Project name: IKS1

Chain sequence(s)	A: GGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTTVLLHQDWLNGKEYKCKVSNKALPAPIEKTISIKS
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.6861
• Maximal score value: 1.9053
• Average score: -0.8958
• Total score value: -94.0583

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
236	G	A	-0.8046
237	G	A	-0.8556
238	P	A	0.0000
239	S	A	-0.2999
240	V	A	0.0000
241	F	A	1.3816
242	L	A	1.0947
243	F	A	1.4293
244	P	A	0.2642
245	P	A	0.0000
246	K	A	-2.4458
247	P	A	-1.2979
248	K	A	-1.8294
249	D	A	-1.4193
250	T	A	0.0000
251	L	A	1.1460
252	M	A	1.3203
253	I	A	1.9053
254	S	A	0.3313
255	R	A	-1.3432
256	T	A	-0.7583
257	P	A	0.0000
258	E	A	-1.0258
259	V	A	0.0000
260	T	A	0.3834
261	C	A	0.0000
262	V	A	0.0000
263	V	A	0.0000
264	V	A	-0.6064
265	D	A	-1.5665
266	V	A	0.0000
267	S	A	-2.0611
268	H	A	-2.1328
269	E	A	-2.7042
270	D	A	-2.2683
271	P	A	-2.3112
272	E	A	-2.9487
273	V	A	-1.8983
274	K	A	-2.2337
275	F	A	-1.2750
276	N	A	-1.4298
277	W	A	0.0000
278	Y	A	-0.9251
279	V	A	-0.9820
280	D	A	-2.0867
281	G	A	-0.9768
282	V	A	0.2899
283	E	A	-1.3116
284	V	A	-0.6978
285	H	A	-1.7715
286	N	A	-1.6725
287	A	A	-1.6032
288	K	A	-2.3279
289	T	A	-2.0300
290	K	A	-2.7303
291	P	A	-2.5396
292	R	A	-3.5488
293	E	A	-3.6861
294	E	A	-3.1020
295	Q	A	-1.7610
296	Y	A	0.1366
297	N	A	-0.7867
298	S	A	-1.2156
299	T	A	-1.8836
300	Y	A	-2.4932
301	R	A	-2.6412
302	V	A	0.0000
303	V	A	0.0000
304	S	A	0.0000
305	V	A	-0.7526
306	L	A	0.0000
307	T	A	-0.4608
308	V	A	0.0000
309	L	A	1.0501
310	H	A	0.5713
311	Q	A	-0.4493
312	D	A	-0.8771
313	W	A	0.0000
314	L	A	0.2012
315	N	A	-1.4165
316	G	A	-1.3895
317	K	A	-1.9285
318	E	A	-2.0581
319	Y	A	0.0000
320	K	A	-1.6811
321	C	A	0.0000
322	K	A	-1.7699
323	V	A	0.0000
324	S	A	-1.5128
325	N	A	0.0000
326	K	A	-2.4673
327	A	A	-1.3355
328	L	A	-0.6125
329	P	A	-0.4389
330	A	A	-0.4495
331	P	A	-0.9876
332	I	A	-0.7359
333	E	A	-2.1482
334	K	A	-1.1983
335	T	A	-0.9539
336	I	A	0.0016
337	S	A	0.0000
338	I	A	0.3083
339	K	A	-1.3060
340	S	A	-0.6546