| Chain sequence(s) |
A: ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYQQFFAIVQLIGTRKQAENFAYRLELNNGHRRRLTWEATPRSIHEGIATAIMMNSDCLVFDTSIAQLFAENNGNLGINVTISMC C: PKPTCMVPPMP B: SVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC D: KPTCMVPPMP |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 91 | A | A | -0.1895 | |
| 92 | N | A | -0.7459 | |
| 93 | S | A | 0.3592 | |
| 94 | V | A | 2.0896 | |
| 95 | L | A | 2.0792 | |
| 96 | F | A | 1.0030 | |
| 97 | P | A | -0.2565 | |
| 98 | C | A | 0.0000 | |
| 99 | K | A | -1.7711 | |
| 100 | Y | A | -1.3713 | |
| 101 | A | A | -1.0513 | |
| 102 | S | A | -0.8758 | |
| 103 | S | A | -1.0702 | |
| 104 | G | A | -1.0069 | |
| 105 | C | A | 0.0000 | |
| 106 | E | A | -1.4346 | |
| 107 | I | A | 0.0484 | |
| 108 | T | A | 0.2754 | |
| 109 | L | A | 0.0000 | |
| 110 | P | A | 0.0161 | |
| 111 | H | A | -0.8965 | |
| 112 | T | A | -1.6053 | |
| 113 | E | A | -2.6273 | |
| 114 | K | A | -2.3184 | |
| 115 | A | A | -2.3509 | |
| 116 | D | A | -2.9331 | |
| 117 | H | A | -2.3701 | |
| 118 | E | A | -2.3985 | |
| 119 | E | A | -2.4994 | |
| 120 | L | A | -0.8123 | |
| 121 | C | A | 0.0000 | |
| 122 | E | A | -1.8692 | |
| 123 | F | A | -1.2277 | |
| 124 | R | A | -1.5511 | |
| 125 | P | A | -0.8979 | |
| 126 | Y | A | 0.0000 | |
| 127 | S | A | -1.2469 | |
| 128 | C | A | -0.6680 | |
| 129 | P | A | 0.0000 | |
| 130 | C | A | -0.1358 | |
| 131 | P | A | -0.0900 | |
| 133 | A | A | -0.3457 | |
| 134 | S | A | -0.4700 | |
| 135 | C | A | -0.9211 | |
| 136 | K | A | -1.8089 | |
| 137 | W | A | -1.3042 | |
| 138 | Q | A | -1.6346 | |
| 139 | G | A | -1.0368 | |
| 140 | S | A | -0.9291 | |
| 141 | L | A | -0.9460 | |
| 142 | D | A | -1.6556 | |
| 143 | A | A | -0.9475 | |
| 144 | V | A | 0.0000 | |
| 145 | M | A | -0.1886 | |
| 146 | P | A | -0.4490 | |
| 147 | H | A | 0.0000 | |
| 148 | L | A | 0.0000 | |
| 149 | M | A | -0.5641 | |
| 150 | H | A | -1.7331 | |
| 151 | Q | A | -1.9495 | |
| 152 | H | A | -1.5649 | |
| 153 | K | A | -2.1506 | |
| 154 | S | A | -1.1783 | |
| 155 | I | A | -0.4958 | |
| 156 | T | A | -0.1413 | |
| 157 | T | A | -0.3032 | |
| 158 | L | A | -0.8012 | |
| 159 | Q | A | -1.7992 | |
| 160 | G | A | -1.7705 | |
| 161 | E | A | -2.0412 | |
| 162 | D | A | -2.6126 | |
| 163 | I | A | 0.0000 | |
| 164 | V | A | -0.3298 | |
| 165 | F | A | 0.0000 | |
| 166 | L | A | 0.0663 | |
| 167 | A | A | 0.0000 | |
| 168 | T | A | -1.3120 | |
| 169 | D | A | -2.3448 | |
| 170 | I | A | 0.0000 | |
| 171 | N | A | -1.9165 | |
| 172 | L | A | -0.8513 | |
| 173 | P | A | -0.6415 | |
| 174 | G | A | -0.8489 | |
| 175 | A | A | -1.0556 | |
| 176 | V | A | -0.6876 | |
| 177 | D | A | -0.5435 | |
| 178 | W | A | 0.0000 | |
| 179 | V | A | 0.0000 | |
| 180 | M | A | 0.0000 | |
| 181 | M | A | 0.0000 | |
| 182 | Q | A | 0.0000 | |
| 183 | S | A | -0.6524 | |
| 184 | C | A | 0.0000 | |
| 185 | F | A | 0.5323 | |
| 186 | G | A | 0.0296 | |
| 187 | F | A | 0.2605 | |
| 188 | H | A | -0.1844 | |
| 189 | F | A | 0.0000 | |
| 190 | M | A | 0.0000 | |
| 191 | L | A | 0.0000 | |
| 192 | V | A | 0.0000 | |
| 193 | L | A | 0.0000 | |
| 194 | E | A | -0.4614 | |
| 195 | K | A | 0.0000 | |
| 196 | Q | A | -1.6562 | |
| 197 | E | A | -2.4492 | |
| 198 | K | A | -1.7607 | |
| 199 | Y | A | 0.2001 | |
| 203 | Q | A | -1.6977 | |
| 204 | Q | A | 0.0000 | |
| 205 | F | A | 0.0000 | |
| 206 | F | A | 0.0000 | |
| 207 | A | A | 0.0000 | |
| 208 | I | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | Q | A | 0.0000 | |
| 211 | L | A | 0.0000 | |
| 212 | I | A | 0.0000 | |
| 213 | G | A | 0.0000 | |
| 214 | T | A | -1.7592 | |
| 215 | R | A | -2.5900 | |
| 216 | K | A | -2.9727 | |
| 217 | Q | A | -2.2474 | |
| 218 | A | A | 0.0000 | |
| 219 | E | A | -3.0788 | |
| 220 | N | A | -1.9535 | |
| 221 | F | A | 0.0000 | |
| 222 | A | A | -0.6088 | |
| 223 | Y | A | 0.0000 | |
| 224 | R | A | -1.2604 | |
| 225 | L | A | 0.0000 | |
| 226 | E | A | -0.9273 | |
| 227 | L | A | 0.0000 | |
| 228 | N | A | -2.0607 | |
| 229 | G | A | -2.0080 | |
| 230 | H | A | -2.0406 | |
| 231 | R | A | -2.3840 | |
| 232 | R | A | -1.9514 | |
| 233 | R | A | -1.8849 | |
| 234 | L | A | 0.0000 | |
| 235 | T | A | 0.0000 | |
| 236 | W | A | 0.0000 | |
| 237 | E | A | -1.4280 | |
| 238 | A | A | 0.0000 | |
| 239 | T | A | 0.0000 | |
| 240 | P | A | 0.0000 | |
| 241 | R | A | -1.1929 | |
| 242 | S | A | 0.0000 | |
| 243 | I | A | 0.0000 | |
| 244 | H | A | 0.0000 | |
| 245 | E | A | -2.1314 | |
| 246 | G | A | -1.0767 | |
| 247 | I | A | 0.0000 | |
| 248 | A | A | -0.1692 | |
| 249 | T | A | -0.2848 | |
| 250 | A | A | 0.0000 | |
| 251 | I | A | 0.0000 | |
| 252 | M | A | 0.4610 | |
| 253 | N | A | -0.8123 | |
| 254 | S | A | 0.0000 | |
| 255 | D | A | 0.0000 | |
| 256 | C | A | 0.0000 | |
| 257 | L | A | 0.0000 | |
| 258 | V | A | 0.0000 | |
| 259 | F | A | 0.0000 | |
| 260 | D | A | -0.8374 | |
| 261 | T | A | -1.0317 | |
| 262 | S | A | -0.6901 | |
| 263 | I | A | 0.0000 | |
| 264 | A | A | 0.0000 | |
| 265 | Q | A | -1.6751 | |
| 266 | L | A | -0.9286 | |
| 267 | F | A | 0.0000 | |
| 268 | A | A | -2.0483 | |
| 269 | E | A | -2.6577 | |
| 270 | N | A | -2.6352 | |
| 271 | G | A | -2.4240 | |
| 272 | N | A | -2.0102 | |
| 273 | L | A | 0.0000 | |
| 274 | G | A | -0.4997 | |
| 275 | I | A | 0.0000 | |
| 276 | N | A | -0.9238 | |
| 277 | V | A | 0.0000 | |
| 278 | T | A | -1.3333 | |
| 279 | I | A | 0.0000 | |
| 280 | S | A | -0.0289 | |
| 281 | M | A | 0.7896 | |
| 282 | C | A | 0.5397 | |
| 93 | S | B | 0.9022 | |
| 94 | V | B | 2.2215 | |
| 95 | L | B | 2.0145 | |
| 96 | F | B | 1.0593 | |
| 97 | P | B | -0.1812 | |
| 98 | C | B | 0.0000 | |
| 99 | K | B | -1.7678 | |
| 100 | Y | B | -1.1644 | |
| 101 | A | B | -0.9265 | |
| 102 | S | B | -0.8136 | |
| 103 | S | B | -0.7305 | |
| 104 | G | B | -0.8361 | |
| 105 | C | B | 0.0000 | |
| 106 | E | B | -1.3123 | |
| 107 | I | B | 0.7482 | |
| 108 | T | B | 0.6595 | |
| 109 | L | B | 0.4959 | |
| 110 | P | B | 0.1632 | |
| 111 | H | B | -1.0615 | |
| 112 | T | B | -1.3874 | |
| 113 | E | B | -2.2079 | |
| 114 | K | B | -1.8757 | |
| 115 | A | B | -2.0267 | |
| 116 | D | B | -2.7429 | |
| 117 | H | B | -1.5484 | |
| 118 | E | B | 0.0000 | |
| 119 | E | B | -2.1382 | |
| 120 | L | B | -0.3773 | |
| 121 | C | B | 0.0000 | |
| 122 | E | B | -1.3914 | |
| 123 | F | B | -0.3963 | |
| 124 | R | B | -0.8973 | |
| 125 | P | B | -0.6603 | |
| 126 | Y | B | 0.0000 | |
| 127 | S | B | -1.0446 | |
| 128 | C | B | -0.6838 | |
| 129 | P | B | -0.1712 | |
| 130 | C | B | 0.0000 | |
| 131 | P | B | -0.2927 | |
| 132 | G | B | -0.7039 | |
| 133 | A | B | -0.5494 | |
| 134 | S | B | -0.6333 | |
| 135 | C | B | -1.0549 | |
| 136 | K | B | -1.8518 | |
| 137 | W | B | -1.2480 | |
| 138 | Q | B | -1.5837 | |
| 139 | G | B | -0.9940 | |
| 140 | S | B | -0.8631 | |
| 141 | L | B | -0.9288 | |
| 142 | D | B | -1.7002 | |
| 143 | A | B | -0.9957 | |
| 144 | V | B | 0.0000 | |
| 145 | M | B | -0.3379 | |
| 146 | P | B | -0.7593 | |
| 147 | H | B | -1.1367 | |
| 148 | L | B | 0.0000 | |
| 149 | M | B | -0.8094 | |
| 150 | H | B | -1.9070 | |
| 151 | Q | B | -2.0645 | |
| 152 | H | B | -1.6617 | |
| 153 | K | B | -2.2823 | |
| 154 | S | B | -1.1830 | |
| 155 | I | B | -0.5335 | |
| 156 | T | B | -0.1323 | |
| 157 | T | B | -0.3540 | |
| 158 | L | B | -0.6972 | |
| 159 | Q | B | -1.5343 | |
| 160 | G | B | -1.7095 | |
| 161 | E | B | -1.9147 | |
| 162 | D | B | -2.3217 | |
| 163 | I | B | 0.0000 | |
| 164 | V | B | -0.2690 | |
| 165 | F | B | 0.0000 | |
| 166 | L | B | 0.3434 | |
| 167 | A | B | 0.0000 | |
| 168 | T | B | 0.0000 | |
| 169 | D | B | -2.3217 | |
| 170 | I | B | 0.0000 | |
| 171 | N | B | -1.7408 | |
| 172 | L | B | -0.5403 | |
| 173 | P | B | -0.6952 | |
| 174 | G | B | -1.0134 | |
| 175 | A | B | -0.7038 | |
| 176 | V | B | 0.0000 | |
| 177 | D | B | -0.5678 | |
| 178 | W | B | 0.0000 | |
| 179 | V | B | 0.0000 | |
| 180 | M | B | 0.0000 | |
| 181 | M | B | 0.0000 | |
| 182 | Q | B | 0.0000 | |
| 183 | S | B | -0.6679 | |
| 184 | C | B | 0.0000 | |
| 185 | F | B | 0.4565 | |
| 186 | G | B | 0.0297 | |
| 187 | F | B | 0.2041 | |
| 188 | H | B | -0.1780 | |
| 189 | F | B | 0.0000 | |
| 190 | M | B | 0.0000 | |
| 191 | L | B | 0.0000 | |
| 192 | V | B | 0.0000 | |
| 193 | L | B | 0.0000 | |
| 194 | E | B | -0.5644 | |
| 195 | K | B | 0.0000 | |
| 196 | Q | B | -1.7203 | |
| 197 | E | B | -2.6410 | |
| 198 | K | B | -2.6944 | |
| 199 | Y | B | -1.7591 | |
| 200 | D | B | -2.6872 | |
| 201 | G | B | -2.0888 | |
| 202 | H | B | -2.1660 | |
| 203 | Q | B | -2.1613 | |
| 204 | Q | B | -1.3696 | |
| 205 | F | B | 0.0000 | |
| 206 | F | B | 0.0000 | |
| 207 | A | B | 0.0000 | |
| 208 | I | B | 0.0000 | |
| 209 | V | B | 0.0000 | |
| 210 | Q | B | 0.0000 | |
| 211 | L | B | 0.0000 | |
| 212 | I | B | 0.0000 | |
| 213 | G | B | 0.0000 | |
| 214 | T | B | -1.5610 | |
| 215 | R | B | -2.1844 | |
| 216 | K | B | -2.8127 | |
| 217 | Q | B | -2.0952 | |
| 218 | A | B | 0.0000 | |
| 219 | E | B | -2.9127 | |
| 220 | N | B | -1.6965 | |
| 221 | F | B | 0.0000 | |
| 222 | A | B | -0.5276 | |
| 223 | Y | B | 0.0000 | |
| 224 | R | B | -1.1811 | |
| 225 | L | B | 0.0000 | |
| 226 | E | B | -1.0969 | |
| 227 | L | B | 0.0000 | |
| 228 | N | B | -2.3081 | |
| 229 | G | B | -2.3623 | |
| 230 | H | B | -2.1881 | |
| 231 | R | B | -2.7047 | |
| 232 | R | B | -2.1796 | |
| 233 | R | B | -2.2248 | |
| 234 | L | B | 0.0000 | |
| 235 | T | B | 0.0000 | |
| 236 | W | B | 0.0000 | |
| 237 | E | B | -1.2547 | |
| 238 | A | B | 0.0000 | |
| 239 | T | B | -1.2296 | |
| 240 | P | B | 0.0000 | |
| 241 | R | B | -0.9232 | |
| 242 | S | B | 0.0000 | |
| 243 | I | B | 0.0000 | |
| 244 | H | B | -1.0934 | |
| 245 | E | B | -1.3929 | |
| 246 | G | B | -0.6777 | |
| 247 | I | B | -0.1362 | |
| 248 | A | B | 0.0492 | |
| 249 | T | B | -0.0931 | |
| 250 | A | B | 0.0000 | |
| 251 | I | B | 0.0000 | |
| 252 | M | B | 0.4653 | |
| 253 | N | B | -0.8356 | |
| 254 | S | B | 0.0000 | |
| 255 | D | B | 0.0000 | |
| 256 | C | B | 0.0000 | |
| 257 | L | B | 0.0000 | |
| 258 | V | B | 0.0000 | |
| 259 | F | B | 0.0000 | |
| 260 | D | B | -0.8918 | |
| 261 | T | B | -1.0863 | |
| 262 | S | B | -0.7545 | |
| 263 | I | B | 0.0000 | |
| 264 | A | B | 0.0000 | |
| 265 | Q | B | -1.7784 | |
| 266 | L | B | -1.2107 | |
| 267 | F | B | 0.0000 | |
| 268 | A | B | -2.1559 | |
| 269 | E | B | -2.7399 | |
| 270 | N | B | -2.5662 | |
| 271 | G | B | -2.4480 | |
| 272 | N | B | -2.0846 | |
| 273 | L | B | 0.0000 | |
| 274 | G | B | -0.4974 | |
| 275 | I | B | 0.0000 | |
| 276 | N | B | -0.9399 | |
| 277 | V | B | 0.0000 | |
| 278 | T | B | -1.2441 | |
| 279 | I | B | 0.0000 | |
| 280 | S | B | 0.0265 | |
| 281 | M | B | 0.8822 | |
| 282 | C | B | 0.6245 | |
| 462 | P | C | -1.0484 | |
| 463 | K | C | -2.0668 | |
| 464 | P | C | -1.2769 | |
| 465 | T | C | -0.2665 | |
| 466 | C | C | 0.4820 | |
| 467 | M | C | 0.7644 | |
| 468 | V | C | 0.0000 | |
| 469 | P | C | -0.4650 | |
| 470 | P | C | -0.4643 | |
| 471 | M | C | -0.1199 | |
| 472 | P | C | -0.2940 | |
| 463 | K | D | -1.9483 | |
| 464 | P | D | -1.3879 | |
| 465 | T | D | -0.3575 | |
| 466 | C | D | 0.6063 | |
| 467 | M | D | 0.9759 | |
| 468 | V | D | 0.0000 | |
| 469 | P | D | -0.3546 | |
| 470 | P | D | -0.4130 | |
| 471 | M | D | -0.0815 | |
| 472 | P | D | -0.2433 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine