Project name: 6bhz:H
Status: done
submitted: 2019-03-20 16:20:01, status changed: 2019-03-20 17:34:04
Settings
|
Chain sequence(s)
|
H: EVQLVEESGGGLVVQPGGSLRLSSCCAASGFNNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCCSSRWGGDGFYAMDYWGQGTLVTVSSASSTKGPSVFPLAPTAALGCCLVKDYFPEPVTVSWNSGALTSGVHTFPAVVLQSSGLYSSLSSVVTVPSSSLGTQTYICCNVNHKPSNTKVDKKVEP
|
| Distance of aggregation |
10 Å |
| Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-2.9452
-
Maximal score value
-
2.4629
-
Average score
-
-0.5662
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Total score value
-
-120.0383
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
| residue index |
residue name |
chain |
Aggrescan3D score |
|
| 1 |
E |
H |
-2.1664 |
|
| 2 |
V |
H |
-1.5106 |
|
| 3 |
Q |
H |
-1.2498 |
|
| 4 |
L |
H |
0.0000 |
|
| 5 |
V |
H |
1.0862 |
|
| 6 |
E |
H |
0.0000 |
|
| 7 |
S |
H |
-0.4074 |
|
| 8 |
G |
H |
-0.9214 |
|
| 9 |
G |
H |
-0.4889 |
|
| 10 |
G |
H |
-0.0016 |
|
| 11 |
L |
H |
0.0877 |
|
| 12 |
V |
H |
-0.5193 |
|
| 13 |
Q |
H |
-1.4585 |
|
| 14 |
P |
H |
-1.6016 |
|
| 15 |
G |
H |
-1.4591 |
|
| 16 |
G |
H |
-1.2486 |
|
| 17 |
S |
H |
-1.5135 |
|
| 18 |
L |
H |
-1.4093 |
|
| 19 |
R |
H |
-2.3524 |
|
| 20 |
L |
H |
0.0000 |
|
| 21 |
S |
H |
-0.3788 |
|
| 22 |
C |
H |
0.0000 |
|
| 23 |
A |
H |
0.0097 |
|
| 24 |
A |
H |
0.0000 |
|
| 25 |
S |
H |
-0.9633 |
|
| 26 |
G |
H |
-1.4090 |
|
| 27 |
F |
H |
-1.2979 |
|
| 28 |
N |
H |
-2.0182 |
|
| 29 |
I |
H |
0.0000 |
|
| 30 |
K |
H |
-2.4253 |
|
| 31 |
D |
H |
-2.7755 |
|
| 32 |
T |
H |
0.0000 |
|
| 33 |
Y |
H |
-0.5456 |
|
| 34 |
I |
H |
0.0000 |
|
| 35 |
H |
H |
0.0000 |
|
| 36 |
W |
H |
0.0000 |
|
| 37 |
V |
H |
0.0000 |
|
| 38 |
R |
H |
0.0000 |
|
| 39 |
Q |
H |
-0.5374 |
|
| 40 |
A |
H |
-1.1149 |
|
| 41 |
P |
H |
-1.0700 |
|
| 42 |
G |
H |
-1.5812 |
|
| 43 |
K |
H |
-2.1079 |
|
| 44 |
G |
H |
-0.9849 |
|
| 45 |
L |
H |
0.5353 |
|
| 46 |
E |
H |
-0.3537 |
|
| 47 |
W |
H |
0.1161 |
|
| 48 |
V |
H |
0.0000 |
|
| 49 |
A |
H |
0.0000 |
|
| 50 |
R |
H |
-0.9612 |
|
| 51 |
I |
H |
0.0000 |
|
| 52 |
Y |
H |
-0.2555 |
|
| 53 |
P |
H |
-0.8958 |
|
| 54 |
T |
H |
-1.0189 |
|
| 55 |
N |
H |
-0.7524 |
|
| 56 |
G |
H |
-0.2379 |
|
| 57 |
Y |
H |
0.5297 |
|
| 58 |
T |
H |
-0.5654 |
|
| 59 |
R |
H |
-2.1556 |
|
| 60 |
Y |
H |
-2.0187 |
|
| 61 |
A |
H |
-1.8889 |
|
| 62 |
D |
H |
-2.7260 |
|
| 63 |
S |
H |
-1.8225 |
|
| 64 |
V |
H |
0.0000 |
|
| 65 |
K |
H |
-2.9452 |
|
| 66 |
G |
H |
-1.9283 |
|
| 67 |
R |
H |
-1.9227 |
|
| 68 |
F |
H |
0.0000 |
|
| 69 |
T |
H |
-1.4005 |
|
| 70 |
I |
H |
0.0000 |
|
| 71 |
S |
H |
-0.1719 |
|
| 72 |
A |
H |
-0.7879 |
|
| 73 |
D |
H |
-1.3972 |
|
| 74 |
T |
H |
-1.7438 |
|
| 75 |
S |
H |
-1.5312 |
|
| 76 |
K |
H |
-2.1921 |
|
| 77 |
N |
H |
-1.6711 |
|
| 78 |
T |
H |
-0.8012 |
|
| 79 |
A |
H |
0.0000 |
|
| 80 |
Y |
H |
-0.5602 |
|
| 81 |
L |
H |
0.0000 |
|
| 82 |
Q |
H |
-1.7994 |
|
| 83 |
M |
H |
0.0000 |
|
| 84 |
N |
H |
-2.2370 |
|
| 85 |
S |
H |
-1.5036 |
|
| 86 |
L |
H |
0.0000 |
|
| 87 |
R |
H |
-2.1327 |
|
| 88 |
A |
H |
-1.5828 |
|
| 89 |
E |
H |
-2.1694 |
|
| 90 |
D |
H |
0.0000 |
|
| 91 |
T |
H |
-0.6660 |
|
| 92 |
A |
H |
0.0000 |
|
| 93 |
V |
H |
0.4058 |
|
| 94 |
Y |
H |
0.0000 |
|
| 95 |
Y |
H |
0.4453 |
|
| 96 |
C |
H |
0.0000 |
|
| 97 |
S |
H |
0.0000 |
|
| 98 |
R |
H |
-0.3145 |
|
| 99 |
W |
H |
-0.0799 |
|
| 100 |
G |
H |
0.0000 |
|
| 101 |
G |
H |
-0.5181 |
|
| 102 |
D |
H |
-1.4243 |
|
| 103 |
G |
H |
0.2530 |
|
| 104 |
F |
H |
1.8051 |
|
| 105 |
Y |
H |
1.6160 |
|
| 106 |
A |
H |
0.7839 |
|
| 107 |
M |
H |
0.3635 |
|
| 108 |
D |
H |
0.0509 |
|
| 109 |
Y |
H |
0.0728 |
|
| 110 |
W |
H |
0.3089 |
|
| 111 |
G |
H |
0.0442 |
|
| 112 |
Q |
H |
-0.7416 |
|
| 113 |
G |
H |
-0.0928 |
|
| 114 |
T |
H |
0.0582 |
|
| 115 |
L |
H |
0.3040 |
|
| 116 |
V |
H |
0.0000 |
|
| 117 |
T |
H |
-0.3292 |
|
| 118 |
V |
H |
0.0000 |
|
| 119 |
S |
H |
-0.8533 |
|
| 120 |
S |
H |
-0.6580 |
|
| 121 |
A |
H |
-0.4310 |
|
| 122 |
S |
H |
-0.5174 |
|
| 123 |
T |
H |
-0.6927 |
|
| 124 |
K |
H |
-1.0930 |
|
| 125 |
G |
H |
-1.4682 |
|
| 126 |
P |
H |
0.0000 |
|
| 127 |
S |
H |
-0.0691 |
|
| 128 |
V |
H |
0.0000 |
|
| 129 |
F |
H |
0.9268 |
|
| 130 |
P |
H |
0.0703 |
|
| 131 |
L |
H |
0.5101 |
|
| 132 |
A |
H |
-0.4372 |
|
| 133 |
P |
H |
-0.3766 |
|
| 142 |
T |
H |
-0.2825 |
|
| 143 |
A |
H |
-0.1646 |
|
| 144 |
A |
H |
0.0780 |
|
| 145 |
L |
H |
0.0000 |
|
| 146 |
G |
H |
0.0000 |
|
| 147 |
C |
H |
0.0000 |
|
| 148 |
L |
H |
0.6772 |
|
| 149 |
V |
H |
0.0000 |
|
| 150 |
K |
H |
-0.2084 |
|
| 151 |
D |
H |
-0.5432 |
|
| 152 |
Y |
H |
0.0000 |
|
| 153 |
F |
H |
0.0000 |
|
| 154 |
P |
H |
0.0000 |
|
| 155 |
E |
H |
-0.4883 |
|
| 156 |
P |
H |
-0.8520 |
|
| 157 |
V |
H |
-0.9011 |
|
| 158 |
T |
H |
-0.8042 |
|
| 159 |
V |
H |
-0.2770 |
|
| 160 |
S |
H |
-0.4370 |
|
| 161 |
W |
H |
0.0000 |
|
| 162 |
N |
H |
-0.7172 |
|
| 163 |
S |
H |
-0.6226 |
|
| 164 |
G |
H |
-0.5354 |
|
| 165 |
A |
H |
-0.2567 |
|
| 166 |
L |
H |
-0.0231 |
|
| 167 |
T |
H |
-0.3058 |
|
| 168 |
S |
H |
-0.3704 |
|
| 169 |
G |
H |
-0.4599 |
|
| 170 |
V |
H |
0.0467 |
|
| 171 |
H |
H |
-0.3535 |
|
| 172 |
T |
H |
0.1889 |
|
| 173 |
F |
H |
0.9931 |
|
| 174 |
P |
H |
0.7099 |
|
| 175 |
A |
H |
1.2434 |
|
| 176 |
V |
H |
2.4629 |
|
| 177 |
L |
H |
2.0405 |
|
| 178 |
Q |
H |
0.6753 |
|
| 179 |
S |
H |
0.0784 |
|
| 180 |
S |
H |
-0.2171 |
|
| 181 |
G |
H |
0.2055 |
|
| 182 |
L |
H |
0.3319 |
|
| 183 |
Y |
H |
0.8398 |
|
| 184 |
S |
H |
0.0000 |
|
| 185 |
L |
H |
0.0000 |
|
| 186 |
S |
H |
0.6590 |
|
| 187 |
S |
H |
0.0000 |
|
| 188 |
V |
H |
0.4712 |
|
| 189 |
V |
H |
0.0000 |
|
| 190 |
T |
H |
-0.2320 |
|
| 191 |
V |
H |
0.0000 |
|
| 192 |
P |
H |
-0.4012 |
|
| 193 |
S |
H |
-0.4320 |
|
| 194 |
S |
H |
-0.5102 |
|
| 195 |
S |
H |
-0.5460 |
|
| 196 |
L |
H |
-0.7053 |
|
| 197 |
G |
H |
-1.0981 |
|
| 198 |
T |
H |
-0.9167 |
|
| 199 |
Q |
H |
-1.2362 |
|
| 200 |
T |
H |
-1.1129 |
|
| 201 |
Y |
H |
0.0000 |
|
| 202 |
I |
H |
-1.1746 |
|
| 203 |
C |
H |
0.0000 |
|
| 204 |
N |
H |
-1.5342 |
|
| 205 |
V |
H |
0.0000 |
|
| 206 |
N |
H |
-2.5669 |
|
| 207 |
H |
H |
0.0000 |
|
| 208 |
K |
H |
-2.9212 |
|
| 209 |
P |
H |
-1.6576 |
|
| 210 |
S |
H |
-1.9035 |
|
| 211 |
N |
H |
-2.6775 |
|
| 212 |
T |
H |
-2.2585 |
|
| 213 |
K |
H |
-2.9293 |
|
| 214 |
V |
H |
-1.6759 |
|
| 215 |
D |
H |
-2.3003 |
|
| 216 |
K |
H |
-1.9386 |
|
| 217 |
K |
H |
-2.3679 |
|
| 218 |
V |
H |
0.0000 |
|
| 219 |
E |
H |
-2.4874 |
|
| 220 |
P |
H |
-1.3076 |
|