Project name: ColH PKD2a

Chain sequence(s)	A: NSLPYGKINGTYKGTEKEKIKFSSEGSFDPDGKIVSYEWDFGDGNKSNEENPEHSYDKVGTYTVKLKVTDDKGESSVSTTTAEIKD; C: NSLPYGKINGTYKGTEKEKIKFSSEGSFDPDGKIVSYEWDFGDGNKSNEENPEHSYDKVGTYTVKLKVTDDKGESSVSTTTAEIKD; B: NSLPYGKINGTYKGTEKEKIKFSSEGSFDPDGKIVSYEWDFGDGNKSNEENPEHSYDKVGTYTVKLKVTDDKGESSVSTTTAEIKD; E: NSLPYGKINGTYKGTEKEKIKFSSEGSFDPDGKIVSYEWDFGDGNKSNEENPEHSYDKVGTYTVKLKVTDDKGESSVSTTTAEIKD; D: NSLPYGKINGTYKGTEKEKIKFSSEGSFDPDGKIVSYEWDFGDGNKSNEENPEHSYDKVGTYTVKLKVTDDKGESSVSTTTAEIKD; G: NSLPYGKINGTYKGTEKEKIKFSSEGSFDPDGKIVSYEWDFGDGNKSNEENPEHSYDKVGTYTVKLKVTDDKGESSVSTTTAEIKD; F: NSLPYGKINGTYKGTEKEKIKFSSEGSFDPDGKIVSYEWDFGDGNKSNEENPEHSYDKVGTYTVKLKVTDDKGESSVSTTTAEIKD; H: NSLPYGKINGTYKGTEKEKIKFSSEGSFDPDGKIVSYEWDFGDGNKSNEENPEHSYDKVGTYTVKLKVTDDKGESSVSTTTAEIKD
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.7428
• Maximal score value: 0.5095
• Average score: -1.5462
• Total score value: -1063.8066

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
685	N	A	-2.4678
686	S	A	0.0000
687	L	A	-1.2134
688	P	A	0.0000
689	Y	A	0.0000
690	G	A	-0.3361
691	K	A	0.0000
692	I	A	0.0000
693	N	A	-0.8216
694	G	A	-0.4376
695	T	A	-0.7335
696	Y	A	-1.3225
697	K	A	-2.5969
698	G	A	0.0000
699	T	A	-3.3865
700	E	A	-4.1204
701	K	A	-4.1815
702	E	A	-3.9977
703	K	A	-3.8718
704	I	A	0.0000
705	K	A	-3.3011
706	F	A	0.0000
707	S	A	0.0000
708	S	A	0.0000
709	E	A	-2.5979
710	G	A	0.0000
711	S	A	-1.2200
712	F	A	0.0000
713	D	A	0.0000
714	P	A	0.0000
715	D	A	-2.9407
716	G	A	-2.4789
717	K	A	-2.3099
718	I	A	-0.5799
719	V	A	0.5095
720	S	A	-0.7991
721	Y	A	-1.6803
722	E	A	-3.0600
723	W	A	0.0000
724	D	A	-2.6283
725	F	A	0.0000
726	G	A	-1.3248
727	D	A	-1.7896
728	G	A	-2.0447
729	N	A	-2.3188
730	K	A	-3.4236
731	S	A	-3.1366
732	N	A	-3.5679
733	E	A	-4.0756
734	E	A	-3.4935
735	N	A	-3.1835
736	P	A	0.0000
737	E	A	-3.7625
738	H	A	-2.9471
739	S	A	-3.2714
740	Y	A	0.0000
741	D	A	-3.6321
742	K	A	-3.4458
743	V	A	-2.2080
744	G	A	-1.5139
745	T	A	-1.1425
746	Y	A	-0.4843
747	T	A	-0.6164
748	V	A	0.0000
749	K	A	-1.3061
750	L	A	0.0000
751	K	A	-1.2804
752	V	A	0.0000
753	T	A	-0.9158
754	D	A	0.0000
755	D	A	-2.3277
756	K	A	-2.7048
757	G	A	-1.7887
758	E	A	-1.9760
759	S	A	-0.9799
760	S	A	-0.3406
761	V	A	-0.2739
762	S	A	-0.3663
763	T	A	0.0000
764	T	A	-0.3157
765	T	A	-0.7289
766	A	A	0.0000
767	E	A	-2.0471
768	I	A	0.0000
769	K	A	-2.8835
770	D	A	-2.8758
685	N	B	-2.4120
686	S	B	0.0000
687	L	B	-1.0119
688	P	B	0.0000
689	Y	B	0.0000
690	G	B	-0.3742
691	K	B	0.0000
692	I	B	0.0000
693	N	B	-0.8314
694	G	B	-0.4736
695	T	B	-0.7477
696	Y	B	-1.3370
697	K	B	-2.6326
698	G	B	0.0000
699	T	B	-3.7350
700	E	B	-4.7428
701	K	B	-4.4387
702	E	B	-4.1699
703	K	B	-3.9418
704	I	B	0.0000
705	K	B	-3.3543
706	F	B	0.0000
707	S	B	-2.1960
708	S	B	0.0000
709	E	B	-2.8390
710	G	B	0.0000
711	S	B	-1.2828
712	F	B	0.0000
713	D	B	0.0000
714	P	B	0.0000
715	D	B	-3.1294
716	G	B	-2.5516
717	K	B	-2.3464
718	I	B	-0.6853
719	V	B	0.3364
720	S	B	-0.9044
721	Y	B	-1.7246
722	E	B	-2.7501
723	W	B	0.0000
724	D	B	-2.4288
725	F	B	0.0000
726	G	B	-1.5158
727	D	B	-2.0917
728	G	B	-1.8440
729	N	B	-2.4477
730	K	B	-3.3802
731	S	B	-3.1946
732	N	B	-3.5389
733	E	B	-4.2020
734	E	B	-3.8051
735	N	B	-3.4613
736	P	B	0.0000
737	E	B	-3.8438
738	H	B	-3.0577
739	S	B	-3.5250
740	Y	B	0.0000
741	D	B	-3.7852
742	K	B	-3.5826
743	V	B	-2.2904
744	G	B	-1.4979
745	T	B	-1.0803
746	Y	B	-0.4834
747	T	B	-0.6102
748	V	B	0.0000
749	K	B	-1.2720
750	L	B	0.0000
751	K	B	-1.2178
752	V	B	0.0000
753	T	B	-0.9140
754	D	B	0.0000
755	D	B	-2.3755
756	K	B	-2.6166
757	G	B	-1.7374
758	E	B	-1.8973
759	S	B	-0.9631
760	S	B	-0.3552
761	V	B	-0.3103
762	S	B	0.0000
763	T	B	-0.5792
764	T	B	-0.3371
765	T	B	-0.7084
766	A	B	0.0000
767	E	B	-2.1110
768	I	B	0.0000
769	K	B	-3.1431
770	D	B	-3.0835
685	N	C	-2.4385
686	S	C	0.0000
687	L	C	-1.0768
688	P	C	0.0000
689	Y	C	0.0000
690	G	C	-0.4833
691	K	C	0.0000
692	I	C	0.0000
693	N	C	-0.7859
694	G	C	-0.4513
695	T	C	-0.7582
696	Y	C	-1.3782
697	K	C	-2.6532
698	G	C	0.0000
699	T	C	-3.3974
700	E	C	-4.0759
701	K	C	-4.0874
702	E	C	-3.8498
703	K	C	-3.7994
704	I	C	0.0000
705	K	C	-3.3576
706	F	C	0.0000
707	S	C	-2.2169
708	S	C	0.0000
709	E	C	-2.7235
710	G	C	0.0000
711	S	C	-1.2111
712	F	C	0.0000
713	D	C	0.0000
714	P	C	0.0000
715	D	C	-2.9555
716	G	C	-2.4876
717	K	C	-2.3395
718	I	C	-0.6722
719	V	C	0.3136
720	S	C	-1.0645
721	Y	C	-2.0836
722	E	C	-3.3999
723	W	C	0.0000
724	D	C	-2.4595
725	F	C	0.0000
726	G	C	-1.4684
727	D	C	-2.1017
728	G	C	-1.8137
729	N	C	-2.3954
730	K	C	-3.4294
731	S	C	-3.3307
732	N	C	-3.7675
733	E	C	-4.3258
734	E	C	-3.9203
735	N	C	-3.4964
736	P	C	0.0000
737	E	C	-3.8315
738	H	C	-3.0409
739	S	C	-3.2834
740	Y	C	0.0000
741	D	C	-3.6078
742	K	C	-3.4768
743	V	C	-2.3140
744	G	C	-1.5364
745	T	C	-1.1655
746	Y	C	-0.5210
747	T	C	-0.5796
748	V	C	0.0000
749	K	C	-1.3781
750	L	C	0.0000
751	K	C	-1.8145
752	V	C	0.0000
753	T	C	-1.1276
754	D	C	0.0000
755	D	C	-2.3813
756	K	C	-2.6065
757	G	C	-1.7630
758	E	C	-1.9360
759	S	C	-1.1525
760	S	C	-0.5660
761	V	C	-0.6576
762	S	C	-0.4968
763	T	C	0.0000
764	T	C	-0.3035
765	T	C	-0.7247
766	A	C	0.0000
767	E	C	-2.1932
768	I	C	0.0000
769	K	C	-3.0115
770	D	C	-2.9213
685	N	D	-2.5635
686	S	D	0.0000
687	L	D	-1.1043
688	P	D	0.0000
689	Y	D	0.0000
690	G	D	-0.4084
691	K	D	0.0000
692	I	D	0.0000
693	N	D	-0.8260
694	G	D	-0.4353
695	T	D	-0.7813
696	Y	D	-1.4048
697	K	D	-2.6900
698	G	D	0.0000
699	T	D	-3.3789
700	E	D	-4.0728
701	K	D	-4.0744
702	E	D	-3.8850
703	K	D	-3.8017
704	I	D	0.0000
705	K	D	-3.2693
706	F	D	0.0000
707	S	D	-1.9956
708	S	D	0.0000
709	E	D	-2.6738
710	G	D	0.0000
711	S	D	-1.2272
712	F	D	0.0000
713	D	D	0.0000
714	P	D	0.0000
715	D	D	-2.7004
716	G	D	-2.6383
717	K	D	-2.6457
718	I	D	-1.0755
719	V	D	-0.2718
720	S	D	-1.1285
721	Y	D	-1.7534
722	E	D	-3.0529
723	W	D	0.0000
724	D	D	-2.3665
725	F	D	0.0000
726	G	D	-1.4828
727	D	D	-1.8754
728	G	D	-2.0835
729	N	D	-2.2567
730	K	D	-3.2392
731	S	D	-3.1008
732	N	D	-3.4792
733	E	D	-3.9820
734	E	D	-3.4019
735	N	D	-3.0837
736	P	D	0.0000
737	E	D	-3.7061
738	H	D	-2.9726
739	S	D	-3.3060
740	Y	D	0.0000
741	D	D	-3.4998
742	K	D	-3.2772
743	V	D	-1.9880
744	G	D	-1.3732
745	T	D	-1.1160
746	Y	D	-0.4750
747	T	D	-0.6261
748	V	D	0.0000
749	K	D	-1.5670
750	L	D	0.0000
751	K	D	-1.6259
752	V	D	0.0000
753	T	D	-1.3953
754	D	D	0.0000
755	D	D	-3.4227
756	K	D	-3.5842
757	G	D	-2.3888
758	E	D	-2.4508
759	S	D	-1.2379
760	S	D	-0.4494
761	V	D	-0.4839
762	S	D	0.0000
763	T	D	0.0000
764	T	D	-0.3826
765	T	D	-0.8145
766	A	D	0.0000
767	E	D	-2.2596
768	I	D	0.0000
769	K	D	-2.8996
770	D	D	-2.8275
685	N	E	-2.2849
686	S	E	-1.5136
687	L	E	-0.9730
688	P	E	0.0000
689	Y	E	0.1668
690	G	E	-0.3928
691	K	E	-0.7725
692	I	E	0.0000
693	N	E	-0.8553
694	G	E	-0.4901
695	T	E	-0.7527
696	Y	E	-1.3522
697	K	E	-2.3976
698	G	E	0.0000
699	T	E	-3.2099
700	E	E	-3.9549
701	K	E	-2.9465
702	E	E	-2.6831
703	K	E	-2.0757
704	I	E	0.0000
705	K	E	-2.7419
706	F	E	0.0000
707	S	E	-2.3193
708	S	E	0.0000
709	E	E	-2.4080
710	G	E	-1.1285
711	S	E	-0.7590
712	F	E	-0.1605
713	D	E	0.0000
714	P	E	-1.3395
715	D	E	-2.8163
716	G	E	-2.4823
717	K	E	-2.1792
718	I	E	-0.6519
719	V	E	0.1694
720	S	E	-0.9605
721	Y	E	-1.7498
722	E	E	-2.9812
723	W	E	0.0000
724	D	E	-2.3723
725	F	E	0.0000
726	G	E	-1.6098
727	D	E	-2.1195
728	G	E	-2.2951
729	N	E	-2.4822
730	K	E	-3.3182
731	S	E	-3.2079
732	N	E	-3.5595
733	E	E	-4.1770
734	E	E	-3.7632
735	N	E	-3.5014
736	P	E	0.0000
737	E	E	-3.3185
738	H	E	-2.2994
739	S	E	-2.3420
740	Y	E	0.0000
741	D	E	-3.3104
742	K	E	-3.3539
743	V	E	-2.1574
744	G	E	-1.4824
745	T	E	-1.0679
746	Y	E	-0.4009
747	T	E	-0.5311
748	V	E	0.0000
749	K	E	-1.2033
750	L	E	0.0000
751	K	E	-1.2652
752	V	E	0.0000
753	T	E	-0.9838
754	D	E	0.0000
755	D	E	-2.8502
756	K	E	-2.9795
757	G	E	-1.9686
758	E	E	-2.1384
759	S	E	-1.0636
760	S	E	-0.4074
761	V	E	-0.3525
762	S	E	0.0000
763	T	E	0.0000
764	T	E	-0.2815
765	T	E	-0.7002
766	A	E	0.0000
767	E	E	-2.1627
768	I	E	0.0000
769	K	E	-3.1196
770	D	E	-2.9339
685	N	F	-2.2665
686	S	F	-1.4796
687	L	F	-1.1960
688	P	F	0.0000
689	Y	F	0.1074
690	G	F	-0.3623
691	K	F	-0.8046
692	I	F	0.0000
693	N	F	-1.0378
694	G	F	-0.5799
695	T	F	-0.7385
696	Y	F	-1.2879
697	K	F	-2.4963
698	G	F	0.0000
699	T	F	-3.6163
700	E	F	-4.6323
701	K	F	-4.3870
702	E	F	-4.0880
703	K	F	-3.9137
704	I	F	0.0000
705	K	F	-3.3667
706	F	F	0.0000
707	S	F	-2.4306
708	S	F	0.0000
709	E	F	-2.5107
710	G	F	-1.2648
711	S	F	-0.7158
712	F	F	-0.2908
713	D	F	-1.1661
714	P	F	-1.3289
715	D	F	-2.5807
716	G	F	-2.5273
717	K	F	-2.3080
718	I	F	-0.7794
719	V	F	0.0283
720	S	F	-0.9890
721	Y	F	-1.7222
722	E	F	-3.0133
723	W	F	0.0000
724	D	F	-2.7279
725	F	F	0.0000
726	G	F	-1.3611
727	D	F	-1.7706
728	G	F	-2.0209
729	N	F	-2.2905
730	K	F	-3.4237
731	S	F	-3.1966
732	N	F	-3.5960
733	E	F	-4.2327
734	E	F	-3.8715
735	N	F	-3.6349
736	P	F	0.0000
737	E	F	-3.8416
738	H	F	-2.9689
739	S	F	-3.3620
740	Y	F	0.0000
741	D	F	-3.7552
742	K	F	-3.5673
743	V	F	-2.1968
744	G	F	-1.5500
745	T	F	-1.0607
746	Y	F	-0.4100
747	T	F	-0.6232
748	V	F	0.0000
749	K	F	-1.5336
750	L	F	0.0000
751	K	F	-1.1996
752	V	F	0.0000
753	T	F	-1.0152
754	D	F	0.0000
755	D	F	-3.1389
756	K	F	-2.9816
757	G	F	-2.0147
758	E	F	-2.1840
759	S	F	-1.0684
760	S	F	-0.3480
761	V	F	-0.2873
762	S	F	0.0000
763	T	F	0.0000
764	T	F	-0.3650
765	T	F	-0.6387
766	A	F	0.0000
767	E	F	-1.7923
768	I	F	0.0000
769	K	F	-3.0555
770	D	F	-3.0670
685	N	G	-1.9723
686	S	G	-1.4001
687	L	G	-0.8028
688	P	G	0.0000
689	Y	G	0.1010
690	G	G	-0.3910
691	K	G	-0.8082
692	I	G	0.0000
693	N	G	-0.9373
694	G	G	-0.5345
695	T	G	-0.7953
696	Y	G	-1.4045
697	K	G	-2.6787
698	G	G	0.0000
699	T	G	-3.4625
700	E	G	-4.1931
701	K	G	-4.1748
702	E	G	-3.9990
703	K	G	-3.8640
704	I	G	0.0000
705	K	G	-3.2745
706	F	G	0.0000
707	S	G	-2.0336
708	S	G	0.0000
709	E	G	-2.2388
710	G	G	-1.1462
711	S	G	-0.7331
712	F	G	-0.2814
713	D	G	-1.1196
714	P	G	-1.3997
715	D	G	-2.6394
716	G	G	-2.2232
717	K	G	-2.0757
718	I	G	-0.7241
719	V	G	-0.3954
720	S	G	-0.9884
721	Y	G	-1.5659
722	E	G	-2.6778
723	W	G	0.0000
724	D	G	-2.3993
725	F	G	0.0000
726	G	G	-1.4724
727	D	G	-2.0589
728	G	G	-1.7989
729	N	G	-2.3978
730	K	G	-3.3702
731	S	G	-3.0382
732	N	G	-3.2761
733	E	G	-3.6565
734	E	G	-2.8881
735	N	G	-2.7556
736	P	G	0.0000
737	E	G	-3.6613
738	H	G	-3.0072
739	S	G	-3.3496
740	Y	G	0.0000
741	D	G	-3.6451
742	K	G	-3.4837
743	V	G	-2.3018
744	G	G	-1.5432
745	T	G	-1.1634
746	Y	G	-0.5408
747	T	G	-0.6439
748	V	G	0.0000
749	K	G	-1.2849
750	L	G	0.0000
751	K	G	-1.2061
752	V	G	0.0000
753	T	G	0.0000
754	D	G	0.0000
755	D	G	-2.2663
756	K	G	-2.2430
757	G	G	-2.0099
758	E	G	-1.6982
759	S	G	-0.6431
760	S	G	-0.3543
761	V	G	-0.3828
762	S	G	0.0000
763	T	G	0.0000
764	T	G	-0.3324
765	T	G	-0.7462
766	A	G	0.0000
767	E	G	-2.2247
768	I	G	0.0000
769	K	G	-2.9809
770	D	G	-2.9142
685	N	H	-2.1949
686	S	H	-1.3917
687	L	H	-0.9116
688	P	H	0.0000
689	Y	H	0.0968
690	G	H	-0.3832
691	K	H	-0.7998
692	I	H	0.0000
693	N	H	-0.8915
694	G	H	-0.5181
695	T	H	-0.7602
696	Y	H	-1.3705
697	K	H	-2.6065
698	G	H	0.0000
699	T	H	-3.4240
700	E	H	-4.1778
701	K	H	-4.1864
702	E	H	-3.9559
703	K	H	-3.8600
704	I	H	0.0000
705	K	H	-3.3243
706	F	H	0.0000
707	S	H	-2.2523
708	S	H	0.0000
709	E	H	-2.3841
710	G	H	-1.1906
711	S	H	-0.8149
712	F	H	-0.2564
713	D	H	-1.0377
714	P	H	-1.2166
715	D	H	-2.3317
716	G	H	-2.3063
717	K	H	-2.1591
718	I	H	-0.6795
719	V	H	0.1420
720	S	H	-0.9200
721	Y	H	-1.6753
722	E	H	-2.9627
723	W	H	0.0000
724	D	H	-2.5403
725	F	H	0.0000
726	G	H	-1.5469
727	D	H	-2.0899
728	G	H	-1.8177
729	N	H	-2.4158
730	K	H	-3.4297
731	S	H	-3.1549
732	N	H	-3.4837
733	E	H	-4.0206
734	E	H	-3.4634
735	N	H	-3.2867
736	P	H	0.0000
737	E	H	-3.7674
738	H	H	-3.0489
739	S	H	-3.2807
740	Y	H	0.0000
741	D	H	-3.6504
742	K	H	-3.4594
743	V	H	-2.2053
744	G	H	-1.4505
745	T	H	-1.0830
746	Y	H	-0.5400
747	T	H	-0.6718
748	V	H	0.0000
749	K	H	-1.5498
750	L	H	0.0000
751	K	H	-1.3203
752	V	H	0.0000
753	T	H	-0.9833
754	D	H	0.0000
755	D	H	-2.8118
756	K	H	-2.9436
757	G	H	-1.9464
758	E	H	-2.0851
759	S	H	-1.0224
760	S	H	-0.3592
761	V	H	-0.3726
762	S	H	-0.4862
763	T	H	0.0000
764	T	H	-0.3893
765	T	H	-0.7510
766	A	H	0.0000
767	E	H	-2.0616
768	I	H	0.0000
769	K	H	-2.8757
770	D	H	-2.8840