Project name: AWS5-2

Chain sequence(s)	H: VKLVESGGGLVKPGGSLKLSCAASGFAFSTYDMSWIRQTPEKRLEWVATISTGGTYTYYPDSVKGRFTISRDNARNTLYLQMSSLRSEDTALYYCSRRPYYFDYWGQGTTLTVSS; L: IKMTQSPSSMYASLGERVTITCKASQDINSYLSWFQQKPGKSPKTLIYRVNRLVDGVPSRFSGSGSGQDYSLTISSLEYEDMGIYYCLQYDEFPLTFGAGTKLELK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4438
• Maximal score value: 1.2456
• Average score: -0.6501
• Total score value: -143.6821

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	I	L	-0.7880
3	K	L	-1.8179
4	M	L	0.0000
5	T	L	-1.1489
6	Q	L	0.0000
7	S	L	-0.5831
8	P	L	-0.4340
9	S	L	-0.4735
10	S	L	-0.3331
11	M	L	0.2554
12	Y	L	0.5929
13	A	L	0.0000
14	S	L	-0.7374
15	L	L	-0.2502
16	G	L	-1.1166
17	E	L	-2.0169
18	R	L	-2.4350
19	V	L	0.0000
20	T	L	-0.5285
21	I	L	0.0000
22	T	L	-0.8939
23	C	L	0.0000
24	K	L	-3.0701
25	A	L	0.0000
26	S	L	-2.0667
27	Q	L	-2.6198
28	D	L	-2.8028
29	I	L	0.0000
30	N	L	-1.8326
31	S	L	-1.4756
32	Y	L	-0.6475
33	L	L	0.0000
34	S	L	0.0000
35	W	L	0.0000
36	F	L	0.0000
37	Q	L	0.0000
38	Q	L	0.0000
39	K	L	-1.5291
40	P	L	-1.0956
41	G	L	-1.6797
42	K	L	-2.5838
43	S	L	-1.6546
44	P	L	0.0000
45	K	L	-1.1716
46	T	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	0.0000
50	R	L	-1.3332
51	V	L	0.0000
52	N	L	-2.3917
53	R	L	-2.6474
54	L	L	-1.3368
55	V	L	-1.2641
56	D	L	-2.0006
57	G	L	-1.1904
58	V	L	-0.6084
59	P	L	-0.5948
60	S	L	-0.5884
61	R	L	-0.8034
62	F	L	0.0000
63	S	L	-0.9303
64	G	L	-1.2323
65	S	L	-1.4653
66	G	L	-1.6973
67	S	L	-1.9516
68	G	L	-2.3271
69	Q	L	-3.2148
70	D	L	-3.2422
71	Y	L	0.0000
72	S	L	-1.0223
73	L	L	0.0000
74	T	L	-0.6406
75	I	L	0.0000
76	S	L	-1.5775
77	S	L	-1.4188
78	L	L	0.0000
79	E	L	-1.1857
80	Y	L	-0.5915
81	E	L	-1.7302
82	D	L	0.0000
83	M	L	-0.4949
84	G	L	0.0000
85	I	L	-0.1611
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	L	L	0.0000
90	Q	L	0.0000
91	Y	L	0.0000
92	D	L	-1.0557
93	E	L	-1.1411
94	F	L	0.7191
95	P	L	0.1357
96	L	L	0.0000
97	T	L	-0.4835
98	F	L	-0.4154
99	G	L	0.0000
100	A	L	-0.8536
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-0.4759
104	L	L	0.0000
105	E	L	-0.5087
106	L	L	-0.4883
107	K	L	-1.2145
2	V	H	0.8144
3	K	H	-0.9142
4	L	H	0.0000
5	V	H	-0.2269
6	E	H	0.0000
7	S	H	-0.6529
8	G	H	-0.8706
9	G	H	-0.3292
10	G	H	0.4414
11	L	H	1.1061
12	V	H	-0.2791
13	K	H	-1.8075
14	P	H	-1.7669
15	G	H	-1.3444
16	G	H	-0.9294
17	S	H	-1.1208
18	L	H	-0.8394
19	K	H	-1.8442
20	L	H	0.0000
21	S	H	-0.5346
22	C	H	0.0000
23	A	H	-0.6290
24	A	H	0.0000
25	S	H	-0.7009
26	G	H	-0.2381
27	F	H	0.1648
28	A	H	0.1217
29	F	H	0.0000
30	S	H	-0.8043
31	T	H	-0.1559
32	Y	H	-0.1070
33	D	H	-0.3676
34	M	H	0.0000
35	S	H	0.0000
36	W	H	0.0000
37	I	H	0.0000
38	R	H	0.0000
39	Q	H	0.0000
40	T	H	0.0000
41	P	H	-2.1217
42	E	H	-3.2860
43	K	H	-3.4438
44	R	H	-3.2793
45	L	H	0.0000
46	E	H	-0.9321
47	W	H	0.0000
48	V	H	0.0000
49	A	H	0.0000
50	T	H	0.0000
51	I	H	0.0000
52	S	H	0.0525
52A	T	H	-0.3959
53	G	H	-0.6104
54	G	H	-0.3205
55	T	H	0.2850
56	Y	H	1.2456
57	T	H	0.9383
58	Y	H	0.9688
59	Y	H	-0.3099
60	P	H	0.0000
61	D	H	-2.5003
62	S	H	-1.6189
63	V	H	0.0000
64	K	H	-2.5486
65	G	H	-1.7366
66	R	H	-1.4842
67	F	H	0.0000
68	T	H	-0.7692
69	I	H	0.0000
70	S	H	-0.3656
71	R	H	-1.0766
72	D	H	-1.6515
73	N	H	-1.7709
74	A	H	-1.4845
75	R	H	-2.5102
76	N	H	-1.8950
77	T	H	-1.2008
78	L	H	0.0000
79	Y	H	-0.5622
80	L	H	0.0000
81	Q	H	-1.4191
82	M	H	0.0000
82A	S	H	-1.0185
82B	S	H	-1.0145
82C	L	H	0.0000
83	R	H	-2.5187
84	S	H	-2.0932
85	E	H	-2.4110
86	D	H	0.0000
87	T	H	-0.6856
88	A	H	0.0000
89	L	H	0.0175
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	S	H	0.0000
94	R	H	0.1676
95	R	H	0.0520
96	P	H	0.4776
97	Y	H	1.1046
98	Y	H	0.6766
99	F	H	0.0000
101	D	H	0.0326
102	Y	H	0.1491
103	W	H	0.0000
104	G	H	0.0000
105	Q	H	-1.6384
106	G	H	-0.7268
107	T	H	-0.3417
108	T	H	0.0098
109	L	H	0.0000
110	T	H	-0.1891
111	V	H	0.0000
112	S	H	-1.0172
113	S	H	-0.7339