Project name: corneodesmosin

Chain sequence(s)	A: MGSSRAPWMGRVGGHGMMALLLAGLLLPGTLAKSIGTFSDPCKDPTRITSPNDPCLTGKGDSSGFSSYSGSSSSGSSISSARSSGGGSSGSSSGSSIAQGGSAGSFKPGTGYSQVSYSSGSGSSLQGASGSSQLGSSSSHSGNSGSHSGSSSSHSSSSSSFQFSSSSFQVGNGSALPTNDNSYRGILNPSQPGQSSSSSQTSGVSSSGQSVSSNQRPCSSDIPDSPCSGGPIVSHSGPYIPSSHSVSGGQRPVVVVVDQHGSGAPGVVQGPPCSNGGLPGKPCPPITSVDKSYGGYEVVGGSSDSYLVPGMTYSKGKIYPVGYFTKENPVKGSPGVPSFAAGPPISEGKYFSSNPIIPSQSAASSAIAFQPVGTGGVQLCGGGSTGSKGPCSPSSSRVPSSSSISSSSGSPYHPCGSASQSPCSPPGTGSFSSSSSSQSSGKIILQPCGSKSSSSGHPCMSVSSLTLTGGPDGSPHPDPSAGAKPCGSSSAGKIPCRSIRDILAQVKPLGPQLADPEVFLPQGELLDSP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.1733
• Maximal score value: 3.3372
• Average score: -0.1673
• Total score value: -88.483

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.7577
2	G	A	-0.3170
3	S	A	-0.7647
4	S	A	-1.2297
5	R	A	-1.9388
6	A	A	-0.7545
7	P	A	0.0578
8	W	A	1.0513
9	M	A	1.0225
10	G	A	-0.1121
11	R	A	-0.9871
12	V	A	0.4425
13	G	A	-0.7087
14	G	A	-0.7919
15	H	A	-0.9152
16	G	A	-0.0442
17	M	A	1.5483
18	M	A	1.8214
19	A	A	1.7752
20	L	A	3.0058
21	L	A	3.3372
22	L	A	3.0980
23	A	A	2.5833
24	G	A	2.3284
25	L	A	3.2829
26	L	A	3.1650
27	L	A	2.3555
28	P	A	1.0215
29	G	A	0.4215
30	T	A	0.3869
31	L	A	0.9097
32	A	A	0.1079
33	K	A	-0.9712
34	S	A	-0.0235
35	I	A	1.5572
36	G	A	0.6639
37	T	A	0.9577
38	F	A	1.6662
39	S	A	-0.1898
40	D	A	-1.1383
41	P	A	-1.0287
42	C	A	-0.6711
43	K	A	-2.2954
44	D	A	-1.9308
45	P	A	-1.1487
46	T	A	-1.0246
47	R	A	-1.3343
48	I	A	0.8683
49	T	A	-0.3441
50	S	A	-0.9988
51	P	A	-1.2478
52	N	A	-2.3215
53	D	A	-2.3016
54	P	A	-0.6601
55	C	A	0.5722
56	L	A	1.2543
57	T	A	0.2342
58	G	A	-0.8468
59	K	A	-2.3707
60	G	A	-2.2911
61	D	A	-2.5328
62	S	A	-1.3859
63	S	A	-0.4592
64	G	A	0.2737
65	F	A	1.5217
66	S	A	0.8327
67	S	A	0.6704
68	Y	A	0.9589
69	S	A	0.1087
70	G	A	-0.4269
71	S	A	-0.6336
72	S	A	-0.5596
73	S	A	-0.5619
74	S	A	-0.6266
75	G	A	-0.7548
76	S	A	-0.2126
77	S	A	0.5080
78	I	A	1.7096
79	S	A	0.7626
80	S	A	-0.2217
81	A	A	-1.0016
82	R	A	-2.0187
83	S	A	-1.4016
84	S	A	-1.0138
85	G	A	-0.9655
86	G	A	-1.0365
87	G	A	-0.9425
88	S	A	-0.7567
89	S	A	-0.6790
90	G	A	-0.7743
91	S	A	-0.6632
92	S	A	-0.6074
93	S	A	-0.6258
94	G	A	-0.7538
95	S	A	-0.1988
96	S	A	0.5695
97	I	A	1.6639
98	A	A	0.3483
99	Q	A	-1.0983
100	G	A	-1.3250
101	G	A	-1.0616
102	S	A	-0.6021
103	A	A	-0.4272
104	G	A	-0.2243
105	S	A	0.1348
106	F	A	0.8183
107	K	A	-1.0723
108	P	A	-1.0415
109	G	A	-1.0041
110	T	A	-0.3297
111	G	A	-0.0311
112	Y	A	0.6935
113	S	A	0.1017
114	Q	A	-0.2033
115	V	A	1.3374
116	S	A	1.0681
117	Y	A	1.4774
118	S	A	0.2081
119	S	A	-0.3018
120	G	A	-0.8245
121	S	A	-0.7581
122	G	A	-0.8219
123	S	A	-0.2960
124	S	A	0.0680
125	L	A	0.6462
126	Q	A	-0.5942
127	G	A	-0.7354
128	A	A	-0.6500
129	S	A	-0.5526
130	G	A	-0.8458
131	S	A	-0.9790
132	S	A	-0.6862
133	Q	A	-0.5893
134	L	A	0.5817
135	G	A	-0.1297
136	S	A	-0.2915
137	S	A	-0.5613
138	S	A	-0.6769
139	S	A	-0.8899
140	H	A	-1.3531
141	S	A	-1.3199
142	G	A	-1.5711
143	N	A	-1.7923
144	S	A	-1.1993
145	G	A	-1.1386
146	S	A	-1.0268
147	H	A	-1.3898
148	S	A	-1.0156
149	G	A	-0.9098
150	S	A	-0.6328
151	S	A	-0.5602
152	S	A	-0.6839
153	S	A	-0.8849
154	H	A	-1.2940
155	S	A	-0.9381
156	S	A	-0.6756
157	S	A	-0.5172
158	S	A	-0.5088
159	S	A	-0.0655
160	S	A	0.3301
161	F	A	1.5799
162	Q	A	0.6376
163	F	A	1.5690
164	S	A	0.3217
165	S	A	-0.0575
166	S	A	-0.0267
167	S	A	0.3034
168	F	A	1.6012
169	Q	A	0.5199
170	V	A	1.1492
171	G	A	-0.6941
172	N	A	-1.4160
173	G	A	-1.2751
174	S	A	-0.3615
175	A	A	0.5523
176	L	A	1.3780
177	P	A	0.3492
178	T	A	-0.8576
179	N	A	-2.6520
180	D	A	-3.1733
181	N	A	-2.2468
182	S	A	-0.8698
183	Y	A	0.1833
184	R	A	-1.0040
185	G	A	0.2369
186	I	A	1.8749
187	L	A	1.6337
188	N	A	-0.1525
189	P	A	-0.8800
190	S	A	-1.2123
191	Q	A	-1.5730
192	P	A	-1.3218
193	G	A	-1.4724
194	Q	A	-1.6203
195	S	A	-1.0346
196	S	A	-0.7112
197	S	A	-0.5100
198	S	A	-0.7148
199	S	A	-0.9997
200	Q	A	-1.4272
201	T	A	-0.9184
202	S	A	-0.3544
203	G	A	0.1962
204	V	A	1.3607
205	S	A	0.3876
206	S	A	-0.1850
207	S	A	-0.8801
208	G	A	-1.3593
209	Q	A	-1.2474
210	S	A	-0.1117
211	V	A	1.2721
212	S	A	0.1011
213	S	A	-1.0355
214	N	A	-2.4698
215	Q	A	-2.7688
216	R	A	-2.6812
217	P	A	-1.1518
218	C	A	0.0341
219	S	A	-0.2822
220	S	A	-0.3810
221	D	A	-1.1327
222	I	A	0.4663
223	P	A	-0.6705
224	D	A	-1.5503
225	S	A	-0.5724
226	P	A	-0.3281
227	C	A	0.0515
228	S	A	-0.3896
229	G	A	-0.3453
230	G	A	-0.0499
231	P	A	0.8161
232	I	A	2.3523
233	V	A	2.2029
234	S	A	0.5958
235	H	A	-0.4188
236	S	A	-0.6108
237	G	A	-0.3486
238	P	A	0.4876
239	Y	A	1.8173
240	I	A	2.3025
241	P	A	0.7369
242	S	A	0.0535
243	S	A	-0.4480
244	H	A	-1.1901
245	S	A	-0.9861
246	V	A	-0.4858
247	S	A	-0.6881
248	G	A	-1.1905
249	G	A	-1.6569
250	Q	A	-2.2202
251	R	A	-2.1950
252	P	A	-0.1210
253	V	A	1.7949
254	V	A	3.3023
255	V	A	2.7167
256	V	A	2.2529
257	V	A	0.5842
258	D	A	-1.5428
259	Q	A	-2.2392
260	H	A	-2.4338
261	G	A	-1.7726
262	S	A	-1.0802
263	G	A	-0.5216
264	A	A	-0.1910
265	P	A	0.0609
266	G	A	0.5947
267	V	A	1.9804
268	V	A	1.7447
269	Q	A	-0.3332
270	G	A	-0.6742
271	P	A	-0.7275
272	P	A	-0.2653
273	C	A	-0.3463
274	S	A	-1.1553
275	N	A	-1.4521
276	G	A	-0.9066
277	G	A	-0.6241
278	L	A	0.4055
279	P	A	-0.5671
280	G	A	-1.3421
281	K	A	-1.7407
282	P	A	-1.2410
283	C	A	-0.1015
284	P	A	0.4730
285	P	A	1.6052
286	I	A	2.8060
287	T	A	1.3041
288	S	A	0.3529
289	V	A	0.3532
290	D	A	-1.9019
291	K	A	-1.9550
292	S	A	-0.6972
293	Y	A	0.3317
294	G	A	-0.0739
295	G	A	-0.0541
296	Y	A	1.0965
297	E	A	0.2475
298	V	A	2.3013
299	V	A	1.6208
300	G	A	0.4203
301	G	A	-0.1932
302	S	A	-1.0001
303	S	A	-0.9082
304	D	A	-1.4388
305	S	A	-0.5682
306	Y	A	0.9583
307	L	A	1.0542
308	V	A	2.2071
309	P	A	0.9062
310	G	A	0.8566
311	M	A	1.3732
312	T	A	0.7183
313	Y	A	0.0723
314	S	A	-0.7785
315	K	A	-1.8489
316	G	A	-0.8130
317	K	A	-0.9099
318	I	A	0.3142
319	Y	A	0.8326
320	P	A	0.0000
321	V	A	2.2187
322	G	A	1.8244
323	Y	A	2.3119
324	F	A	1.9958
325	T	A	-0.5427
326	K	A	-2.2073
327	E	A	-2.8693
328	N	A	-2.4553
329	P	A	-1.1440
330	V	A	0.0087
331	K	A	-1.4340
332	G	A	-0.9799
333	S	A	-0.4201
334	P	A	-0.3098
335	G	A	0.1270
336	V	A	1.5158
337	P	A	1.3706
338	S	A	1.4863
339	F	A	2.6013
340	A	A	1.4435
341	A	A	1.0173
342	G	A	0.7817
343	P	A	-0.2103
344	P	A	-0.0600
345	I	A	0.3544
346	S	A	-0.5451
347	E	A	-2.0475
348	G	A	-1.2068
349	K	A	-1.1995
350	Y	A	0.8882
351	F	A	1.5132
352	S	A	0.3269
353	S	A	-0.1763
354	N	A	-0.5100
355	P	A	0.7245
356	I	A	2.3698
357	I	A	2.4242
358	P	A	0.7223
359	S	A	-0.1379
360	Q	A	-1.2148
361	S	A	-0.8653
362	A	A	-0.3980
363	A	A	-0.1091
364	S	A	-0.0480
365	S	A	0.2080
366	A	A	1.1299
367	I	A	2.3676
368	A	A	1.6159
369	F	A	2.0776
370	Q	A	0.2824
371	P	A	0.4055
372	V	A	1.2715
373	G	A	-0.0177
374	T	A	-0.1115
375	G	A	-0.3489
376	G	A	-0.0523
377	V	A	1.2817
378	Q	A	0.3596
379	L	A	1.5135
380	C	A	0.9911
381	G	A	-0.1723
382	G	A	-0.6459
383	G	A	-0.8392
384	S	A	-0.6609
385	T	A	-0.5551
386	G	A	-1.1027
387	S	A	-1.4138
388	K	A	-2.1933
389	G	A	-1.3525
390	P	A	-0.6154
391	C	A	0.3502
392	S	A	-0.1160
393	P	A	-0.3949
394	S	A	-0.5416
395	S	A	-0.8583
396	S	A	-0.8771
397	R	A	-1.1938
398	V	A	0.6478
399	P	A	0.2038
400	S	A	-0.1025
401	S	A	-0.5408
402	S	A	-0.0588
403	S	A	0.7066
404	I	A	1.6979
405	S	A	0.5454
406	S	A	-0.0686
407	S	A	-0.5755
408	S	A	-0.6394
409	G	A	-0.7665
410	S	A	-0.3326
411	P	A	-0.0109
412	Y	A	0.6277
413	H	A	-0.4823
414	P	A	-0.3902
415	C	A	-0.0075
416	G	A	-0.3273
417	S	A	-0.3014
418	A	A	-0.4953
419	S	A	-0.8376
420	Q	A	-1.4429
421	S	A	-0.8301
422	P	A	-0.3099
423	C	A	0.4145
424	S	A	-0.0911
425	P	A	-0.4555
426	P	A	-0.6659
427	G	A	-0.7930
428	T	A	-0.6194
429	G	A	-0.3547
430	S	A	0.4316
431	F	A	1.5813
432	S	A	0.6190
433	S	A	-0.0313
434	S	A	-0.5523
435	S	A	-0.5313
436	S	A	-0.7667
437	S	A	-1.0396
438	Q	A	-1.5602
439	S	A	-1.3104
440	S	A	-1.0291
441	G	A	-0.8049
442	K	A	-0.2709
443	I	A	2.2830
444	I	A	2.8063
445	L	A	2.3094
446	Q	A	0.4064
447	P	A	0.0117
448	C	A	0.0190
449	G	A	-0.8353
450	S	A	-1.2112
451	K	A	-1.9942
452	S	A	-1.3229
453	S	A	-0.9755
454	S	A	-0.8740
455	S	A	-0.8466
456	G	A	-1.0971
457	H	A	-1.1022
458	P	A	-0.2583
459	C	A	0.9880
460	M	A	1.5343
461	S	A	1.2130
462	V	A	2.0588
463	S	A	1.0526
464	S	A	1.0285
465	L	A	1.9254
466	T	A	1.2789
467	L	A	1.5854
468	T	A	0.4764
469	G	A	-0.7868
470	G	A	-1.3355
471	P	A	-1.6230
472	D	A	-2.4387
473	G	A	-1.8832
474	S	A	-1.5653
475	P	A	-1.4111
476	H	A	-1.8227
477	P	A	-1.7682
478	D	A	-2.4295
479	P	A	-1.4759
480	S	A	-1.0324
481	A	A	-1.0814
482	G	A	-1.3975
483	A	A	-1.0722
484	K	A	-1.6782
485	P	A	-0.9063
486	C	A	0.0659
487	G	A	-0.1239
488	S	A	-0.4638
489	S	A	-0.5092
490	S	A	-0.5955
491	A	A	-0.4762
492	G	A	-0.7899
493	K	A	-0.9926
494	I	A	0.8193
495	P	A	-0.3180
496	C	A	-0.5491
497	R	A	-1.1445
498	S	A	-0.4493
499	I	A	1.2209
500	R	A	-0.7896
501	D	A	-0.7803
502	I	A	1.1348
503	L	A	1.2866
504	A	A	0.1181
505	Q	A	-0.4667
506	V	A	1.0336
507	K	A	-0.5922
508	P	A	0.1085
509	L	A	0.8774
510	G	A	-0.0138
511	P	A	-0.1027
512	Q	A	-0.5379
513	L	A	0.3749
514	A	A	-0.5746
515	D	A	-1.4998
516	P	A	-0.4062
517	E	A	-0.6698
518	V	A	1.5641
519	F	A	2.4276
520	L	A	2.0099
521	P	A	0.2853
522	Q	A	-0.9474
523	G	A	-1.2143
524	E	A	-1.4494
525	L	A	0.6936
526	L	A	0.8922
527	D	A	-0.9997
528	S	A	-0.6515
529	P	A	-0.5726