Project name: 5Y14

Chain sequence(s)	A: TVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARIL; C: TVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARIL; B: TVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARIL; E: YTSLIHSLIEESQNQQEKNEQELLEL; D: TSLIHSLIEESQNQQEKNEQELLELD; F: YTSLIHSLIEESQNQQEKNEQELLELD
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.9281
• Maximal score value: 1.4749
• Average score: -0.789
• Total score value: -166.4843

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
27	T	C	-0.0496
28	V	C	0.2225
29	Q	C	-1.0650
30	A	C	-0.7219
31	R	C	-1.1116
32	Q	C	-1.7617
33	L	C	0.0000
34	L	C	0.0000
35	S	C	-1.1452
36	G	C	0.0000
37	I	C	0.0000
38	V	C	0.0000
39	Q	C	-1.5319
40	Q	C	0.0000
41	Q	C	0.0000
42	N	C	-1.5174
43	N	C	-1.8016
44	L	C	0.0000
45	L	C	0.0000
46	R	C	-1.7992
47	A	C	0.0000
48	I	C	0.0000
49	E	C	-1.3234
50	A	C	0.0000
51	Q	C	0.0000
52	Q	C	0.0000
53	H	C	-0.3329
54	L	C	0.0000
55	L	C	0.0000
56	Q	C	0.4628
57	L	C	1.1581
58	T	C	0.0000
59	V	C	0.5716
60	W	C	0.6575
61	G	C	-0.4488
62	I	C	0.0000
63	K	C	-1.8706
64	Q	C	-2.0366
65	L	C	0.0000
66	Q	C	-0.8233
67	A	C	-0.9998
68	R	C	-1.2389
69	I	C	0.7636
70	L	C	1.1433
27	T	B	0.2796
28	V	B	0.9733
29	Q	B	-0.9735
30	A	B	0.0000
31	R	B	-0.7302
32	Q	B	-1.7171
33	L	B	0.0000
34	L	B	0.0000
35	S	B	-0.8336
36	G	B	0.0000
37	I	B	0.0000
38	V	B	0.0000
39	Q	B	-1.4374
40	Q	B	0.0000
41	Q	B	0.0000
42	N	B	-1.6031
43	N	B	-1.7844
44	L	B	0.0000
45	L	B	0.0000
46	R	B	-1.9501
47	A	B	0.0000
48	I	B	0.0000
49	E	B	-1.5129
50	A	B	-0.6532
51	Q	B	0.0000
52	Q	B	0.0000
53	H	B	-0.6768
54	L	B	0.0720
55	L	B	0.0000
56	Q	B	0.4889
57	L	B	1.4749
58	T	B	0.0000
59	V	B	0.6456
60	W	B	0.6799
61	G	B	-0.4203
62	I	B	0.0000
63	K	B	-2.0594
64	Q	B	-2.2662
65	L	B	0.0000
66	Q	B	-1.6669
67	A	B	-1.4472
68	R	B	-1.9447
69	I	B	-0.4838
70	L	B	0.6519
27	T	A	-0.2721
28	V	A	-0.1086
29	Q	A	-1.2239
30	A	A	-1.1910
31	R	A	-1.0660
32	Q	A	-1.1908
33	L	A	0.0000
34	L	A	0.0000
35	S	A	-0.7189
36	G	A	0.0000
37	I	A	0.0000
38	V	A	0.0000
39	Q	A	-0.9629
40	Q	A	0.0000
41	Q	A	0.0000
42	N	A	-1.2967
43	N	A	0.0000
44	L	A	0.0000
45	L	A	0.0000
46	R	A	-2.1863
47	A	A	0.0000
48	I	A	0.0000
49	E	A	-1.6816
50	A	A	0.0000
51	Q	A	0.0000
52	Q	A	0.0000
53	H	A	-0.5232
54	L	A	0.0000
55	L	A	0.0000
56	Q	A	0.2998
57	L	A	1.2262
58	T	A	0.0000
59	V	A	0.0000
60	W	A	0.7628
61	G	A	0.0000
62	I	A	0.0000
63	K	A	-1.7889
64	Q	A	-1.5673
65	L	A	0.0000
66	Q	A	-1.8770
67	A	A	-1.5238
68	R	A	-1.5800
69	I	A	0.0419
70	L	A	1.2190
127	Y	F	1.2264
128	T	F	0.6283
129	S	F	0.4812
130	L	F	1.2397
131	I	F	0.0000
132	H	F	-0.8714
133	S	F	-1.0078
134	L	F	-1.4788
135	I	F	0.0000
136	E	F	-3.4422
137	E	F	-3.4147
138	S	F	0.0000
139	Q	F	-3.4729
140	N	F	-3.6897
141	Q	F	-3.1356
142	Q	F	0.0000
143	E	F	-3.8264
144	K	F	-3.6195
145	N	F	0.0000
146	E	F	-2.6891
147	Q	F	-2.8266
148	E	F	-2.8354
149	L	F	0.0000
150	L	F	-0.7458
151	E	F	-2.3099
152	L	F	-1.9020
153	D	F	-1.8092
127	Y	E	1.4070
128	T	E	0.6017
129	S	E	0.5421
130	L	E	1.0887
131	I	E	0.0000
132	H	E	-0.8036
133	S	E	-1.2183
134	L	E	0.0000
135	I	E	0.0000
136	E	E	-3.5541
137	E	E	-3.6920
138	S	E	0.0000
139	Q	E	-3.7518
140	N	E	-3.8289
141	Q	E	-3.3312
142	Q	E	0.0000
143	E	E	-3.8655
144	K	E	-3.4938
145	N	E	0.0000
146	E	E	-2.5452
147	Q	E	-2.5586
148	E	E	-2.2270
149	L	E	0.0000
150	L	E	0.2178
151	E	E	-1.0975
152	L	E	0.7161
128	T	D	0.0767
129	S	D	0.2100
130	L	D	0.9573
131	I	D	0.0000
132	H	D	-1.2874
133	S	D	-1.1908
134	L	D	-1.5682
135	I	D	0.0000
136	E	D	-3.4877
137	E	D	-3.4905
138	S	D	0.0000
139	Q	D	-3.4418
140	N	D	-3.7511
141	Q	D	-3.3054
142	Q	D	0.0000
143	E	D	-3.8960
144	K	D	-3.9281
145	N	D	0.0000
146	E	D	-2.4971
147	Q	D	-2.7861
148	E	D	-2.8967
149	L	D	0.0000
150	L	D	-0.6453
151	E	D	-2.2939
152	L	D	-1.8845
153	D	D	-1.7782