Project name: AAAC

Chain sequence(s)	A: MAQGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPEDCTSFSINASPGVVVDIAHGPPAKKKSTGSSTWPLDPGVEVTLTMKVASGSTGDQKVQISYYGPKTPPVKALLYLTGVEISLCADITRTGKVKPTRAVKDQRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDMSLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATRGKLSSKCSVVLGPKWPSHYLMVPGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFRVAPWIMTPNTQPPQEVYACSIFENEDFLKSVTTLAMKAKCKLTICPEEENMDDQWMQDEMEIGYIQAPHKTLPVVFDSPRNRGLKEFPIKRVMGPDFGYVTRGPQTGGISGLDSFGNLEVSPPVTVRGKEYPLGRILFGDSCYPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVPAPDRKGFRLLLASPRSCYKLFQEQQNEGHGEALLFEGIKKKKQQKIKNILSNKTLREHNSFVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPKPFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIRHGEVHCGTNVRRKPFSFKWWNMVP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.6737
• Maximal score value: 1.411
• Average score: -0.7298
• Total score value: -483.8707

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.6833
2	A	A	-0.0187
3	Q	A	-0.3581
4	G	A	-0.1340
5	T	A	-0.0273
6	L	A	0.1181
7	I	A	0.0000
8	R	A	-1.8221
9	V	A	0.0000
10	T	A	-1.6625
11	P	A	-1.6788
12	E	A	-2.6058
13	Q	A	-2.3939
14	P	A	-1.3751
15	T	A	-1.1888
16	H	A	-0.9884
17	A	A	-0.4050
18	V	A	0.0825
19	C	A	0.0000
20	V	A	0.0000
21	L	A	-0.3925
22	G	A	-0.5102
23	T	A	-0.0305
24	L	A	0.4400
25	T	A	0.0000
26	Q	A	-0.7488
27	L	A	0.0000
28	D	A	-1.0253
29	I	A	0.0000
30	C	A	-0.6157
31	S	A	-0.5830
32	S	A	-1.0085
33	A	A	-1.0236
34	P	A	-1.7362
35	E	A	-2.7101
36	D	A	-2.9551
37	C	A	-1.5037
38	T	A	-0.8390
39	S	A	-0.4537
40	F	A	0.0000
41	S	A	0.0000
42	I	A	0.0000
43	N	A	-1.6249
44	A	A	-0.9074
45	S	A	-0.7392
46	P	A	-0.6989
47	G	A	-0.3257
48	V	A	0.0000
49	V	A	0.0048
50	V	A	-0.2787
51	D	A	-1.4635
52	I	A	-0.8839
53	A	A	-1.1411
54	H	A	-1.5271
55	G	A	-1.0606
56	P	A	-0.8866
57	P	A	-1.4238
58	A	A	-1.3728
59	K	A	-2.9979
60	K	A	-3.4747
61	K	A	-3.1706
62	S	A	-1.7300
63	T	A	-1.2077
64	G	A	-1.4353
65	S	A	-1.4904
66	S	A	-1.9269
67	T	A	-1.1654
68	W	A	-0.6320
69	P	A	-0.6439
70	L	A	-0.5261
71	D	A	-1.8333
72	P	A	-1.3926
73	G	A	-1.4736
74	V	A	-1.3413
75	E	A	-1.8793
76	V	A	0.0000
77	T	A	-0.5425
78	L	A	0.0000
79	T	A	-0.0709
80	M	A	0.0000
81	K	A	-0.7855
82	V	A	0.6529
83	A	A	-0.2680
84	S	A	0.0000
85	G	A	-1.0212
86	S	A	-1.1921
87	T	A	-0.9500
88	G	A	-0.6593
89	D	A	-0.8762
90	Q	A	-0.8920
91	K	A	-1.4351
92	V	A	0.0000
93	Q	A	-1.3181
94	I	A	0.0000
95	S	A	0.0000
96	Y	A	0.0000
97	Y	A	-0.4567
98	G	A	-1.3733
99	P	A	-1.3440
100	K	A	-2.1370
101	T	A	-1.3517
102	P	A	-0.9213
103	P	A	-0.5168
104	V	A	-0.6137
105	K	A	-1.8063
106	A	A	0.0000
107	L	A	-0.9877
108	L	A	0.0000
109	Y	A	-0.4792
110	L	A	0.0000
111	T	A	0.0000
112	G	A	0.0000
113	V	A	0.0000
114	E	A	-1.1758
115	I	A	0.0000
116	S	A	-0.9504
117	L	A	0.0000
118	C	A	0.0000
119	A	A	0.0000
120	D	A	-1.1652
121	I	A	0.0000
122	T	A	-0.8635
123	R	A	-0.9081
124	T	A	-1.1922
125	G	A	-1.6540
126	K	A	-2.2985
127	V	A	0.0000
128	K	A	-1.8285
129	P	A	-1.4021
130	T	A	-1.4040
131	R	A	-1.7812
132	A	A	-0.7425
133	V	A	0.2691
134	K	A	-1.7060
135	D	A	-2.2108
136	Q	A	0.0000
137	R	A	-1.6467
138	T	A	-1.0180
139	W	A	-0.3244
140	T	A	0.2774
141	W	A	0.7208
142	G	A	0.0000
143	P	A	0.0728
144	C	A	0.4808
145	G	A	0.2553
146	Q	A	-0.7684
147	G	A	0.0000
148	A	A	0.0000
149	I	A	0.0000
150	L	A	0.0000
151	L	A	0.0000
152	V	A	0.0000
153	N	A	0.0000
154	C	A	0.0000
155	D	A	0.0000
156	R	A	-0.6040
157	D	A	-0.9830
158	N	A	-0.3225
159	L	A	0.4610
160	E	A	-1.2713
161	S	A	-0.7459
162	S	A	-0.6238
163	A	A	-0.7702
164	M	A	-0.7439
165	D	A	-1.2780
166	C	A	0.0000
167	E	A	-2.6009
168	D	A	-2.4921
169	D	A	-2.1309
170	E	A	-2.0853
171	V	A	-0.7901
172	L	A	0.2906
173	D	A	-0.7816
174	S	A	-1.4618
175	E	A	-2.4593
176	D	A	0.0000
177	L	A	-0.7830
178	Q	A	-1.9128
179	D	A	0.0000
180	M	A	0.0000
181	S	A	0.0000
182	L	A	0.1285
183	M	A	0.0000
184	T	A	-0.4438
185	L	A	0.0000
186	S	A	-1.3473
187	T	A	0.0000
188	K	A	-2.2798
189	T	A	0.0000
190	P	A	0.0000
191	K	A	-3.0064
192	D	A	-2.6135
193	F	A	0.0000
194	F	A	-0.7802
195	T	A	-1.1509
196	N	A	-1.1620
197	H	A	0.0000
198	T	A	0.1247
199	L	A	0.0000
200	V	A	0.0000
201	L	A	0.0000
202	H	A	-0.3342
203	V	A	0.0000
204	A	A	-1.2514
205	R	A	-2.4677
206	S	A	-1.5898
207	E	A	-1.4602
208	M	A	-1.8146
209	D	A	-2.4621
210	K	A	-1.2168
211	V	A	0.0000
212	R	A	0.0000
213	V	A	0.0000
214	F	A	0.0000
215	Q	A	-0.6735
216	A	A	-1.1535
217	T	A	-2.0010
218	R	A	-2.7585
219	G	A	-2.1316
220	K	A	-1.8302
221	L	A	-0.0059
222	S	A	-1.0335
223	S	A	-1.9886
224	K	A	-2.2067
225	C	A	-1.2412
226	S	A	-0.9205
227	V	A	-0.2479
228	V	A	0.0000
229	L	A	0.0000
230	G	A	0.0000
231	P	A	-1.7865
232	K	A	-1.9294
233	W	A	-0.6754
234	P	A	-1.0288
235	S	A	-0.3939
236	H	A	0.2772
237	Y	A	0.9357
238	L	A	0.0000
239	M	A	1.2030
240	V	A	0.0000
241	P	A	-1.1654
242	G	A	-1.9647
243	G	A	-2.3637
244	K	A	-2.8925
245	H	A	-1.9530
246	N	A	-1.9330
247	M	A	0.0000
248	D	A	-0.6173
249	F	A	0.0000
250	Y	A	0.3015
251	V	A	0.0000
252	E	A	0.0000
253	A	A	0.0000
254	L	A	-0.5906
255	A	A	-0.3305
256	F	A	0.0000
257	P	A	0.0000
258	D	A	-1.1653
259	T	A	-1.2682
260	D	A	-2.0217
261	F	A	0.0000
262	P	A	-0.7157
263	G	A	0.0000
264	L	A	0.2770
265	I	A	0.0000
266	T	A	-0.1458
267	L	A	0.0000
268	T	A	-0.3810
269	I	A	0.0000
270	S	A	0.0000
271	L	A	0.0000
272	L	A	0.0000
273	D	A	-0.6320
274	T	A	-0.7107
275	S	A	-0.8323
276	N	A	-0.5413
277	L	A	0.4667
278	E	A	-0.7540
279	L	A	0.4269
280	P	A	-0.2353
281	E	A	-0.8488
282	A	A	0.2466
283	V	A	1.4084
284	V	A	0.7759
285	F	A	0.0000
286	Q	A	-0.3501
287	D	A	-0.8770
288	S	A	0.0000
289	V	A	0.0000
290	V	A	0.0000
291	F	A	0.0000
292	R	A	-0.0243
293	V	A	0.0000
294	A	A	0.0000
295	P	A	0.0000
296	W	A	0.0000
297	I	A	0.0000
298	M	A	0.0000
299	T	A	0.0000
300	P	A	0.0000
301	N	A	0.0000
302	T	A	-0.4718
303	Q	A	-0.7949
304	P	A	-1.0186
305	P	A	-1.3677
306	Q	A	-1.7599
307	E	A	-1.5598
308	V	A	0.0000
309	Y	A	0.0000
310	A	A	0.0000
311	C	A	0.0000
312	S	A	-0.7337
313	I	A	-0.4601
314	F	A	0.4382
315	E	A	-1.4839
316	N	A	0.0000
317	E	A	-3.2696
318	D	A	-3.6201
319	F	A	0.0000
320	L	A	0.0000
321	K	A	-2.8488
322	S	A	-1.5488
323	V	A	0.0000
324	T	A	-0.8753
325	T	A	-0.7758
326	L	A	0.0000
327	A	A	0.0000
328	M	A	-0.7687
329	K	A	-1.7631
330	A	A	-1.7807
331	K	A	-2.3043
332	C	A	0.0000
333	K	A	-2.0394
334	L	A	-0.5229
335	T	A	-0.0279
336	I	A	0.9146
337	C	A	0.0000
338	P	A	-1.2289
339	E	A	-1.9802
340	E	A	-2.6687
341	E	A	-2.4807
342	N	A	0.0000
343	M	A	-1.2471
344	D	A	-1.8510
345	D	A	0.0000
346	Q	A	0.0000
347	W	A	-0.3724
348	M	A	0.0000
349	Q	A	0.0000
350	D	A	-0.4333
351	E	A	0.0000
352	M	A	0.0000
353	E	A	0.0000
354	I	A	0.0000
355	G	A	0.0000
356	Y	A	0.0000
357	I	A	0.0000
358	Q	A	0.0000
359	A	A	0.0000
360	P	A	-0.9397
361	H	A	-1.2143
362	K	A	-0.9416
363	T	A	-0.5479
364	L	A	0.0000
365	P	A	-0.5108
366	V	A	0.0000
367	V	A	0.0000
368	F	A	0.0000
369	D	A	0.0000
370	S	A	0.0000
371	P	A	0.0000
372	R	A	-1.3488
373	N	A	-2.0928
374	R	A	-2.5771
375	G	A	-1.9594
376	L	A	0.0000
377	K	A	-2.4170
378	E	A	-2.3897
379	F	A	0.0000
380	P	A	0.0000
381	I	A	-1.2736
382	K	A	-2.6113
383	R	A	-2.6443
384	V	A	0.0000
385	M	A	0.0000
386	G	A	-0.8114
387	P	A	-1.0091
388	D	A	-1.7277
389	F	A	-0.5506
390	G	A	0.0000
391	Y	A	0.2533
392	V	A	0.0000
393	T	A	-0.3324
394	R	A	-0.8449
395	G	A	-0.9566
396	P	A	-0.9709
397	Q	A	-1.5297
398	T	A	-0.9394
399	G	A	-0.9200
400	G	A	-0.7610
401	I	A	-0.4376
402	S	A	-0.3402
403	G	A	-0.2455
404	L	A	0.0000
405	D	A	0.0000
406	S	A	0.0000
407	F	A	0.0000
408	G	A	0.0000
409	N	A	0.0000
410	L	A	0.0000
411	E	A	0.0000
412	V	A	0.0000
413	S	A	0.0000
414	P	A	0.0000
415	P	A	-0.6319
416	V	A	0.0000
417	T	A	-2.1363
418	V	A	0.0000
419	R	A	-3.1456
420	G	A	-2.6544
421	K	A	-3.1889
422	E	A	-2.8511
423	Y	A	0.0000
424	P	A	-0.6468
425	L	A	0.0000
426	G	A	0.0000
427	R	A	0.0000
428	I	A	0.0000
429	L	A	0.0000
430	F	A	0.0000
431	G	A	0.0000
432	D	A	0.0000
433	S	A	0.1061
434	C	A	1.1586
435	Y	A	1.4110
436	P	A	-0.2440
437	S	A	-1.0691
438	N	A	-2.2966
439	D	A	-2.3380
440	S	A	-1.3318
441	R	A	-1.1228
442	Q	A	-0.9608
443	M	A	0.0000
444	H	A	-1.2042
445	Q	A	-1.6125
446	A	A	-1.0140
447	L	A	0.0000
448	Q	A	0.0000
449	D	A	-1.1766
450	F	A	0.0000
451	L	A	0.0000
452	S	A	-0.6227
453	A	A	0.0000
454	Q	A	0.0000
455	Q	A	-0.8219
456	V	A	0.0000
457	Q	A	0.0000
458	A	A	-0.3745
459	P	A	-0.5451
460	V	A	0.0000
461	K	A	-1.1080
462	L	A	0.0000
463	Y	A	0.3285
464	S	A	0.0000
465	D	A	0.0000
466	W	A	0.0000
467	L	A	0.0000
468	S	A	-0.4599
469	V	A	0.0429
470	G	A	0.0000
471	H	A	0.0000
472	V	A	0.0000
473	D	A	0.0000
474	E	A	-0.2327
475	F	A	0.0000
476	L	A	0.0000
477	S	A	0.0000
478	F	A	0.0000
479	V	A	0.0000
480	P	A	-0.6671
481	A	A	0.0000
482	P	A	-1.3691
483	D	A	-2.3303
484	R	A	-2.9620
485	K	A	-2.3534
486	G	A	-1.7559
487	F	A	0.0000
488	R	A	0.0000
489	L	A	0.0000
490	L	A	0.0000
491	L	A	0.0000
492	A	A	0.0000
493	S	A	0.0000
494	P	A	0.0000
495	R	A	-2.5261
496	S	A	-1.7183
497	C	A	0.0000
498	Y	A	-1.8607
499	K	A	-2.8498
500	L	A	-2.0388
501	F	A	0.0000
502	Q	A	-2.9377
503	E	A	-3.6737
504	Q	A	-3.1053
505	Q	A	-3.4496
506	N	A	-3.3576
507	E	A	-3.4604
508	G	A	-2.6583
509	H	A	-2.5067
510	G	A	0.0000
511	E	A	-2.6278
512	A	A	-1.2082
513	L	A	-1.1454
514	L	A	0.0000
515	F	A	0.0000
516	E	A	-1.7834
517	G	A	-1.5696
518	I	A	0.0000
519	K	A	-3.3043
520	K	A	-3.3066
521	K	A	-3.1691
522	K	A	-2.9980
523	Q	A	-2.2450
524	Q	A	-2.0166
525	K	A	-2.2609
526	I	A	0.0000
527	K	A	-2.5312
528	N	A	-2.6311
529	I	A	0.0000
530	L	A	0.0000
531	S	A	-1.7910
532	N	A	-2.4544
533	K	A	-3.0248
534	T	A	-2.1269
535	L	A	0.0000
536	R	A	-2.7648
537	E	A	-2.7898
538	H	A	-1.7252
539	N	A	0.0000
540	S	A	-1.5447
541	F	A	-0.8205
542	V	A	0.0000
543	E	A	-1.9342
544	R	A	-2.2428
545	C	A	0.0000
546	I	A	0.0000
547	D	A	-2.7027
548	W	A	-1.2951
549	N	A	0.0000
550	R	A	-2.3807
551	E	A	-3.0681
552	L	A	0.0000
553	L	A	0.0000
554	K	A	-2.4523
555	R	A	-2.9960
556	E	A	-1.9284
557	L	A	0.0000
558	G	A	-1.8430
559	L	A	0.0000
560	A	A	-1.3471
561	E	A	-1.9295
562	S	A	-1.1034
563	D	A	0.0000
564	I	A	0.0000
565	I	A	-0.2637
566	D	A	-0.8640
567	I	A	0.0000
568	P	A	0.0000
569	Q	A	0.0000
570	L	A	0.0000
571	F	A	0.0000
572	K	A	-1.2335
573	L	A	-1.1660
574	K	A	-1.9540
575	E	A	-1.6435
576	F	A	0.3548
577	S	A	-0.5169
578	K	A	-0.7016
579	A	A	0.0000
580	E	A	-1.0567
581	A	A	-0.1525
582	F	A	0.0332
583	F	A	0.0000
584	P	A	0.0000
585	N	A	0.0000
586	M	A	0.0000
587	V	A	0.0000
588	N	A	0.0000
589	M	A	0.0000
590	L	A	0.0000
591	V	A	0.0000
592	L	A	0.0000
593	G	A	-0.7673
594	K	A	-1.6294
595	H	A	-1.2950
596	L	A	0.0000
597	G	A	0.0000
598	I	A	0.0000
599	P	A	0.0000
600	K	A	-0.4665
601	P	A	0.0000
602	F	A	-0.2834
603	G	A	0.0000
604	P	A	0.0000
605	V	A	-0.1299
606	I	A	-0.9966
607	N	A	-1.6948
608	G	A	-1.5469
609	R	A	-2.2457
610	C	A	0.0000
611	C	A	0.0000
612	L	A	0.0000
613	E	A	0.0000
614	E	A	-2.3919
615	K	A	-1.3910
616	V	A	0.0000
617	C	A	-1.4025
618	S	A	-1.1550
619	L	A	-0.5502
620	L	A	0.0000
621	E	A	-1.9893
622	P	A	-1.0828
623	L	A	-1.0211
624	G	A	-1.2915
625	L	A	0.0000
626	Q	A	-1.7122
627	C	A	-0.9879
628	T	A	-0.2391
629	F	A	-0.0865
630	I	A	0.0000
631	N	A	-0.7613
632	D	A	0.0000
633	F	A	0.0000
634	F	A	1.0961
635	T	A	0.0716
636	Y	A	0.0000
637	H	A	0.2321
638	I	A	1.1460
639	R	A	-0.6012
640	H	A	-0.9367
641	G	A	0.0000
642	E	A	0.0000
643	V	A	0.0000
644	H	A	0.0000
645	C	A	0.0000
646	G	A	0.0000
647	T	A	0.0000
648	N	A	0.0000
649	V	A	-0.5164
650	R	A	-1.1425
651	R	A	0.0000
652	K	A	-1.9156
653	P	A	-0.9634
654	F	A	0.0000
655	S	A	-0.2815
656	F	A	0.1879
657	K	A	-0.5813
658	W	A	0.0000
659	W	A	0.0000
660	N	A	-0.0450
661	M	A	0.0000
662	V	A	1.0464
663	P	A	-0.0523