Project name: 3f9ad48ee1fb061

Chain sequence(s)	A: EDNIRRLRALADGVQKV; H: QIQLVQSGPDLKKPGETVKISCRTSGYAFTNYGVNWVKQAPGKGLKWMGWINTNTGQTTYAEEFRGRFAISLETSASTAFLTISNLKNEDSATYFCARLIYDGDYISSDFWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC; L: DIQMTQSPDSLSASVGETVTITCGASENIYGALNWYQRRKQGKSPQLLIYGATNLADGMSSRFSGSRSGRQYSLKISSLHPDDVATYYCQNALSMPYTFGGGTNLETKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5407
• Maximal score value: 1.5246
• Average score: -0.7742
• Total score value: -352.2811

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
152	E	A	-2.8315
153	D	A	-2.7686
154	N	A	-2.4739
155	I	A	-1.0382
156	R	A	-1.4303
157	R	A	-1.6879
158	L	A	0.4528
159	R	A	-0.2784
160	A	A	0.0000
161	L	A	1.1429
162	A	A	0.5394
163	D	A	-0.0505
164	G	A	-0.1934
165	V	A	-0.2521
166	Q	A	0.0000
167	K	A	-1.3564
168	V	A	0.2678
1	Q	H	-1.4785
2	I	H	-0.6444
3	Q	H	-1.0931
4	L	H	0.0000
5	V	H	0.5689
6	Q	H	0.0000
7	S	H	-0.6062
8	G	H	-0.8229
9	P	H	-0.9482
10	D	H	-1.2850
11	L	H	-0.9129
12	K	H	-1.7967
13	K	H	-2.7372
14	P	H	-2.5895
15	G	H	-2.2100
16	E	H	-1.9671
17	T	H	-1.6203
18	V	H	0.0000
19	K	H	-1.7768
20	I	H	0.0000
21	S	H	-0.7501
22	C	H	0.0000
23	R	H	-1.4271
24	T	H	0.0000
25	S	H	-0.9475
26	G	H	-1.0078
27	Y	H	-0.4865
28	A	H	-0.2987
29	F	H	0.0000
30	T	H	-1.0468
31	N	H	-1.2195
32	Y	H	-0.4258
33	G	H	0.0000
34	V	H	0.0000
35	N	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	K	H	-0.8706
39	Q	H	-1.1361
40	A	H	-1.3883
41	P	H	-1.1136
42	G	H	-1.4738
43	K	H	-2.3559
44	G	H	-1.5493
45	L	H	0.0000
46	K	H	-1.5792
47	W	H	0.0000
48	M	H	0.0000
49	G	H	0.0000
50	W	H	0.0000
51	I	H	0.0000
52	N	H	0.0000
53	T	H	0.0000
54	N	H	-1.7841
55	T	H	-1.1945
56	G	H	-1.2189
57	Q	H	-1.5777
58	T	H	-0.7001
59	T	H	-0.7321
60	Y	H	-1.2519
61	A	H	0.0000
62	E	H	-3.5407
63	E	H	-3.4233
64	F	H	0.0000
65	R	H	-3.1973
66	G	H	-2.2378
67	R	H	-1.6709
68	F	H	0.0000
69	A	H	-0.6359
70	I	H	0.0000
71	S	H	-0.6486
72	L	H	-0.8415
73	E	H	-1.9572
74	T	H	-1.2047
75	S	H	-0.7589
76	A	H	-0.9867
77	S	H	-1.0374
78	T	H	0.0000
79	A	H	0.0000
80	F	H	-0.7196
81	L	H	0.0000
82	T	H	-0.7948
83	I	H	0.0000
84	S	H	-1.4607
85	N	H	-2.1604
86	L	H	0.0000
87	K	H	-3.1296
88	N	H	-3.0796
89	E	H	-2.8113
90	D	H	0.0000
91	S	H	-1.3488
92	A	H	0.0000
93	T	H	-0.3279
94	Y	H	0.0000
95	F	H	0.0000
96	C	H	0.0000
97	A	H	0.0000
98	R	H	0.0000
99	L	H	0.0000
100	I	H	-0.0279
101	Y	H	0.0000
102	D	H	-1.3792
103	G	H	-1.2801
104	D	H	-2.0016
105	Y	H	-0.9432
106	I	H	0.0000
107	S	H	0.0000
108	S	H	0.0000
109	D	H	-0.0785
110	F	H	0.3448
111	W	H	-0.0474
112	G	H	0.0000
113	Q	H	-1.2600
114	G	H	-0.7208
115	T	H	0.0000
116	T	H	-0.5513
117	L	H	0.0000
118	T	H	-1.1689
119	V	H	0.0000
120	S	H	-1.4908
121	S	H	-1.0360
122	A	H	-0.6111
123	S	H	-0.6958
124	T	H	-0.9693
125	K	H	-1.1665
126	G	H	-1.3353
127	P	H	0.0000
128	S	H	-0.4331
129	V	H	0.0000
130	F	H	0.0000
131	P	H	-1.0715
132	L	H	0.0000
133	A	H	0.0000
134	P	H	0.0000
135	S	H	0.0000
136	S	H	-0.5853
137	K	H	-0.6080
138	S	H	0.0000
139	T	H	-0.5491
140	S	H	-0.6685
141	G	H	-0.8749
142	G	H	-0.8979
143	T	H	-0.5804
144	A	H	0.0000
145	A	H	0.0000
146	L	H	0.0000
147	G	H	0.0000
148	C	H	0.0000
149	L	H	0.0000
150	V	H	0.0000
151	K	H	-0.2365
152	D	H	-0.4050
153	Y	H	0.0000
154	F	H	-0.1801
155	P	H	0.0000
156	E	H	-0.6805
157	P	H	-0.6638
158	V	H	-0.5769
159	T	H	-0.5801
160	V	H	-0.1916
161	S	H	-0.3722
162	W	H	0.0000
163	N	H	-0.7131
164	S	H	-0.6293
165	G	H	-0.4817
166	A	H	-0.2231
167	L	H	0.0138
168	T	H	-0.1523
169	S	H	-0.1620
170	G	H	-0.1229
171	V	H	0.1659
172	H	H	-0.3656
173	T	H	-0.1898
174	F	H	0.0000
175	P	H	-0.2727
176	A	H	0.3341
177	V	H	0.8022
178	L	H	1.5246
179	Q	H	0.4001
180	S	H	-0.0676
181	S	H	-0.2166
182	G	H	0.0504
183	L	H	0.2870
184	Y	H	0.6542
185	S	H	0.0000
186	L	H	0.0000
187	S	H	0.0000
188	S	H	0.0000
189	V	H	0.0000
190	V	H	0.0000
191	T	H	-0.1274
192	V	H	0.0000
193	P	H	-0.6167
194	S	H	-0.5494
195	S	H	-0.5732
196	S	H	-0.5497
197	L	H	-0.6489
198	G	H	-1.0194
199	T	H	-0.6484
200	Q	H	-1.1239
201	T	H	-1.0550
202	Y	H	0.0000
203	I	H	-1.1779
204	C	H	0.0000
205	N	H	-1.3788
206	V	H	0.0000
207	N	H	-1.9686
208	H	H	0.0000
209	K	H	-2.6700
210	P	H	-1.6889
211	S	H	-1.7841
212	N	H	-2.4955
213	T	H	-2.0535
214	K	H	-2.6654
215	V	H	-1.5980
216	D	H	-2.2061
217	K	H	-1.8870
218	K	H	-2.3183
219	V	H	0.0000
220	E	H	-2.5383
221	P	H	-1.4220
222	K	H	-1.3334
223	S	H	-0.9007
224	C	H	-0.9110
1	D	L	-2.4243
2	I	L	-1.7545
3	Q	L	-1.9590
4	M	L	0.0000
5	T	L	-0.7108
6	Q	L	-0.9994
7	S	L	-0.9123
8	P	L	-1.3293
9	D	L	-2.3225
10	S	L	-1.6523
11	L	L	-1.0425
12	S	L	-0.9015
13	A	L	0.0000
14	S	L	-0.8873
15	V	L	0.0612
16	G	L	-0.6630
17	E	L	-1.3650
18	T	L	-1.0303
19	V	L	0.0000
20	T	L	-0.5784
21	I	L	0.0000
22	T	L	-0.6595
23	C	L	0.0000
24	G	L	-1.7222
25	A	L	0.0000
26	S	L	-2.1609
27	E	L	-2.9976
28	N	L	-2.0730
29	I	L	0.0000
30	Y	L	-1.2178
31	G	L	0.0000
32	A	L	0.0000
33	L	L	0.0000
34	N	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	-0.8449
38	R	L	-1.4432
39	K	L	-2.1901
40	Q	L	-2.5595
41	G	L	-2.3135
42	K	L	-2.7603
43	S	L	-1.6419
44	P	L	0.0000
45	Q	L	-0.7129
46	L	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	0.0762
50	G	L	0.0000
51	A	L	0.0000
52	T	L	-0.4741
53	N	L	-0.6693
54	L	L	-0.4203
55	A	L	0.0000
56	D	L	-1.9732
57	G	L	-1.2324
58	M	L	-0.6970
59	S	L	-0.5042
60	S	L	-0.4067
61	R	L	-0.8055
62	F	L	0.0000
63	S	L	-0.8926
64	G	L	-0.7909
65	S	L	-1.0598
66	R	L	-1.4797
67	S	L	-1.5416
68	G	L	-2.0390
69	R	L	-2.9794
70	Q	L	-2.4928
71	Y	L	0.0000
72	S	L	-0.9439
73	L	L	0.0000
74	K	L	-1.4753
75	I	L	0.0000
76	S	L	-1.1587
77	S	L	-0.9334
78	L	L	0.0000
79	H	L	-1.4436
80	P	L	-2.0977
81	D	L	-2.7678
82	D	L	0.0000
83	V	L	-1.7852
84	A	L	0.0000
85	T	L	-1.2079
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	Q	L	0.0000
90	N	L	0.0000
91	A	L	0.0000
92	L	L	0.0000
93	S	L	-0.1626
94	M	L	-0.2965
95	P	L	-0.7849
96	Y	L	0.0000
97	T	L	-0.6840
98	F	L	-0.4118
99	G	L	0.0000
100	G	L	-1.5260
101	G	L	-1.3297
102	T	L	0.0000
103	N	L	-1.9014
104	L	L	0.0000
105	E	L	-1.9480
106	T	L	0.0000
107	K	L	-1.5428
108	R	L	-0.8901
109	T	L	-0.0616
110	V	L	0.3274
111	A	L	-0.0923
112	A	L	-0.1325
113	P	L	0.0000
114	S	L	-0.1269
115	V	L	-0.0385
116	F	L	0.0000
117	I	L	0.0000
118	F	L	0.0000
119	P	L	0.0000
120	P	L	0.0000
121	S	L	0.0000
122	D	L	-2.7552
123	E	L	-2.6315
124	Q	L	0.0000
125	L	L	-2.0729
126	K	L	-2.7258
127	S	L	-1.7007
128	G	L	-1.2079
129	T	L	-1.1743
130	A	L	0.0000
131	S	L	0.0000
132	V	L	0.0000
133	V	L	0.0000
134	C	L	0.0000
135	L	L	0.0000
136	L	L	0.0000
137	N	L	0.0000
138	N	L	-1.0997
139	F	L	0.0000
140	Y	L	0.0000
141	P	L	-1.8130
142	R	L	-3.1685
143	E	L	-3.2386
144	A	L	-2.4264
145	K	L	-2.4613
146	V	L	0.0000
147	Q	L	-0.7268
148	W	L	0.0000
149	K	L	-0.6392
150	V	L	0.0000
151	D	L	-2.0392
152	N	L	-1.5949
153	A	L	-0.3075
154	L	L	0.6634
155	Q	L	-0.1137
156	S	L	-0.4174
157	G	L	-0.8728
158	N	L	-0.8001
159	S	L	-1.1192
160	Q	L	-1.2817
161	E	L	-1.9396
162	S	L	-1.0061
163	V	L	-1.0543
164	T	L	-1.3490
165	E	L	-2.5592
166	Q	L	0.0000
167	D	L	-2.4525
168	S	L	-2.7266
169	K	L	-2.8875
170	D	L	-2.3422
171	S	L	0.0000
172	T	L	0.0000
173	Y	L	0.0000
174	S	L	0.0000
175	L	L	0.0000
176	S	L	0.0000
177	S	L	0.0000
178	T	L	-0.6796
179	L	L	0.0000
180	T	L	-0.4175
181	L	L	-0.6583
182	S	L	-1.0168
183	K	L	-2.0376
184	A	L	-1.7716
185	D	L	-2.3784
186	Y	L	0.0000
187	E	L	-3.2641
188	K	L	-3.4880
189	H	L	-2.9643
190	K	L	-3.1895
191	V	L	-1.4592
192	Y	L	0.0000
193	A	L	0.0000
194	C	L	0.0000
195	E	L	-0.5006
196	V	L	0.0000
197	T	L	-1.1755
198	H	L	0.0000
199	Q	L	-1.7350
200	G	L	-0.4255
201	L	L	-0.2231
202	S	L	-0.4475
203	S	L	-0.4055
204	P	L	-0.4897
205	V	L	0.2567
206	T	L	-0.1743
207	K	L	-0.2850
208	S	L	-0.3127
209	F	L	0.0000
210	N	L	-1.7299
211	R	L	-2.3892
212	G	L	-2.1285
213	E	L	-2.4783
214	C	L	-1.4683