Project name: 31065a64aceb752

Chain sequence(s)	A: FYPSYHSTPQRPGTPEAAAKDHHEGQPRSVCALEENAKRALISCVQTHLTADTTQKLSAVKDQLHCDDVYCVFVRICDRNNGTLEHPSNEFFSNAEKTDIRSAVVTCRENLQRQAEAAKTSGGGGSQQLLKLEECKASAKESIPGFKNITLSPCDKDPCVINKGEKYNVTFYAEATDDADYLMVSDSEQQQTDTINIQSARSISCYYIDVPCNVTKGEVFRGSVTLRILGAFAPGNLTYKLGVGHGKRTFACGVSNLIVEGGGGSMIAVYTNDRMSALEGYAFVGSACTTHRQLLGEDTAYTFRGIRIVTHEIGHALGCSHDGTSAPGIVKAFVPNSLHCPWGDGYIMSYEQHDSRSMRFSSCCRYDISQMSWSREASCLHVNDSMKYPLNWLIKYKLPGDFLSLNRQCEIAYPNLWRTYYVQKTYKWYCKGYCFVPGHQFRAADHYWDFLFVDGTVCLNELRMDTTAGYASTENAFQIKEGIENYPTRNKNKFGGGGSSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKS
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.1265
• Maximal score value: 2.0024
• Average score: -0.7043
• Total score value: -469.0936

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	F	A	1.8419
2	Y	A	1.7221
3	P	A	0.5967
4	S	A	-0.1552
5	Y	A	-0.3239
6	H	A	-1.2989
7	S	A	-1.6080
8	T	A	-1.5538
9	P	A	-2.0761
10	Q	A	-3.0574
11	R	A	-2.9536
12	P	A	-1.6668
13	G	A	0.0000
14	T	A	-1.2285
15	P	A	0.0000
16	E	A	-1.7160
17	A	A	0.0000
18	A	A	-2.5670
19	A	A	0.0000
20	K	A	-3.5556
21	D	A	-4.1265
22	H	A	-3.3314
23	H	A	-3.8110
24	E	A	-3.9008
25	G	A	-2.6957
26	Q	A	-2.9795
27	P	A	-1.7561
28	R	A	-1.3439
29	S	A	0.2821
30	V	A	2.0024
31	C	A	1.3848
32	A	A	-0.0313
33	L	A	0.0000
34	E	A	0.4708
35	E	A	-0.2648
36	N	A	0.0000
37	A	A	0.0000
38	K	A	0.0000
39	R	A	-0.8285
40	A	A	-0.0711
41	L	A	0.1202
42	I	A	0.0000
43	S	A	-0.0909
44	C	A	0.0513
45	V	A	0.0000
46	Q	A	-0.7325
47	T	A	-0.4558
48	H	A	-1.0108
49	L	A	-0.5013
50	T	A	-0.3142
51	A	A	-0.6098
52	D	A	-1.1153
53	T	A	0.0000
54	T	A	-0.9559
55	Q	A	-1.3031
56	K	A	-1.3390
57	L	A	0.0000
58	S	A	-1.1102
59	A	A	-1.1224
60	V	A	-0.7500
61	K	A	0.0000
62	D	A	-2.4779
63	Q	A	-1.7473
64	L	A	-0.9127
65	H	A	-2.0057
66	C	A	0.0000
67	D	A	-2.8125
68	D	A	-2.2224
69	V	A	-0.5973
70	Y	A	0.6101
71	C	A	0.0000
72	V	A	0.0000
73	F	A	0.0000
74	V	A	0.0000
75	R	A	-1.0934
76	I	A	0.0000
77	C	A	-0.8495
78	D	A	-2.4232
79	R	A	-3.1702
80	N	A	-3.0784
81	N	A	-2.8950
82	G	A	-2.2845
83	T	A	-1.9063
84	L	A	0.0000
85	E	A	-1.4298
86	H	A	-0.9107
87	P	A	-1.1702
88	S	A	-1.6145
89	N	A	-1.9735
90	E	A	-1.2214
91	F	A	0.0000
92	F	A	-0.4036
93	S	A	-1.1303
94	N	A	-1.9066
95	A	A	-1.1793
96	E	A	-1.5608
97	K	A	-1.5957
98	T	A	-1.2959
99	D	A	-1.0470
100	I	A	0.1122
101	R	A	-1.2856
102	S	A	-0.6244
103	A	A	-0.0718
104	V	A	-0.1607
105	V	A	-0.4130
106	T	A	0.0000
107	C	A	0.0000
108	R	A	-2.4510
109	E	A	-2.2418
110	N	A	-1.7526
111	L	A	-1.5154
112	Q	A	-2.2745
113	R	A	-2.0822
114	Q	A	-1.3243
115	A	A	-1.2334
116	E	A	-1.4773
117	A	A	-0.9311
118	A	A	0.0000
119	K	A	-1.1384
120	T	A	-0.9321
121	S	A	-0.9030
122	G	A	-0.4093
123	G	A	0.0000
124	G	A	-0.9977
125	G	A	0.0000
126	S	A	-1.1261
127	Q	A	-0.6991
128	Q	A	0.0000
129	L	A	-0.2612
130	L	A	0.0000
131	K	A	-1.1841
132	L	A	0.0000
133	E	A	-1.2310
134	E	A	-1.8766
135	C	A	0.0000
136	K	A	-1.2533
137	A	A	-1.3882
138	S	A	-2.1296
139	A	A	0.0000
140	K	A	-2.5678
141	E	A	-3.0075
142	S	A	-2.1096
143	I	A	-1.4374
144	P	A	-1.1114
145	G	A	-1.2704
146	F	A	-1.5369
147	K	A	-2.6093
148	N	A	-1.9731
149	I	A	0.0000
150	T	A	-0.2411
151	L	A	0.5647
152	S	A	0.0000
153	P	A	-0.9978
154	C	A	-1.2393
155	D	A	-2.5223
156	K	A	-2.9033
157	D	A	-1.8572
158	P	A	-1.7084
159	C	A	0.0000
160	V	A	-1.4224
161	I	A	-1.3293
162	N	A	-2.6116
163	K	A	-3.1823
164	G	A	-3.1534
165	E	A	-3.5260
166	K	A	-3.1139
167	Y	A	-1.8898
168	N	A	-1.9356
169	V	A	-0.8807
170	T	A	-0.6510
171	F	A	0.0000
172	Y	A	0.0000
173	A	A	0.0000
174	E	A	0.0000
175	A	A	0.0000
176	T	A	-1.8237
177	D	A	-2.9866
178	D	A	-2.7246
179	A	A	-1.8971
180	D	A	-1.5355
181	Y	A	-0.9326
182	L	A	0.0000
183	M	A	0.0000
184	V	A	0.0000
185	S	A	0.0000
186	D	A	-2.7287
187	S	A	-2.4008
188	E	A	-2.7359
189	Q	A	-2.7111
190	Q	A	-2.9089
191	Q	A	-2.6963
192	T	A	-1.4877
193	D	A	-0.8047
194	T	A	0.0000
195	I	A	0.0000
196	N	A	0.0000
197	I	A	0.0000
198	Q	A	-0.4803
199	S	A	0.0000
200	A	A	-1.4327
201	R	A	-2.1137
202	S	A	0.0000
203	I	A	0.0000
204	S	A	0.0000
205	C	A	0.0000
206	Y	A	0.0000
207	Y	A	0.0000
208	I	A	-0.3478
209	D	A	-1.6560
210	V	A	-1.2277
211	P	A	-1.5777
212	C	A	0.0000
213	N	A	-1.7585
214	V	A	0.0000
215	T	A	-1.4515
216	K	A	-2.2634
217	G	A	-1.9561
218	E	A	-1.5126
219	V	A	-0.5967
220	F	A	-0.7418
221	R	A	-2.0528
222	G	A	-1.9247
223	S	A	-1.4820
224	V	A	0.0000
225	T	A	0.0000
226	L	A	0.0000
227	R	A	-0.2813
228	I	A	0.0000
229	L	A	0.2701
230	G	A	0.0000
231	A	A	-0.1091
232	F	A	-0.2033
233	A	A	-0.6493
234	P	A	-1.2153
235	G	A	-1.1966
236	N	A	-1.3335
237	L	A	0.0000
238	T	A	0.0000
239	Y	A	0.1272
240	K	A	0.0000
241	L	A	0.4181
242	G	A	0.2174
243	V	A	0.9883
244	G	A	-0.4670
245	H	A	-1.6912
246	G	A	-2.0798
247	K	A	-2.4826
248	R	A	-1.7724
249	T	A	-0.6339
250	F	A	-0.2514
251	A	A	0.0000
252	C	A	0.0885
253	G	A	0.0097
254	V	A	0.6556
255	S	A	-0.0114
256	N	A	-0.2802
257	L	A	0.0293
258	I	A	0.0000
259	V	A	0.4161
260	E	A	0.0000
261	G	A	-1.0403
262	G	A	-1.6218
263	G	A	-1.5869
264	G	A	-1.3050
265	S	A	-0.9791
266	M	A	0.0000
267	I	A	0.0000
268	A	A	0.0002
269	V	A	-0.1222
270	Y	A	0.0949
271	T	A	-1.4588
272	N	A	-2.3854
273	D	A	-2.5882
274	R	A	-2.2673
275	M	A	-0.4714
276	S	A	-0.1525
277	A	A	0.3490
278	L	A	0.6587
279	E	A	-1.4694
280	G	A	-0.5772
281	Y	A	0.6744
282	A	A	0.0000
283	F	A	1.3008
284	V	A	1.9775
285	G	A	0.8345
286	S	A	0.3462
287	A	A	0.0000
288	C	A	-0.5227
289	T	A	-0.5828
290	T	A	-0.4819
291	H	A	-0.5230
292	R	A	0.0000
293	Q	A	0.0000
294	L	A	0.0000
295	L	A	0.0000
296	G	A	0.0000
297	E	A	-2.0067
298	D	A	-2.0528
299	T	A	-0.7012
300	A	A	0.1155
301	Y	A	1.4422
302	T	A	1.0342
303	F	A	1.6458
304	R	A	-0.4620
305	G	A	0.1188
306	I	A	1.9679
307	R	A	0.0000
308	I	A	0.0000
309	V	A	0.8214
310	T	A	0.8617
311	H	A	0.4549
312	E	A	0.0000
313	I	A	1.1184
314	G	A	0.0000
315	H	A	0.8646
316	A	A	0.0000
317	L	A	0.8047
318	G	A	0.0000
319	C	A	0.0000
320	S	A	-0.2513
321	H	A	-0.5530
322	D	A	-0.1582
323	G	A	0.0000
324	T	A	0.9632
325	S	A	0.0000
326	A	A	0.1405
327	P	A	0.1621
328	G	A	0.4880
329	I	A	1.6417
330	V	A	1.7460
331	K	A	-0.1849
332	A	A	0.4272
333	F	A	0.8335
334	V	A	0.4314
335	P	A	-0.2700
336	N	A	-1.0359
337	S	A	0.0016
338	L	A	0.1642
339	H	A	0.2840
340	C	A	0.0000
341	P	A	0.3768
342	W	A	0.0148
343	G	A	-1.4817
344	D	A	-2.1715
345	G	A	0.0000
346	Y	A	-1.1958
347	I	A	0.0000
348	M	A	0.0000
349	S	A	-0.5002
350	Y	A	-1.7413
351	E	A	-2.4033
352	Q	A	-2.7779
353	H	A	-2.7583
354	D	A	-3.3775
355	S	A	-2.2303
356	R	A	-2.2011
357	S	A	0.0000
358	M	A	-0.0691
359	R	A	-1.8485
360	F	A	-0.9423
361	S	A	0.0000
362	S	A	-0.3791
363	C	A	0.0000
364	C	A	0.0000
365	R	A	-1.7809
366	Y	A	-0.5518
367	D	A	-0.7316
368	I	A	-0.2315
369	S	A	-0.3664
370	Q	A	-0.9123
371	M	A	-0.6693
372	S	A	-0.4418
373	W	A	-0.3980
374	S	A	-1.4118
375	R	A	-2.6545
376	E	A	-2.4018
377	A	A	0.0000
378	S	A	-1.0859
379	C	A	-0.3231
380	L	A	-0.1717
381	H	A	-1.2992
382	V	A	-1.3781
383	N	A	-2.4745
384	D	A	-3.0473
385	S	A	-2.1331
386	M	A	-1.4545
387	K	A	-2.0770
388	Y	A	-0.8681
389	P	A	-0.2093
390	L	A	-0.6299
391	N	A	-1.0379
392	W	A	-0.6793
393	L	A	-0.2355
394	I	A	0.0000
395	K	A	-1.2575
396	Y	A	-0.0053
397	K	A	-0.6523
398	L	A	0.1843
399	P	A	-0.3347
400	G	A	-1.0824
401	D	A	-2.4424
402	F	A	0.0000
403	L	A	-0.4299
404	S	A	0.0000
405	L	A	0.0000
406	N	A	-0.6869
407	R	A	-0.8341
408	Q	A	-0.0078
409	C	A	0.0000
410	E	A	-0.7434
411	I	A	1.1699
412	A	A	0.6042
413	Y	A	1.1488
414	P	A	-0.1002
415	N	A	-0.2591
416	L	A	0.8515
417	W	A	0.7563
418	R	A	0.0000
419	T	A	0.0000
420	Y	A	0.5865
421	Y	A	0.1145
422	V	A	-0.5004
423	Q	A	-1.7085
424	K	A	-1.9296
425	T	A	-0.6601
426	Y	A	0.4025
427	K	A	-0.2057
428	W	A	0.0000
429	Y	A	0.6128
430	C	A	0.8246
431	K	A	-0.3977
432	G	A	0.0000
433	Y	A	0.0000
434	C	A	0.0000
435	F	A	0.0000
436	V	A	0.8421
437	P	A	0.2386
438	G	A	0.0000
439	H	A	0.0000
440	Q	A	-0.2817
441	F	A	0.6616
442	R	A	-0.7314
443	A	A	-0.4170
444	A	A	-0.3380
445	D	A	-1.7368
446	H	A	-1.2232
447	Y	A	0.2776
448	W	A	-0.4742
449	D	A	-1.2012
450	F	A	0.0719
451	L	A	1.4351
452	F	A	0.0000
453	V	A	1.8173
454	D	A	0.5186
455	G	A	-0.0203
456	T	A	1.0911
457	V	A	1.8762
458	C	A	1.1111
459	L	A	1.0974
460	N	A	-0.8370
461	E	A	-1.4103
462	L	A	-1.0079
463	R	A	-0.8319
464	M	A	0.0000
465	D	A	0.0030
466	T	A	0.9046
467	T	A	0.1085
468	A	A	-0.0952
469	G	A	0.0609
470	Y	A	-0.3696
471	A	A	0.3493
472	S	A	0.0000
473	T	A	0.0000
474	E	A	-1.3555
475	N	A	-1.3298
476	A	A	-0.2283
477	F	A	0.6047
478	Q	A	0.0000
479	I	A	-0.3972
480	K	A	-1.9635
481	E	A	-2.5109
482	G	A	-1.7944
483	I	A	-1.6777
484	E	A	-2.5275
485	N	A	-1.6927
486	Y	A	0.0000
487	P	A	-1.0396
488	T	A	-1.4122
489	R	A	-2.5349
490	N	A	-2.2623
491	K	A	-3.0586
492	N	A	-2.4655
493	K	A	0.0000
494	F	A	-0.6734
495	G	A	-0.5295
496	G	A	-0.7891
497	G	A	0.0000
498	G	A	-1.5909
499	S	A	-1.5563
500	S	A	-2.2524
501	E	A	-2.4635
502	I	A	0.0000
503	K	A	-0.7232
504	Y	A	0.6785
505	H	A	0.1183
506	N	A	-0.5893
507	Y	A	0.0000
508	N	A	-1.2925
509	S	A	-1.2909
510	N	A	-1.5246
511	G	A	0.0000
512	F	A	0.0000
513	N	A	0.0000
514	P	A	-1.8848
515	K	A	-2.1221
516	G	A	-1.7259
517	P	A	-0.8513
518	G	A	-0.7247
519	P	A	-0.5744
520	G	A	0.0000
521	I	A	0.0000
522	L	A	0.0000
523	F	A	0.0000
524	G	A	0.0000
525	D	A	0.0000
526	A	A	0.0000
527	F	A	0.0000
528	I	A	0.0000
529	P	A	-0.2524
530	A	A	-0.1713
531	I	A	0.0000
532	V	A	0.2236
533	Q	A	0.0000
534	P	A	-0.5691
535	V	A	-0.3266
536	S	A	-0.8242
537	Q	A	-1.4234
538	I	A	0.0000
539	F	A	-0.1060
540	P	A	-0.6737
541	G	A	-0.7062
542	P	A	-0.8719
543	G	A	-0.9288
544	P	A	-0.7941
545	G	A	-0.8897
546	I	A	-0.5496
547	L	A	0.0000
548	F	A	0.0000
549	N	A	0.0000
550	S	A	0.0000
551	L	A	0.0000
552	Q	A	0.0000
553	Y	A	0.0000
554	T	A	0.0000
555	N	A	-1.0842
556	V	A	0.0000
557	V	A	0.0000
558	K	A	-1.2752
559	D	A	-1.6085
560	Y	A	-0.4179
561	W	A	-0.1967
562	G	A	-1.2953
563	N	A	-2.2965
564	D	A	-2.6956
565	L	A	-1.9430
566	G	A	-1.5775
567	P	A	-1.3410
568	G	A	-1.2096
569	P	A	-1.6733
570	G	A	-1.9697
571	K	A	-2.6545
572	E	A	-2.3591
573	T	A	0.0000
574	V	A	0.0000
575	L	A	0.0000
576	R	A	-0.0830
577	V	A	0.0000
578	A	A	0.0000
579	V	A	0.0000
580	T	A	-0.4138
581	A	A	-0.8351
582	Q	A	-1.7213
583	H	A	0.0000
584	P	A	-0.9764
585	K	A	-1.4112
586	P	A	0.0000
587	A	A	0.1021
588	S	A	0.3674
589	L	A	1.5636
590	M	A	0.8353
591	G	A	-0.1725
592	P	A	-0.3760
593	G	A	-0.5975
594	P	A	-1.2315
595	G	A	-1.3541
596	Y	A	0.0000
597	D	A	-1.5064
598	A	A	0.0000
599	G	A	0.0000
600	I	A	0.0000
601	E	A	0.0000
602	L	A	0.0000
603	A	A	0.0000
604	H	A	0.0000
605	L	A	0.0000
606	L	A	0.0766
607	A	A	0.0000
608	F	A	0.0000
609	N	A	-0.9944
610	K	A	-1.6678
611	Y	A	-0.7851
612	G	A	-0.8745
613	P	A	-1.2663
614	G	A	-1.3502
615	P	A	-0.7596
616	G	A	-1.1201
617	H	A	-1.3911
618	D	A	-2.0758
619	K	A	-2.1728
620	K	A	-1.4587
621	Q	A	-0.8189
622	F	A	0.4571
623	A	A	0.0000
624	A	A	0.0000
625	L	A	0.9123
626	M	A	0.9761
627	L	A	0.0000
628	Y	A	0.7319
629	E	A	0.0000
630	E	A	-2.8132
631	D	A	-2.2980
632	G	A	-1.2743
633	T	A	0.0000
634	L	A	0.0000
635	R	A	0.0000
636	V	A	0.0000
637	E	A	0.0000
638	G	A	0.0000
639	V	A	-0.4000
640	G	A	-0.9461
641	P	A	-1.3797
642	G	A	-1.4488
643	P	A	-1.5502
644	G	A	-1.7613
645	K	A	-2.0741
646	R	A	0.0000
647	H	A	-2.1572
648	G	A	-1.9027
649	K	A	-2.1010
650	R	A	-1.5344
651	L	A	-0.2212
652	R	A	0.0000
653	V	A	0.3033
654	T	A	-0.3209
655	K	A	-1.0754
656	V	A	0.0000
657	I	A	1.0370
658	P	A	0.0000
659	H	A	-1.6032
660	A	A	-1.1426
661	K	A	-2.4935
662	Y	A	-2.4772
663	N	A	-3.0865
664	E	A	-3.6700
665	K	A	-3.2021
666	S	A	-1.7475