Project name: 35d8a8f13ca27b2

Chain sequence(s)	A: KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPRAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.9784
• Maximal score value: 0.689
• Average score: -1.0821
• Total score value: -400.3732

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	K	A	-2.7672
2	I	A	0.0000
3	E	A	-3.4685
4	E	A	-3.2952
5	G	A	-2.0989
6	K	A	-2.2046
7	L	A	0.0000
8	V	A	-0.3972
9	I	A	0.0000
10	W	A	0.0000
11	I	A	0.0000
12	N	A	-1.6187
13	G	A	-1.8690
14	D	A	-1.1475
15	K	A	-1.1513
16	G	A	0.0000
17	Y	A	-1.1241
18	N	A	-1.9722
19	G	A	0.0000
20	L	A	0.0000
21	A	A	-1.7313
22	E	A	-2.8931
23	V	A	0.0000
24	G	A	0.0000
25	K	A	-3.9182
26	K	A	-3.5685
27	F	A	0.0000
28	E	A	-3.8382
29	K	A	-3.9620
30	D	A	-3.3644
31	T	A	-2.0611
32	G	A	-2.3194
33	I	A	-2.0733
34	K	A	-2.6453
35	V	A	-1.5334
36	T	A	-0.5497
37	V	A	-0.4968
38	E	A	-1.3535
39	H	A	-1.9004
40	P	A	-2.1192
41	D	A	-3.3292
42	K	A	-3.4480
43	L	A	0.0000
44	E	A	-2.2343
45	E	A	-2.8688
46	K	A	-2.5109
47	F	A	0.0000
48	P	A	-1.3351
49	Q	A	-1.7050
50	V	A	-1.0346
51	A	A	0.0000
52	A	A	-0.5469
53	T	A	-0.8012
54	G	A	-1.1859
55	D	A	-1.9759
56	G	A	-1.1420
57	P	A	0.0000
58	D	A	0.0000
59	I	A	0.0000
60	I	A	0.0000
61	F	A	0.0000
62	W	A	-0.0596
63	A	A	-0.1341
64	H	A	0.0000
65	D	A	0.0000
66	R	A	-0.6983
67	F	A	0.0000
68	G	A	0.0000
69	G	A	-0.8708
70	Y	A	0.0000
71	A	A	-1.3983
72	Q	A	-1.6046
73	S	A	-1.0606
74	G	A	-1.1598
75	L	A	0.0000
76	L	A	0.0000
77	A	A	-1.1333
78	E	A	-2.3109
79	I	A	0.0000
80	T	A	-1.4540
81	P	A	0.0000
82	D	A	-2.8646
83	K	A	-3.1666
84	A	A	-2.1163
85	F	A	0.0000
86	Q	A	-2.4459
87	D	A	-2.7028
88	K	A	-2.3718
89	L	A	0.0000
90	Y	A	-0.4096
91	P	A	-0.3868
92	F	A	0.5497
93	T	A	0.0000
94	W	A	0.0000
95	D	A	-2.0882
96	A	A	0.0000
97	V	A	0.0000
98	R	A	-3.3776
99	Y	A	-2.5182
100	N	A	-2.3133
101	G	A	-2.3303
102	K	A	-2.9678
103	L	A	-2.2766
104	I	A	0.0000
105	A	A	0.0000
106	Y	A	0.0000
107	P	A	0.0000
108	I	A	0.0000
109	A	A	0.0000
110	V	A	0.0000
111	E	A	-0.3464
112	A	A	0.0000
113	L	A	0.0000
114	S	A	0.0000
115	L	A	0.0000
116	I	A	0.0000
117	Y	A	0.0000
118	N	A	0.0000
119	K	A	-2.2323
120	D	A	-2.4597
121	L	A	-1.4128
122	L	A	0.0000
123	P	A	-1.6972
124	N	A	-1.9692
125	P	A	-1.1350
126	P	A	0.0000
127	K	A	-2.3204
128	T	A	-2.1637
129	W	A	0.0000
130	E	A	-2.3641
131	E	A	-2.5253
132	I	A	0.0000
133	P	A	-1.9079
134	A	A	-1.7384
135	L	A	-1.6481
136	D	A	0.0000
137	K	A	-3.4673
138	E	A	-3.4474
139	L	A	0.0000
140	K	A	-3.7111
141	A	A	-2.8286
142	K	A	-3.2173
143	G	A	-2.6696
144	K	A	-2.8897
145	S	A	-2.0764
146	A	A	0.0000
147	L	A	0.0000
148	M	A	-0.1900
149	F	A	0.0000
150	N	A	-0.5757
151	L	A	0.0000
152	Q	A	-1.2444
153	E	A	-0.8720
154	P	A	0.0000
155	Y	A	-0.2488
156	F	A	0.0000
157	T	A	0.0000
158	W	A	0.0000
159	P	A	0.0000
160	L	A	0.0000
161	I	A	0.0000
162	A	A	0.0000
163	A	A	0.0000
164	D	A	-1.6819
165	G	A	-0.8604
166	G	A	0.0000
167	Y	A	-0.2604
168	A	A	0.0000
169	F	A	0.0000
170	K	A	-1.3013
171	Y	A	-0.9062
172	E	A	-2.8082
173	N	A	-2.6902
174	G	A	-2.2222
175	K	A	-2.5795
176	Y	A	-1.4636
177	D	A	-1.8541
178	I	A	-0.8248
179	K	A	-2.1115
180	D	A	-1.3063
181	V	A	0.0000
182	G	A	0.0000
183	V	A	0.0000
184	D	A	-2.0711
185	N	A	-1.2256
186	A	A	-0.7455
187	G	A	0.0000
188	A	A	0.0000
189	K	A	-1.2005
190	A	A	-0.5370
191	G	A	0.0000
192	L	A	0.0000
193	T	A	-0.5232
194	F	A	-0.5220
195	L	A	0.0000
196	V	A	0.0000
197	D	A	-2.3211
198	L	A	0.0000
199	I	A	-2.7086
200	K	A	-3.4879
201	N	A	-3.4000
202	K	A	-3.5110
203	H	A	-2.4787
204	M	A	0.0000
205	N	A	-2.6494
206	A	A	-2.0514
207	D	A	-2.2121
208	T	A	0.0000
209	D	A	-0.9661
210	Y	A	0.0294
211	S	A	0.2290
212	I	A	0.6890
213	A	A	0.0000
214	E	A	-0.4030
215	A	A	-0.6188
216	A	A	0.0000
217	F	A	0.0000
218	N	A	-2.0832
219	K	A	-2.5986
220	G	A	-2.3949
221	E	A	-2.6047
222	T	A	0.0000
223	A	A	0.0000
224	M	A	0.0000
225	T	A	0.0000
226	I	A	0.0000
227	N	A	0.0000
228	G	A	0.0000
229	P	A	0.0000
230	R	A	-0.8118
231	A	A	0.0000
232	W	A	0.0000
233	S	A	-1.2430
234	N	A	-1.3592
235	I	A	0.0000
236	D	A	-2.1819
237	T	A	-1.4513
238	S	A	-1.9460
239	K	A	-2.6303
240	V	A	-2.1968
241	N	A	-2.3938
242	Y	A	-1.3222
243	G	A	-0.5743
244	V	A	0.1723
245	T	A	0.0456
246	V	A	-0.0829
247	L	A	0.0000
248	P	A	0.0000
249	T	A	-1.5293
250	F	A	0.0000
251	K	A	-2.4793
252	G	A	-2.0382
253	Q	A	-1.8687
254	P	A	-1.3794
255	S	A	0.0000
256	K	A	-1.7854
257	P	A	0.0000
258	F	A	0.0000
259	V	A	0.0000
260	G	A	0.0000
261	V	A	0.0000
262	L	A	0.0000
263	S	A	0.0000
264	A	A	0.0000
265	G	A	0.0000
266	I	A	0.0000
267	N	A	0.0000
268	A	A	-0.5400
269	A	A	-0.6462
270	S	A	0.0000
271	P	A	-1.6190
272	N	A	0.0000
273	K	A	-1.7808
274	E	A	-2.4211
275	L	A	-1.6253
276	A	A	0.0000
277	K	A	-2.2147
278	E	A	-2.1309
279	F	A	0.0000
280	L	A	0.0000
281	E	A	-1.4327
282	N	A	-1.7317
283	Y	A	-1.3668
284	L	A	0.0000
285	L	A	0.0000
286	T	A	-1.7432
287	D	A	-2.3744
288	E	A	-2.5568
289	G	A	0.0000
290	L	A	0.0000
291	E	A	-2.3743
292	A	A	-2.2580
293	V	A	0.0000
294	N	A	-1.8101
295	K	A	-2.4708
296	D	A	-1.8731
297	K	A	-1.6304
298	P	A	-1.0575
299	L	A	0.0000
300	G	A	0.0000
301	A	A	0.0000
302	V	A	0.0000
303	A	A	0.0000
304	L	A	0.0000
305	K	A	-2.0603
306	S	A	-1.9169
307	Y	A	0.0000
308	E	A	-2.2565
309	E	A	-3.3191
310	E	A	-3.4374
311	L	A	-2.2590
312	A	A	-2.1558
313	K	A	-2.7913
314	D	A	-1.6682
315	P	A	-0.9699
316	R	A	-0.8631
317	I	A	0.0000
318	A	A	-0.7926
319	A	A	0.0000
320	T	A	0.0000
321	M	A	-1.0127
322	E	A	-1.8143
323	N	A	0.0000
324	A	A	-1.7275
325	Q	A	-2.4316
326	K	A	-2.3420
327	G	A	-2.1478
328	E	A	-2.1711
329	I	A	-0.7332
330	M	A	0.0000
331	P	A	0.0000
332	N	A	-0.4036
333	I	A	-0.3924
334	P	A	-0.5285
335	Q	A	-0.2840
336	M	A	0.0000
337	S	A	-0.2626
338	A	A	-0.3340
339	F	A	0.0000
340	W	A	0.0000
341	Y	A	0.6022
342	A	A	0.0000
343	V	A	0.0000
344	R	A	-1.0025
345	T	A	-0.5884
346	A	A	0.0000
347	V	A	0.0000
348	I	A	-0.9071
349	N	A	-1.3275
350	A	A	0.0000
351	A	A	0.0000
352	S	A	-1.6358
353	G	A	-1.7143
354	R	A	-2.4296
355	Q	A	-2.0726
356	T	A	-1.9276
357	V	A	-1.9720
358	D	A	-3.4758
359	E	A	-3.7888
360	A	A	0.0000
361	L	A	0.0000
362	K	A	-3.9784
363	D	A	-3.6850
364	A	A	0.0000
365	Q	A	-2.3329
366	T	A	-2.2351
367	R	A	-2.3415
368	I	A	0.0000
369	T	A	-1.6811
370	K	A	-2.2629