Project name: 20190218h8C12swissnodyn

Chain sequence(s)	H: QVQLQESGPGLVKPSETLSLTCTVSGFSLNSFGWSWIRQPPGKGLEWIGYIWAGKNTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARAGYGNSLDYWGQGTTLTVSSDIVMTQSPDSLAVSLGERATINCKSSQSLLNSGNQRNYLTWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQNNYYFPLTFGTGTKLEIK
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.2549
• Maximal score value: 1.7728
• Average score: -0.2515
• Total score value: -57.8477

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.1983
2	V	H	0.0000
3	Q	H	-1.1983
4	L	H	0.0000
5	Q	H	-0.6934
6	E	H	0.0000
7	S	H	-0.2488
8	G	H	-0.5288
9	P	H	-0.3211
10	G	H	-0.0530
11	L	H	1.4912
12	V	H	0.0000
13	K	H	-1.7171
14	P	H	-0.4408
15	S	H	-0.5921
16	E	H	-1.8629
17	T	H	-0.3761
18	L	H	0.0000
19	S	H	-0.2345
20	L	H	0.0000
21	T	H	-0.0409
22	C	H	0.0000
23	T	H	-0.0576
24	V	H	0.0000
25	S	H	-0.2512
26	G	H	-0.3335
27	F	H	0.7782
28	S	H	0.0842
29	L	H	0.0000
30	N	H	-1.3114
31	S	H	-0.3656
32	F	H	0.3804
33	G	H	0.0000
34	W	H	0.0000
35	S	H	0.0000
36	W	H	0.0000
37	I	H	0.0000
38	R	H	0.0000
39	Q	H	-0.1521
40	P	H	-0.1068
41	P	H	-0.3472
42	G	H	-0.8279
43	K	H	-1.7970
44	G	H	-0.3679
45	L	H	0.0000
46	E	H	-0.4795
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	Y	H	0.1654
51	I	H	0.0000
52	W	H	0.8390
53	A	H	0.0792
54	G	H	-0.7787
55	K	H	-2.0218
56	N	H	-1.5944
57	T	H	-0.3790
58	N	H	-0.5491
59	Y	H	0.1276
60	N	H	-0.1361
61	P	H	-0.3140
62	S	H	-0.2263
63	L	H	0.0000
64	K	H	-1.7465
65	S	H	-0.5932
66	R	H	-0.4161
67	V	H	0.0000
68	T	H	-0.1890
69	I	H	0.0000
70	S	H	-0.1169
71	V	H	0.0000
72	D	H	-0.7706
73	T	H	-0.2508
74	S	H	-0.5368
75	K	H	-1.7890
76	N	H	-0.6406
77	Q	H	-0.3592
78	F	H	0.0000
79	S	H	-0.0573
80	L	H	0.0000
81	K	H	-1.3382
82	L	H	0.0000
83	S	H	-0.1837
84	S	H	-0.2320
85	V	H	0.0000
86	T	H	-0.0422
87	A	H	0.0594
88	A	H	0.0691
89	D	H	0.0000
90	T	H	-0.0170
91	A	H	0.0000
92	V	H	0.4109
93	Y	H	0.0000
94	Y	H	0.0000
95	C	H	0.0000
96	A	H	0.0000
97	R	H	0.0000
98	A	H	-0.0213
99	G	H	0.0775
100	Y	H	1.2705
101	G	H	0.1159
102	N	H	-0.2283
103	S	H	0.0000
104	L	H	0.0000
105	D	H	-0.4580
106	Y	H	0.2710
107	W	H	0.1869
108	G	H	0.0000
109	Q	H	-1.1983
110	G	H	0.0000
111	T	H	-0.0215
112	T	H	-0.0133
113	L	H	0.0000
114	T	H	-0.0259
115	V	H	0.0000
116	S	H	-0.1601
117	S	H	-0.2352
118	D	H	-1.7894
119	I	H	0.0000
120	V	H	1.7728
121	M	H	0.0000
122	T	H	-0.0943
123	Q	H	-0.1798
124	S	H	-0.2281
125	P	H	-0.4702
126	D	H	-1.8435
127	S	H	-0.5987
128	L	H	0.2797
129	A	H	-0.2650
130	V	H	0.0000
131	S	H	-0.0544
132	L	H	1.4419
133	G	H	-0.5258
134	E	H	-2.2549
135	R	H	-2.2096
136	A	H	0.0000
137	T	H	-0.0488
138	I	H	0.0000
139	N	H	-0.2044
140	C	H	0.0000
141	K	H	-1.5969
142	S	H	0.0000
143	S	H	-0.4337
144	Q	H	-1.2610
145	S	H	-0.3566
146	L	H	0.0000
147	L	H	0.2947
148	N	H	-0.4061
149	S	H	-0.5054
150	G	H	-0.7411
151	N	H	-1.5782
152	Q	H	-1.5535
153	R	H	-0.7912
154	N	H	-0.1523
155	Y	H	0.2074
156	L	H	0.0000
157	T	H	0.0000
158	W	H	0.0000
159	Y	H	0.0000
160	Q	H	0.0000
161	Q	H	0.0000
162	K	H	-0.5384
163	P	H	-0.4304
164	G	H	-0.6263
165	Q	H	-0.7055
166	P	H	-0.1521
167	P	H	0.0000
168	K	H	-1.0149
169	L	H	0.0000
170	L	H	0.0000
171	I	H	0.0000
172	Y	H	0.0000
173	W	H	0.2406
174	A	H	0.0000
175	S	H	-0.2261
176	T	H	-0.1965
177	R	H	-0.7582
178	E	H	-0.5331
179	S	H	-0.3663
180	G	H	-0.5056
181	V	H	0.0000
182	P	H	-0.4200
183	D	H	-1.8621
184	R	H	-0.6325
185	F	H	0.0000
186	S	H	-0.1461
187	G	H	-0.1548
188	S	H	-0.2756
189	G	H	-0.3453
190	S	H	-0.2225
191	G	H	-0.1283
192	T	H	-0.2613
193	D	H	-1.3290
194	F	H	0.0000
195	T	H	-0.0425
196	L	H	0.0000
197	T	H	-0.0194
198	I	H	0.0000
199	S	H	-0.4686
200	S	H	-0.3618
201	L	H	0.0000
202	Q	H	-0.5209
203	A	H	-0.3742
204	E	H	-1.8091
205	D	H	0.0000
206	V	H	0.4671
207	A	H	0.0000
208	V	H	0.0000
209	Y	H	0.0000
210	Y	H	0.0000
211	C	H	0.0000
212	Q	H	0.0000
213	N	H	0.0000
214	N	H	0.0000
215	Y	H	0.4866
216	Y	H	1.5980
217	F	H	1.5712
218	P	H	0.3483
219	L	H	0.0000
220	T	H	-0.0113
221	F	H	0.0000
222	G	H	0.0000
223	T	H	-0.0816
224	G	H	-0.0712
225	T	H	0.0000
226	K	H	-1.1777
227	L	H	0.0000
228	E	H	-1.5913
229	I	H	0.5711
230	K	H	-1.4859