Project name: 3e5f7cfeee116e

Chain sequence(s)	A: AGLGGAGLYGGSLSPLGSFSSLGGIGYLGGLSPFGGLGNPLSSLGYPGLLGGQGGKFPGDLRLITEPTSGLPVSEAVYVGLERQRLVPAPYRVPRPAPVPVPHVVPQPFTVDVPIPQPFEVPVGPGPGSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKSEAAAKFYPSYHSTPQRPGTP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.828
• Maximal score value: 2.1799
• Average score: -0.5041
• Total score value: -158.795

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	A	A	0.9431
2	G	A	0.0000
3	L	A	1.2855
4	G	A	0.4266
5	G	A	0.8681
6	A	A	0.5018
7	G	A	0.2335
8	L	A	1.3528
9	Y	A	0.7759
10	G	A	-0.2277
11	G	A	-0.1673
12	S	A	0.2418
13	L	A	0.9978
14	S	A	0.6397
15	P	A	0.5194
16	L	A	1.3231
17	G	A	1.3137
18	S	A	0.0000
19	F	A	2.1799
20	S	A	0.9861
21	S	A	0.0000
22	L	A	1.4351
23	G	A	0.4114
24	G	A	0.6530
25	I	A	1.4045
26	G	A	0.3779
27	Y	A	0.7887
28	L	A	0.5298
29	G	A	-0.5306
30	G	A	-0.9124
31	L	A	0.0000
32	S	A	0.0000
33	P	A	-0.2568
34	F	A	0.8624
35	G	A	0.0000
36	G	A	0.0000
37	L	A	0.0000
38	G	A	0.0000
39	N	A	0.0000
40	P	A	0.0000
41	L	A	0.0000
42	S	A	0.0000
43	S	A	0.7663
44	L	A	0.0000
45	G	A	0.4765
46	Y	A	0.1206
47	P	A	-0.3372
48	G	A	-0.6529
49	L	A	-0.7800
50	L	A	0.0000
51	G	A	-1.4551
52	G	A	0.0000
53	Q	A	-1.8961
54	G	A	-1.6119
55	G	A	-1.3696
56	K	A	-1.5427
57	F	A	-0.3030
58	P	A	-0.7835
59	G	A	0.0000
60	D	A	-1.1465
61	L	A	0.0000
62	R	A	-1.6303
63	L	A	-0.2565
64	I	A	0.0000
65	T	A	-1.1317
66	E	A	-1.9957
67	P	A	-1.2411
68	T	A	-0.6955
69	S	A	-0.5282
70	G	A	-0.5147
71	L	A	-0.1398
72	P	A	-0.8063
73	V	A	0.0000
74	S	A	-0.8190
75	E	A	-1.0777
76	A	A	0.0000
77	V	A	0.1387
78	Y	A	0.7492
79	V	A	0.0528
80	G	A	0.0000
81	L	A	0.0480
82	E	A	-1.6352
83	R	A	-1.9301
84	Q	A	-1.6145
85	R	A	-1.4714
86	L	A	0.8166
87	V	A	1.2585
88	P	A	0.6599
89	A	A	0.6134
90	P	A	0.1196
91	Y	A	0.6737
92	R	A	-0.6481
93	V	A	0.5708
94	P	A	-0.8074
95	R	A	-1.8913
96	P	A	-0.7908
97	A	A	-0.2484
98	P	A	0.4909
99	V	A	1.9261
100	P	A	1.2395
101	V	A	1.8979
102	P	A	0.8413
103	H	A	0.5921
104	V	A	2.1183
105	V	A	1.9567
106	P	A	0.4638
107	Q	A	-0.3998
108	P	A	-0.0609
109	F	A	1.1102
110	T	A	0.3782
111	V	A	-0.6021
112	D	A	-1.6694
113	V	A	-0.7806
114	P	A	-0.5420
115	I	A	-0.3690
116	P	A	-0.6222
117	Q	A	-1.1441
118	P	A	-0.8865
119	F	A	-0.7721
120	E	A	-2.1691
121	V	A	0.0000
122	P	A	-1.0880
123	V	A	-0.9589
124	G	A	-0.6852
125	P	A	-0.9409
126	G	A	-1.0997
127	P	A	-0.9842
128	G	A	-1.1971
129	S	A	-1.4294
130	E	A	-2.2645
131	I	A	0.0000
132	K	A	-2.1090
133	Y	A	-1.3363
134	H	A	-1.1943
135	N	A	-0.2687
136	Y	A	-0.0327
137	N	A	0.0000
138	S	A	-0.5389
139	N	A	-0.9428
140	G	A	0.0000
141	F	A	-0.5344
142	N	A	-0.9320
143	P	A	0.0000
144	K	A	-2.4760
145	G	A	-1.6581
146	P	A	-1.3803
147	G	A	-0.9439
148	P	A	-0.2940
149	G	A	-0.0090
150	I	A	1.4479
151	L	A	1.8664
152	F	A	0.0000
153	G	A	0.7781
154	D	A	0.0000
155	A	A	0.7031
156	F	A	1.4806
157	I	A	0.0000
158	P	A	0.0000
159	A	A	0.5592
160	I	A	0.5233
161	V	A	0.0000
162	Q	A	-0.3705
163	P	A	-0.3823
164	V	A	-0.2605
165	S	A	-0.7998
166	Q	A	-1.1175
167	I	A	-0.3349
168	F	A	-0.6689
169	P	A	-0.7541
170	G	A	-0.8372
171	P	A	-0.6520
172	G	A	-0.5638
173	P	A	0.0000
174	G	A	0.0000
175	I	A	0.0000
176	L	A	0.0000
177	F	A	0.6528
178	N	A	-0.4362
179	S	A	-0.1100
180	L	A	0.0000
181	Q	A	-0.5755
182	Y	A	-0.4232
183	T	A	-0.7246
184	N	A	-1.1809
185	V	A	0.0000
186	V	A	0.0000
187	K	A	-1.8368
188	D	A	-2.1170
189	Y	A	-1.0733
190	W	A	0.0000
191	G	A	0.0000
192	N	A	-2.6383
193	D	A	-2.6920
194	L	A	0.0000
195	G	A	-1.7252
196	P	A	-1.3903
197	G	A	-1.1366
198	P	A	-1.1770
199	G	A	-1.4461
200	K	A	-2.2420
201	E	A	-2.6486
202	T	A	-1.3621
203	V	A	-0.8236
204	L	A	-0.4661
205	R	A	-0.3466
206	V	A	0.0091
207	A	A	0.0000
208	V	A	0.5773
209	T	A	-0.2356
210	A	A	-0.9279
211	Q	A	-1.7173
212	H	A	-1.7653
213	P	A	-1.4704
214	K	A	-1.6687
215	P	A	-0.8385
216	A	A	0.0000
217	S	A	-0.2649
218	L	A	-0.4415
219	M	A	0.0000
220	G	A	-0.7732
221	P	A	-0.8320
222	G	A	-1.0539
223	P	A	-1.2920
224	G	A	0.0000
225	Y	A	-1.1769
226	D	A	-1.9122
227	A	A	-1.0664
228	G	A	0.0000
229	I	A	-0.4313
230	E	A	-0.7109
231	L	A	0.0000
232	A	A	0.0000
233	H	A	-0.0047
234	L	A	0.0000
235	L	A	0.0000
236	A	A	0.3635
237	F	A	0.4932
238	N	A	0.0000
239	K	A	-0.0068
240	Y	A	0.9433
241	G	A	-0.0084
242	P	A	-0.5774
243	G	A	-0.3356
244	P	A	-0.7040
245	G	A	-1.1619
246	H	A	-1.1794
247	D	A	-2.0745
248	K	A	-2.7223
249	K	A	-2.2817
250	Q	A	0.0000
251	F	A	0.0000
252	A	A	0.0000
253	A	A	0.0000
254	L	A	0.0000
255	M	A	0.0000
256	L	A	-0.3195
257	Y	A	0.1430
258	E	A	0.0000
259	E	A	-0.8886
260	D	A	-1.8222
261	G	A	-1.1382
262	T	A	-0.4593
263	L	A	-0.4558
264	R	A	-0.9426
265	V	A	0.0000
266	E	A	0.0000
267	G	A	0.0000
268	V	A	0.0000
269	G	A	-1.4748
270	P	A	-1.2075
271	G	A	-1.3408
272	P	A	-1.1886
273	G	A	-2.2802
274	K	A	-2.9049
275	R	A	-3.0131
276	H	A	-2.1564
277	G	A	-1.9140
278	K	A	-3.2734
279	R	A	-3.2263
280	L	A	-2.4695
281	R	A	-2.2377
282	V	A	0.0000
283	T	A	-1.1495
284	K	A	-1.7776
285	V	A	-0.3530
286	I	A	-0.3896
287	P	A	-0.6260
288	H	A	-0.7427
289	A	A	-1.4789
290	K	A	-2.2183
291	Y	A	-1.2396
292	N	A	-2.9668
293	E	A	-3.8280
294	K	A	-3.5650
295	S	A	-2.8040
296	E	A	-3.3720
297	A	A	-2.1065
298	A	A	-0.8070
299	A	A	-0.8390
300	K	A	-1.1553
301	F	A	1.2719
302	Y	A	1.1994
303	P	A	0.1317
304	S	A	0.3398
305	Y	A	0.9906
306	H	A	-0.4649
307	S	A	-0.5318
308	T	A	-0.7899
309	P	A	-1.2813
310	Q	A	-2.0010
311	R	A	-2.4701
312	P	A	-1.5906
313	G	A	-1.2357
314	T	A	-1.2496
315	P	A	-0.5411