Project name: 2cad2b02b4a0162

Chain sequence(s)	A: QVLTQTASSVSAAVGGTVTISCQSSQSVYNKNWLGWYQQKPGQPPRLLIYGASTLASGVPSRFSGSGSGTQFTLTISDVQCDDAATYYCAGGYSNNIVSFGGGTRVVVEGGGGSGGGGSGGGGSQSVEESGGRLVTPGTPLTLTCTVSGFSLSNYAMSWVRQAPGKGLEWIGIVSISAGTYYAVVLRVTSPTTEDTATYFCATGGYTGNVWGPGTLVTVSSGSSSAPSTCSKPTCPPPELLGGPSVFIFPPKPKDTLMISRTPEVTCVVVDVSQDDPEVQFTWYINNEQVRTARPPLREQQFNSTIRVVSTLPIAHQDWLRGKEFKCKVHNKALPAPIEKTISKARGQPLEPKVYTMGPPREELSSRSVSLACMINGFYPSDISVEWEKNGKAEDNYKTTPAVLDSDGSYFLYSKLSVPTSEWQRGDVFTCSVMHEALHNHYTQKSISRS
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.0365
• Maximal score value: 2.5428
• Average score: -0.5743
• Total score value: -258.4208

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	Q	A	-0.7488
3	V	A	0.6719
4	L	A	0.3046
5	T	A	-0.5989
6	Q	A	-1.0885
7	T	A	-0.7486
8	A	A	-0.4821
9	S	A	-0.3444
10	S	A	-0.2178
11	V	A	0.1745
12	S	A	-0.0352
13	A	A	0.1783
14	A	A	0.0055
15	V	A	-0.3467
16	G	A	-1.0593
17	G	A	-0.7648
18	T	A	-0.6813
19	V	A	-0.1200
20	T	A	-0.0423
21	I	A	0.0000
22	S	A	-0.4821
23	C	A	0.0000
24	Q	A	-0.9875
25	S	A	-0.1485
26	S	A	-0.0726
27	Q	A	-0.4820
28	S	A	0.0340
29	V	A	0.8949
30	Y	A	0.1318
31	N	A	-1.3154
32	K	A	-1.6439
33	N	A	-0.9057
34	W	A	0.1812
35	L	A	0.0000
36	G	A	0.0000
37	W	A	0.0000
38	Y	A	0.3912
39	Q	A	0.0000
40	Q	A	-1.1178
41	K	A	-1.5345
42	P	A	-1.1592
43	G	A	-1.0723
44	Q	A	-1.3571
45	P	A	-1.0702
46	P	A	-0.9238
47	R	A	-0.7654
48	L	A	0.6219
49	L	A	0.0000
50	I	A	0.0000
51	Y	A	0.4512
52	G	A	0.0591
53	A	A	0.1132
54	S	A	0.0326
55	T	A	0.3065
56	L	A	0.8309
57	A	A	0.3280
58	S	A	-0.2324
59	G	A	-0.4730
60	V	A	-0.1089
61	P	A	-0.2578
62	S	A	-0.7108
63	R	A	-1.1580
64	F	A	0.0000
65	S	A	-0.6005
66	G	A	-0.6321
67	S	A	-0.7685
68	G	A	-0.9560
69	S	A	-0.7118
70	G	A	-0.6412
71	T	A	-0.3164
72	Q	A	-0.8923
73	F	A	-0.3384
74	T	A	-0.5121
75	L	A	0.0000
76	T	A	-0.3648
77	I	A	0.0000
78	S	A	-1.2959
79	D	A	-2.1191
80	V	A	0.0000
81	Q	A	-1.6959
82	C	A	-1.0574
83	D	A	-1.9859
84	D	A	-1.4658
85	A	A	-0.9891
86	A	A	0.0000
87	T	A	-0.3661
88	Y	A	0.0000
89	Y	A	-0.0778
90	C	A	0.0000
91	A	A	0.0000
92	G	A	0.8557
93	G	A	0.5415
94	Y	A	0.8526
95	S	A	-0.9699
96	N	A	-1.3367
97	N	A	-0.0732
98	I	A	2.2463
99	V	A	2.5428
100	S	A	1.4480
101	F	A	2.0230
102	G	A	0.2392
103	G	A	-0.2220
104	G	A	-0.0050
105	T	A	-0.0490
106	R	A	-0.5027
107	V	A	1.7434
108	V	A	1.9350
109	V	A	1.3783
110	E	A	0.3962
111	G	A	-0.3953
112	G	A	-0.8721
113	G	A	-0.8157
114	G	A	-0.5877
115	S	A	0.0000
116	G	A	-0.3413
117	G	A	-0.1982
118	G	A	-0.3147
119	G	A	-0.5615
120	S	A	-0.7606
121	G	A	-0.3174
122	G	A	-0.6421
123	G	A	-0.9697
124	G	A	-0.8359
125	S	A	-0.9612
126	Q	A	-1.6052
127	S	A	-0.7633
128	V	A	0.0820
129	E	A	-1.9893
130	E	A	-2.2316
131	S	A	-1.2634
132	G	A	0.0000
133	G	A	-0.4081
134	R	A	-0.3445
135	L	A	1.1073
136	V	A	0.9531
137	T	A	0.4391
138	P	A	0.0900
139	G	A	0.3628
140	T	A	0.0898
141	P	A	0.4982
142	L	A	1.7704
143	T	A	1.4135
144	L	A	0.0000
145	T	A	0.0000
146	C	A	0.0000
147	T	A	0.5171
148	V	A	0.0000
149	S	A	0.4651
150	G	A	-0.1928
151	F	A	0.0000
152	S	A	0.0000
153	L	A	-0.3555
154	S	A	-0.5554
155	N	A	-0.9234
156	Y	A	0.0000
157	A	A	0.1081
158	M	A	0.0000
159	S	A	-0.7582
160	W	A	0.0000
161	V	A	-0.8705
162	R	A	-2.2583
163	Q	A	-2.0874
164	A	A	-1.3264
165	P	A	-1.2410
166	G	A	-1.9716
167	K	A	-1.9938
168	G	A	-0.9285
169	L	A	-0.6889
170	E	A	-1.1955
171	W	A	0.1937
172	I	A	0.9565
173	G	A	0.5574
174	I	A	1.6917
175	V	A	2.4232
176	S	A	1.2927
177	I	A	1.2294
178	S	A	0.1673
179	A	A	-0.4441
180	G	A	-0.4143
181	T	A	0.0000
182	Y	A	0.9838
183	Y	A	1.5023
184	A	A	0.0000
200	V	A	0.9683
201	V	A	0.0000
202	L	A	0.5412
203	R	A	0.3003
204	V	A	1.5580
205	T	A	0.0000
206	S	A	0.1368
207	P	A	-0.2838
208	T	A	-0.7505
209	T	A	-0.9651
210	E	A	-1.3916
211	D	A	-2.0423
212	T	A	-1.0993
213	A	A	-0.6963
214	T	A	-0.2149
215	Y	A	0.0000
216	F	A	0.2406
217	C	A	0.0000
218	A	A	-0.4810
219	T	A	0.0000
220	G	A	0.0000
221	G	A	0.0000
222	Y	A	0.7539
223	T	A	-0.6781
224	G	A	-0.9802
225	N	A	-0.9045
226	V	A	0.1619
227	W	A	0.9724
228	G	A	0.0000
229	P	A	-0.2360
230	G	A	0.1289
231	T	A	0.3636
232	L	A	0.0000
233	V	A	0.0000
234	T	A	-0.2610
235	V	A	0.4904
236	S	A	-0.3123
237	S	A	-0.6950
238	G	A	-0.5787
239	S	A	-0.3544
240	S	A	-0.3153
241	S	A	-0.4468
242	A	A	-0.4184
243	P	A	-0.5368
244	S	A	-0.4193
245	T	A	-0.2448
246	C	A	0.0499
247	S	A	-0.6407
248	K	A	-1.7259
249	P	A	-1.0057
250	T	A	-0.3250
251	C	A	0.2327
252	P	A	-0.3443
253	P	A	-0.5824
254	P	A	-0.9019
255	E	A	-0.9837
256	L	A	1.0971
257	L	A	1.5393
258	G	A	0.2818
259	G	A	-0.0839
260	P	A	0.0000
261	S	A	0.0155
262	V	A	0.0000
263	F	A	1.3859
264	I	A	0.9709
265	F	A	1.1234
266	P	A	-0.1941
267	P	A	0.0000
268	K	A	-2.1199
269	P	A	-1.3200
270	K	A	-0.9915
271	D	A	0.0000
272	T	A	0.0000
273	L	A	-0.0992
274	M	A	0.7355
275	I	A	1.6431
276	S	A	0.3111
277	R	A	-0.9162
278	T	A	-0.7198
279	P	A	0.0000
280	E	A	-1.0528
281	V	A	0.0000
282	T	A	0.2715
283	C	A	0.0000
284	V	A	0.0000
285	V	A	0.0000
286	V	A	-0.8271
287	D	A	-2.1153
288	V	A	0.0000
289	S	A	-2.3370
290	Q	A	-2.8091
291	D	A	-2.9676
292	D	A	-2.5053
293	P	A	-2.7603
294	E	A	-2.9933
295	V	A	-1.7757
296	Q	A	-1.7538
297	F	A	-0.9873
298	T	A	-1.0147
299	W	A	0.0000
300	Y	A	-1.9622
301	I	A	-1.8322
302	N	A	-2.7601
303	N	A	-3.0122
304	E	A	-3.0085
305	Q	A	-2.4145
306	V	A	-1.4979
307	R	A	-2.1307
308	T	A	-1.4486
309	A	A	-1.5567
310	R	A	-2.0909
311	P	A	-1.1314
312	P	A	-0.6988
313	L	A	-0.2596
314	R	A	-2.6468
315	E	A	-2.9787
316	Q	A	-2.5919
317	Q	A	-1.4713
318	F	A	0.6276
319	N	A	-0.9052
320	S	A	-1.0519
321	T	A	-2.1501
322	I	A	0.0000
323	R	A	-2.3797
324	V	A	0.0000
325	V	A	-0.4249
326	S	A	0.0000
327	T	A	-0.7097
328	L	A	0.0000
329	P	A	-0.7368
330	I	A	0.0000
331	A	A	-0.9023
332	H	A	-0.8912
333	Q	A	-1.9146
334	D	A	-1.7000
335	W	A	0.0000
336	L	A	-1.3718
337	R	A	-2.6690
338	G	A	-2.0489
339	K	A	-2.0222
340	E	A	-1.8711
341	F	A	0.0000
342	K	A	-1.9725
343	C	A	0.0000
344	K	A	-1.4181
345	V	A	0.0000
346	H	A	-1.5324
347	N	A	0.0000
348	K	A	-2.5106
349	A	A	-1.2722
350	L	A	0.0000
351	P	A	-0.3294
352	A	A	-0.6919
353	P	A	-0.8763
354	I	A	-0.7518
355	E	A	-2.0219
356	K	A	-1.2188
357	T	A	-0.8316
358	I	A	-0.0970
359	S	A	-0.9911
360	K	A	-1.2715
361	A	A	-1.2401
362	R	A	-2.5496
363	G	A	-1.8826
364	Q	A	-1.8729
365	P	A	-1.3075
366	L	A	-1.0374
367	E	A	-2.4577
368	P	A	0.0000
369	K	A	-2.0675
370	V	A	0.0000
371	Y	A	0.3204
372	T	A	0.0000
373	M	A	0.2775
374	G	A	-0.5761
375	P	A	0.0000
376	P	A	-1.6377
377	R	A	-2.8260
378	E	A	-2.8762
379	E	A	-2.0687
380	L	A	-1.6766
381	S	A	-1.4550
382	S	A	-1.4402
383	R	A	-2.0473
384	S	A	-1.2305
385	V	A	0.0000
386	S	A	-0.5303
387	L	A	0.0000
388	A	A	-0.1804
389	C	A	0.0000
390	M	A	0.3470
391	I	A	0.0000
392	N	A	-0.6920
393	G	A	-1.3000
394	F	A	0.0000
395	Y	A	-0.6672
396	P	A	0.0000
397	S	A	0.0969
398	D	A	-1.2125
399	I	A	-0.6635
400	S	A	-0.4683
401	V	A	0.0000
402	E	A	-1.3595
403	W	A	0.0000
404	E	A	-2.1712
405	K	A	-1.9077
406	N	A	-2.2202
407	G	A	-2.2792
408	K	A	-2.9510
409	A	A	-2.2381
410	E	A	-2.4775
411	D	A	-3.0365
412	N	A	-2.7501
413	Y	A	-2.4199
414	K	A	-2.6127
415	T	A	-1.1808
416	T	A	-0.4116
417	P	A	0.0681
418	A	A	0.6923
419	V	A	1.5532
420	L	A	1.2187
421	D	A	-0.6751
422	S	A	-1.2044
423	D	A	-2.0888
424	G	A	-0.9415
425	S	A	0.0000
426	Y	A	0.4813
427	F	A	0.5648
428	L	A	0.0000
429	Y	A	0.3871
430	S	A	0.0000
431	K	A	-2.1826
432	L	A	0.0000
433	S	A	-1.3892
434	V	A	0.0000
435	P	A	-1.0675
436	T	A	-1.5610
437	S	A	-1.8201
438	E	A	-1.8059
439	W	A	0.0000
440	Q	A	-2.8177
441	R	A	-2.9750
442	G	A	-2.0407
443	D	A	-1.2933
444	V	A	0.2910
445	F	A	0.0000
446	T	A	-0.9617
447	C	A	0.0000
448	S	A	0.0000
449	V	A	0.0000
450	M	A	-0.4174
451	H	A	0.0000
452	E	A	-1.1158
453	A	A	-1.3402
454	L	A	0.0000
455	H	A	-1.9409
456	N	A	-1.7976
457	H	A	-1.3365
458	Y	A	-0.3459
459	T	A	-1.0592
460	Q	A	-1.5023
461	K	A	-1.5221
462	S	A	-0.4807
463	I	A	0.0000
464	S	A	-0.8495
465	R	A	-2.0434
466	S	A	-1.0957