Project name: AWS4-1

Chain sequence(s)	H: VQLQESGPGLVKPSQSLSLTCTVTGYSITTDYAWNWIRQFPGNKLECMGYINYSGSTSFNPSLKSRISITRDTSKNQFFLQLNSVTTEDTATYYCARWDYGRGGSYAMDYWGQGTSVTVSS; L: IVLTQSPASLAVSLGQRATISCRASESVDSYGNSFMHWYQQKPGQPPKLLIYLASNLESGVPARFSGSGSRTDFTLTIDPVEADDAATYYCQQNNEDPWTFGGGTKLEIK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.1772
• Maximal score value: 1.3223
• Average score: -0.6214
• Total score value: -143.5417

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	I	L	0.4206
3	V	L	1.3223
4	L	L	0.0000
5	T	L	-0.5489
6	Q	L	-0.6840
7	S	L	-0.8032
8	P	L	-0.4431
9	A	L	-0.5991
10	S	L	-1.0219
11	L	L	-0.5457
12	A	L	-1.2365
13	V	L	0.0000
14	S	L	-1.1075
15	L	L	0.0588
16	G	L	-1.2607
17	Q	L	-2.2822
18	R	L	-2.6488
19	A	L	0.0000
20	T	L	-0.6188
21	I	L	0.0000
22	S	L	-0.8560
23	C	L	0.0000
24	R	L	-2.5786
25	A	L	0.0000
26	S	L	-1.1434
27	E	L	-2.4474
28	S	L	-2.4569
29	V	L	0.0000
30	D	L	-1.9775
30A	S	L	-0.6203
30B	Y	L	0.6151
30C	G	L	-0.3219
30D	N	L	-0.9809
31	S	L	-1.0672
32	F	L	-0.6993
33	M	L	0.0000
34	H	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	0.0000
39	K	L	-1.5884
40	P	L	-1.2059
41	G	L	-1.4597
42	Q	L	-2.1501
43	P	L	-1.4813
44	P	L	0.0000
45	K	L	-1.7709
46	L	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	-0.0476
50	L	L	-0.2991
51	A	L	0.0000
52	S	L	-0.8137
53	N	L	-1.0043
54	L	L	-0.2241
55	E	L	0.0000
56	S	L	-0.4653
57	G	L	-0.5198
58	V	L	0.0000
59	P	L	-0.3283
60	A	L	-0.3150
61	R	L	-1.0109
62	F	L	0.0000
63	S	L	-0.5754
64	G	L	-0.4736
65	S	L	-0.7703
66	G	L	-1.3365
67	S	L	-1.9724
68	R	L	-3.1772
69	T	L	-2.7068
70	D	L	-2.4334
71	F	L	0.0000
72	T	L	-0.7687
73	L	L	0.0000
74	T	L	-0.8247
75	I	L	0.0000
76	D	L	-2.1876
77	P	L	-1.7829
78	V	L	0.0000
79	E	L	-1.7064
80	A	L	-1.4723
81	D	L	-2.1516
82	D	L	0.0000
83	A	L	-1.6653
84	A	L	-1.2037
85	T	L	0.0000
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	Q	L	0.0000
90	Q	L	0.0000
91	N	L	0.0000
92	N	L	-1.4631
93	E	L	-2.2651
94	D	L	-2.2691
95	P	L	-1.1024
96	W	L	-0.4954
97	T	L	-0.0304
98	F	L	0.0000
99	G	L	0.0000
100	G	L	-1.0178
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-2.0199
104	L	L	0.0000
105	E	L	-2.3619
106	I	L	-1.5518
107	K	L	-1.8005
2	V	H	0.7982
3	Q	H	-0.7754
4	L	H	0.0000
5	Q	H	-1.2858
6	E	H	0.0000
7	S	H	-0.6303
8	G	H	-0.5829
9	P	H	-0.1819
10	G	H	0.1500
11	L	H	0.9026
12	V	H	0.0000
13	K	H	-1.5919
14	P	H	-1.4706
15	S	H	-1.4246
16	Q	H	-2.0227
17	S	H	-1.5418
18	L	H	0.0000
19	S	H	-0.7821
20	L	H	0.0000
21	T	H	-0.3827
22	C	H	0.0000
23	T	H	-0.8975
24	V	H	0.0000
25	T	H	-0.5215
26	G	H	-0.0288
27	Y	H	0.3273
28	S	H	-0.0811
29	I	H	0.0000
30	T	H	-0.1578
31	T	H	-0.0710
31A	D	H	-0.0451
32	Y	H	0.1897
33	A	H	0.0703
34	W	H	0.0000
35	N	H	0.0000
36	W	H	0.0000
37	I	H	0.0000
38	R	H	0.0000
39	Q	H	0.0000
40	F	H	-1.2165
41	P	H	-1.2516
42	G	H	-1.5448
43	N	H	-2.3207
44	K	H	-2.5098
45	L	H	0.0000
46	E	H	-0.7114
47	C	H	0.0000
48	M	H	0.0000
49	G	H	0.0000
50	Y	H	0.1928
51	I	H	0.0000
52	N	H	-0.1742
53	Y	H	0.0856
54	S	H	-0.2567
55	G	H	-0.3899
56	S	H	-0.3530
57	T	H	-0.1227
58	S	H	-0.3837
59	F	H	-0.5146
60	N	H	-0.8914
61	P	H	-1.1695
62	S	H	-0.8890
63	L	H	0.0000
64	K	H	-2.0238
65	S	H	-1.3968
66	R	H	-1.4691
67	I	H	0.0000
68	S	H	-0.7177
69	I	H	0.0000
70	T	H	-0.4093
71	R	H	-0.8622
72	D	H	-1.2499
73	T	H	-1.1291
74	S	H	-1.3423
75	K	H	-2.1705
76	N	H	-1.3591
77	Q	H	-1.1240
78	F	H	0.0000
79	F	H	-0.0319
80	L	H	0.0000
81	Q	H	-0.8899
82	L	H	0.0000
82A	N	H	-1.4373
82B	S	H	-1.3208
82C	V	H	0.0000
83	T	H	-1.3321
84	T	H	-1.2605
85	E	H	-1.8628
86	D	H	0.0000
87	T	H	-0.4905
88	A	H	0.0000
89	T	H	-0.3857
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	A	H	0.0000
94	R	H	0.0000
95	W	H	0.0000
96	D	H	0.1979
97	Y	H	-0.0092
98	G	H	-0.8751
99	R	H	-1.9782
100	G	H	-1.1534
100A	G	H	0.0000
100B	S	H	-0.1647
100C	Y	H	0.3918
100D	A	H	0.0000
100E	M	H	0.0000
101	D	H	0.0000
102	Y	H	0.0611
103	W	H	-0.6021
104	G	H	0.0000
105	Q	H	-1.7987
106	G	H	0.0000
107	T	H	-0.6577
108	S	H	-0.1580
109	V	H	0.0000
110	T	H	-0.1061
111	V	H	0.0000
112	S	H	-0.6017
113	S	H	-0.5602