| Chain sequence(s) |
A: KVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFTLN P: STTPAPTTK |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
| Mutated residues | LA421P |
| Energy difference between WT (input) and mutated protein (by FoldX) | 5.40369 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 75 | K | A | -2.7471 | |
| 76 | V | A | -2.6931 | |
| 77 | R | A | -3.0452 | |
| 78 | W | A | -2.3399 | |
| 79 | P | A | -1.9592 | |
| 80 | D | A | -2.7204 | |
| 81 | F | A | 0.0000 | |
| 82 | N | A | -2.3902 | |
| 83 | Q | A | -2.2688 | |
| 84 | E | A | -2.6850 | |
| 85 | A | A | -1.5008 | |
| 86 | Y | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | G | A | -1.0530 | |
| 89 | G | A | -0.6766 | |
| 90 | T | A | -0.2017 | |
| 91 | M | A | 0.0990 | |
| 92 | V | A | -0.9470 | |
| 93 | R | A | -2.1039 | |
| 94 | S | A | -1.6330 | |
| 95 | G | A | -1.7128 | |
| 96 | Q | A | -2.2231 | |
| 97 | D | A | -2.5451 | |
| 98 | P | A | -1.4298 | |
| 99 | Y | A | -0.9526 | |
| 100 | A | A | -1.3285 | |
| 101 | R | A | -1.8853 | |
| 102 | N | A | 0.0000 | |
| 103 | K | A | -1.6584 | |
| 104 | F | A | 0.0000 | |
| 105 | N | A | -1.0683 | |
| 106 | Q | A | 0.0000 | |
| 107 | V | A | -0.3109 | |
| 108 | E | A | -1.3134 | |
| 109 | S | A | 0.0000 | |
| 110 | D | A | -1.1623 | |
| 111 | K | A | -2.0171 | |
| 112 | L | A | -1.5339 | |
| 113 | R | A | -2.4823 | |
| 114 | M | A | -1.3534 | |
| 115 | D | A | -1.0682 | |
| 116 | R | A | -0.7997 | |
| 117 | A | A | -0.4334 | |
| 118 | I | A | -0.5716 | |
| 119 | P | A | -1.1621 | |
| 120 | D | A | -2.4998 | |
| 121 | T | A | -1.7053 | |
| 122 | R | A | -2.1331 | |
| 123 | H | A | -2.2178 | |
| 124 | D | A | -3.3455 | |
| 125 | Q | A | -2.9377 | |
| 126 | C | A | 0.0000 | |
| 127 | Q | A | -3.5332 | |
| 128 | R | A | -3.6152 | |
| 129 | K | A | -2.9061 | |
| 130 | Q | A | -2.0447 | |
| 131 | W | A | -0.6748 | |
| 132 | R | A | -0.7713 | |
| 133 | V | A | 0.4454 | |
| 134 | D | A | -1.1379 | |
| 135 | L | A | 0.0000 | |
| 136 | P | A | -0.8330 | |
| 137 | A | A | -1.2147 | |
| 138 | T | A | 0.0000 | |
| 139 | S | A | 0.0000 | |
| 140 | V | A | 0.0000 | |
| 141 | V | A | 0.0000 | |
| 142 | I | A | 0.0000 | |
| 143 | T | A | -0.2711 | |
| 144 | F | A | 0.0000 | |
| 145 | H | A | -0.4937 | |
| 146 | N | A | -1.0923 | |
| 147 | E | A | 0.0000 | |
| 148 | A | A | 0.0000 | |
| 149 | R | A | 0.0000 | |
| 150 | S | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | L | A | 0.0000 | |
| 153 | L | A | 0.0000 | |
| 154 | R | A | 0.0000 | |
| 155 | T | A | 0.0000 | |
| 156 | V | A | 0.0000 | |
| 157 | V | A | 0.0000 | |
| 158 | S | A | 0.0000 | |
| 159 | V | A | 0.0000 | |
| 160 | L | A | -0.9537 | |
| 161 | K | A | -1.5993 | |
| 162 | K | A | -1.4564 | |
| 163 | S | A | 0.0000 | |
| 164 | P | A | -0.8007 | |
| 165 | P | A | -1.2541 | |
| 166 | H | A | -1.4173 | |
| 167 | L | A | 0.0000 | |
| 168 | I | A | 0.0000 | |
| 169 | K | A | -2.0541 | |
| 170 | E | A | 0.0000 | |
| 171 | I | A | 0.0000 | |
| 172 | I | A | 0.0000 | |
| 173 | L | A | 0.0000 | |
| 174 | V | A | 0.0000 | |
| 175 | D | A | 0.0000 | |
| 176 | D | A | 0.0000 | |
| 177 | Y | A | -0.9741 | |
| 178 | S | A | 0.0000 | |
| 179 | N | A | -1.9021 | |
| 180 | D | A | -2.1354 | |
| 181 | P | A | -1.5833 | |
| 182 | E | A | -1.8964 | |
| 183 | D | A | -1.3626 | |
| 184 | G | A | 0.0000 | |
| 185 | A | A | -0.7804 | |
| 186 | L | A | -0.3952 | |
| 187 | L | A | 0.0000 | |
| 188 | G | A | -1.2535 | |
| 189 | K | A | -2.4918 | |
| 190 | I | A | 0.0000 | |
| 191 | E | A | -2.0401 | |
| 192 | K | A | -1.8572 | |
| 193 | V | A | 0.0000 | |
| 194 | R | A | -0.7602 | |
| 195 | V | A | -0.0584 | |
| 196 | L | A | -0.1741 | |
| 197 | R | A | -0.9245 | |
| 198 | N | A | 0.0000 | |
| 199 | D | A | -2.6833 | |
| 200 | R | A | -2.7405 | |
| 201 | R | A | -1.5545 | |
| 202 | E | A | -1.3524 | |
| 203 | G | A | 0.0000 | |
| 204 | L | A | -0.2414 | |
| 205 | M | A | 0.0000 | |
| 206 | R | A | -0.5641 | |
| 207 | S | A | 0.0000 | |
| 208 | R | A | -0.7931 | |
| 209 | V | A | -1.0623 | |
| 210 | R | A | -1.4648 | |
| 211 | G | A | 0.0000 | |
| 212 | A | A | 0.0000 | |
| 213 | D | A | -2.4053 | |
| 214 | A | A | -1.3183 | |
| 215 | A | A | 0.0000 | |
| 216 | Q | A | -1.9374 | |
| 217 | A | A | 0.0000 | |
| 218 | K | A | -0.9871 | |
| 219 | V | A | 0.0000 | |
| 220 | L | A | 0.0000 | |
| 221 | T | A | 0.0000 | |
| 222 | F | A | 0.0000 | |
| 223 | L | A | 0.0000 | |
| 224 | D | A | -0.5448 | |
| 225 | S | A | 0.0000 | |
| 226 | H | A | 0.0000 | |
| 227 | C | A | 0.0000 | |
| 228 | E | A | 0.0000 | |
| 229 | C | A | 0.0000 | |
| 230 | N | A | 0.0000 | |
| 231 | E | A | -2.4813 | |
| 232 | H | A | -1.6390 | |
| 233 | W | A | 0.0000 | |
| 234 | L | A | 0.0000 | |
| 235 | E | A | 0.0000 | |
| 236 | P | A | -0.5818 | |
| 237 | L | A | 0.0000 | |
| 238 | L | A | 0.0000 | |
| 239 | E | A | -1.1706 | |
| 240 | R | A | -1.4056 | |
| 241 | V | A | 0.0000 | |
| 242 | A | A | -1.9444 | |
| 243 | E | A | -2.7066 | |
| 244 | D | A | -2.4298 | |
| 245 | R | A | -2.0940 | |
| 246 | T | A | -1.2087 | |
| 247 | R | A | -1.4071 | |
| 248 | V | A | 0.0000 | |
| 249 | V | A | 0.0000 | |
| 250 | S | A | 0.0000 | |
| 251 | P | A | 0.0000 | |
| 252 | I | A | 0.0000 | |
| 253 | I | A | 0.0000 | |
| 254 | D | A | 0.0000 | |
| 255 | V | A | -0.0185 | |
| 256 | I | A | 0.0000 | |
| 257 | N | A | -1.6643 | |
| 258 | M | A | -1.6058 | |
| 259 | D | A | -2.0246 | |
| 260 | N | A | -2.4774 | |
| 261 | F | A | 0.0000 | |
| 262 | Q | A | -1.7839 | |
| 263 | Y | A | 0.0000 | |
| 264 | V | A | -0.3301 | |
| 265 | G | A | 0.0000 | |
| 266 | A | A | 0.0000 | |
| 267 | S | A | -0.7845 | |
| 268 | A | A | -0.7008 | |
| 269 | D | A | -0.7855 | |
| 270 | L | A | 0.0000 | |
| 271 | K | A | -0.5650 | |
| 272 | G | A | 0.0000 | |
| 273 | G | A | 0.0000 | |
| 274 | F | A | 0.0000 | |
| 275 | D | A | -1.3929 | |
| 276 | W | A | 0.0000 | |
| 277 | N | A | -0.4850 | |
| 278 | L | A | 0.0000 | |
| 279 | V | A | -0.0689 | |
| 280 | F | A | 0.0000 | |
| 281 | K | A | -1.0213 | |
| 282 | W | A | -0.4426 | |
| 283 | D | A | -0.4387 | |
| 284 | Y | A | 0.4758 | |
| 285 | M | A | 0.0000 | |
| 286 | T | A | -1.2572 | |
| 287 | P | A | -1.8176 | |
| 288 | E | A | -3.0534 | |
| 289 | Q | A | -2.3566 | |
| 290 | R | A | -2.8166 | |
| 291 | R | A | -3.6335 | |
| 292 | S | A | -2.6254 | |
| 293 | R | A | -2.4871 | |
| 294 | Q | A | -2.5671 | |
| 295 | G | A | -1.7264 | |
| 296 | N | A | -1.4105 | |
| 297 | P | A | -1.7170 | |
| 298 | V | A | 0.0000 | |
| 299 | A | A | -0.6889 | |
| 300 | P | A | -0.5240 | |
| 301 | I | A | 0.0000 | |
| 302 | K | A | -1.3310 | |
| 303 | T | A | 0.0000 | |
| 304 | P | A | 0.0000 | |
| 305 | M | A | 0.0000 | |
| 306 | I | A | 0.0000 | |
| 307 | A | A | 0.0000 | |
| 308 | G | A | 0.0000 | |
| 309 | G | A | -0.2730 | |
| 310 | L | A | 0.0000 | |
| 311 | F | A | 0.0000 | |
| 312 | V | A | 0.0000 | |
| 313 | M | A | 0.0000 | |
| 314 | D | A | 0.0000 | |
| 315 | K | A | -0.6291 | |
| 316 | F | A | 0.6306 | |
| 317 | Y | A | 0.0000 | |
| 318 | F | A | 0.0000 | |
| 319 | E | A | -1.4547 | |
| 320 | E | A | -1.7970 | |
| 321 | L | A | 0.0000 | |
| 322 | G | A | -0.9363 | |
| 323 | K | A | -1.1804 | |
| 324 | Y | A | 0.0000 | |
| 325 | D | A | 0.0000 | |
| 326 | M | A | 0.4781 | |
| 327 | M | A | 0.5450 | |
| 328 | M | A | 0.0000 | |
| 329 | D | A | -0.2235 | |
| 330 | V | A | 0.0000 | |
| 331 | W | A | 0.1893 | |
| 332 | G | A | 0.0000 | |
| 333 | G | A | 0.0000 | |
| 334 | E | A | 0.0000 | |
| 335 | N | A | -0.0756 | |
| 336 | L | A | 0.0000 | |
| 337 | E | A | 0.0000 | |
| 338 | I | A | 0.0000 | |
| 339 | S | A | 0.0000 | |
| 340 | F | A | 0.0000 | |
| 341 | R | A | 0.0000 | |
| 342 | V | A | 0.0000 | |
| 343 | W | A | 0.0000 | |
| 344 | Q | A | 0.0000 | |
| 345 | C | A | -0.8092 | |
| 346 | G | A | -0.6257 | |
| 347 | G | A | 0.0000 | |
| 348 | S | A | -0.6680 | |
| 349 | L | A | 0.0000 | |
| 350 | E | A | 0.0000 | |
| 351 | I | A | 0.0000 | |
| 352 | I | A | 0.0000 | |
| 353 | P | A | 0.0000 | |
| 354 | C | A | 0.0000 | |
| 355 | S | A | 0.0000 | |
| 356 | R | A | 0.0000 | |
| 357 | V | A | 0.0000 | |
| 358 | G | A | 0.0000 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 0.0000 | |
| 361 | F | A | 0.0000 | |
| 362 | R | A | -1.7176 | |
| 363 | K | A | -2.4473 | |
| 364 | Q | A | -2.0822 | |
| 365 | H | A | -1.2442 | |
| 366 | P | A | -1.0344 | |
| 367 | Y | A | -0.3753 | |
| 368 | T | A | -0.1073 | |
| 369 | F | A | -0.2299 | |
| 370 | P | A | -0.5373 | |
| 371 | G | A | -0.7566 | |
| 372 | G | A | -0.6243 | |
| 373 | S | A | -0.5097 | |
| 374 | G | A | -0.7028 | |
| 375 | T | A | -0.7780 | |
| 376 | V | A | 0.0000 | |
| 377 | F | A | -0.1177 | |
| 378 | A | A | 0.0000 | |
| 379 | R | A | -1.1282 | |
| 380 | N | A | 0.0000 | |
| 381 | T | A | 0.0000 | |
| 382 | R | A | -0.7800 | |
| 383 | R | A | 0.0000 | |
| 384 | A | A | 0.0000 | |
| 385 | A | A | 0.0000 | |
| 386 | E | A | -0.7903 | |
| 387 | V | A | 0.0000 | |
| 388 | W | A | 0.0000 | |
| 389 | M | A | 0.0000 | |
| 390 | D | A | -1.8931 | |
| 391 | E | A | -2.5669 | |
| 392 | Y | A | -1.3936 | |
| 393 | K | A | -1.4478 | |
| 394 | N | A | -1.7635 | |
| 395 | F | A | -0.9759 | |
| 396 | Y | A | 0.0000 | |
| 397 | Y | A | -0.7837 | |
| 398 | A | A | -0.6705 | |
| 399 | A | A | -0.1774 | |
| 400 | V | A | -0.1507 | |
| 401 | P | A | -0.6959 | |
| 402 | S | A | -1.0084 | |
| 403 | A | A | 0.0000 | |
| 404 | R | A | -2.3029 | |
| 405 | N | A | -2.1571 | |
| 406 | V | A | 0.0000 | |
| 407 | P | A | -1.1437 | |
| 408 | Y | A | -0.9277 | |
| 409 | G | A | -1.1843 | |
| 410 | N | A | -1.6937 | |
| 411 | I | A | 0.0000 | |
| 412 | Q | A | -2.0633 | |
| 413 | S | A | -1.6514 | |
| 414 | R | A | 0.0000 | |
| 415 | L | A | -1.7572 | |
| 416 | E | A | -3.0762 | |
| 417 | L | A | -2.2881 | |
| 418 | R | A | -2.2716 | |
| 419 | K | A | -3.3071 | |
| 420 | K | A | -3.0418 | |
| 421 | P | A | -2.1937 | mutated: LA421P |
| 422 | S | A | -1.8515 | |
| 423 | C | A | -1.2810 | |
| 424 | K | A | -1.4710 | |
| 425 | P | A | -1.3293 | |
| 426 | F | A | 0.0000 | |
| 427 | K | A | -2.6907 | |
| 428 | W | A | -1.8073 | |
| 429 | Y | A | 0.0000 | |
| 430 | L | A | 0.0000 | |
| 431 | E | A | -3.0028 | |
| 432 | N | A | -2.4462 | |
| 433 | V | A | -1.4976 | |
| 434 | Y | A | 0.0000 | |
| 435 | P | A | -2.1953 | |
| 436 | E | A | -2.1693 | |
| 437 | L | A | -1.6879 | |
| 438 | R | A | -2.1499 | |
| 439 | V | A | -0.8374 | |
| 440 | P | A | -1.3870 | |
| 441 | D | A | -2.8479 | |
| 442 | H | A | -2.6859 | |
| 443 | Q | A | -2.7877 | |
| 444 | D | A | -2.3430 | |
| 445 | I | A | -0.3960 | |
| 446 | A | A | 0.4047 | |
| 447 | F | A | 0.7380 | |
| 448 | G | A | 0.0000 | |
| 449 | A | A | -0.6588 | |
| 450 | L | A | 0.0000 | |
| 451 | Q | A | -1.1087 | |
| 452 | Q | A | 0.0000 | |
| 453 | G | A | -1.0171 | |
| 454 | T | A | -0.8409 | |
| 455 | N | A | -0.8825 | |
| 456 | C | A | 0.0000 | |
| 457 | L | A | 0.0000 | |
| 458 | D | A | 0.0000 | |
| 459 | T | A | 0.0000 | |
| 460 | L | A | 0.7710 | |
| 461 | G | A | -0.0975 | |
| 462 | H | A | 0.1545 | |
| 463 | F | A | 1.0314 | |
| 464 | A | A | -0.2764 | |
| 465 | D | A | -1.3978 | |
| 466 | G | A | -0.3806 | |
| 467 | V | A | 0.0191 | |
| 468 | V | A | 0.0000 | |
| 469 | G | A | 0.0000 | |
| 470 | V | A | 0.4897 | |
| 471 | Y | A | 0.4969 | |
| 472 | E | A | -1.4813 | |
| 473 | C | A | -1.2452 | |
| 474 | H | A | -1.5943 | |
| 475 | N | A | -2.1397 | |
| 476 | A | A | -1.2956 | |
| 477 | G | A | -1.3426 | |
| 478 | G | A | -1.2187 | |
| 479 | N | A | -0.8583 | |
| 480 | Q | A | 0.0000 | |
| 481 | E | A | -0.8932 | |
| 482 | W | A | 0.0000 | |
| 483 | A | A | 0.0000 | |
| 484 | L | A | -0.4936 | |
| 485 | T | A | -1.4270 | |
| 486 | K | A | -2.6563 | |
| 487 | E | A | -3.7323 | |
| 488 | K | A | -2.6310 | |
| 489 | S | A | -1.8951 | |
| 490 | V | A | 0.0000 | |
| 491 | K | A | -0.4982 | |
| 492 | H | A | 0.0000 | |
| 493 | M | A | -0.1033 | |
| 494 | D | A | -1.2563 | |
| 495 | L | A | 0.0000 | |
| 496 | C | A | 0.0000 | |
| 497 | L | A | 0.0000 | |
| 498 | T | A | 0.0000 | |
| 499 | V | A | 0.0000 | |
| 500 | V | A | -0.6513 | |
| 501 | D | A | -1.8680 | |
| 502 | R | A | -2.2755 | |
| 503 | A | A | -1.1043 | |
| 504 | P | A | -0.8289 | |
| 505 | G | A | -0.6881 | |
| 506 | S | A | -0.7243 | |
| 507 | L | A | -0.1243 | |
| 508 | I | A | 0.0000 | |
| 509 | K | A | -0.5313 | |
| 510 | L | A | 0.0000 | |
| 511 | Q | A | -0.6999 | |
| 512 | G | A | -0.9286 | |
| 513 | C | A | -1.4577 | |
| 514 | R | A | -2.8551 | |
| 515 | E | A | -3.5459 | |
| 516 | N | A | -2.9428 | |
| 517 | D | A | -1.9778 | |
| 518 | S | A | -1.5046 | |
| 519 | R | A | -1.3526 | |
| 520 | Q | A | 0.0000 | |
| 521 | K | A | -1.5295 | |
| 522 | W | A | 0.0000 | |
| 523 | E | A | -1.0508 | |
| 524 | Q | A | -2.0090 | |
| 525 | I | A | -1.9242 | |
| 526 | E | A | -2.6905 | |
| 527 | G | A | -2.2888 | |
| 528 | N | A | -2.8002 | |
| 529 | S | A | -2.3486 | |
| 530 | K | A | -1.8272 | |
| 531 | L | A | 0.0000 | |
| 532 | R | A | -1.1016 | |
| 533 | H | A | 0.0000 | |
| 534 | V | A | -0.5609 | |
| 535 | G | A | -0.7411 | |
| 536 | S | A | -0.9072 | |
| 537 | N | A | -1.2894 | |
| 538 | L | A | 0.0000 | |
| 539 | C | A | 0.0000 | |
| 540 | L | A | 0.0000 | |
| 541 | D | A | 0.0000 | |
| 542 | S | A | -0.7959 | |
| 543 | R | A | -1.6191 | |
| 544 | T | A | -1.3680 | |
| 545 | A | A | -1.0922 | |
| 546 | K | A | -2.1035 | |
| 547 | S | A | -1.3532 | |
| 548 | G | A | -0.8919 | |
| 549 | G | A | 0.0000 | |
| 550 | L | A | 0.0000 | |
| 551 | S | A | 0.0000 | |
| 552 | V | A | 0.0000 | |
| 553 | E | A | -0.4202 | |
| 554 | V | A | 0.3705 | |
| 555 | C | A | 0.0453 | |
| 556 | G | A | 0.0642 | |
| 557 | P | A | 0.1080 | |
| 558 | A | A | 0.2965 | |
| 559 | L | A | 0.9566 | |
| 560 | S | A | -0.0813 | |
| 561 | Q | A | 0.0000 | |
| 562 | Q | A | -1.2120 | |
| 563 | W | A | 0.0000 | |
| 564 | K | A | -2.1461 | |
| 565 | F | A | -0.4417 | |
| 566 | T | A | 0.1838 | |
| 567 | L | A | 0.9891 | |
| 568 | N | A | -0.6005 | |
| 5 | S | P | -0.8574 | |
| 6 | T | P | -0.9493 | |
| 7 | T | P | -0.6390 | |
| 8 | P | P | -0.6268 | |
| 9 | A | P | -0.4309 | |
| 10 | P | P | 0.0000 | |
| 11 | T | P | -0.3725 | |
| 12 | T | P | -0.7837 | |
| 13 | K | P | -1.7160 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine