Project name: 327f6c3e7258377

Chain sequence(s)	A: SASIAIGGDNDDTGLRWGGDGIVQIVANNNAIVGGWNSTDIFTEAGKHITSNGNLNQWGGGAIYCRDLNVS; C: GSASIAIGDNDTGLRWGGDGIVQIVANNNAIVGGWNSTDIFTEAGKHITSNGNLNQWGGGAIYCRDLNVS; B: GALGSASIAIGDNDTGLRWGGDGIVQIVANNAIVVGGWNSTDIFTEAGKHITSNGNLNQWGGGAIYCRDLNVS; D: AVQQGPWVGSSYVAETGQNWASLAANELRVTEERPFWISSFIGRSKEEIWEWTGENHSFNKDWLIGELRNRGGTPVVINIRAHQVSYTPGAPLFEFPGDLPNAYITLNIYADIYGRGGTGGVAYLGGNPGGDCIHNWIGNNRLRINNQGWICGGGGGGGGFRVGHTEAGGGGGRPLGAGGVSSLNLNGDDNATLGAPGRGYQLGNDYAGNGGDVGNNPGSASSAEMGGGAAGRAVVGTSSPQQWINVGNIAGSWL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.3626
• Maximal score value: 1.4901
• Average score: -0.5412
• Total score value: -247.3198

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	A	D	-0.8210
3	V	D	0.0000
4	Q	D	-1.2600
5	G	D	-0.7733
6	P	D	-0.5271
7	W	D	-0.1177
8	V	D	0.0000
9	G	D	0.0000
10	S	D	-0.4767
11	S	D	-0.2662
12	Y	D	0.0000
13	V	D	-0.2563
14	A	D	-0.2542
15	E	D	-0.9331
16	T	D	0.0000
17	G	D	-0.6456
18	Q	D	-0.5225
19	N	D	-0.4718
20	W	D	0.3280
21	A	D	0.0000
22	S	D	-0.0533
23	L	D	0.4902
24	A	D	0.0000
25	A	D	0.0000
26	N	D	-1.8041
27	E	D	-1.8424
28	L	D	0.0000
29	R	D	-2.7996
30	V	D	0.0000
31	T	D	-2.0542
32	E	D	-2.7800
33	R	D	-2.2191
34	P	D	-1.6194
35	F	D	0.0000
36	W	D	-0.1168
37	I	D	0.0000
38	S	D	-0.0489
39	S	D	-0.0446
40	F	D	0.0000
41	I	D	0.0902
42	G	D	-0.7602
43	R	D	-1.5616
44	S	D	-1.6156
45	K	D	-1.7206
46	E	D	-1.3463
47	E	D	-0.2104
48	I	D	0.7435
49	W	D	-0.1423
50	E	D	-1.6323
51	W	D	-1.3784
52	T	D	-1.5702
53	G	D	-2.0003
54	E	D	-2.7309
55	N	D	-1.8023
56	H	D	-1.0307
57	S	D	-0.5457
58	F	D	0.0000
59	N	D	-0.9911
60	K	D	-1.1151
61	D	D	-1.7991
62	W	D	-0.4535
63	L	D	0.0000
64	I	D	-1.2580
65	G	D	-1.6946
66	E	D	-2.0235
67	L	D	0.0000
68	R	D	-3.3626
69	N	D	-3.0348
70	R	D	-2.7519
71	G	D	-2.0061
72	G	D	-1.5074
73	T	D	-1.5208
74	P	D	0.0000
75	V	D	0.0000
76	V	D	0.0000
77	I	D	0.0000
78	N	D	0.0000
79	I	D	0.0000
80	R	D	-1.8135
81	A	D	-1.7562
82	H	D	-1.4376
83	Q	D	0.0000
84	V	D	0.0000
85	S	D	0.0000
86	Y	D	0.3090
87	T	D	-0.0166
88	P	D	-0.4465
89	G	D	-0.6123
90	A	D	-0.5789
91	P	D	0.0000
92	L	D	0.0000
93	F	D	0.0000
94	E	D	-0.6572
95	F	D	0.0000
96	P	D	-0.6845
97	G	D	-1.2064
98	D	D	-2.1692
99	L	D	0.0000
100	P	D	-1.5911
101	N	D	0.0000
102	A	D	-0.2553
103	Y	D	-0.4734
104	I	D	0.0000
105	T	D	0.0000
106	L	D	0.0000
107	N	D	-0.5495
108	I	D	0.0000
109	Y	D	-0.2735
110	A	D	0.0000
111	D	D	-0.7020
112	I	D	0.0000
113	Y	D	0.0000
114	G	D	0.0000
115	R	D	-0.2895
116	G	D	0.0000
117	G	D	0.0000
118	T	D	-0.7358
119	G	D	0.0000
120	G	D	0.0000
121	V	D	0.8663
122	A	D	0.0000
123	Y	D	1.4901
124	L	D	1.2543
125	G	D	-0.0620
126	G	D	-0.6299
127	N	D	-1.4255
128	P	D	-1.3184
129	G	D	0.0000
130	G	D	0.0000
131	D	D	-0.8812
132	C	D	0.0000
133	I	D	0.0000
134	H	D	-0.2416
135	N	D	0.0000
136	W	D	-0.2305
137	I	D	0.0000
138	G	D	-1.0268
139	N	D	-1.8243
140	R	D	-1.3112
141	L	D	0.0000
142	R	D	-0.7715
143	I	D	0.0000
144	N	D	-0.0214
145	N	D	0.0000
146	Q	D	-1.1978
147	G	D	-0.6253
148	W	D	-0.0049
149	I	D	0.0000
150	C	D	0.0000
151	G	D	0.0000
152	G	D	0.0000
153	G	D	0.0000
154	G	D	0.0000
155	G	D	0.0000
156	G	D	0.0000
157	G	D	0.0000
158	G	D	0.0000
159	F	D	0.0000
160	R	D	-0.5359
161	V	D	0.5839
162	G	D	-0.4664
163	H	D	-1.0310
164	T	D	-0.5433
165	E	D	-0.3988
166	A	D	0.0000
167	G	D	0.0000
168	G	D	0.0000
169	G	D	0.0000
170	G	D	0.0000
171	G	D	0.0000
172	R	D	-1.0591
173	P	D	0.0000
174	L	D	-0.4167
175	G	D	0.0000
176	A	D	-0.8388
177	G	D	0.0000
178	G	D	0.0000
179	V	D	1.2278
180	S	D	0.0000
181	S	D	0.1846
182	L	D	0.3045
183	N	D	-0.4489
184	L	D	-0.1697
185	N	D	-0.7396
186	G	D	-1.6701
187	D	D	-2.9656
188	N	D	-2.5930
189	A	D	0.0000
190	T	D	-0.5821
191	L	D	-0.2098
192	G	D	-0.5345
193	A	D	-0.8729
194	P	D	-1.6530
195	G	D	0.0000
196	R	D	-3.0780
197	G	D	0.0000
198	Y	D	-0.8722
199	Q	D	-0.8717
200	L	D	0.2677
201	G	D	-0.9191
202	N	D	-1.8347
203	D	D	-1.5432
204	Y	D	-1.2060
205	A	D	0.0000
206	G	D	0.0000
207	N	D	-2.0956
208	G	D	0.0000
209	G	D	0.0000
210	D	D	-1.8645
211	V	D	0.0000
212	G	D	-1.4125
213	N	D	-1.9889
214	P	D	-1.4551
215	G	D	-1.3399
216	S	D	-1.2493
217	A	D	-0.9211
218	S	D	0.0000
219	S	D	-1.2720
220	A	D	-0.7948
221	E	D	-1.7072
222	M	D	-0.5122
223	G	D	-0.7829
224	G	D	-1.1201
225	G	D	0.0000
226	A	D	-0.9331
227	A	D	-1.3647
228	G	D	0.0000
229	R	D	-1.2429
230	A	D	0.0000
231	V	D	0.0000
232	V	D	0.1006
233	G	D	0.1450
234	T	D	-0.0709
235	S	D	-0.2489
236	P	D	0.0000
237	Q	D	-0.8006
238	W	D	0.4787
239	I	D	1.2852
240	N	D	-0.0142
241	V	D	0.3286
242	G	D	-0.5973
243	N	D	-0.9299
244	I	D	-0.0654
245	A	D	-0.5242
246	G	D	-0.8864
247	S	D	-0.2535
248	W	D	0.8306
249	L	D	1.0162
570	S	A	-0.7741
571	A	A	-0.2767
572	S	A	-0.3138
573	I	A	-0.1145
574	A	A	-0.6834
575	I	A	0.0000
576	G	A	-1.0955
577	D	A	-1.9501
578	N	A	-2.4929
579	D	A	-2.7544
580	T	A	0.0000
581	G	A	0.0000
582	L	A	0.0000
583	R	A	-0.1054
584	W	A	0.2036
585	G	A	-0.0830
586	G	A	-0.6437
587	D	A	-2.1161
588	G	A	-1.8531
589	I	A	-0.2884
590	V	A	0.0000
591	Q	A	-0.0584
592	I	A	0.0000
593	V	A	0.0000
594	A	A	0.0000
595	N	A	-2.7009
596	N	A	-2.1664
597	A	A	-1.0411
598	I	A	-0.2626
599	V	A	0.0000
600	G	A	0.0000
601	G	A	0.0000
602	W	A	0.0000
603	N	A	-0.6132
604	S	A	-0.8263
605	T	A	-0.5497
606	D	A	-0.6185
607	I	A	0.0314
608	F	A	-0.2046
609	T	A	0.0000
610	E	A	-1.4649
611	A	A	-1.0344
612	G	A	-1.2507
613	K	A	-1.1841
614	H	A	-0.8930
615	I	A	0.0000
616	T	A	0.0000
617	S	A	0.0000
618	N	A	-0.8343
619	G	A	0.0000
620	N	A	-0.6667
621	L	A	0.0000
622	N	A	0.0000
623	Q	A	0.0000
624	W	A	-0.0457
625	G	A	-0.7802
626	G	A	-0.9367
627	G	A	-0.7843
628	A	A	0.0000
629	I	A	0.0000
630	Y	A	0.1557
631	C	A	0.0000
632	R	A	-1.0241
633	D	A	0.0000
634	L	A	0.0000
635	N	A	-0.1262
636	V	A	0.0000
637	S	A	-0.6215
566	G	B	-1.0085
567	A	B	-1.2077
568	L	B	0.0000
569	G	B	-0.8301
570	S	B	-0.4744
571	A	B	-0.3264
572	S	B	-0.4233
573	I	B	-0.0946
574	A	B	-0.7790
575	I	B	0.0000
576	G	B	-0.9039
577	D	B	-1.9035
578	N	B	-2.4857
579	D	B	-2.4283
580	T	B	0.0000
581	G	B	0.0000
582	L	B	0.0000
583	R	B	-0.2402
584	W	B	-0.2539
585	G	B	-0.4886
586	G	B	-0.9675
587	D	B	-2.3355
588	G	B	0.0000
589	I	B	-0.4450
590	V	B	0.0000
591	Q	B	-0.1470
592	I	B	0.0000
593	V	B	0.0000
594	A	B	0.0000
595	N	B	-2.5466
596	N	B	-2.1162
597	A	B	-1.0947
598	I	B	-0.4160
599	V	B	0.0000
600	G	B	0.0000
601	G	B	0.0000
602	W	B	0.0000
603	N	B	-0.6014
604	S	B	-0.8539
605	T	B	-0.6737
606	D	B	-0.6161
607	I	B	0.0345
608	F	B	-0.1495
609	T	B	0.0000
610	E	B	-1.3256
611	A	B	-0.9349
612	G	B	-1.1907
613	K	B	-1.1852
614	H	B	-0.8848
615	I	B	0.0000
616	T	B	0.0000
617	S	B	0.0000
618	N	B	-1.0942
619	G	B	0.0000
620	N	B	-0.7083
621	L	B	0.0000
622	N	B	0.0000
623	Q	B	0.0000
624	W	B	0.0944
625	G	B	-0.7189
626	G	B	-0.9159
627	G	B	-0.7526
628	A	B	0.0000
629	I	B	0.0000
630	Y	B	0.2379
631	C	B	0.0000
632	R	B	-0.9985
633	D	B	0.0000
634	L	B	0.0000
635	N	B	0.0000
636	V	B	0.0000
637	S	B	-0.4804
569	G	C	-1.0647
570	S	C	-0.4037
571	A	C	-0.0008
572	S	C	-0.3354
573	I	C	-0.3449
574	A	C	-1.2524
575	I	C	0.0000
576	G	C	-1.6368
577	D	C	-3.0901
578	N	C	-3.0548
579	D	C	-3.3066
580	T	C	0.0000
581	G	C	0.0000
582	L	C	0.0000
583	R	C	0.2252
584	W	C	0.4452
585	G	C	-0.0834
586	G	C	-0.7162
587	D	C	-1.8780
588	G	C	0.0000
589	I	C	-0.2897
590	V	C	0.0000
591	Q	C	-0.0129
592	I	C	0.0000
593	V	C	0.0000
594	A	C	0.0000
595	N	C	-2.8628
596	N	C	-2.1768
597	A	C	-1.0534
598	I	C	-0.2428
599	V	C	0.0000
600	G	C	0.0000
601	G	C	0.0000
602	W	C	0.0000
603	N	C	-0.6294
604	S	C	-0.8809
605	T	C	-0.5631
606	D	C	-0.6025
607	I	C	0.0202
608	F	C	-0.2319
609	T	C	0.0000
610	E	C	-1.5661
611	A	C	-1.1039
612	G	C	-1.2977
613	K	C	-1.2165
614	H	C	-0.8984
615	I	C	0.0000
616	T	C	0.0000
617	S	C	0.0000
618	N	C	-0.9775
619	G	C	0.0000
620	N	C	-0.6909
621	L	C	0.0000
622	N	C	0.0000
623	Q	C	0.0000
624	W	C	0.4278
625	G	C	-0.5801
626	G	C	-0.8600
627	G	C	-0.7105
628	A	C	0.0000
629	I	C	0.0000
630	Y	C	0.1762
631	C	C	0.0000
632	R	C	-0.9736
633	D	C	0.0000
634	L	C	0.0000
635	N	C	-0.2389
636	V	C	0.0000
637	S	C	-1.0363