Project name: 2f0fb6acf71be1a

Chain sequence(s)	P: IVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWVLTAAHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVISNDVCAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGGPLVCNGVLQGITSWGSEPCALPERPSLYTKVVHYRKWIKDTIVANP; L: DIVLTQSPASLAVSLGQRATISCKASQSVDFDGDSYMNWYQQKPGQPPKLLIFAASNLASGIPARLSGSGSGTDFTLNIQPVEEEDAATYYCQQSNEDPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR; H: QVQLQQSGDDLVKPGASVKLSCKASGYTFTTYYINWMRQRPGQGLEWIGRIAPASGTTYSSEMFKDKATLTVDTSSNTAYIQLSSLSSEDSAVYFCARADYGFNSGEAMDYWGQGTSVTVSSAKTTAPPVYPLAPVCGDTTGSSVTLGCLVKGYFPESVTLLWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIVPRDCGCKPC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.2126
• Maximal score value: 1.3479
• Average score: -0.6826
• Total score value: -464.8313

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
16	I	P	0.0000
17	V	P	0.0000
18	G	P	-0.6020
19	G	P	-0.5255
20	W	P	-0.9253
21	E	P	-2.7135
22	C	P	0.0000
23	E	P	-3.2003
24	K	P	-3.1384
25	H	P	-2.1713
26	S	P	-1.5811
27	Q	P	-1.0706
28	P	P	0.0000
29	W	P	-0.2089
30	Q	P	0.0000
31	V	P	0.0000
32	L	P	0.0000
33	V	P	0.0000
34	A	P	-1.4419
35	S	P	-2.4324
36	R	P	-3.2458
37	G	P	-2.1389
38	R	P	-2.5734
39	A	P	-1.0626
41	V	P	-0.5979
42	C	P	0.0000
43	G	P	0.0000
44	G	P	0.0000
45	V	P	0.0000
46	L	P	0.0000
47	V	P	0.0000
48	H	P	-0.5767
49	P	P	-0.8144
50	Q	P	-1.1215
51	W	P	0.0000
52	V	P	0.0000
53	L	P	0.0000
54	T	P	0.0000
55	A	P	0.0000
56	A	P	0.0000
57	H	P	-0.0605
58	C	P	0.0000
59	I	P	-0.5920
60	R	P	-2.4275
61	N	P	-2.9636
62	K	P	-3.2378
63	S	P	-2.1462
64	V	P	-0.3944
65	I	P	0.0000
66	L	P	0.8043
67	L	P	0.0000
68	G	P	0.0000
69	R	P	-0.7601
70	H	P	0.0000
71	S	P	0.0000
72	L	P	0.0395
73	F	P	0.6778
75	H	P	-0.6508
76	P	P	-0.9634
77	E	P	-1.5453
78	D	P	-2.1536
79	T	P	-1.4930
80	G	P	-0.6414
81	Q	P	0.0435
82	V	P	1.3479
83	F	P	0.1361
84	Q	P	-1.2995
85	V	P	0.0000
86	S	P	-1.4776
87	H	P	-1.6977
88	S	P	-0.9932
89	F	P	-0.0540
90	P	P	-0.0536
91	H	P	0.0000
92	P	P	-0.1392
93	L	P	0.0000
94	Y	P	0.0000
95	D	P	-0.2140
95A	M	P	0.0057
95B	S	P	-0.4496
95C	L	P	-0.5210
95D	L	P	-0.2984
95E	K	P	-1.7724
95F	N	P	-1.7932
95G	R	P	-1.8483
95H	F	P	-0.3068
95I	L	P	-0.9433
95J	R	P	-2.2233
95K	P	P	-1.7180
96	G	P	-1.5078
97	D	P	-1.3773
98	D	P	-0.8982
99	S	P	0.0000
100	S	P	0.0000
101	H	P	0.0000
102	D	P	0.0000
103	L	P	0.0000
104	M	P	0.0000
105	L	P	0.0000
106	L	P	0.0000
107	R	P	-1.2331
108	L	P	0.0000
109	S	P	-1.4296
110	E	P	-2.2644
111	P	P	-1.4799
112	A	P	0.0000
113	E	P	-1.7694
114	L	P	-0.1389
115	T	P	-0.9498
116	D	P	-1.9773
117	A	P	0.0000
118	V	P	0.0000
119	K	P	-1.1763
120	V	P	-0.2377
121	M	P	0.0000
122	D	P	-1.6601
123	L	P	-0.6477
124	P	P	0.0000
125	T	P	-1.4836
128	Q	P	-1.9319
129	E	P	-1.7615
130	P	P	-0.8162
131	A	P	0.2151
132	L	P	1.1710
133	G	P	0.2969
134	T	P	-0.0201
135	T	P	-0.1914
136	C	P	0.0000
137	Y	P	0.3631
138	A	P	0.0000
139	S	P	0.0000
140	G	P	0.0000
141	W	P	0.0000
142	G	P	0.0000
143	S	P	0.0000
144	I	P	0.1465
145	E	P	-0.9894
146	P	P	-1.6362
147	E	P	-2.7254
148	E	P	-1.7304
149	F	P	0.9021
150	L	P	0.9784
151	T	P	0.3418
152	P	P	0.0000
153	K	P	-1.3881
154	K	P	-1.7386
155	L	P	0.0000
156	Q	P	-1.2771
157	C	P	0.0000
158	V	P	0.0000
159	D	P	-0.2282
160	L	P	0.0000
161	H	P	-0.2971
162	V	P	0.0000
163	I	P	0.2598
164	S	P	-0.1332
165	N	P	-1.0133
166	D	P	-1.8424
167	V	P	-0.9235
168	C	P	0.0000
169	A	P	-1.1838
170	Q	P	-1.7222
171	V	P	-1.0810
172	H	P	0.0000
173	P	P	-1.2165
174	Q	P	-1.5239
175	K	P	-1.4226
176	V	P	-0.8864
177	T	P	-0.7681
178	K	P	-0.8146
179	F	P	0.0000
180	M	P	0.0000
181	L	P	0.0000
182	C	P	0.0000
183	A	P	0.0000
184	G	P	0.0000
185	R	P	-1.0672
186	W	P	-0.7011
186A	T	P	-0.6687
186B	G	P	-0.9362
187	G	P	-0.7156
188	K	P	-0.8641
189	S	P	-0.5919
190	T	P	0.0000
191	C	P	0.0000
192	S	P	-0.4654
193	G	P	0.2777
194	D	P	0.0000
195	S	P	-0.0995
196	G	P	0.0000
197	G	P	0.0000
198	P	P	0.0000
199	L	P	0.0000
200	V	P	0.0000
201	C	P	0.0000
202	N	P	-1.3441
203	G	P	-1.1471
208	V	P	-1.1271
209	L	P	0.0000
210	Q	P	0.0000
211	G	P	0.0000
212	I	P	0.0000
213	T	P	0.0000
214	S	P	0.0000
215	W	P	-0.0302
216	G	P	-0.6088
217	S	P	-0.9352
218	E	P	-2.1282
219	P	P	-2.1338
220	C	P	-1.5024
221	A	P	-1.1944
222	L	P	-0.7706
223	P	P	-1.1512
223A	E	P	-1.7978
224	R	P	-1.7526
225	P	P	0.0000
226	S	P	0.0000
227	L	P	0.0000
228	Y	P	0.0000
229	T	P	0.0000
230	K	P	0.0000
231	V	P	0.0000
232	V	P	0.0000
233	H	P	-0.5133
234	Y	P	0.0000
235	R	P	0.0000
236	K	P	-1.1780
237	W	P	-0.6657
238	I	P	0.0000
239	K	P	-1.2053
240	D	P	-1.6497
241	T	P	-0.5491
242	I	P	0.0218
243	V	P	0.9399
244	A	P	0.1427
245	N	P	-0.3320
246	P	P	0.0393
1	D	L	-1.8828
2	I	L	0.0000
3	V	L	0.8159
4	L	L	0.0000
5	T	L	-0.6243
6	Q	L	-0.6154
7	S	L	-0.6609
8	P	L	-0.5356
9	A	L	-0.6959
10	S	L	-0.8965
11	L	L	-0.6914
12	A	L	-0.8349
13	V	L	0.0000
14	S	L	-1.6549
15	L	L	-1.2969
16	G	L	-1.6714
17	Q	L	-2.4890
18	R	L	-2.9401
19	A	L	0.0000
20	T	L	-0.6909
21	I	L	0.0000
22	S	L	-1.0288
23	C	L	0.0000
24	K	L	-2.1799
25	A	L	0.0000
26	S	L	-0.8475
27	Q	L	-1.3048
27A	S	L	-1.2107
27B	V	L	0.0000
27C	D	L	-1.0999
27D	F	L	-1.0624
28	D	L	-2.0038
29	G	L	-1.6450
30	D	L	-1.0581
31	S	L	0.0000
32	Y	L	0.0000
33	M	L	0.0000
34	N	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	-1.2069
39	K	L	-1.5588
40	P	L	-1.3546
41	G	L	-1.2832
42	Q	L	-1.8598
43	P	L	-1.2932
44	P	L	0.0000
45	K	L	-1.4296
46	L	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	F	L	0.1691
50	A	L	0.0000
51	A	L	0.0000
52	S	L	-0.3552
53	N	L	-0.1731
54	L	L	0.2720
55	A	L	0.0000
56	S	L	-0.3445
57	G	L	-0.3917
58	I	L	-0.1544
59	P	L	-0.1221
60	A	L	-0.1852
61	R	L	-0.8835
62	L	L	0.0000
63	S	L	-0.4335
64	G	L	-0.3291
65	S	L	-0.8106
66	G	L	-1.2824
67	S	L	-1.1968
68	G	L	-1.3292
69	T	L	-1.8674
70	D	L	-2.7204
71	F	L	0.0000
72	T	L	-0.9539
73	L	L	0.0000
74	N	L	-0.9232
75	I	L	0.0000
76	Q	L	-2.2399
77	P	L	-1.9885
78	V	L	0.0000
79	E	L	-2.4100
80	E	L	-3.2510
81	E	L	-3.0528
82	D	L	0.0000
83	A	L	0.0000
84	A	L	-1.4686
85	T	L	0.0000
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	Q	L	0.0000
90	Q	L	0.0000
91	S	L	0.0000
92	N	L	-0.9997
93	E	L	-2.3308
94	D	L	-2.2481
95	P	L	-1.7982
96	Y	L	0.0000
97	T	L	-0.3443
98	F	L	0.2909
99	G	L	0.0000
100	G	L	-0.4743
101	G	L	-0.8882
102	T	L	0.0000
103	K	L	-1.8493
104	L	L	0.0000
105	E	L	-1.6068
106	I	L	0.0000
107	K	L	-2.3100
108	R	L	-1.9206
109	A	L	-1.4863
110	D	L	-2.5770
111	A	L	-1.3020
112	A	L	-0.7247
113	P	L	0.0000
114	T	L	-0.1520
115	V	L	0.0000
116	S	L	-0.0247
117	I	L	0.0000
118	F	L	0.0000
119	P	L	0.0000
120	P	L	0.0000
121	S	L	0.0000
122	S	L	-1.0669
123	E	L	-1.7917
124	Q	L	0.0000
125	L	L	-1.1066
126	T	L	-0.8825
127	S	L	-0.8960
128	G	L	-1.1793
129	G	L	-1.1419
130	A	L	0.0000
131	S	L	0.0000
132	V	L	0.0000
133	V	L	0.0000
134	C	L	0.0000
135	F	L	0.0000
136	L	L	0.0000
137	N	L	0.0000
138	N	L	-0.9402
139	F	L	0.0000
140	Y	L	0.0000
141	P	L	-2.4345
142	K	L	-2.9213
143	D	L	-2.8753
144	I	L	-1.8542
145	N	L	-2.0213
146	V	L	-0.8753
147	K	L	-1.7112
148	W	L	0.0000
149	K	L	-2.3702
150	I	L	0.0000
151	D	L	-2.7260
152	G	L	-1.8743
153	S	L	-1.9693
154	E	L	-3.1586
155	R	L	-2.5799
156	Q	L	-2.5047
157	N	L	-2.1068
158	G	L	-0.9763
159	V	L	-0.6779
160	L	L	0.0295
161	N	L	-0.1281
162	S	L	0.0680
163	W	L	-0.3506
164	T	L	-1.1064
165	D	L	-2.2196
166	Q	L	-2.0107
167	D	L	-2.2034
168	S	L	-2.5271
169	K	L	-2.8791
170	D	L	-2.1419
171	S	L	0.0000
172	T	L	0.0000
173	Y	L	0.0000
174	S	L	0.0000
175	M	L	0.0000
176	S	L	0.0000
177	S	L	0.0000
178	T	L	0.0311
179	L	L	0.0000
180	T	L	-0.3575
181	L	L	0.0000
182	T	L	-1.7620
183	K	L	-2.7261
184	D	L	-3.6135
185	E	L	-3.3428
186	Y	L	0.0000
187	E	L	-4.2126
188	R	L	-4.0384
189	H	L	-3.0180
190	N	L	-3.2402
191	S	L	-2.4618
192	Y	L	0.0000
193	T	L	-1.0325
194	C	L	0.0000
195	E	L	-0.2795
196	A	L	0.0000
197	T	L	-1.0814
198	H	L	0.0000
199	K	L	-2.7300
200	T	L	-1.6184
201	S	L	-1.0269
202	T	L	-0.6234
203	S	L	-0.3456
204	P	L	-0.4243
205	I	L	0.6242
206	V	L	0.8189
207	K	L	-0.0916
208	S	L	-0.8852
209	F	L	0.0000
210	N	L	-2.3534
211	R	L	-2.5038
1	Q	H	-1.4975
2	V	H	-1.0542
3	Q	H	-1.8875
4	L	H	0.0000
5	Q	H	-2.2627
6	Q	H	-1.7422
7	S	H	-1.6027
8	G	H	-1.8227
9	D	H	-2.3805
10	D	H	-1.6842
11	L	H	-1.0502
12	V	H	0.0000
13	K	H	-1.8113
14	P	H	-1.4107
15	G	H	-1.0820
16	A	H	-0.7813
17	S	H	-0.9694
18	V	H	-1.0924
19	K	H	-1.9121
20	L	H	0.0000
21	S	H	0.0000
22	C	H	0.0000
23	K	H	-2.0050
24	A	H	0.0000
25	S	H	-1.5123
26	G	H	-1.0698
27	Y	H	-0.4375
28	T	H	-0.2938
29	F	H	0.0000
30	T	H	-0.2765
31	T	H	0.0000
32	Y	H	0.1058
33	Y	H	0.0000
34	I	H	0.0000
35	N	H	0.0000
36	W	H	0.0000
37	M	H	0.0000
38	R	H	0.0000
39	Q	H	-0.9157
40	R	H	-1.7190
41	P	H	-1.1949
42	G	H	-1.4035
43	Q	H	-1.8094
44	G	H	-1.1011
45	L	H	0.0000
46	E	H	-0.5397
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	R	H	0.0000
51	I	H	0.0000
52	A	H	0.0000
52A	P	H	0.0000
53	A	H	-0.3036
54	S	H	-0.3795
55	G	H	-0.4104
56	T	H	-0.1211
57	T	H	0.0481
58	Y	H	-0.3021
59	S	H	-0.8702
60	S	H	0.0000
61	E	H	-2.2848
62	M	H	-0.7035
63	F	H	0.0000
64	K	H	-2.9234
65	D	H	-2.8575
66	K	H	-1.8173
67	A	H	0.0000
68	T	H	-1.0986
69	L	H	-0.2909
70	T	H	-0.0893
71	V	H	-0.4129
72	D	H	-1.1020
73	T	H	-0.8551
74	S	H	-0.7774
75	S	H	-1.0852
76	N	H	-1.3921
77	T	H	0.0000
78	A	H	0.0000
79	Y	H	-0.5229
80	I	H	0.0000
81	Q	H	-1.3033
82	L	H	0.0000
82A	S	H	-1.1074
82B	S	H	-0.9611
82C	L	H	0.0000
83	S	H	-1.3000
84	S	H	-1.4315
85	E	H	-2.1152
86	D	H	0.0000
87	S	H	-0.8986
88	A	H	0.0000
89	V	H	-0.3337
90	Y	H	0.0000
91	F	H	0.0000
92	C	H	0.0000
93	A	H	0.0000
94	R	H	0.0000
95	A	H	0.0000
96	D	H	-0.2309
97	Y	H	0.0000
98	G	H	0.0000
99	F	H	-0.5722
100	N	H	-0.6984
100A	S	H	0.0000
100B	G	H	0.0000
100C	E	H	0.0000
100D	A	H	0.0000
100E	M	H	0.0000
101	D	H	-0.2747
102	Y	H	-0.0042
103	W	H	-0.6209
104	G	H	0.0000
105	Q	H	-1.7869
106	G	H	-1.2997
107	T	H	0.0000
108	S	H	-1.1660
109	V	H	0.0000
110	T	H	-0.9306
111	V	H	0.0000
112	S	H	-1.1993
113	S	H	-1.3281
114	A	H	-1.4665
115	K	H	-2.0717
116	T	H	-0.8940
117	T	H	-0.3927
118	A	H	-0.3885
119	P	H	-0.3536
120	P	H	-0.4911
121	V	H	0.0000
122	Y	H	0.0000
123	P	H	-0.6625
124	L	H	0.0000
125	A	H	0.0000
126	P	H	-0.1421
127	V	H	-0.6468
128	C	H	-0.6727
129	G	H	-1.2470
130	D	H	-1.8767
131	T	H	-0.9962
132	T	H	-0.8070
133	G	H	-0.8282
134	S	H	-0.5149
135	S	H	-0.3493
136	V	H	0.0323
137	T	H	0.0815
138	L	H	0.0000
139	G	H	0.0000
140	C	H	0.0000
141	L	H	0.0000
142	V	H	0.0000
143	K	H	-0.3936
144	G	H	0.0000
145	Y	H	0.0000
146	F	H	0.0000
147	P	H	-0.8840
148	E	H	-0.8127
149	S	H	-0.6856
150	V	H	-0.2513
151	T	H	-0.1736
152	L	H	-0.0677
153	L	H	-0.0504
154	W	H	0.0000
155	N	H	-0.9685
156	S	H	-0.6620
157	G	H	-0.4589
158	S	H	-0.4545
159	L	H	-0.1695
160	S	H	-0.3050
161	S	H	-0.2506
162	G	H	-0.1401
163	V	H	0.2405
164	H	H	-0.0904
165	T	H	0.1078
166	F	H	0.0000
167	P	H	-0.2711
168	A	H	0.3361
169	V	H	0.9708
170	L	H	1.1049
171	Q	H	-0.0110
172	S	H	-0.7682
173	D	H	-1.6573
174	L	H	-0.5335
175	Y	H	0.2416
176	T	H	0.0000
177	L	H	0.3064
178	S	H	0.0000
179	S	H	0.0000
180	S	H	0.0000
181	V	H	0.0000
182	T	H	0.0942
183	V	H	0.1128
184	T	H	-0.1902
185	S	H	-0.3437
186	S	H	-0.4678
187	T	H	-0.4998
188	W	H	0.0000
189	P	H	-0.3709
190	S	H	-0.8258
191	Q	H	-1.0870
192	S	H	-0.8261
193	I	H	0.0000
194	T	H	-1.2672
195	C	H	0.0000
196	N	H	-1.4325
197	V	H	0.0000
198	A	H	-0.8948
199	H	H	0.0000
200	P	H	-0.8943
201	A	H	-0.6329
202	S	H	-0.4542
203	S	H	-0.6889
204	T	H	-0.9253
205	K	H	-2.0061
206	V	H	-1.6834
207	D	H	-2.6912
208	K	H	-1.8755
209	K	H	-1.9939
210	I	H	0.0000
211	V	H	0.7197
212	P	H	-0.1290
213	R	H	-0.8606
214	D	H	-1.4594
215	C	H	-0.4774
216	G	H	-0.5309
217	C	H	-0.3691
218	K	H	-1.2858
219	P	H	-0.5548
220	C	H	0.2450