Project name: RH5.2

Chain sequence(s)	A: QYHFKELSNYNIANSIDILQEKEGHLDFVIIPHYTFLDYYKHLSYNSIYHKSSTYGKCIAVDAFIKKINETYDKVKSKCNDIKNDLIATIKKLEHPYDINNKNDDSYRYDISDLMNRTFKKMMDEYNTKKKKLIKCIKNHENDFNKICMDMKNYGTNLFEQLSCYNNNFCNTNGIRYHYDEYIHKLILSVKSKNLNKDLSDMTNILQQSELLLTNLNKKMGSYIYIDTIKFIHKEMKHIFNRIEYHTKIINDKTKIIQDKIKLNIWRTFQKDELLKRILDMSNEYSLFITSDHLRQMLYNTFYSKEKHLNNIFHHLIYVLQMKFNDVPIKME
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.3963
• Maximal score value: 1.5494
• Average score: -1.1272
• Total score value: -374.2255

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
146	Q	A	-1.1489
147	Y	A	-1.0408
148	H	A	-1.7620
149	F	A	-1.3166
150	K	A	-1.6395
151	E	A	-2.1938
152	L	A	-0.9166
153	S	A	-0.9460
154	N	A	-1.1683
155	Y	A	-0.0980
156	N	A	-1.2947
157	I	A	-0.8530
158	A	A	-0.9790
159	N	A	-1.2049
160	S	A	-0.3801
161	I	A	0.2049
162	D	A	0.0000
163	I	A	0.1575
164	L	A	0.0000
165	Q	A	-1.8513
166	E	A	-2.3503
167	K	A	-3.3649
168	E	A	-3.5058
169	G	A	-2.6370
170	H	A	-2.7810
171	L	A	0.0000
172	D	A	-1.2421
173	F	A	0.0000
174	V	A	0.3273
175	I	A	0.0000
176	I	A	0.4228
177	P	A	0.3160
178	H	A	0.0000
179	Y	A	0.5285
180	T	A	0.0000
181	F	A	0.0000
182	L	A	-0.2368
183	D	A	0.0000
184	Y	A	0.0000
185	Y	A	0.0000
186	K	A	-0.4678
187	H	A	0.0000
188	L	A	0.0000
189	S	A	0.0000
190	Y	A	0.0000
191	N	A	0.0000
192	S	A	0.0000
193	I	A	0.0000
194	Y	A	0.0000
195	H	A	0.0000
196	K	A	-1.1532
197	S	A	-0.8127
198	S	A	-0.7531
199	T	A	-0.7467
200	Y	A	-0.2351
201	G	A	-0.3750
202	K	A	-0.5813
203	C	A	0.4159
204	I	A	1.5494
205	A	A	0.3614
206	V	A	0.0000
207	D	A	-0.5915
208	A	A	-0.6391
209	F	A	-1.2285
210	I	A	0.0000
211	K	A	-3.3848
212	K	A	-3.5076
213	I	A	0.0000
214	N	A	-3.8830
215	E	A	-4.3963
216	T	A	-3.2126
217	Y	A	-3.1724
218	D	A	-3.9715
219	K	A	-3.6111
220	V	A	-2.7363
221	K	A	-2.4672
222	S	A	-2.6821
223	K	A	-3.0525
224	C	A	0.0000
225	N	A	-3.1704
226	D	A	-3.2127
227	I	A	-2.2287
228	K	A	-2.5678
229	N	A	-2.7251
230	D	A	-1.9314
231	L	A	0.0000
232	I	A	-1.9419
233	A	A	-1.4786
234	T	A	0.0000
235	I	A	0.0000
236	K	A	-2.8560
237	K	A	-2.4818
238	L	A	0.0000
239	E	A	0.0000
240	H	A	-2.1165
241	P	A	-1.3601
242	Y	A	-1.3075
243	D	A	-2.3607
244	I	A	-2.6716
245	N	A	-3.2888
246	N	A	-4.1368
247	K	A	-4.0569
248	N	A	-3.7844
249	D	A	-4.0059
250	D	A	-3.2076
251	S	A	-1.6279
252	Y	A	-0.3973
253	R	A	-0.4928
254	Y	A	-0.1610
255	D	A	-1.5595
256	I	A	-0.9060
257	S	A	-1.2323
294	D	A	-1.5470
295	L	A	-0.7542
296	M	A	-0.5248
297	N	A	0.0000
298	R	A	-2.3926
299	T	A	-1.6214
300	F	A	0.0000
301	K	A	-2.6278
302	K	A	-3.3613
303	M	A	-2.5666
304	M	A	-2.5644
305	D	A	-3.5584
306	E	A	-3.5217
307	Y	A	0.0000
308	N	A	-2.5261
309	T	A	-2.4168
310	K	A	-2.5791
311	K	A	-2.4596
312	K	A	-2.8240
313	K	A	-2.4859
314	L	A	0.0000
315	I	A	-1.8877
316	K	A	-3.0956
317	C	A	-2.3923
318	I	A	0.0000
319	K	A	-2.7985
320	N	A	-2.9850
321	H	A	-3.0310
322	E	A	-3.3794
323	N	A	-3.5541
324	D	A	-3.5670
325	F	A	0.0000
326	N	A	-2.4469
327	K	A	-3.2208
328	I	A	0.0000
329	C	A	0.0000
330	M	A	-1.6550
331	D	A	-2.3743
332	M	A	0.0000
333	K	A	-1.7194
334	N	A	-1.9363
335	Y	A	-1.2159
336	G	A	0.0000
337	T	A	-1.7019
338	N	A	-2.3486
339	L	A	-1.5262
340	F	A	0.0000
341	E	A	-2.7894
342	Q	A	-2.3318
343	L	A	0.0000
344	S	A	-0.9515
345	C	A	-0.2005
346	Y	A	0.6937
347	N	A	-0.5503
348	N	A	-1.8576
349	N	A	-1.7434
350	F	A	-0.2854
351	C	A	0.0000
352	N	A	-1.5987
353	T	A	0.0000
354	N	A	-1.1425
355	G	A	0.0000
356	I	A	0.0000
357	R	A	-1.2586
358	Y	A	-1.0435
359	H	A	0.0000
360	Y	A	0.0000
361	D	A	-2.8100
362	E	A	-2.5739
363	Y	A	-1.2422
364	I	A	0.0000
365	H	A	-1.5990
366	K	A	-1.9604
367	L	A	-0.5087
368	I	A	0.0000
369	L	A	-0.0843
370	S	A	-0.6171
371	V	A	0.0000
372	K	A	-2.2298
373	S	A	-1.4090
374	K	A	-2.5080
375	N	A	-3.1116
376	L	A	0.0000
377	N	A	-3.1624
378	K	A	-3.1827
379	D	A	-2.2683
380	L	A	-1.8409
381	S	A	-1.6862
382	D	A	-1.7187
383	M	A	0.0000
384	T	A	-1.5528
385	N	A	-2.1384
386	I	A	-1.2981
387	L	A	0.0000
388	Q	A	-1.9099
389	Q	A	-1.5588
390	S	A	0.0000
391	E	A	-0.8179
392	L	A	0.4653
393	L	A	0.3020
394	L	A	0.0000
395	T	A	-0.3654
396	N	A	-0.4922
397	L	A	0.0000
398	N	A	-1.1412
399	K	A	-1.9229
400	K	A	-1.0324
401	M	A	-0.2303
402	G	A	0.0000
403	S	A	-0.7396
404	Y	A	0.0000
405	I	A	0.0000
406	Y	A	0.0000
407	I	A	0.0000
408	D	A	0.0000
409	T	A	0.0000
410	I	A	0.0000
411	K	A	0.0000
412	F	A	0.0000
413	I	A	0.0000
414	H	A	0.0000
415	K	A	-2.2890
416	E	A	-1.6573
417	M	A	0.0000
418	K	A	-2.3768
419	H	A	-2.1884
420	I	A	0.0000
421	F	A	-1.4238
422	N	A	-2.0329
423	R	A	-1.4646
424	I	A	0.0000
425	E	A	-1.5475
426	Y	A	-0.3489
427	H	A	0.0000
428	T	A	0.0000
429	K	A	-2.2091
430	I	A	-1.1437
431	I	A	0.0000
432	N	A	-2.5228
433	D	A	-2.8134
434	K	A	-1.9108
435	T	A	0.0000
436	K	A	-2.9167
437	I	A	-1.6331
438	I	A	0.0000
439	Q	A	-1.8942
440	D	A	-2.6293
441	K	A	-1.8351
442	I	A	0.0000
443	K	A	-1.8102
444	L	A	-0.1466
445	N	A	0.0000
446	I	A	-0.2891
447	W	A	0.0863
448	R	A	-1.0447
449	T	A	-1.0713
450	F	A	0.0000
451	Q	A	-1.8862
452	K	A	-2.3986
453	D	A	-2.8228
454	E	A	-2.4415
455	L	A	0.0000
456	L	A	0.0000
457	K	A	-2.9084
458	R	A	-2.3260
459	I	A	0.0000
460	L	A	0.0000
461	D	A	-2.6264
462	M	A	0.0000
463	S	A	0.0000
464	N	A	-0.8748
465	E	A	0.0000
466	Y	A	0.0000
467	S	A	0.0000
468	L	A	0.3321
469	F	A	0.0000
470	I	A	0.0000
471	T	A	0.0000
472	S	A	0.0000
473	D	A	-0.5798
474	H	A	-0.8781
475	L	A	0.0000
476	R	A	0.0000
477	Q	A	-0.7643
478	M	A	-0.5253
479	L	A	0.0000
480	Y	A	-0.1905
481	N	A	-0.9071
482	T	A	0.0000
483	F	A	0.0000
484	Y	A	-0.8178
485	S	A	-1.7516
486	K	A	0.0000
487	E	A	-1.3943
488	K	A	-2.3539
489	H	A	-2.0859
490	L	A	0.0000
491	N	A	-2.1439
492	N	A	-2.4174
493	I	A	0.0000
494	F	A	0.0000
495	H	A	-0.9256
496	H	A	-1.2037
497	L	A	0.0000
498	I	A	1.3507
499	Y	A	1.3321
500	V	A	0.0000
501	L	A	0.3607
502	Q	A	-0.4288
503	M	A	-0.5325
504	K	A	-1.5510
505	F	A	-0.1008
506	N	A	-1.3424
507	D	A	-1.4441
508	V	A	0.4831
509	P	A	1.1290
510	I	A	1.3538
511	K	A	-0.7047
512	M	A	-1.2162
513	E	A	-2.1796