Project name: fabry disease

Status: done

submitted: 2018-11-16 16:26:33, status changed: 2018-11-16 16:46:12
Settings
Chain sequence(s) A: LDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTM
B: LDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTMQ
Distance of aggregation 10 Å
Dynamic mode No
Show buried residues

Minimal score value
-3.2013
Maximal score value
1.4472
Average score
-0.6164
Total score value
-481.3742

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
32 L A 0.0000
33 D A -2.4764
34 N A -1.9521
35 G A -1.5024
36 L A -1.0998
37 A A -1.1762
38 R A -2.1388
39 T A -1.0322
40 P A 0.0000
41 T A 0.0000
42 M A 0.0000
43 G A 0.0000
44 W A 0.0000
45 L A 0.0000
46 H A 0.0000
47 W A 0.1123
48 E A 0.0000
49 R A 0.0000
50 F A 0.0000
51 M A 0.3959
52 C A 0.2601
53 N A -0.2408
54 L A -0.0250
55 D A -1.8582
56 C A -2.0687
57 Q A -2.6095
58 E A -3.0828
59 E A -2.6187
60 P A -2.5336
61 D A -2.9042
62 S A -1.6360
63 C A 0.0000
64 I A 0.0000
65 S A -1.1335
66 E A 0.0000
67 K A -2.1450
68 L A 0.0000
69 F A 0.0000
70 M A -0.9534
71 E A -1.6879
72 M A 0.0000
73 A A 0.0000
74 E A -1.5141
75 L A -0.9075
76 M A 0.0000
77 V A -1.0135
78 S A -1.0389
79 E A -1.4864
80 G A -1.2717
81 W A 0.0000
82 K A -2.0436
83 D A -2.4860
84 A A 0.0000
85 G A -1.4810
86 Y A 0.0000
87 E A -1.7611
88 Y A 0.0000
89 L A 0.0000
90 C A 0.0000
91 I A 0.0000
92 D A 0.0000
93 D A 0.0000
94 C A 0.0000
95 W A 0.0000
96 M A 0.0000
97 A A -1.0874
98 P A -1.0670
99 Q A -1.7929
100 R A -1.9316
101 D A -1.9937
102 S A -1.6724
103 E A -2.2712
104 G A -1.5914
105 R A -1.6118
106 L A 0.0000
107 Q A -1.3949
108 A A 0.0000
109 D A -1.2462
110 P A -1.3728
111 Q A -1.5725
112 R A 0.0000
113 F A 0.0000
114 P A -1.4431
115 H A -2.0442
116 G A -1.7980
117 I A 0.0000
118 R A -3.0579
119 Q A -2.8979
120 L A 0.0000
121 A A 0.0000
122 N A -2.4859
123 Y A -1.5955
124 V A 0.0000
125 H A -1.6821
126 S A -1.2880
127 K A -1.6320
128 G A -1.3386
129 L A 0.0000
130 K A -1.4033
131 L A 0.0000
132 G A 0.0000
133 I A 0.0000
134 Y A 0.0000
135 A A 0.0000
136 D A 0.0000
137 V A 0.0000
138 G A 0.0000
139 N A -1.2066
140 K A -0.8258
141 T A 0.0000
142 C A 0.2298
143 A A 0.0870
144 G A -0.2233
145 F A -0.4929
146 P A -0.9221
147 G A 0.0000
148 S A 0.0000
149 F A 0.0021
150 G A -0.2717
151 Y A -0.1201
152 Y A 0.0000
153 D A -1.7750
154 I A -0.7343
155 D A 0.0000
156 A A 0.0000
157 Q A -1.5697
158 T A 0.0000
159 F A 0.0000
160 A A 0.0000
161 D A -1.4099
162 W A -1.6648
163 G A -1.4946
164 V A 0.0000
165 D A 0.0000
166 L A 0.0000
167 L A 0.0000
168 K A 0.0000
169 F A 0.0000
170 D A 0.0000
171 G A 0.0000
172 C A 0.3133
173 Y A 0.4492
174 C A -0.6045
175 D A -1.9240
176 S A -1.3539
177 L A -1.1564
178 E A -2.6561
179 N A -2.2564
180 L A 0.0000
181 A A -1.9895
182 D A -2.8463
183 G A 0.0000
184 Y A 0.0000
185 K A -1.9369
186 H A -1.6321
187 M A 0.0000
188 S A 0.0000
189 L A -1.1506
190 A A -1.7705
191 L A 0.0000
192 N A -2.4249
193 R A -2.9999
194 T A -2.2550
195 G A -1.9556
196 R A -1.7960
197 S A -1.1722
198 I A 0.0000
199 V A 0.0000
200 Y A 0.0000
201 S A 0.0000
202 C A 0.0000
203 E A 0.0000
204 W A 0.0000
205 P A 0.0000
206 L A 0.2839
207 Y A 0.8880
208 M A 0.0000
209 W A 0.2740
210 P A 0.3762
211 F A 1.2014
212 Q A -0.8798
213 K A -2.0586
214 P A 0.0000
215 N A -2.3901
216 Y A 0.0000
217 T A -1.6614
218 E A -2.2250
219 I A 0.0000
220 R A -1.6004
221 Q A -2.0137
222 Y A -1.2580
223 C A 0.0000
224 N A 0.0000
225 H A 0.0000
226 W A 0.0000
227 R A 0.0000
228 N A 0.0000
229 F A 0.2131
230 A A -0.5801
231 D A -1.7225
232 I A 0.0000
233 D A -1.1190
234 D A 0.0000
235 S A 0.0000
236 W A 0.0000
237 K A -2.1713
238 S A 0.0000
239 I A 0.0000
240 K A -1.1269
241 S A -0.7741
242 I A 0.0000
243 L A 0.0000
244 D A -0.0371
245 W A 0.5691
246 T A 0.0000
247 S A 0.2194
248 F A 1.2884
249 N A -0.1551
250 Q A -1.1146
251 E A -2.3311
252 R A -2.2867
253 I A 0.0000
254 V A -1.5371
255 D A -2.3280
256 V A -1.3172
257 A A 0.0000
258 G A 0.0000
259 P A -1.1917
260 G A 0.0000
261 G A 0.0000
262 W A 0.0000
263 N A 0.0000
264 D A 0.0000
265 P A 0.0000
266 D A 0.0000
267 M A 0.0000
268 L A 0.0000
269 V A 0.0000
270 I A 0.0000
271 G A -0.4405
272 N A -0.2311
273 F A 0.0718
274 G A 0.0000
275 L A 0.0000
276 S A 0.0000
277 W A 0.1930
278 N A 0.0000
279 Q A 0.0000
280 Q A -0.0826
281 V A 0.0000
282 T A 0.0000
283 Q A 0.0000
284 M A 0.0000
285 A A 0.0000
286 L A 0.0000
287 W A 0.0000
288 A A 0.0000
289 I A 0.0000
290 M A 0.0000
291 A A 0.0000
292 A A 0.0000
293 P A 0.0000
294 L A 0.0000
295 F A 0.0000
296 M A 0.0000
297 S A 0.0000
298 N A 0.0000
299 D A 0.0000
300 L A 0.0000
301 R A -1.0152
302 H A -1.1147
303 I A -0.6836
304 S A -0.8212
305 P A -0.9688
306 Q A -1.1588
307 A A 0.0000
308 K A -1.0959
309 A A -0.9827
310 L A 0.0000
311 L A 0.0000
312 Q A -1.4422
313 D A -1.4708
314 K A -2.3610
315 D A -1.7748
316 V A 0.0000
317 I A 0.0000
318 A A -0.7966
319 I A 0.0000
320 N A 0.0000
321 Q A -0.4889
322 D A 0.0000
323 P A -0.4524
324 L A 0.0361
325 G A 0.0000
326 K A -1.2299
327 Q A 0.0000
328 G A 0.0000
329 Y A -0.5346
330 Q A -0.2973
331 L A -0.7409
332 R A -1.6425
333 Q A -2.5352
334 G A -2.5580
335 D A -2.8953
336 N A -2.7688
337 F A 0.0000
338 E A 0.0000
339 V A 0.0000
340 W A 0.0000
341 E A 0.0000
342 R A 0.0000
343 P A -0.3361
344 L A 0.0000
345 S A -0.0904
346 G A -0.3799
347 L A 0.3425
348 A A -0.4248
349 W A 0.0000
350 A A 0.0000
351 V A 0.0000
352 A A 0.0000
353 M A 0.0000
354 I A 0.0000
355 N A 0.0000
356 R A -1.4081
357 Q A -1.2630
358 E A -0.6744
359 I A -0.0990
360 G A 0.0000
361 G A -0.3511
362 P A -0.5843
363 R A -0.8558
364 S A -1.1158
365 Y A -1.0354
366 T A -1.2733
367 I A 0.0000
368 A A -0.9911
369 V A 0.0000
370 A A -0.4837
371 S A -0.4849
372 L A 0.0000
373 G A 0.0000
374 K A -1.2657
375 G A -0.1646
376 V A 0.9792
377 A A 0.0000
378 C A 0.0000
379 N A -0.3467
380 P A -0.4207
381 A A -0.2416
382 C A 0.0000
383 F A 0.0450
384 I A 0.0000
385 T A -1.4687
386 Q A 0.0000
387 L A 0.0000
388 L A 0.0000
389 P A 0.2145
390 V A 0.3137
391 K A -2.0223
392 R A -2.7284
393 K A -2.2196
394 L A -0.5286
395 G A 0.5379
396 F A 1.4472
397 Y A 0.0824
398 E A -1.3467
399 W A -0.2688
400 T A -0.7974
401 S A -1.2342
402 R A -2.4427
403 L A 0.0000
404 R A -2.4134
405 S A 0.0000
406 H A -1.1497
407 I A 0.0000
408 N A -0.6299
409 P A 0.0000
410 T A 0.0000
411 G A 0.0000
412 T A 0.0000
413 V A 0.0000
414 L A 0.0000
415 L A 0.0000
416 Q A -0.9707
417 L A 0.0000
418 E A -1.3450
419 N A 0.0000
420 T A 0.0643
421 M A 0.7117
32 L B 0.0000
33 D B -2.6120
34 N B -1.9331
35 G B -1.5228
36 L B -1.0970
37 A B -1.1907
38 R B -2.1709
39 T B -0.9690
40 P B 0.0000
41 T B 0.0000
42 M B 0.0000
43 G B 0.0000
44 W B 0.0000
45 L B 0.0000
46 H B 0.0000
47 W B 0.0116
48 E B 0.0000
49 R B 0.0000
50 F B 0.0000
51 M B 0.3493
52 C B 0.0774
53 N B -0.5557
54 L B -0.7996
55 D B -2.6920
56 C B -2.3804
57 Q B -2.8230
58 E B -3.2013
59 E B -2.6459
60 P B -2.4689
61 D B -2.5444
62 S B -1.4576
63 C B 0.0000
64 I B 0.0000
65 S B 0.0000
66 E B 0.0000
67 K B -1.8443
68 L B 0.0000
69 F B 0.0000
70 M B -1.0207
71 E B -1.5953
72 M B 0.0000
73 A B 0.0000
74 E B -1.5183
75 L B -0.9578
76 M B 0.0000
77 V B -1.0407
78 S B -1.0292
79 E B -1.5022
80 G B -1.3058
81 W B 0.0000
82 K B -2.0758
83 D B -2.5879
84 A B -1.8744
85 G B -1.5297
86 Y B 0.0000
87 E B -1.9239
88 Y B 0.0000
89 L B 0.0000
90 C B 0.0000
91 I B 0.0000
92 D B -0.0552
93 D B 0.0000
94 C B 0.0000
95 W B 0.0000
96 M B 0.0000
97 A B -1.1926
98 P B -1.1512
99 Q B -1.8725
100 R B -2.0838
101 D B -2.3462
102 S B -1.8086
103 E B -2.3091
104 G B -1.6360
105 R B -1.5889
106 L B 0.0000
107 Q B -1.6358
108 A B 0.0000
109 D B -1.2210
110 P B -1.3923
111 Q B -1.5644
112 R B 0.0000
113 F B 0.0000
114 P B -1.5688
115 H B -2.0404
116 G B -1.8340
117 I B 0.0000
118 R B -3.0048
119 Q B -2.8179
120 L B 0.0000
121 A B 0.0000
122 N B -2.3755
123 Y B -1.4555
124 V B 0.0000
125 H B -1.4592
126 S B -1.0862
127 K B -1.2684
128 G B -1.3217
129 L B 0.0000
130 K B -1.4353
131 L B 0.0000
132 G B 0.0000
133 I B 0.0000
134 Y B 0.0000
135 A B 0.0000
136 D B 0.0000
137 V B 0.0000
138 G B 0.0000
139 N B -1.4894
140 K B -1.2914
141 T B 0.0000
142 C B 0.0610
143 A B -0.1013
144 G B -0.6313
145 F B -0.8272
146 P B 0.0000
147 G B -0.8826
148 S B 0.0000
149 F B -0.1777
150 G B -0.1386
151 Y B 0.2495
152 Y B 0.0000
153 D B -0.6550
154 I B 0.2869
155 D B 0.0000
156 A B 0.0000
157 Q B -1.1875
158 T B 0.0000
159 F B 0.0000
160 A B -1.1270
161 D B -1.2557
162 W B -1.4757
163 G B -1.3791
164 V B 0.0000
165 D B 0.0000
166 L B 0.0000
167 L B 0.0000
168 K B 0.0000
169 F B 0.0000
170 D B 0.0000
171 G B 0.0000
172 C B 0.1389
173 Y B 0.3326
174 C B -0.6477
175 D B -1.8546
176 S B -1.2217
177 L B -1.1194
178 E B -2.5985
179 N B -2.1992
180 L B 0.0000
181 A B -1.9141
182 D B -2.8079
183 G B 0.0000
184 Y B 0.0000
185 K B -1.8928
186 H B -1.4474
187 M B 0.0000
188 S B 0.0000
189 L B -0.6188
190 A B 0.0000
191 L B 0.0000
192 N B -2.3704
193 R B -2.6225
194 T B -2.0092
195 G B -1.7937
196 R B -1.8092
197 S B -0.9529
198 I B 0.0000
199 V B 0.0000
200 Y B 0.0000
201 S B 0.0000
202 C B 0.0000
203 E B 0.0642
204 W B 0.0000
205 P B 0.0000
206 L B 0.1683
207 Y B 0.7650
208 M B -0.0532
209 W B 0.1429
210 P B 0.1382
211 F B 1.1567
212 Q B -1.0355
213 K B -2.2554
214 P B 0.0000
215 N B -2.4934
216 Y B 0.0000
217 T B -1.5115
218 E B -2.4359
219 I B 0.0000
220 R B -1.7051
221 Q B -2.2220
222 Y B -1.3331
223 C B 0.0000
224 N B 0.0000
225 H B 0.0000
226 W B 0.0000
227 R B 0.0000
228 N B 0.0000
229 F B 0.1750
230 A B -0.6115
231 D B -1.7460
232 I B 0.0000
233 D B -1.1128
234 D B 0.0000
235 S B 0.0000
236 W B 0.0000
237 K B -2.1640
238 S B 0.0000
239 I B 0.0000
240 K B -1.1149
241 S B -0.8057
242 I B 0.0000
243 L B 0.0000
244 D B -0.0880
245 W B 0.4618
246 T B 0.0000
247 S B 0.2613
248 F B 1.1389
249 N B -0.4241
250 Q B -1.3612
251 E B -2.6612
252 R B -3.0008
253 I B 0.0000
254 V B -1.8403
255 D B -2.5744
256 V B -1.3609
257 A B 0.0000
258 G B -1.1480
259 P B -1.3352
260 G B 0.0000
261 G B 0.0000
262 W B 0.0000
263 N B 0.0000
264 D B 0.0000
265 P B 0.0000
266 D B 0.0000
267 M B 0.0000
268 L B 0.0000
269 V B 0.0000
270 I B 0.0000
271 G B -0.4543
272 N B -0.3180
273 F B 0.0000
274 G B 0.0000
275 L B 0.0000
276 S B 0.0000
277 W B 0.2856
278 N B 0.0366
279 Q B 0.0000
280 Q B -0.1582
281 V B 0.0000
282 T B 0.0000
283 Q B 0.0000
284 M B 0.0000
285 A B 0.0000
286 L B 0.0000
287 W B 0.0000
288 A B 0.0000
289 I B 0.0000
290 M B 0.0000
291 A B 0.0000
292 A B 0.0000
293 P B 0.0000
294 L B 0.0000
295 F B 0.0000
296 M B 0.0000
297 S B 0.0000
298 N B 0.0000
299 D B 0.0000
300 L B 0.0000
301 R B -1.0199
302 H B -1.1176
303 I B -0.6675
304 S B -0.7915
305 P B -0.9673
306 Q B -1.2563
307 A B 0.0000
308 K B -0.9494
309 A B -0.9102
310 L B 0.0000
311 L B 0.0000
312 Q B -1.3788
313 D B -1.5237
314 K B -2.4708
315 D B -2.0209
316 V B 0.0000
317 I B 0.0000
318 A B -0.9428
319 I B 0.0000
320 N B 0.0000
321 Q B -0.5917
322 D B -0.6116
323 P B -0.6539
324 L B -0.2513
325 G B 0.0000
326 K B -1.8510
327 Q B 0.0000
328 G B 0.0000
329 Y B -0.6662
330 Q B -0.5553
331 L B -1.1351
332 R B -2.4235
333 Q B -2.8567
334 G B -2.6741
335 D B -2.8886
336 N B -2.6998
337 F B 0.0000
338 E B 0.0000
339 V B 0.0000
340 W B 0.0000
341 E B 0.0000
342 R B 0.0000
343 P B 0.0000
344 L B 0.0000
345 S B 0.1023
346 G B 0.0613
347 L B 0.9821
348 A B 0.1216
349 W B 0.0000
350 A B 0.0000
351 V B 0.0000
352 A B 0.0000
353 M B 0.0000
354 I B 0.0000
355 N B 0.0000
356 R B -1.2496
357 Q B -1.2223
358 E B -0.6515
359 I B -0.0534
360 G B 0.0000
361 G B -0.3647
362 P B -0.6448
363 R B -0.8439
364 S B -1.2859
365 Y B -0.7262
366 T B -1.2507
367 I B -0.7923
368 A B -1.0638
369 V B 0.0000
370 A B -0.8016
371 S B -0.4853
372 L B 0.0000
373 G B 0.0000
374 K B -1.5358
375 G B -0.6631
376 V B 0.2531
377 A B 0.0000
378 C B 0.0000
379 N B -1.2857
380 P B -1.1233
381 A B 0.0000
382 C B 0.0000
383 F B 0.0967
384 I B 0.0000
385 T B -1.4640
386 Q B -1.2193
387 L B 0.0000
388 L B 0.0000
389 P B 0.3098
390 V B 0.5617
391 K B -1.5906
392 R B -2.7258
393 K B -2.3474
394 L B -0.8279
395 G B 0.0526
396 F B 1.1224
397 Y B -0.2984
398 E B -1.7086
399 W B -0.9175
400 T B -0.9955
401 S B -1.3125
402 R B -2.4521
403 L B 0.0000
404 R B -2.4550
405 S B -1.5828
406 H B -1.5522
407 I B 0.0000
408 N B -0.6671
409 P B 0.0000
410 T B 0.0000
411 G B 0.0000
412 T B 0.0000
413 V B 0.0000
414 L B 0.0000
415 L B 0.0000
416 Q B -0.8806
417 L B 0.0000
418 E B -0.9077
419 N B -0.3815
420 T B -0.2290
421 M B 0.0270
422 Q B -0.8512

 

Laboratory of Theory of Biopolymers 2015