Project name: 3e236c6739c22dd

Chain sequence(s)	A: TLIQNPSLSLYQDPSRFVTNKKADTARLLPPKTPCVRSRYWTNDTEKVERSLDVYNKINHSGSESYKKFIRRDGRCEKKPWWWKLPRPKKILFKKPRCRVPPQIEHCKKRCSANWEASRRDIFGRNHKKILKTRITNRDLKANITKKVHRLGNCEQPILLNGNKKQHPKPASLMTKKFFMERLKLKTKYDEYLSLNDDREDQFEELIEEKKIYVTRRLPLRMDKKFVQSIHKGYVYPPNGREKKPHDFHGERKGKKGNGGVQDKFCRSKYQVKKVLIHTANGKLTFSSREDHSKWKKNRMKSQAARGGPGPGSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKSEAAAKFYPSYHSTPQRPGTP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -5.2044
• Maximal score value: 1.8479
• Average score: -1.1575
• Total score value: -577.595

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	T	A	0.0020
2	L	A	-0.1167
3	I	A	0.0000
4	Q	A	-0.4471
5	N	A	0.0000
6	P	A	-0.1854
7	S	A	0.0000
8	L	A	0.0000
9	S	A	0.0000
10	L	A	0.0000
11	Y	A	0.0000
12	Q	A	0.0000
13	D	A	0.0000
14	P	A	0.0000
15	S	A	-0.0922
16	R	A	-0.4921
17	F	A	0.0000
18	V	A	0.1838
19	T	A	-0.6500
20	N	A	-1.7813
21	K	A	-2.8455
22	K	A	-2.9617
23	A	A	0.0000
24	D	A	-1.0902
25	T	A	-0.6019
26	A	A	-0.2814
27	R	A	0.4735
28	L	A	1.8479
29	L	A	1.3670
30	P	A	0.2609
31	P	A	-0.8237
32	K	A	-2.1452
33	T	A	-1.6911
34	P	A	-1.2536
35	C	A	0.0000
36	V	A	0.0000
37	R	A	0.0000
38	S	A	0.0000
39	R	A	0.0000
40	Y	A	-0.6406
41	W	A	-1.2567
42	T	A	-1.8645
43	N	A	-2.5334
44	D	A	-3.0494
45	T	A	-2.6088
46	E	A	-3.3765
47	K	A	-3.6414
48	V	A	-2.7431
49	E	A	-2.9736
50	R	A	-2.7451
51	S	A	-1.5285
52	L	A	-1.1477
53	D	A	-2.2187
54	V	A	-1.2107
55	Y	A	0.0000
56	N	A	-1.8749
57	K	A	-2.3370
58	I	A	0.0000
59	N	A	0.0000
60	H	A	-1.7165
61	S	A	-1.2729
62	G	A	0.0000
63	S	A	-1.1161
64	E	A	-1.4757
65	S	A	0.0000
66	Y	A	0.0000
67	K	A	-1.1337
68	K	A	0.0000
69	F	A	0.0000
70	I	A	-1.0982
71	R	A	0.0000
72	R	A	-2.7178
73	D	A	-2.4891
74	G	A	-1.9123
75	R	A	-2.8943
76	C	A	-1.8591
77	E	A	0.0000
78	K	A	-2.4450
79	K	A	-1.8633
80	P	A	-0.8925
81	W	A	0.0000
82	W	A	0.0000
83	W	A	0.4413
84	K	A	0.0000
85	L	A	-0.2283
86	P	A	-0.9984
87	R	A	-1.3812
88	P	A	-1.3389
89	K	A	-2.4111
90	K	A	-2.0122
91	I	A	-0.0218
92	L	A	0.7122
93	F	A	-0.0318
94	K	A	-2.2046
95	K	A	-2.7738
96	P	A	0.0000
97	R	A	-3.3041
98	C	A	-2.9189
99	R	A	-2.6825
100	V	A	-2.3144
101	P	A	-1.2791
102	P	A	-1.8003
103	Q	A	-1.9035
104	I	A	-1.8060
105	E	A	-3.3260
106	H	A	-2.9482
107	C	A	0.0000
108	K	A	-3.8180
109	K	A	-3.1094
110	R	A	-2.3206
111	C	A	0.0000
112	S	A	-1.6323
113	A	A	0.0000
114	N	A	0.0000
115	W	A	-0.8274
116	E	A	0.0000
117	A	A	-0.2333
118	S	A	0.0000
119	R	A	-0.8687
120	R	A	-1.1233
121	D	A	-0.9929
122	I	A	-0.4247
123	F	A	-0.4238
124	G	A	-1.2203
125	R	A	-1.6810
126	N	A	-1.6173
127	H	A	-1.9807
128	K	A	-2.1958
129	K	A	-2.3823
130	I	A	0.0000
131	L	A	-2.0009
132	K	A	-2.0676
133	T	A	-1.4466
134	R	A	-2.0322
135	I	A	0.0000
136	T	A	-1.6027
137	N	A	-1.5205
138	R	A	-2.7735
139	D	A	-2.4329
140	L	A	-1.8961
141	K	A	-2.4917
142	A	A	-1.7582
143	N	A	-1.7176
144	I	A	-0.7737
145	T	A	-1.0328
146	K	A	-2.1606
147	K	A	-2.0423
148	V	A	-1.8971
149	H	A	-1.9997
150	R	A	-1.5610
151	L	A	-1.2096
152	G	A	0.0000
153	N	A	-1.6173
154	C	A	-0.9716
155	E	A	-1.7396
156	Q	A	-1.0247
157	P	A	-0.5672
158	I	A	0.6022
159	L	A	0.0000
160	L	A	0.1908
161	N	A	0.0000
162	G	A	0.0000
163	N	A	0.0000
164	K	A	0.0000
165	K	A	-2.2377
166	Q	A	-2.0537
167	H	A	-1.3152
168	P	A	-1.6186
169	K	A	-1.4977
170	P	A	0.0000
171	A	A	0.0000
172	S	A	0.0000
173	L	A	-1.0329
174	M	A	-0.5514
175	T	A	0.0000
176	K	A	-0.9121
177	K	A	-0.9862
178	F	A	0.0664
179	F	A	0.0000
180	M	A	-0.0431
181	E	A	-1.8496
182	R	A	-1.8708
183	L	A	-0.0441
184	K	A	-0.8931
185	L	A	0.2969
186	K	A	-1.5785
187	T	A	-1.3212
188	K	A	-2.0231
189	Y	A	-1.4265
190	D	A	-1.9937
191	E	A	-1.5389
192	Y	A	0.5840
193	L	A	0.5309
194	S	A	-0.8641
195	L	A	-1.9188
196	N	A	-3.4968
197	D	A	-4.5946
198	D	A	-4.8446
199	R	A	-5.1657
200	E	A	-4.6789
201	D	A	-5.2044
202	Q	A	-4.5564
203	F	A	-3.5597
204	E	A	-4.4117
205	E	A	-4.4964
206	L	A	-2.7640
207	I	A	-2.8169
208	E	A	-3.5369
209	E	A	-2.5141
210	K	A	-2.2142
211	K	A	-2.4727
212	I	A	-1.4013
213	Y	A	-1.5598
214	V	A	-1.0938
215	T	A	-1.2450
216	R	A	-2.0925
217	R	A	-1.3406
218	L	A	-0.6978
219	P	A	-0.7875
220	L	A	-0.6488
221	R	A	-1.8983
222	M	A	-1.4331
223	D	A	-2.2635
224	K	A	-2.9898
225	K	A	-2.4951
226	F	A	-1.1825
227	V	A	0.0000
228	Q	A	-1.2323
229	S	A	-0.5029
230	I	A	0.5705
231	H	A	0.0000
232	K	A	-0.6829
233	G	A	-0.4293
234	Y	A	1.2754
235	V	A	1.0834
236	Y	A	-0.1569
237	P	A	-0.6682
238	P	A	-2.2483
239	N	A	-2.9674
240	G	A	-2.6512
241	R	A	-4.0360
242	E	A	-4.3075
243	K	A	-4.4968
244	K	A	-3.7653
245	P	A	-1.7344
246	H	A	-1.6957
247	D	A	0.0000
248	F	A	-0.0061
249	H	A	-0.8489
250	G	A	-1.2577
251	E	A	-2.6292
252	R	A	-3.9164
253	K	A	-4.0808
254	G	A	0.0000
255	K	A	-3.9653
256	K	A	-3.2932
257	G	A	-2.4777
258	N	A	-2.3079
259	G	A	-2.9429
260	G	A	-1.9861
261	V	A	-1.4177
262	Q	A	-2.3015
263	D	A	-2.7979
264	K	A	-1.6803
265	F	A	0.3920
266	C	A	0.0000
267	R	A	-1.9436
268	S	A	-2.0003
269	K	A	-1.6959
270	Y	A	-1.4483
271	Q	A	-1.2170
272	V	A	-0.8058
273	K	A	-0.8697
274	K	A	-1.0187
275	V	A	-0.0007
276	L	A	0.0657
277	I	A	0.0000
278	H	A	-1.7706
279	T	A	-1.8460
280	A	A	-1.4208
281	N	A	-1.9479
282	G	A	-2.1810
283	K	A	-2.1112
284	L	A	-0.6170
285	T	A	-0.0947
286	F	A	-0.5368
287	S	A	-1.0905
288	S	A	-1.8313
289	R	A	-2.2703
290	E	A	-2.8766
291	D	A	-2.1772
292	H	A	0.0000
293	S	A	-2.9078
294	K	A	-3.3643
295	W	A	0.0000
296	K	A	0.0000
297	K	A	-3.2837
298	N	A	-3.1334
299	R	A	-2.2785
300	M	A	-2.2707
301	K	A	-2.8441
302	S	A	-2.0402
303	Q	A	-1.8430
304	A	A	-1.7083
305	A	A	-1.5701
306	R	A	-2.4001
307	G	A	-1.6766
308	G	A	-1.2388
309	P	A	-0.9342
310	G	A	-1.5660
311	P	A	0.0000
312	G	A	0.0000
313	S	A	-1.9384
314	E	A	-3.0109
315	I	A	0.0000
316	K	A	-2.9202
317	Y	A	-1.8306
318	H	A	-1.0379
319	N	A	-0.4317
320	Y	A	0.5674
321	N	A	0.0000
322	S	A	0.1236
323	N	A	0.0243
324	G	A	-0.2718
325	F	A	0.0000
326	N	A	-1.6756
327	P	A	-1.4074
328	K	A	-2.1592
329	G	A	-1.5624
330	P	A	-1.2505
331	G	A	-0.7191
332	P	A	-0.4948
333	G	A	-0.2394
334	I	A	0.0000
335	L	A	0.0000
336	F	A	-0.4074
337	G	A	0.0000
338	D	A	-1.8053
339	A	A	-0.7309
340	F	A	-0.0815
341	I	A	0.0000
342	P	A	0.0000
343	A	A	0.7227
344	I	A	1.2118
345	V	A	0.0000
346	Q	A	0.0519
347	P	A	0.0000
348	V	A	-0.1924
349	S	A	0.0000
350	Q	A	-0.2214
351	I	A	0.0000
352	F	A	0.4448
353	P	A	0.2296
354	G	A	0.0000
355	P	A	-0.8037
356	G	A	0.0000
357	P	A	-0.8560
358	G	A	-0.5498
359	I	A	0.0000
360	L	A	1.0129
361	F	A	0.0649
362	N	A	-1.0096
363	S	A	-0.6369
364	L	A	-0.2116
365	Q	A	0.1023
366	Y	A	0.4712
367	T	A	-0.3946
368	N	A	-0.9171
369	V	A	-0.4841
370	V	A	-1.4086
371	K	A	-2.2703
372	D	A	-2.4394
373	Y	A	-1.3237
374	W	A	-0.7402
375	G	A	0.0000
376	N	A	-1.7669
377	D	A	-1.7228
378	L	A	0.3403
379	G	A	-0.4972
380	P	A	-0.9977
381	G	A	-0.7936
382	P	A	-1.2430
383	G	A	-2.0372
384	K	A	-2.6869
385	E	A	-2.6709
386	T	A	-1.7768
387	V	A	-0.8280
388	L	A	-1.0679
389	R	A	-1.7154
390	V	A	0.0000
391	A	A	-0.2113
392	V	A	0.0000
393	T	A	0.0000
394	A	A	0.0000
395	Q	A	-1.6637
396	H	A	-1.6463
397	P	A	-1.3969
398	K	A	-2.3164
399	P	A	-1.6247
400	A	A	-1.0544
401	S	A	-0.3003
402	L	A	0.1875
403	M	A	0.1877
404	G	A	-0.0475
405	P	A	-0.4700
406	G	A	-0.3949
407	P	A	-0.5662
408	G	A	0.0000
409	Y	A	-0.1791
410	D	A	-1.1331
411	A	A	-0.5310
412	G	A	-0.4407
413	I	A	-0.3333
414	E	A	-1.5415
415	L	A	-0.7518
416	A	A	-0.4690
417	H	A	-0.2556
418	L	A	0.5814
419	L	A	0.0000
420	A	A	-0.4150
421	F	A	-0.8668
422	N	A	-1.9517
423	K	A	-2.1501
424	Y	A	-0.9194
425	G	A	0.0000
426	P	A	-1.0076
427	G	A	0.0000
428	P	A	-0.4256
429	G	A	0.0000
430	H	A	0.0000
431	D	A	0.0000
432	K	A	-2.2175
433	K	A	-2.5102
434	Q	A	-1.4286
435	F	A	0.0000
436	A	A	0.0000
437	A	A	0.0000
438	L	A	0.0000
439	M	A	-0.3154
440	L	A	0.0000
441	Y	A	-1.4134
442	E	A	-2.3633
443	E	A	-3.1881
444	D	A	-3.2635
445	G	A	-2.2407
446	T	A	0.0000
447	L	A	0.0000
448	R	A	-2.0979
449	V	A	0.0000
450	E	A	-1.7238
451	G	A	0.0000
452	V	A	0.0000
453	G	A	0.0000
454	P	A	-0.8648
455	G	A	-1.2212
456	P	A	0.0000
457	G	A	-2.0286
458	K	A	-2.5321
459	R	A	-2.5695
460	H	A	-2.3939
461	G	A	-1.6595
462	K	A	-1.8831
463	R	A	-2.8637
464	L	A	0.0000
465	R	A	-2.8189
466	V	A	-1.1017
467	T	A	-0.7472
468	K	A	-1.0678
469	V	A	0.8638
470	I	A	0.4408
471	P	A	0.0000
472	H	A	0.0000
473	A	A	0.0000
474	K	A	0.0000
475	Y	A	0.0000
476	N	A	-1.8687
477	E	A	-2.0098
478	K	A	-2.6918
479	S	A	-2.2591
480	E	A	-2.5546
481	A	A	-1.2806
482	A	A	0.0000
483	A	A	-1.3180
484	K	A	-1.3724
485	F	A	0.5907
486	Y	A	1.0139
487	P	A	0.4589
488	S	A	0.1410
489	Y	A	0.7128
490	H	A	-0.5871
491	S	A	-0.6107
492	T	A	-0.9236
493	P	A	-1.4759
494	Q	A	-2.4589
495	R	A	-2.7896
496	P	A	-1.7323
497	G	A	-1.3244
498	T	A	-1.5290
499	P	A	-1.1689