Project name: 2roc chain A

Chain sequence(s)	A: GPLGSEDDLYRQSLEIISRYLREQATGSKDSKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEGDVKSFSRVMVHVFKDGVTNWGRIVTLISFGAFVAKHLKSVNQESFIEPLAETITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGG
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.219
• Maximal score value: 1.141
• Average score: -1.0615
• Total score value: -171.964

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
147	G	A	-0.7166
148	P	A	-0.3185
149	L	A	0.1723
150	G	A	-0.6167
151	S	A	-1.3057
152	E	A	-2.3809
153	D	A	-2.3130
154	D	A	-2.4938
155	L	A	-1.7805
156	Y	A	-1.8648
157	R	A	-2.6682
158	Q	A	-1.9430
159	S	A	0.0000
160	L	A	-1.0387
161	E	A	-1.5378
162	I	A	0.0000
163	I	A	0.0000
164	S	A	0.0000
165	R	A	-1.0267
166	Y	A	0.0000
167	L	A	0.0000
168	R	A	-1.7205
169	E	A	0.0000
170	Q	A	0.0000
171	A	A	-1.0343
172	T	A	-1.0559
173	G	A	-1.4824
174	S	A	-1.9774
175	K	A	-3.0959
176	D	A	-3.1625
177	S	A	-2.6920
178	K	A	-2.9555
179	P	A	-2.2235
180	L	A	0.0000
181	G	A	-2.1059
182	E	A	-2.6767
183	A	A	0.0000
184	G	A	-1.6725
185	A	A	-1.1795
186	A	A	-1.6280
187	G	A	0.0000
188	R	A	-2.7109
189	R	A	-2.4657
190	A	A	0.0000
191	L	A	0.0000
192	E	A	-2.4609
193	T	A	0.0000
194	L	A	0.0000
195	R	A	-1.7279
196	R	A	-2.1974
197	V	A	-1.1585
198	G	A	0.0000
199	D	A	-1.5714
200	G	A	-1.8230
201	V	A	-1.5002
202	Q	A	0.0000
203	R	A	-3.2129
204	N	A	-2.8633
205	H	A	-2.7460
206	E	A	-2.6257
207	T	A	-1.3709
208	A	A	-1.1961
209	F	A	0.0000
210	Q	A	-1.7223
211	G	A	-1.3186
212	M	A	-0.9666
213	L	A	0.0000
214	R	A	-2.8182
215	K	A	-2.6116
216	L	A	-1.6207
217	D	A	-2.2296
218	I	A	0.0000
219	K	A	-2.8776
220	N	A	-3.1561
221	E	A	-3.2190
222	G	A	-2.5228
223	D	A	0.0000
224	V	A	-1.9611
225	K	A	-2.5114
226	S	A	-1.5564
227	F	A	0.0000
228	S	A	-1.0556
229	R	A	-2.0281
230	V	A	-0.6340
231	M	A	0.0000
232	V	A	-0.5001
233	H	A	-1.3979
234	V	A	-0.4326
235	F	A	-0.8756
236	K	A	-2.0907
237	D	A	-1.6266
238	G	A	-0.8869
239	V	A	0.3742
240	T	A	-0.4119
241	N	A	-0.8057
242	W	A	0.0000
243	G	A	-0.4477
244	R	A	-0.5316
245	I	A	0.0000
246	V	A	0.0000
247	T	A	-0.0525
248	L	A	0.0000
249	I	A	0.0000
250	S	A	0.0000
251	F	A	0.0000
252	G	A	0.0000
253	A	A	0.0000
254	F	A	-0.1184
255	V	A	0.0000
256	A	A	0.0000
257	K	A	-0.8378
258	H	A	-0.7803
259	L	A	0.0000
260	K	A	-1.0724
261	S	A	-0.2717
262	V	A	0.6310
263	N	A	-1.0936
264	Q	A	-1.3016
265	E	A	-1.7587
266	S	A	-1.2308
267	F	A	-1.4403
268	I	A	0.0000
269	E	A	-1.6638
270	P	A	-1.1465
271	L	A	0.0000
272	A	A	0.0000
273	E	A	-1.2736
274	T	A	-0.8248
275	I	A	0.0000
276	T	A	0.0000
277	D	A	-0.9321
278	V	A	-0.4651
279	L	A	0.0000
280	V	A	0.0000
281	R	A	-1.8012
282	T	A	-1.3253
283	K	A	-2.0456
284	R	A	-3.0802
285	D	A	-2.8354
286	W	A	-2.1794
287	L	A	0.0000
288	V	A	-1.0467
289	K	A	-2.1443
290	Q	A	-2.0622
291	R	A	-2.5475
292	G	A	0.0000
293	W	A	0.0000
294	D	A	-2.6736
295	G	A	0.0000
296	F	A	0.0000
297	V	A	0.0000
298	E	A	-1.4206
299	F	A	0.9193
300	F	A	0.7517
301	H	A	0.1476
302	V	A	1.1410
303	Q	A	-0.5896
304	D	A	-0.9413
305	L	A	-0.0317
306	E	A	-1.8862
307	G	A	-1.1962
308	G	A	-0.9149