Project name: 40da309c5f02a5b
Status: done
submitted: 2018-12-16 16:38:22, status changed: 2018-12-16 16:47:39
Settings
|
Chain sequence(s)
|
B: SYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHHMFPKMLMKITDLRSSISAKGAERVITLKMEIPGSMPPLIQEMLE
|
| Distance of aggregation |
10 Å |
| Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.3411
-
Maximal score value
-
2.2635
-
Average score
-
-0.8252
-
Total score value
-
-197.2263
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
| residue index |
residue name |
chain |
Aggrescan3D score |
|
| 177 |
S |
B |
-0.2228 |
|
| 178 |
Y |
B |
-0.3615 |
|
| 179 |
T |
B |
0.0784 |
|
| 180 |
L |
B |
-0.1711 |
|
| 181 |
T |
B |
-0.7326 |
|
| 182 |
P |
B |
-1.5477 |
|
| 183 |
E |
B |
-2.4318 |
|
| 184 |
V |
B |
-1.7442 |
|
| 185 |
G |
B |
-1.7979 |
|
| 186 |
E |
B |
-3.0283 |
|
| 187 |
L |
B |
0.0000 |
|
| 188 |
I |
B |
0.0000 |
|
| 189 |
E |
B |
-2.6230 |
|
| 190 |
K |
B |
-2.6071 |
|
| 191 |
V |
B |
0.0000 |
|
| 192 |
R |
B |
-2.6379 |
|
| 193 |
K |
B |
-3.3411 |
|
| 194 |
A |
B |
0.0000 |
|
| 195 |
H |
B |
0.0000 |
|
| 196 |
Q |
B |
-2.7140 |
|
| 197 |
E |
B |
-3.1023 |
|
| 198 |
T |
B |
0.0000 |
|
| 199 |
F |
B |
0.0000 |
|
| 200 |
P |
B |
-1.0393 |
|
| 201 |
A |
B |
-0.5398 |
|
| 202 |
L |
B |
0.0926 |
|
| 203 |
C |
B |
0.1090 |
|
| 204 |
Q |
B |
-0.9014 |
|
| 205 |
L |
B |
-0.6834 |
|
| 206 |
G |
B |
-1.1381 |
|
| 207 |
K |
B |
-1.4784 |
|
| 208 |
Y |
B |
-0.2819 |
|
| 209 |
T |
B |
-0.5220 |
|
| 210 |
T |
B |
-0.9546 |
|
| 211 |
N |
B |
-2.2050 |
|
| 212 |
N |
B |
-2.5571 |
|
| 213 |
S |
B |
-2.2964 |
|
| 214 |
S |
B |
-2.4764 |
|
| 215 |
E |
B |
-3.1533 |
|
| 216 |
Q |
B |
-2.7974 |
|
| 217 |
R |
B |
-2.4977 |
|
| 218 |
V |
B |
-0.5364 |
|
| 219 |
S |
B |
-0.1468 |
|
| 220 |
L |
B |
-0.0870 |
|
| 221 |
D |
B |
-0.5789 |
|
| 222 |
I |
B |
-0.3861 |
|
| 223 |
D |
B |
-2.1907 |
|
| 224 |
L |
B |
0.0000 |
|
| 225 |
W |
B |
0.0000 |
|
| 226 |
D |
B |
-2.8603 |
|
| 227 |
K |
B |
-2.4279 |
|
| 228 |
F |
B |
-1.5019 |
|
| 229 |
S |
B |
0.0000 |
|
| 230 |
E |
B |
-2.6842 |
|
| 231 |
L |
B |
0.0000 |
|
| 232 |
S |
B |
-0.9477 |
|
| 233 |
T |
B |
-0.8036 |
|
| 234 |
K |
B |
-1.0596 |
|
| 235 |
C |
B |
-0.4690 |
|
| 236 |
I |
B |
0.0000 |
|
| 237 |
I |
B |
0.4352 |
|
| 238 |
K |
B |
-0.9242 |
|
| 239 |
T |
B |
0.0000 |
|
| 240 |
V |
B |
-0.5210 |
|
| 241 |
E |
B |
-2.0370 |
|
| 242 |
F |
B |
0.0000 |
|
| 243 |
A |
B |
0.0000 |
|
| 244 |
K |
B |
-2.5623 |
|
| 245 |
Q |
B |
-2.2786 |
|
| 246 |
L |
B |
0.0000 |
|
| 247 |
P |
B |
-0.8061 |
|
| 248 |
G |
B |
-0.5356 |
|
| 249 |
F |
B |
0.0000 |
|
| 250 |
T |
B |
-0.5163 |
|
| 251 |
T |
B |
-0.0989 |
|
| 252 |
L |
B |
0.0000 |
|
| 253 |
T |
B |
0.7497 |
|
| 254 |
I |
B |
2.2635 |
|
| 255 |
A |
B |
0.8128 |
|
| 256 |
D |
B |
0.0000 |
|
| 257 |
Q |
B |
0.8783 |
|
| 258 |
I |
B |
1.3579 |
|
| 259 |
T |
B |
-0.1384 |
|
| 260 |
L |
B |
0.0000 |
|
| 261 |
L |
B |
0.0000 |
|
| 262 |
K |
B |
-0.6590 |
|
| 263 |
A |
B |
-0.2097 |
|
| 264 |
A |
B |
0.0000 |
|
| 265 |
C |
B |
0.0000 |
|
| 266 |
L |
B |
-0.0912 |
|
| 267 |
D |
B |
0.0000 |
|
| 268 |
I |
B |
0.0000 |
|
| 269 |
L |
B |
0.3374 |
|
| 270 |
I |
B |
0.0000 |
|
| 271 |
L |
B |
0.0000 |
|
| 272 |
R |
B |
0.0000 |
|
| 273 |
I |
B |
0.2733 |
|
| 274 |
C |
B |
0.0000 |
|
| 275 |
T |
B |
0.0641 |
|
| 276 |
R |
B |
0.0000 |
|
| 277 |
Y |
B |
0.0000 |
|
| 278 |
T |
B |
-1.0918 |
|
| 279 |
P |
B |
-1.6178 |
|
| 280 |
E |
B |
-2.6171 |
|
| 281 |
Q |
B |
-2.4674 |
|
| 282 |
D |
B |
-1.9407 |
|
| 283 |
T |
B |
0.0000 |
|
| 284 |
M |
B |
0.0000 |
|
| 285 |
T |
B |
0.0000 |
|
| 286 |
F |
B |
0.0000 |
|
| 287 |
S |
B |
-0.7055 |
|
| 288 |
D |
B |
-1.1475 |
|
| 289 |
G |
B |
0.0000 |
|
| 290 |
L |
B |
0.0000 |
|
| 291 |
T |
B |
0.0000 |
|
| 292 |
L |
B |
0.0000 |
|
| 293 |
N |
B |
-1.1364 |
|
| 294 |
R |
B |
-1.4567 |
|
| 295 |
T |
B |
-1.6949 |
|
| 296 |
Q |
B |
0.0000 |
|
| 297 |
M |
B |
0.0000 |
|
| 298 |
H |
B |
-0.9540 |
|
| 299 |
N |
B |
0.0000 |
|
| 300 |
A |
B |
0.0000 |
|
| 301 |
G |
B |
0.0000 |
|
| 302 |
F |
B |
-0.0797 |
|
| 303 |
G |
B |
0.0000 |
|
| 304 |
P |
B |
-0.6272 |
|
| 305 |
L |
B |
0.0000 |
|
| 306 |
T |
B |
0.0000 |
|
| 307 |
D |
B |
-1.6170 |
|
| 308 |
L |
B |
-0.4510 |
|
| 309 |
V |
B |
0.0000 |
|
| 310 |
F |
B |
0.0000 |
|
| 311 |
A |
B |
-0.7168 |
|
| 312 |
F |
B |
0.0000 |
|
| 313 |
A |
B |
0.0000 |
|
| 314 |
N |
B |
-0.9407 |
|
| 315 |
Q |
B |
-0.9769 |
|
| 316 |
L |
B |
0.0000 |
|
| 317 |
L |
B |
-0.3999 |
|
| 318 |
P |
B |
-0.7475 |
|
| 319 |
L |
B |
0.0000 |
|
| 320 |
E |
B |
-1.6650 |
|
| 321 |
M |
B |
-0.8650 |
|
| 322 |
D |
B |
-0.9187 |
|
| 323 |
D |
B |
-1.1834 |
|
| 324 |
A |
B |
0.0000 |
|
| 325 |
E |
B |
0.0000 |
|
| 326 |
T |
B |
0.0000 |
|
| 327 |
G |
B |
0.0000 |
|
| 328 |
L |
B |
0.0000 |
|
| 329 |
L |
B |
0.0000 |
|
| 330 |
S |
B |
0.0000 |
|
| 331 |
A |
B |
0.0000 |
|
| 332 |
I |
B |
0.0000 |
|
| 333 |
C |
B |
0.0000 |
|
| 334 |
L |
B |
0.0000 |
|
| 335 |
I |
B |
0.0000 |
|
| 336 |
C |
B |
-1.1933 |
|
| 337 |
G |
B |
-2.5130 |
|
| 338 |
D |
B |
-2.9159 |
|
| 339 |
R |
B |
-2.3516 |
|
| 340 |
Q |
B |
-2.8541 |
|
| 341 |
D |
B |
-3.0690 |
|
| 342 |
L |
B |
-2.5671 |
|
| 343 |
E |
B |
-2.9164 |
|
| 344 |
Q |
B |
-2.5018 |
|
| 345 |
P |
B |
-2.9962 |
|
| 346 |
D |
B |
-3.1150 |
|
| 347 |
R |
B |
-2.1072 |
|
| 348 |
V |
B |
0.0000 |
|
| 349 |
D |
B |
-2.9996 |
|
| 350 |
M |
B |
-1.1807 |
|
| 351 |
L |
B |
0.0000 |
|
| 352 |
Q |
B |
-1.6801 |
|
| 353 |
E |
B |
-2.2251 |
|
| 354 |
P |
B |
-1.6305 |
|
| 355 |
L |
B |
0.0000 |
|
| 356 |
L |
B |
-1.0300 |
|
| 357 |
E |
B |
-1.8060 |
|
| 358 |
A |
B |
0.0000 |
|
| 359 |
L |
B |
0.0000 |
|
| 360 |
K |
B |
-1.2546 |
|
| 361 |
V |
B |
-0.9702 |
|
| 362 |
Y |
B |
0.0000 |
|
| 363 |
V |
B |
0.0000 |
|
| 364 |
R |
B |
-2.2376 |
|
| 365 |
K |
B |
-2.2133 |
|
| 366 |
R |
B |
-2.7046 |
|
| 367 |
R |
B |
-2.3397 |
|
| 368 |
P |
B |
-2.0209 |
|
| 369 |
S |
B |
-1.8493 |
|
| 370 |
R |
B |
-2.8122 |
|
| 371 |
P |
B |
-2.2334 |
|
| 372 |
H |
B |
-2.0213 |
|
| 373 |
M |
B |
0.0000 |
|
| 374 |
F |
B |
-0.8644 |
|
| 375 |
P |
B |
-0.6804 |
|
| 376 |
K |
B |
-0.9729 |
|
| 377 |
M |
B |
0.0000 |
|
| 378 |
L |
B |
0.1731 |
|
| 379 |
M |
B |
0.3929 |
|
| 380 |
K |
B |
-0.5904 |
|
| 381 |
I |
B |
-0.5161 |
|
| 382 |
T |
B |
-0.8391 |
|
| 383 |
D |
B |
-1.5364 |
|
| 384 |
L |
B |
0.0000 |
|
| 385 |
R |
B |
-2.3209 |
|
| 386 |
S |
B |
-1.5195 |
|
| 387 |
I |
B |
0.0000 |
|
| 388 |
S |
B |
0.0000 |
|
| 389 |
A |
B |
-1.2379 |
|
| 390 |
K |
B |
-1.5590 |
|
| 391 |
G |
B |
0.0000 |
|
| 392 |
A |
B |
-0.8585 |
|
| 393 |
E |
B |
-1.6437 |
|
| 394 |
R |
B |
0.0000 |
|
| 395 |
V |
B |
0.0000 |
|
| 396 |
I |
B |
0.3623 |
|
| 397 |
T |
B |
0.0124 |
|
| 398 |
L |
B |
0.0000 |
|
| 399 |
K |
B |
-0.4719 |
|
| 400 |
M |
B |
0.3381 |
|
| 401 |
E |
B |
-0.7997 |
|
| 402 |
I |
B |
0.0000 |
|
| 403 |
P |
B |
-0.5554 |
|
| 404 |
G |
B |
-0.8225 |
|
| 405 |
S |
B |
-0.7615 |
|
| 406 |
M |
B |
0.0000 |
|
| 407 |
P |
B |
-1.0522 |
|
| 408 |
P |
B |
-0.8102 |
|
| 409 |
L |
B |
-0.6417 |
|
| 410 |
I |
B |
0.0000 |
|
| 411 |
Q |
B |
-1.7929 |
|
| 412 |
E |
B |
-2.2471 |
|
| 413 |
M |
B |
-1.1576 |
|
| 414 |
L |
B |
-1.0436 |
|
| 415 |
E |
B |
-1.6896 |
|
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine