Project name: 421dc197bf86f2b

Chain sequence(s)	H: VQLLESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASIRSGGGRTYYSDNVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCVRYDHYSGSSDYWGQGTLVTVSS; L: YVVMTQSPLSLPVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4279
• Maximal score value: 1.9445
• Average score: -0.6409
• Total score value: -147.4113

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	V	H	1.2862
3	Q	H	0.1206
4	L	H	0.0000
5	L	H	0.4760
6	E	H	0.0000
7	S	H	-0.5061
8	G	H	-0.7845
9	G	H	-0.2001
10	G	H	0.3890
11	L	H	1.1724
12	V	H	0.0000
13	Q	H	-1.3355
14	P	H	-1.5258
15	G	H	-1.3192
16	G	H	0.0000
17	S	H	-1.2515
18	L	H	-1.0173
19	R	H	-2.0876
20	L	H	0.0000
21	S	H	-0.4830
22	C	H	0.0000
23	A	H	-0.2389
24	A	H	0.0000
25	S	H	0.0056
26	G	H	0.1120
27	F	H	0.0793
28	T	H	-0.3977
29	F	H	0.0000
30	S	H	-1.3351
31	N	H	-1.6740
32	Y	H	-0.9844
33	G	H	0.0000
34	M	H	0.0000
35	S	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.7301
40	A	H	-1.0934
41	P	H	-0.9433
42	G	H	-1.4697
43	K	H	-2.3426
44	G	H	-1.5144
45	L	H	0.0000
46	E	H	-0.8456
47	W	H	0.0000
48	V	H	0.0000
49	A	H	0.0000
50	S	H	-0.5677
51	I	H	0.0000
52	R	H	-2.8645
52A	S	H	-2.0388
53	G	H	-1.9301
54	G	H	-1.8413
55	G	H	-2.2441
56	R	H	-2.8279
57	T	H	-1.3753
58	Y	H	-0.3617
59	Y	H	-0.8779
60	S	H	-1.5142
61	D	H	-2.9135
62	N	H	-2.8869
63	V	H	0.0000
64	K	H	-2.8285
65	G	H	-1.9178
66	R	H	-1.6520
67	F	H	0.0000
68	T	H	-0.7544
69	I	H	0.0000
70	S	H	-0.8705
71	R	H	-1.2484
72	D	H	-1.4952
73	N	H	-1.8364
74	A	H	-1.4091
75	K	H	-2.2813
76	N	H	-1.7084
77	S	H	0.0000
78	L	H	0.0000
79	Y	H	-0.4586
80	L	H	0.0000
81	Q	H	-1.1314
82	M	H	0.0000
82A	N	H	-1.4598
82B	S	H	-1.2210
82C	L	H	0.0000
83	R	H	-2.2228
84	A	H	-1.6962
85	E	H	-2.3419
86	D	H	0.0000
87	T	H	-0.5224
88	A	H	0.0000
89	L	H	0.3347
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	V	H	0.0000
94	R	H	0.0000
95	Y	H	0.1817
96	D	H	0.0000
97	H	H	-0.1751
98	Y	H	0.9794
99	S	H	0.0000
100	G	H	0.0054
100A	S	H	0.0000
100B	S	H	0.0000
101	D	H	0.0000
102	Y	H	0.7178
103	W	H	0.0000
104	G	H	0.0000
105	Q	H	-1.2515
106	G	H	0.0000
107	T	H	0.0690
108	L	H	0.6796
109	V	H	0.0000
110	T	H	0.1201
111	V	H	0.0000
112	S	H	-0.7222
113	S	H	-0.4842
1	Y	L	1.9445
2	V	L	0.0000
3	V	L	1.6412
4	M	L	0.0000
5	T	L	-0.3312
6	Q	L	0.0000
7	S	L	-0.1855
8	P	L	0.2168
9	L	L	0.7483
10	S	L	-0.0994
11	L	L	-0.4018
12	P	L	-1.1283
13	V	L	0.0000
14	T	L	-1.9031
15	P	L	-2.0212
16	G	L	-2.1122
17	E	L	-2.9620
18	P	L	-2.5499
19	A	L	0.0000
20	S	L	-0.9452
21	I	L	0.0000
22	S	L	-0.8779
23	C	L	0.0000
24	K	L	-1.8067
25	S	L	0.0000
26	S	L	-0.2151
27	Q	L	-0.4963
27A	S	L	-0.4511
27B	L	L	0.0000
27C	L	L	0.3095
27D	D	L	-1.0451
27E	S	L	-1.3347
28	D	L	-2.3834
29	G	L	-1.7154
30	K	L	-1.5972
31	T	L	-0.4888
32	Y	L	-0.0723
33	L	L	0.0000
34	N	L	0.0000
35	W	L	0.0000
36	L	L	0.0000
37	L	L	0.0000
38	Q	L	-1.1736
39	K	L	-1.8042
40	P	L	-1.3064
41	G	L	-1.5181
42	Q	L	-2.1947
43	S	L	-1.5154
44	P	L	0.0000
45	Q	L	-1.3113
46	R	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	-0.2873
50	L	L	-0.4142
51	V	L	0.0000
52	S	L	-0.8804
53	K	L	-1.3738
54	L	L	-0.8941
55	D	L	-0.9794
56	S	L	-0.6627
57	G	L	-0.8294
58	V	L	0.0000
59	P	L	-1.2902
60	D	L	-2.1795
61	R	L	-2.4609
62	F	L	0.0000
63	S	L	-1.6438
64	G	L	-0.9847
65	S	L	-1.0907
66	G	L	-1.0468
67	S	L	-0.6488
68	G	L	-0.5224
69	T	L	-1.2190
70	D	L	-2.0945
71	F	L	0.0000
72	T	L	-1.1984
73	L	L	0.0000
74	K	L	-2.3045
75	I	L	0.0000
76	S	L	-2.6925
77	R	L	-3.4279
78	V	L	0.0000
79	E	L	-2.3407
80	A	L	-1.5715
81	E	L	-2.1057
82	D	L	0.0000
83	V	L	-0.9892
84	G	L	0.0000
85	V	L	-0.3416
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	W	L	0.0000
90	Q	L	0.0000
91	G	L	-0.0288
92	T	L	-0.1358
93	H	L	0.7330
94	F	L	1.8763
95	P	L	0.9691
96	R	L	0.4465
97	T	L	0.5365
98	F	L	0.0004
99	G	L	0.0000
100	Q	L	-0.9285
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-0.9126
104	V	L	0.0000
105	E	L	-1.6216
106	I	L	-1.5767
107	K	L	-1.9233