| Chain sequence(s) |
A: IFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQF B: ADVCMDPEPIVRIVGRNGLCVDVRDGRFHNGNAIQLWPCKSNTDANQLWTLKRDNTIRSNGKCLTTYGYSPGVYVMIYDCNTAATDATRWQIWDNGTIINPRSSLVLAATSGNSGTTLTVQTNIYAVSQGWLPTNNTQPFVTTIVGLYGLCLQANSGQVWIEDCSSEKAEQQWALYADGSIRPQQNRDNCLTSDSNIRETVVKILSCGPASSGQRWMFKNDGTILNLYSGLVLDVRASDPSLKQIILYPLHGDPNQIWLPLF |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | I | A | 2.0846 | |
| 2 | F | A | 0.4358 | |
| 3 | P | A | -0.7717 | |
| 4 | K | A | -2.4527 | |
| 5 | Q | A | -2.0541 | |
| 6 | Y | A | 0.0000 | |
| 7 | P | A | -0.4101 | |
| 8 | I | A | 0.2041 | |
| 9 | I | A | 0.0000 | |
| 10 | N | A | -1.3474 | |
| 11 | F | A | 0.0000 | |
| 12 | T | A | -0.8669 | |
| 13 | T | A | 0.0000 | |
| 14 | A | A | -0.9929 | |
| 15 | G | A | -0.6963 | |
| 16 | A | A | -0.7531 | |
| 17 | T | A | -1.0659 | |
| 18 | V | A | -0.9106 | |
| 19 | Q | A | -1.6981 | |
| 20 | S | A | -1.2596 | |
| 21 | Y | A | 0.0000 | |
| 22 | T | A | -1.4623 | |
| 23 | N | A | -1.9708 | |
| 24 | F | A | 0.0000 | |
| 25 | I | A | 0.0000 | |
| 26 | R | A | -2.6171 | |
| 27 | A | A | -1.7934 | |
| 28 | V | A | 0.0000 | |
| 29 | R | A | -1.7122 | |
| 30 | G | A | -1.8778 | |
| 31 | R | A | -1.9033 | |
| 32 | L | A | 0.0000 | |
| 33 | T | A | -0.7659 | |
| 34 | T | A | -0.6857 | |
| 35 | G | A | -0.6696 | |
| 36 | A | A | -0.2749 | |
| 37 | D | A | -0.1863 | |
| 38 | V | A | 0.3649 | |
| 39 | R | A | 0.0000 | |
| 40 | H | A | 0.0000 | |
| 41 | E | A | -0.4768 | |
| 42 | I | A | 0.0000 | |
| 43 | P | A | -0.0966 | |
| 44 | V | A | 0.0000 | |
| 45 | L | A | 0.0000 | |
| 46 | P | A | -0.7301 | |
| 47 | N | A | -0.8221 | |
| 48 | R | A | -1.4384 | |
| 49 | V | A | 0.4329 | |
| 50 | G | A | -0.1306 | |
| 51 | L | A | -0.3623 | |
| 52 | P | A | -0.1512 | |
| 53 | I | A | -0.4306 | |
| 54 | N | A | -0.9236 | |
| 55 | Q | A | -1.1921 | |
| 56 | R | A | -0.7866 | |
| 57 | F | A | 0.0000 | |
| 58 | I | A | 0.0000 | |
| 59 | L | A | -0.1076 | |
| 60 | V | A | 0.0000 | |
| 61 | E | A | -1.2051 | |
| 62 | L | A | 0.0000 | |
| 63 | S | A | -1.0791 | |
| 64 | N | A | 0.0000 | |
| 65 | H | A | -1.6937 | |
| 66 | A | A | -1.3843 | |
| 67 | E | A | -2.0736 | |
| 68 | L | A | -0.8783 | |
| 69 | S | A | -1.0042 | |
| 70 | V | A | 0.0000 | |
| 71 | T | A | -0.6878 | |
| 72 | L | A | 0.0000 | |
| 73 | A | A | 0.0000 | |
| 74 | L | A | 0.0000 | |
| 75 | D | A | 0.0000 | |
| 76 | V | A | 0.0000 | |
| 77 | T | A | 0.0000 | |
| 78 | N | A | -0.5838 | |
| 79 | A | A | 0.0000 | |
| 80 | Y | A | -0.0348 | |
| 81 | V | A | 0.0000 | |
| 82 | V | A | 0.1589 | |
| 83 | G | A | 0.0000 | |
| 84 | Y | A | 0.0000 | |
| 85 | R | A | -1.3705 | |
| 86 | A | A | 0.0000 | |
| 87 | G | A | -1.0079 | |
| 88 | N | A | -2.5890 | |
| 89 | S | A | -1.9971 | |
| 90 | A | A | 0.0000 | |
| 91 | Y | A | -0.3796 | |
| 92 | F | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | H | A | -1.1415 | |
| 95 | P | A | -2.1528 | |
| 96 | D | A | -2.7557 | |
| 97 | N | A | -2.8171 | |
| 98 | Q | A | -3.1773 | |
| 99 | E | A | -3.4669 | |
| 100 | D | A | -2.9075 | |
| 101 | A | A | -2.4929 | |
| 102 | E | A | -2.7678 | |
| 103 | A | A | 0.0000 | |
| 104 | I | A | -0.6896 | |
| 105 | T | A | -0.5188 | |
| 106 | H | A | -0.2530 | |
| 107 | L | A | 0.0000 | |
| 108 | F | A | -1.0977 | |
| 109 | T | A | -1.3512 | |
| 110 | D | A | -2.5184 | |
| 111 | V | A | -2.6455 | |
| 112 | Q | A | -2.9290 | |
| 113 | N | A | -2.8988 | |
| 114 | R | A | -2.5678 | |
| 115 | Y | A | -0.1072 | |
| 116 | T | A | 0.0005 | |
| 117 | F | A | 0.0000 | |
| 118 | A | A | 0.0113 | |
| 119 | F | A | -0.7581 | |
| 120 | G | A | -1.6099 | |
| 121 | G | A | 0.0000 | |
| 122 | N | A | -2.2707 | |
| 123 | Y | A | 0.0000 | |
| 124 | D | A | -3.0177 | |
| 125 | R | A | -3.0882 | |
| 126 | L | A | 0.0000 | |
| 127 | E | A | -1.9019 | |
| 128 | Q | A | -2.1628 | |
| 129 | L | A | -1.0094 | |
| 130 | A | A | -0.8468 | |
| 131 | G | A | -1.1472 | |
| 132 | N | A | -0.9536 | |
| 133 | L | A | -0.3287 | |
| 134 | R | A | 0.0000 | |
| 135 | E | A | -1.7712 | |
| 136 | N | A | -1.8733 | |
| 137 | I | A | 0.0000 | |
| 138 | E | A | -2.0502 | |
| 139 | L | A | 0.0000 | |
| 140 | G | A | 0.0000 | |
| 141 | N | A | -1.8863 | |
| 142 | G | A | -1.8196 | |
| 143 | P | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | E | A | -1.6088 | |
| 146 | E | A | -2.1032 | |
| 147 | A | A | 0.0000 | |
| 148 | I | A | 0.0000 | |
| 149 | S | A | -0.7366 | |
| 150 | A | A | -0.4712 | |
| 151 | L | A | 0.0000 | |
| 152 | Y | A | 0.1952 | |
| 153 | Y | A | 0.5403 | |
| 154 | Y | A | 0.1540 | |
| 155 | S | A | -0.2426 | |
| 156 | T | A | -0.2343 | |
| 157 | G | A | -0.6291 | |
| 158 | G | A | -0.6139 | |
| 159 | T | A | -0.5328 | |
| 160 | Q | A | -0.9578 | |
| 161 | L | A | 0.0480 | |
| 162 | P | A | -0.5359 | |
| 163 | T | A | -0.4477 | |
| 164 | L | A | 0.0000 | |
| 165 | A | A | 0.0000 | |
| 166 | R | A | -0.7660 | |
| 167 | S | A | 0.0000 | |
| 168 | F | A | 0.0000 | |
| 169 | I | A | 0.0000 | |
| 170 | I | A | 0.0000 | |
| 171 | C | A | 0.0000 | |
| 172 | I | A | 0.0000 | |
| 173 | Q | A | 0.0000 | |
| 174 | M | A | 0.0000 | |
| 175 | I | A | 0.0000 | |
| 176 | S | A | 0.0000 | |
| 177 | E | A | 0.0000 | |
| 178 | A | A | 0.0000 | |
| 179 | A | A | 0.0000 | |
| 180 | R | A | 0.0000 | |
| 181 | F | A | 0.0000 | |
| 182 | Q | A | -0.4083 | |
| 183 | Y | A | 0.0000 | |
| 184 | I | A | 0.0000 | |
| 185 | E | A | 0.0000 | |
| 186 | G | A | -0.2116 | |
| 187 | E | A | 0.0000 | |
| 188 | M | A | 0.0000 | |
| 189 | R | A | -1.3720 | |
| 190 | T | A | -0.9854 | |
| 191 | R | A | 0.0000 | |
| 192 | I | A | 0.0000 | |
| 193 | R | A | -2.0009 | |
| 194 | Y | A | -1.1154 | |
| 195 | N | A | -2.6440 | |
| 196 | R | A | -3.5142 | |
| 197 | R | A | -3.1763 | |
| 198 | S | A | -2.2522 | |
| 199 | A | A | -1.6792 | |
| 200 | P | A | 0.0000 | |
| 201 | D | A | -1.4041 | |
| 202 | P | A | -1.2597 | |
| 203 | S | A | 0.0000 | |
| 204 | V | A | 0.0000 | |
| 205 | I | A | -0.4299 | |
| 206 | T | A | -0.5754 | |
| 207 | L | A | 0.0000 | |
| 208 | E | A | 0.0000 | |
| 209 | N | A | -1.0043 | |
| 210 | S | A | 0.0000 | |
| 211 | W | A | 0.0000 | |
| 212 | G | A | -1.3614 | |
| 213 | R | A | -1.9984 | |
| 214 | L | A | 0.0000 | |
| 215 | S | A | 0.0000 | |
| 216 | T | A | -1.1241 | |
| 217 | A | A | -0.8970 | |
| 218 | I | A | 0.0000 | |
| 219 | Q | A | 0.0000 | |
| 220 | E | A | -1.2589 | |
| 221 | S | A | 0.0000 | |
| 222 | N | A | -1.4849 | |
| 223 | Q | A | -0.9858 | |
| 224 | G | A | 0.0000 | |
| 225 | A | A | 0.0000 | |
| 226 | F | A | 0.0000 | |
| 227 | A | A | -0.1653 | |
| 228 | S | A | -0.0886 | |
| 229 | P | A | -0.5042 | |
| 230 | I | A | -0.7314 | |
| 231 | Q | A | -1.4718 | |
| 232 | L | A | 0.0000 | |
| 233 | Q | A | -1.8075 | |
| 234 | R | A | -1.8657 | |
| 235 | R | A | -1.7643 | |
| 236 | N | A | -2.3379 | |
| 237 | G | A | -1.9557 | |
| 238 | S | A | -2.0131 | |
| 239 | K | A | -2.3072 | |
| 240 | F | A | -1.1827 | |
| 241 | S | A | -1.0090 | |
| 242 | V | A | 0.0000 | |
| 243 | Y | A | -0.1583 | |
| 244 | D | A | 0.0000 | |
| 245 | V | A | 0.0000 | |
| 246 | S | A | -0.0487 | |
| 247 | I | A | 0.4315 | |
| 248 | L | A | 0.0000 | |
| 249 | I | A | 0.0000 | |
| 250 | P | A | 0.0000 | |
| 251 | I | A | 0.0000 | |
| 252 | I | A | 0.0000 | |
| 253 | A | A | 0.0000 | |
| 254 | L | A | 0.0000 | |
| 255 | M | A | 0.0000 | |
| 256 | V | A | -0.5307 | |
| 257 | Y | A | -0.6681 | |
| 258 | R | A | -1.2644 | |
| 259 | C | A | 0.0000 | |
| 260 | A | A | -0.4184 | |
| 261 | P | A | -0.4909 | |
| 262 | P | A | -0.2907 | |
| 263 | P | A | -0.3497 | |
| 264 | S | A | -0.4779 | |
| 265 | S | A | -0.4275 | |
| 266 | Q | A | -0.1764 | |
| 267 | F | A | 0.5564 | |
| 1 | A | B | -0.5478 | |
| 2 | D | B | -1.2245 | |
| 3 | V | B | -0.0824 | |
| 4 | C | B | 0.0000 | |
| 5 | M | B | -0.1019 | |
| 6 | D | B | -2.0367 | |
| 7 | P | B | -1.3841 | |
| 8 | E | B | -1.1805 | |
| 9 | P | B | 0.0000 | |
| 10 | I | B | 1.7931 | |
| 11 | V | B | 0.0000 | |
| 12 | R | B | 0.0000 | |
| 13 | I | B | 0.0000 | |
| 14 | V | B | 0.0000 | |
| 15 | G | B | 0.0000 | |
| 16 | R | B | 0.0000 | |
| 17 | N | B | -1.0559 | |
| 18 | G | B | -0.2968 | |
| 19 | L | B | -0.1977 | |
| 20 | C | B | 0.0000 | |
| 21 | V | B | 0.0000 | |
| 22 | D | B | 0.0000 | |
| 23 | V | B | 0.0000 | |
| 24 | R | B | -1.7929 | |
| 25 | D | B | -2.6676 | |
| 26 | G | B | -2.3168 | |
| 27 | R | B | -2.8129 | |
| 28 | F | B | -1.8982 | |
| 29 | H | B | -1.6449 | |
| 30 | N | B | -1.5283 | |
| 31 | G | B | -0.6575 | |
| 32 | N | B | 0.0000 | |
| 33 | A | B | 0.0000 | |
| 34 | I | B | 0.0000 | |
| 35 | Q | B | 0.0000 | |
| 36 | L | B | 0.0000 | |
| 37 | W | B | 0.1524 | |
| 38 | P | B | -0.0932 | |
| 39 | C | B | -0.3619 | |
| 40 | K | B | -0.9396 | |
| 41 | S | B | -1.2445 | |
| 42 | N | B | -1.7571 | |
| 43 | T | B | -1.2598 | |
| 44 | D | B | -1.6229 | |
| 45 | A | B | -1.0747 | |
| 46 | N | B | 0.0000 | |
| 47 | Q | B | 0.0000 | |
| 48 | L | B | 0.0052 | |
| 49 | W | B | 0.0000 | |
| 50 | T | B | -0.0319 | |
| 51 | L | B | 0.0000 | |
| 52 | K | B | -1.8918 | |
| 53 | R | B | -3.0835 | |
| 54 | D | B | -2.2605 | |
| 55 | N | B | -2.3539 | |
| 56 | T | B | 0.0000 | |
| 57 | I | B | 0.0000 | |
| 58 | R | B | -0.8003 | |
| 59 | S | B | 0.0000 | |
| 60 | N | B | -1.7720 | |
| 61 | G | B | -1.3388 | |
| 62 | K | B | -1.4520 | |
| 63 | C | B | 0.0000 | |
| 64 | L | B | 0.0000 | |
| 65 | T | B | 0.0000 | |
| 66 | T | B | 0.0000 | |
| 67 | Y | B | 1.5198 | |
| 68 | G | B | 0.8276 | |
| 69 | Y | B | 0.1948 | |
| 70 | S | B | -0.1280 | |
| 71 | P | B | -0.4504 | |
| 72 | G | B | -0.2135 | |
| 73 | V | B | 0.5850 | |
| 74 | Y | B | 0.6346 | |
| 75 | V | B | 0.0000 | |
| 76 | M | B | 0.0000 | |
| 77 | I | B | 0.0000 | |
| 78 | Y | B | -0.6191 | |
| 79 | D | B | -1.2506 | |
| 80 | C | B | -1.0336 | |
| 81 | N | B | -1.3555 | |
| 82 | T | B | -0.8123 | |
| 83 | A | B | 0.0000 | |
| 84 | A | B | -0.5890 | |
| 85 | T | B | -1.1623 | |
| 86 | D | B | -2.1609 | |
| 87 | A | B | 0.0000 | |
| 88 | T | B | 0.0000 | |
| 89 | R | B | -1.8198 | |
| 90 | W | B | 0.0000 | |
| 91 | Q | B | -0.8449 | |
| 92 | I | B | 0.0000 | |
| 93 | W | B | -0.1413 | |
| 94 | D | B | -0.4966 | |
| 95 | N | B | -0.4391 | |
| 96 | G | B | -0.1673 | |
| 97 | T | B | 0.0000 | |
| 98 | I | B | 0.0000 | |
| 99 | I | B | 0.0000 | |
| 100 | N | B | 0.0000 | |
| 101 | P | B | -1.5729 | |
| 102 | R | B | -2.1557 | |
| 103 | S | B | -1.1966 | |
| 104 | S | B | -0.7014 | |
| 105 | L | B | 0.0000 | |
| 106 | V | B | 0.0000 | |
| 107 | L | B | 0.0000 | |
| 108 | A | B | 0.0000 | |
| 109 | A | B | 0.0000 | |
| 110 | T | B | -0.4084 | |
| 111 | S | B | -0.7566 | |
| 112 | G | B | -0.9600 | |
| 113 | N | B | -1.4889 | |
| 114 | S | B | -0.7618 | |
| 115 | G | B | -0.6607 | |
| 116 | T | B | -0.4912 | |
| 117 | T | B | -0.1372 | |
| 118 | L | B | 0.0000 | |
| 119 | T | B | 0.1536 | |
| 120 | V | B | 0.0000 | |
| 121 | Q | B | -0.3015 | |
| 122 | T | B | -0.1750 | |
| 123 | N | B | 0.4061 | |
| 124 | I | B | 1.4165 | |
| 125 | Y | B | 1.0618 | |
| 126 | A | B | 0.0000 | |
| 127 | V | B | 0.0000 | |
| 128 | S | B | -0.1041 | |
| 129 | Q | B | 0.0000 | |
| 130 | G | B | 0.0000 | |
| 131 | W | B | 0.0000 | |
| 132 | L | B | 0.1228 | |
| 133 | P | B | 0.0000 | |
| 134 | T | B | 0.0000 | |
| 135 | N | B | -0.6163 | |
| 136 | N | B | -1.1323 | |
| 137 | T | B | -1.0450 | |
| 138 | Q | B | -1.3175 | |
| 139 | P | B | -0.5050 | |
| 140 | F | B | 0.1404 | |
| 141 | V | B | 0.1113 | |
| 142 | T | B | 0.0000 | |
| 143 | T | B | -0.0768 | |
| 144 | I | B | 0.0000 | |
| 145 | V | B | 0.3591 | |
| 146 | G | B | 0.2622 | |
| 147 | L | B | 0.0000 | |
| 148 | Y | B | 0.5431 | |
| 149 | G | B | 0.0029 | |
| 150 | L | B | -0.2912 | |
| 151 | C | B | 0.0000 | |
| 152 | L | B | 0.0000 | |
| 153 | Q | B | 0.0000 | |
| 154 | A | B | -1.6309 | |
| 155 | N | B | -1.9030 | |
| 156 | S | B | -1.7708 | |
| 157 | G | B | -1.4408 | |
| 158 | Q | B | -2.1549 | |
| 159 | V | B | 0.0000 | |
| 160 | W | B | -1.2352 | |
| 161 | I | B | 0.0000 | |
| 162 | E | B | -1.5495 | |
| 163 | D | B | -1.9554 | |
| 164 | C | B | -1.4513 | |
| 165 | S | B | -1.6402 | |
| 166 | S | B | -1.7215 | |
| 167 | E | B | -2.5813 | |
| 168 | K | B | -2.3756 | |
| 169 | A | B | -1.6704 | |
| 170 | E | B | -2.2325 | |
| 171 | Q | B | 0.0000 | |
| 172 | Q | B | -1.3802 | |
| 173 | W | B | 0.0000 | |
| 174 | A | B | 0.0000 | |
| 175 | L | B | 0.1529 | |
| 176 | Y | B | -0.0014 | |
| 177 | A | B | -0.1034 | |
| 178 | D | B | 0.0000 | |
| 179 | G | B | -0.0057 | |
| 180 | S | B | 0.0000 | |
| 181 | I | B | 0.0000 | |
| 182 | R | B | 0.0000 | |
| 183 | P | B | -1.8171 | |
| 184 | Q | B | -1.8774 | |
| 185 | Q | B | -2.5892 | |
| 186 | N | B | -2.9291 | |
| 187 | R | B | -2.5554 | |
| 188 | D | B | -2.9149 | |
| 189 | N | B | -2.1415 | |
| 190 | C | B | 0.0000 | |
| 191 | L | B | 0.0000 | |
| 192 | T | B | 0.0000 | |
| 193 | S | B | 0.0000 | |
| 194 | D | B | -2.1965 | |
| 195 | S | B | 0.0000 | |
| 196 | N | B | -1.0398 | |
| 197 | I | B | 0.1789 | |
| 198 | R | B | -1.4386 | |
| 199 | E | B | -2.3813 | |
| 200 | T | B | -1.9246 | |
| 201 | V | B | -1.2705 | |
| 202 | V | B | 0.0000 | |
| 203 | K | B | -1.3473 | |
| 204 | I | B | 0.0000 | |
| 205 | L | B | -0.4068 | |
| 206 | S | B | -1.1366 | |
| 207 | C | B | 0.0000 | |
| 208 | G | B | -1.1867 | |
| 209 | P | B | -0.5202 | |
| 210 | A | B | 0.0000 | |
| 211 | S | B | -0.1894 | |
| 212 | S | B | 0.1332 | |
| 213 | G | B | 0.0000 | |
| 214 | Q | B | 0.0000 | |
| 215 | R | B | 0.0000 | |
| 216 | W | B | 0.0000 | |
| 217 | M | B | -0.0415 | |
| 218 | F | B | 0.0000 | |
| 219 | K | B | -0.8704 | |
| 220 | N | B | -1.3355 | |
| 221 | D | B | -1.9975 | |
| 222 | G | B | -0.9022 | |
| 223 | T | B | 0.0000 | |
| 224 | I | B | 0.0000 | |
| 225 | L | B | 0.4366 | |
| 226 | N | B | 0.0000 | |
| 227 | L | B | 0.0000 | |
| 228 | Y | B | 1.1977 | |
| 229 | S | B | 0.3662 | |
| 230 | G | B | 0.2099 | |
| 231 | L | B | 0.0000 | |
| 232 | V | B | 0.0000 | |
| 233 | L | B | 0.0000 | |
| 234 | D | B | 0.0000 | |
| 235 | V | B | 0.0000 | |
| 236 | R | B | -2.0660 | |
| 237 | A | B | -0.8729 | |
| 238 | S | B | -0.9231 | |
| 239 | D | B | -1.1972 | |
| 240 | P | B | -1.2325 | |
| 241 | S | B | -1.0896 | |
| 242 | L | B | -0.9935 | |
| 243 | K | B | -2.2171 | |
| 244 | Q | B | -2.0265 | |
| 245 | I | B | 0.0000 | |
| 246 | I | B | 0.0000 | |
| 247 | L | B | 0.0000 | |
| 248 | Y | B | -0.0082 | |
| 249 | P | B | 0.2389 | |
| 250 | L | B | 0.4072 | |
| 251 | H | B | -1.0658 | |
| 252 | G | B | -1.6108 | |
| 253 | D | B | -2.1139 | |
| 254 | P | B | -1.1376 | |
| 255 | N | B | -0.9911 | |
| 256 | Q | B | 0.0000 | |
| 257 | I | B | -0.3199 | |
| 258 | W | B | 0.0000 | |
| 259 | L | B | 0.1679 | |
| 260 | P | B | 0.0000 | |
| 261 | L | B | 0.1713 | |
| 262 | F | B | 0.0000 |