0.1180
419	Q	A	-0.5390
420	R	A	-0.6283
421	V	A	0.0000
422	E	A	0.0000
423	V	A	-0.2216
424	L	A	-0.6232
425	D	A	-2.2274
426	N	A	-2.1417
427	T	A	-1.0761