Project name: 2e4e4bdf76c7c67
Status: done
submitted: 2018-12-16 16:51:17, status changed: 2018-12-16 17:02:55
Settings
|
Chain sequence(s)
|
B: KAEKIRVALEKIKEAQVKKLVIRVHMSDDSSKTMMVDERQTVRQVLDNLMDKSHCGYSLDWSLVETVSELQMERIFEDHENLVENLLNWTRDSQNKLIFMERIEKYALFKNPQNYLLGKKETAEMADRNKEVLLEECFCCGSSVTVPEIEGVLWLKDDGKKSWKKRYFLLRASGIYYVPDLVCFLQLDHVNVYYGQDYRNKYKAPTDYCLVLKHPQIQKKSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYMNYQEALKRT
|
| Distance of aggregation |
10 Å |
| Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-4.3113
-
Maximal score value
-
1.8358
-
Average score
-
-1.0299
-
Total score value
-
-268.8076
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
| residue index |
residue name |
chain |
Aggrescan3D score |
|
| 252 |
K |
B |
-2.5376 |
|
| 253 |
A |
B |
-2.0337 |
|
| 254 |
E |
B |
-2.8278 |
|
| 255 |
K |
B |
-2.0134 |
|
| 256 |
I |
B |
0.2007 |
|
| 257 |
R |
B |
-1.3634 |
|
| 258 |
V |
B |
0.2689 |
|
| 259 |
A |
B |
-0.2551 |
|
| 260 |
L |
B |
-0.3806 |
|
| 261 |
E |
B |
-2.2252 |
|
| 262 |
K |
B |
-2.7532 |
|
| 263 |
I |
B |
-1.1712 |
|
| 264 |
K |
B |
-2.7786 |
|
| 265 |
E |
B |
-3.8131 |
|
| 266 |
A |
B |
-2.3976 |
|
| 267 |
Q |
B |
-2.4912 |
|
| 268 |
V |
B |
-2.7185 |
|
| 269 |
K |
B |
-3.1019 |
|
| 270 |
K |
B |
-1.7604 |
|
| 271 |
L |
B |
0.5917 |
|
| 272 |
V |
B |
1.8153 |
|
| 273 |
I |
B |
0.0000 |
|
| 274 |
R |
B |
-1.9277 |
|
| 275 |
V |
B |
0.0000 |
|
| 276 |
H |
B |
-1.7632 |
|
| 277 |
M |
B |
-1.5245 |
|
| 278 |
S |
B |
-1.7751 |
|
| 279 |
D |
B |
-2.7095 |
|
| 280 |
D |
B |
-2.6873 |
|
| 281 |
S |
B |
-1.8847 |
|
| 282 |
S |
B |
-2.0380 |
|
| 283 |
K |
B |
-2.2504 |
|
| 284 |
T |
B |
-0.9825 |
|
| 285 |
M |
B |
0.0722 |
|
| 286 |
M |
B |
1.3320 |
|
| 287 |
V |
B |
0.0000 |
|
| 288 |
D |
B |
0.0000 |
|
| 289 |
E |
B |
-3.1465 |
|
| 290 |
R |
B |
-3.4623 |
|
| 291 |
Q |
B |
-2.0433 |
|
| 292 |
T |
B |
-1.5965 |
|
| 293 |
V |
B |
0.0000 |
|
| 294 |
R |
B |
-1.1014 |
|
| 295 |
Q |
B |
-1.6403 |
|
| 296 |
V |
B |
0.0000 |
|
| 297 |
L |
B |
0.0000 |
|
| 298 |
D |
B |
-1.8344 |
|
| 299 |
N |
B |
-1.9655 |
|
| 300 |
L |
B |
0.0000 |
|
| 301 |
M |
B |
-1.8517 |
|
| 302 |
D |
B |
-3.2175 |
|
| 303 |
K |
B |
-3.0927 |
|
| 304 |
S |
B |
-2.3755 |
|
| 305 |
H |
B |
-1.8839 |
|
| 306 |
C |
B |
-1.0392 |
|
| 307 |
G |
B |
-0.1396 |
|
| 308 |
Y |
B |
0.8030 |
|
| 309 |
S |
B |
0.2169 |
|
| 310 |
L |
B |
-0.0002 |
|
| 311 |
D |
B |
-0.0555 |
|
| 312 |
W |
B |
-0.2715 |
|
| 313 |
S |
B |
0.0000 |
|
| 314 |
L |
B |
0.0000 |
|
| 315 |
V |
B |
0.0000 |
|
| 316 |
E |
B |
0.0000 |
|
| 317 |
T |
B |
-0.8685 |
|
| 318 |
V |
B |
0.0000 |
|
| 319 |
S |
B |
-1.9226 |
|
| 320 |
E |
B |
-2.9675 |
|
| 321 |
L |
B |
0.0000 |
|
| 322 |
Q |
B |
-1.6124 |
|
| 323 |
M |
B |
0.0000 |
|
| 324 |
E |
B |
-0.3905 |
|
| 325 |
R |
B |
0.0000 |
|
| 326 |
I |
B |
0.1860 |
|
| 327 |
F |
B |
0.0000 |
|
| 328 |
E |
B |
0.0000 |
|
| 329 |
D |
B |
0.0000 |
|
| 330 |
H |
B |
-0.6779 |
|
| 331 |
E |
B |
-1.1294 |
|
| 332 |
N |
B |
-1.8442 |
|
| 333 |
L |
B |
0.0000 |
|
| 334 |
V |
B |
0.0000 |
|
| 335 |
E |
B |
-1.9965 |
|
| 336 |
N |
B |
-0.7802 |
|
| 337 |
L |
B |
0.0751 |
|
| 338 |
L |
B |
0.5178 |
|
| 339 |
N |
B |
-0.5090 |
|
| 340 |
W |
B |
-0.8445 |
|
| 341 |
T |
B |
-1.7824 |
|
| 342 |
R |
B |
-2.7178 |
|
| 343 |
D |
B |
-2.9975 |
|
| 344 |
S |
B |
-2.5425 |
|
| 345 |
Q |
B |
-2.4692 |
|
| 346 |
N |
B |
-1.6674 |
|
| 347 |
K |
B |
-1.3053 |
|
| 348 |
L |
B |
0.0000 |
|
| 349 |
I |
B |
-0.6076 |
|
| 350 |
F |
B |
0.0000 |
|
| 351 |
M |
B |
-0.6568 |
|
| 352 |
E |
B |
-1.3493 |
|
| 353 |
R |
B |
-0.1471 |
|
| 354 |
I |
B |
1.3269 |
|
| 355 |
E |
B |
0.3203 |
|
| 356 |
K |
B |
0.0000 |
|
| 357 |
Y |
B |
0.0000 |
|
| 358 |
A |
B |
-0.1624 |
|
| 359 |
L |
B |
0.0000 |
|
| 360 |
F |
B |
0.0000 |
|
| 361 |
K |
B |
-1.8087 |
|
| 362 |
N |
B |
-1.6815 |
|
| 363 |
P |
B |
0.0000 |
|
| 364 |
Q |
B |
0.0000 |
|
| 365 |
N |
B |
-1.5436 |
|
| 366 |
Y |
B |
-0.8920 |
|
| 367 |
L |
B |
-0.2135 |
|
| 368 |
L |
B |
-0.8070 |
|
| 369 |
G |
B |
-2.3134 |
|
| 370 |
K |
B |
-3.3625 |
|
| 371 |
K |
B |
-3.5179 |
|
| 372 |
E |
B |
-3.2796 |
|
| 373 |
T |
B |
-2.1323 |
|
| 374 |
A |
B |
-1.7078 |
|
| 375 |
E |
B |
-2.0134 |
|
| 376 |
M |
B |
-1.9233 |
|
| 377 |
A |
B |
-2.3316 |
|
| 378 |
D |
B |
-3.6143 |
|
| 379 |
R |
B |
-3.3626 |
|
| 380 |
N |
B |
-2.7990 |
|
| 381 |
K |
B |
-3.0354 |
|
| 382 |
E |
B |
-2.9685 |
|
| 383 |
V |
B |
-1.3550 |
|
| 384 |
L |
B |
-1.4377 |
|
| 385 |
L |
B |
0.0000 |
|
| 386 |
E |
B |
-2.6325 |
|
| 387 |
E |
B |
-2.4124 |
|
| 388 |
C |
B |
0.0000 |
|
| 389 |
F |
B |
0.0000 |
|
| 390 |
C |
B |
-1.4335 |
|
| 391 |
G |
B |
-1.3142 |
|
| 392 |
S |
B |
-0.4488 |
|
| 393 |
S |
B |
-0.6289 |
|
| 394 |
V |
B |
-0.6054 |
|
| 395 |
T |
B |
-0.6130 |
|
| 396 |
V |
B |
-0.5059 |
|
| 397 |
P |
B |
0.0000 |
|
| 398 |
E |
B |
-2.5520 |
|
| 399 |
I |
B |
0.0000 |
|
| 400 |
E |
B |
-1.5894 |
|
| 401 |
G |
B |
-0.0419 |
|
| 402 |
V |
B |
0.7495 |
|
| 403 |
L |
B |
0.0000 |
|
| 404 |
W |
B |
-0.7112 |
|
| 405 |
L |
B |
0.0000 |
|
| 406 |
K |
B |
0.0000 |
|
| 407 |
D |
B |
-2.5008 |
|
| 408 |
D |
B |
-3.1713 |
|
| 409 |
G |
B |
-2.9962 |
|
| 410 |
K |
B |
-3.6705 |
|
| 411 |
K |
B |
-3.6171 |
|
| 412 |
S |
B |
-2.1776 |
|
| 413 |
W |
B |
-1.7188 |
|
| 414 |
K |
B |
-1.3909 |
|
| 415 |
K |
B |
-1.6803 |
|
| 416 |
R |
B |
-0.3087 |
|
| 417 |
Y |
B |
0.9779 |
|
| 418 |
F |
B |
0.0000 |
|
| 419 |
L |
B |
-0.3416 |
|
| 420 |
L |
B |
0.0000 |
|
| 421 |
R |
B |
-1.7501 |
|
| 422 |
A |
B |
-0.9830 |
|
| 423 |
S |
B |
-1.0056 |
|
| 424 |
G |
B |
0.0000 |
|
| 425 |
I |
B |
0.0000 |
|
| 426 |
Y |
B |
0.5604 |
|
| 427 |
Y |
B |
1.4309 |
|
| 428 |
V |
B |
1.8358 |
|
| 429 |
P |
B |
0.4543 |
|
| 438 |
D |
B |
-1.0722 |
|
| 439 |
L |
B |
0.7640 |
|
| 440 |
V |
B |
1.4403 |
|
| 441 |
C |
B |
0.9190 |
|
| 442 |
F |
B |
0.7458 |
|
| 443 |
L |
B |
-0.4184 |
|
| 444 |
Q |
B |
-1.7685 |
|
| 445 |
L |
B |
0.0000 |
|
| 446 |
D |
B |
-2.7351 |
|
| 447 |
H |
B |
-2.3977 |
|
| 448 |
V |
B |
0.0000 |
|
| 449 |
N |
B |
0.0000 |
|
| 450 |
V |
B |
0.0000 |
|
| 451 |
Y |
B |
0.0000 |
|
| 452 |
Y |
B |
-0.3091 |
|
| 453 |
G |
B |
0.0000 |
|
| 454 |
Q |
B |
-2.0893 |
|
| 455 |
D |
B |
-3.3341 |
|
| 456 |
Y |
B |
0.0000 |
|
| 457 |
R |
B |
-4.3113 |
|
| 458 |
N |
B |
-4.0035 |
|
| 459 |
K |
B |
-3.4080 |
|
| 460 |
Y |
B |
-3.1488 |
|
| 461 |
K |
B |
-4.0481 |
|
| 462 |
A |
B |
0.0000 |
|
| 463 |
P |
B |
-1.6674 |
|
| 464 |
T |
B |
-2.2560 |
|
| 465 |
D |
B |
-3.0340 |
|
| 466 |
Y |
B |
-1.1887 |
|
| 467 |
C |
B |
0.0000 |
|
| 468 |
L |
B |
0.0000 |
|
| 469 |
V |
B |
0.0000 |
|
| 470 |
L |
B |
0.0000 |
|
| 471 |
K |
B |
0.0000 |
|
| 472 |
H |
B |
-1.1690 |
|
| 473 |
P |
B |
-1.0310 |
|
| 474 |
Q |
B |
-1.4768 |
|
| 475 |
I |
B |
-1.1874 |
|
| 476 |
Q |
B |
-1.9892 |
|
| 477 |
K |
B |
-3.2271 |
|
| 478 |
K |
B |
-2.8457 |
|
| 479 |
S |
B |
-1.7926 |
|
| 480 |
Q |
B |
-2.0959 |
|
| 481 |
Y |
B |
0.0367 |
|
| 482 |
I |
B |
0.0000 |
|
| 483 |
K |
B |
-0.5378 |
|
| 484 |
Y |
B |
0.0000 |
|
| 485 |
L |
B |
0.0000 |
|
| 486 |
C |
B |
0.0000 |
|
| 487 |
C |
B |
0.0000 |
|
| 488 |
D |
B |
-1.9783 |
|
| 489 |
D |
B |
-1.4872 |
|
| 490 |
V |
B |
-0.1324 |
|
| 491 |
R |
B |
-0.9321 |
|
| 492 |
T |
B |
0.0000 |
|
| 493 |
L |
B |
0.0000 |
|
| 494 |
H |
B |
-0.1140 |
|
| 495 |
Q |
B |
0.0000 |
|
| 496 |
W |
B |
0.0000 |
|
| 497 |
V |
B |
0.0000 |
|
| 498 |
N |
B |
0.0000 |
|
| 499 |
G |
B |
0.0000 |
|
| 500 |
I |
B |
0.0000 |
|
| 501 |
R |
B |
0.0000 |
|
| 502 |
I |
B |
0.0000 |
|
| 503 |
A |
B |
-0.6429 |
|
| 504 |
K |
B |
-1.1334 |
|
| 505 |
Y |
B |
-0.6395 |
|
| 506 |
G |
B |
-0.5954 |
|
| 507 |
K |
B |
-1.3854 |
|
| 508 |
Q |
B |
-0.8297 |
|
| 509 |
L |
B |
0.0000 |
|
| 510 |
Y |
B |
0.0000 |
|
| 511 |
M |
B |
-0.2383 |
|
| 512 |
N |
B |
0.0000 |
|
| 513 |
Y |
B |
-0.3397 |
|
| 514 |
Q |
B |
-0.8495 |
|
| 515 |
E |
B |
-1.0246 |
|
| 516 |
A |
B |
-0.5688 |
|
| 517 |
L |
B |
-0.3634 |
|
| 518 |
K |
B |
-1.7201 |
|
| 519 |
R |
B |
-1.0194 |
|
| 520 |
T |
B |
-0.1786 |
|
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine