Project name: 427d39c5d5525cd

Chain sequence(s)	A: MERRRITSAARRSYVSSGEMMVGGLAPGRRLGPGTRLSLARMPPPLPTRVDFSLAGALNAGFKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQEHKDVM
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.2248
• Maximal score value: 1.2616
• Average score: -0.7565
• Total score value: -326.8153

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-1.4906
2	E	A	-3.0589
3	R	A	-2.5065
4	R	A	-3.8355
5	R	A	-3.6503
6	I	A	-2.2605
7	T	A	-3.1428
8	S	A	-2.7850
9	A	A	-2.0682
10	A	A	-2.1747
11	R	A	-2.9366
12	R	A	-2.6558
13	S	A	-0.7082
14	Y	A	0.4161
15	V	A	0.4431
16	S	A	0.0391
17	S	A	-0.1257
18	G	A	-0.8207
19	E	A	-1.8117
20	M	A	-0.5614
21	M	A	0.0003
22	V	A	0.0000
23	G	A	0.0000
24	G	A	0.0851
25	L	A	0.4143
26	A	A	0.0000
27	P	A	0.0000
28	G	A	0.0000
29	R	A	-0.2143
30	R	A	0.0000
31	L	A	0.0000
32	G	A	0.0000
33	P	A	0.0000
34	G	A	0.0000
35	T	A	0.0000
36	R	A	0.0000
37	L	A	0.0000
38	S	A	0.0000
39	L	A	0.0000
40	A	A	0.0000
41	R	A	0.0000
42	M	A	0.0000
43	P	A	0.0000
44	P	A	0.0000
45	P	A	-0.7186
46	L	A	0.3127
47	P	A	0.0000
48	T	A	-0.7849
49	R	A	-2.3662
50	V	A	-1.4645
51	D	A	-1.3693
52	F	A	-0.3429
53	S	A	0.1020
54	L	A	1.1427
55	A	A	0.3321
56	G	A	-0.3124
57	A	A	-0.0159
58	L	A	0.0000
59	N	A	-1.6409
60	A	A	-1.6654
61	G	A	0.0000
62	F	A	0.0000
63	K	A	-3.4048
64	E	A	-3.3335
65	T	A	0.0000
66	R	A	-2.9699
67	A	A	-2.0881
68	S	A	0.0000
69	E	A	0.0000
70	R	A	-1.3654
71	A	A	-0.4862
72	E	A	0.0000
73	M	A	0.0136
74	M	A	0.0190
75	E	A	-0.8550
76	L	A	0.0000
77	N	A	0.0000
78	D	A	-1.2744
79	R	A	-1.6937
80	F	A	0.0000
81	A	A	-0.8522
82	S	A	-1.2106
83	Y	A	0.0000
84	I	A	0.0000
85	E	A	-0.7705
86	K	A	-1.7023
87	V	A	0.0000
88	R	A	-0.6026
89	F	A	-0.3363
90	L	A	0.0000
91	E	A	0.0000
92	Q	A	-1.6413
93	Q	A	-1.3272
94	N	A	0.0000
95	K	A	-1.0702
96	A	A	-0.8942
97	L	A	-0.9144
98	A	A	-0.9823
99	A	A	-1.0232
100	E	A	-1.8844
101	L	A	0.0000
102	N	A	-1.5705
103	Q	A	-1.7726
104	L	A	-1.7054
105	R	A	-1.6290
106	A	A	-1.0344
107	K	A	-1.0114
108	E	A	0.0000
109	P	A	-0.5211
110	T	A	-0.2919
111	K	A	-0.6222
112	L	A	0.7352
113	A	A	-0.1921
114	D	A	-1.3068
115	V	A	-0.3187
116	Y	A	-0.8174
117	Q	A	-1.4677
118	A	A	-1.4550
119	E	A	-1.8607
120	L	A	0.0000
121	R	A	-2.5114
122	E	A	-2.4083
123	L	A	0.0000
124	R	A	-1.9252
125	L	A	-0.8925
126	R	A	-2.0671
127	L	A	0.0000
128	D	A	-1.9085
129	Q	A	-1.8949
130	L	A	0.0000
131	T	A	0.0000
132	A	A	-1.5380
133	N	A	-1.2978
134	S	A	0.0000
135	A	A	-0.7782
136	R	A	-1.9862
137	L	A	0.0000
138	E	A	-0.9350
139	V	A	-0.4006
140	E	A	-2.0727
141	R	A	0.0000
142	D	A	-2.5274
143	N	A	-2.4615
144	L	A	0.0000
145	A	A	0.0000
146	Q	A	-2.2986
147	D	A	-1.8556
148	L	A	0.0000
149	A	A	-1.2127
150	T	A	-0.9187
151	V	A	-0.9342
152	R	A	-1.4014
153	Q	A	-1.5464
154	K	A	-1.7800
155	L	A	0.0000
156	Q	A	-1.7682
157	D	A	-2.0081
158	E	A	-1.6412
159	T	A	0.0000
160	N	A	-1.4071
161	L	A	0.0769
162	R	A	0.0000
163	L	A	-0.9491
164	E	A	-1.8196
165	A	A	-0.9937
166	E	A	0.0000
167	N	A	-1.3070
168	N	A	-1.0112
169	L	A	0.0623
170	A	A	0.0000
171	A	A	-0.4171
172	Y	A	0.9082
173	R	A	0.0000
174	Q	A	-1.5951
175	E	A	-2.2218
176	A	A	-2.2277
177	D	A	-2.5227
178	E	A	-2.0902
179	A	A	0.0000
180	T	A	-0.5834
181	L	A	0.6013
182	A	A	-0.4127
183	R	A	0.0000
184	L	A	0.0860
185	D	A	-1.0026
186	L	A	0.0000
187	E	A	-1.4876
188	R	A	-2.7122
189	K	A	-1.6783
190	I	A	-1.3953
191	E	A	-2.7752
192	S	A	-1.5770
193	L	A	0.0000
194	E	A	0.0000
195	E	A	-1.0557
196	E	A	-0.9900
197	I	A	0.0000
198	R	A	-0.4098
199	F	A	-0.4080
200	L	A	0.0000
201	R	A	0.0000
202	K	A	-0.3537
203	I	A	-0.5047
204	H	A	-1.5578
205	E	A	0.0000
206	E	A	-2.7470
207	E	A	-2.4149
208	V	A	0.0000
209	R	A	-0.8632
210	E	A	0.0000
211	L	A	0.0000
212	Q	A	0.0000
213	E	A	0.0000
214	Q	A	0.0000
215	L	A	0.8468
216	A	A	0.1488
217	R	A	-0.3621
218	Q	A	-1.0141
219	Q	A	0.0000
220	V	A	0.6794
221	H	A	-0.1810
222	V	A	-1.0522
223	E	A	-1.6173
224	L	A	-0.8277
225	D	A	-1.1793
226	V	A	0.0000
227	A	A	-0.6032
228	K	A	0.0000
229	P	A	0.0000
230	D	A	0.0000
231	L	A	0.4024
232	T	A	0.2286
233	A	A	0.0600
234	A	A	0.0000
235	L	A	-0.7066
236	K	A	-1.2519
237	E	A	-0.9454
238	I	A	0.0000
239	R	A	-0.9302
240	T	A	-0.5078
241	Q	A	-0.1032
242	Y	A	0.7962
243	E	A	-0.1880
244	A	A	0.1621
245	M	A	0.3525
246	A	A	0.0000
247	S	A	-0.4479
248	S	A	-0.6798
249	N	A	-0.8700
250	M	A	0.0000
251	H	A	-1.5794
252	E	A	-1.7705
253	A	A	0.0000
254	E	A	-2.1781
255	E	A	-2.5626
256	W	A	-1.0015
257	Y	A	-0.9099
258	R	A	-1.8436
259	S	A	-0.7769
260	K	A	0.0000
261	F	A	0.8721
262	A	A	0.1621
263	D	A	-0.2450
264	L	A	0.0000
265	T	A	-0.0823
266	D	A	-1.2171
267	A	A	0.0000
268	A	A	0.0000
269	A	A	-0.7180
270	R	A	-1.3590
271	N	A	0.0000
272	A	A	-0.7470
273	E	A	-1.3478
274	L	A	0.3897
275	L	A	-0.1158
276	R	A	-2.1150
277	Q	A	-1.9851
278	A	A	-0.9481
279	K	A	0.0000
280	H	A	-1.5492
281	E	A	-0.8040
282	A	A	0.0000
283	N	A	0.0000
284	D	A	-0.4666
285	Y	A	0.0000
286	R	A	0.0000
287	R	A	0.0000
288	Q	A	0.0000
289	L	A	0.0000
290	Q	A	0.0000
291	S	A	0.0000
292	L	A	0.0000
293	T	A	0.0000
294	C	A	0.0000
295	D	A	-0.6203
296	L	A	0.0000
297	E	A	-1.1911
298	S	A	-0.9055
299	L	A	0.0000
300	R	A	-1.1511
301	G	A	-0.5874
302	T	A	0.0000
303	N	A	0.0000
304	E	A	-1.1227
305	S	A	-1.0120
306	L	A	0.0000
307	E	A	0.0000
308	R	A	-2.4377
309	Q	A	0.0000
310	M	A	0.0000
311	R	A	-2.8143
312	E	A	-2.4283
313	Q	A	0.0000
314	E	A	-2.1340
315	E	A	-2.9647
316	R	A	-2.3228
317	H	A	0.0000
318	V	A	-0.6956
319	R	A	-2.0652
320	E	A	0.0000
321	A	A	0.0000
322	A	A	-0.9117
323	S	A	-1.2912
324	Y	A	0.0000
325	Q	A	-1.7742
326	E	A	-2.6289
327	A	A	-2.3039
328	L	A	-2.0346
329	A	A	-2.9642
330	R	A	-3.9507
331	L	A	0.0000
332	E	A	-4.2248
333	E	A	-4.2140
334	E	A	-3.6346
335	G	A	-2.5970
336	Q	A	-1.6142
337	S	A	-0.5767
338	L	A	0.4792
339	K	A	0.0000
340	D	A	-1.4663
341	E	A	-1.5176
342	M	A	0.0000
343	A	A	-1.9678
344	R	A	-2.7819
345	H	A	-2.7235
346	L	A	0.0000
347	Q	A	-2.2299
348	E	A	-2.7561
349	Y	A	0.0000
350	Q	A	0.0000
351	D	A	-1.3917
352	L	A	0.0000
353	L	A	0.0000
354	N	A	-0.8989
355	V	A	0.1557
356	K	A	0.0000
357	L	A	-0.0336
358	A	A	0.2372
359	L	A	0.0000
360	D	A	0.0000
361	I	A	0.4280
362	E	A	-0.4048
363	I	A	0.0000
364	A	A	0.0000
365	T	A	0.0000
366	Y	A	0.0000
367	R	A	0.0000
368	K	A	0.0000
369	L	A	0.0000
370	L	A	0.0000
371	E	A	0.0000
372	G	A	0.0000
373	E	A	0.0000
374	E	A	0.0000
375	N	A	0.0000
376	R	A	0.0494
377	I	A	0.0000
378	T	A	0.0000
379	I	A	0.0787
380	P	A	-0.0207
381	V	A	0.7044
382	Q	A	0.1489
383	T	A	0.7046
384	F	A	1.2616
385	S	A	0.1155
386	N	A	0.0000
387	L	A	0.5369
388	Q	A	-0.4525
389	I	A	0.0000
390	R	A	-1.9709
391	E	A	-1.1052
392	T	A	-0.6621
393	S	A	-1.3354
394	L	A	-1.0717
395	D	A	0.0000
396	T	A	-1.0717
397	K	A	-1.6624
398	S	A	-1.0923
399	V	A	-0.9117
400	S	A	0.0000
401	E	A	-1.5520
402	G	A	0.0000
403	H	A	-0.9846
404	L	A	-0.1442
405	K	A	-1.8367
406	R	A	-1.2726
407	N	A	-1.5058
408	I	A	-0.6592
409	V	A	-0.8155
410	V	A	0.0000
411	K	A	0.0000
412	T	A	-1.0962
413	V	A	-0.9701
414	E	A	-1.1841
415	M	A	0.0000
416	R	A	0.0000
417	D	A	0.0000
418	G	A	0.0000
419	E	A	0.0000
420	V	A	-1.1427
421	I	A	0.0000
422	K	A	-1.8778
423	E	A	-2.7945
424	S	A	-1.9432
425	K	A	-2.5166
426	Q	A	-2.3743
427	E	A	0.0000
428	H	A	0.0000
429	K	A	-1.9726
430	D	A	-0.8311
431	V	A	0.0000
432	M	A	-0.4302