Project name: Full TAU and CyPB

Status: done

submitted: 2019-02-21 00:49:07, status changed: 2019-02-21 01:08:35
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Chain sequence(s) A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
B: KKGPKVTVKVYFDLRIGDEDVGRVIFGLFGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENFKLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDKPLKDVIIADCGKIEVEKPFAIAKE
Distance of aggregation 10 Å
Dynamic mode No
Show buried residues

Minimal score value
-4.1017
Maximal score value
1.8638
Average score
-1.1565
Total score value
-718.1961

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A -0.0447
2 A A -1.3089
3 E A -2.3676
4 P A -2.2741
5 R A -3.0145
6 Q A -2.4412
7 E A -1.6768
8 F A 0.0000
9 E A -1.9929
10 V A 0.0000
11 M A -1.4394
12 E A -2.5449
13 D A -2.7393
14 H A 0.0000
15 A A -1.8211
16 G A -1.7636
17 T A -1.4672
18 Y A -1.8056
19 G A 0.0000
20 L A -1.3339
21 G A -1.9892
22 D A -3.1069
23 R A -3.0292
24 K A -2.7619
25 D A -2.1689
26 Q A 0.0000
27 G A 0.0000
28 G A -0.0758
29 Y A 0.8369
30 T A 0.7303
31 M A 0.5667
32 H A -0.9731
33 Q A -2.4991
34 D A -3.6123
35 Q A 0.0000
36 E A -2.7829
37 G A -2.9774
38 D A -3.3203
39 T A -2.4930
40 D A -2.6128
41 A A -1.8532
42 G A -1.1572
43 L A -0.3500
44 K A -2.3602
45 E A -2.8503
46 S A -1.3330
47 P A -0.1569
48 L A 0.5752
49 Q A -0.2581
50 T A 0.0000
51 P A 0.0000
52 T A -2.9777
53 E A -3.5560
54 D A -2.3676
55 G A -1.8623
56 S A -1.5720
57 E A -2.7391
58 E A -2.3585
59 P A -1.7001
60 G A -1.4868
61 S A -1.8890
62 E A -2.4324
63 T A -2.1727
64 S A -1.8957
65 D A -2.1661
66 A A -1.5400
67 K A -2.3811
68 S A -1.1769
69 T A -1.0029
70 P A -1.3460
71 T A 0.0000
72 A A 0.0000
73 E A -2.0927
74 D A -1.4550
75 V A -0.2065
76 T A -0.3680
77 A A 0.4003
78 P A 0.6075
79 L A 1.2237
80 V A 0.1304
81 D A -1.9933
82 E A -2.4924
83 G A -1.8873
84 A A -1.4605
85 P A -1.4287
86 G A -1.8105
87 K A -2.7855
88 Q A -2.1562
89 A A -1.4635
90 A A -1.3278
91 A A -1.2698
92 Q A -1.6160
93 P A -1.7077
94 H A -2.1204
95 T A -1.9933
96 E A -2.7905
97 I A -1.4652
98 P A -1.9699
99 E A -2.7419
100 G A -2.1062
101 T A -1.8795
102 T A -1.7094
103 A A -2.2560
104 E A -2.9798
105 E A -2.6330
106 A A -2.0361
107 G A -1.9428
108 I A -1.1322
109 G A -2.0702
110 D A -2.6466
111 T A -1.9119
112 P A -1.3557
113 S A -1.3963
114 L A -1.6978
115 E A -2.7650
116 D A -2.6301
117 E A -1.7531
118 A A 0.0000
119 A A -0.5307
120 G A -1.0336
121 H A -1.0573
122 V A 0.8357
123 T A -0.4584
124 Q A -0.7532
125 A A -0.9945
126 R A 0.0000
127 M A -0.2213
128 V A -0.2900
129 S A -1.2260
130 K A -2.2380
131 S A -2.1095
132 K A -2.9124
133 D A -3.6531
134 G A -2.0890
135 T A -1.5278
136 G A -1.8079
137 S A -2.6431
138 D A -3.2343
139 D A -3.6883
140 K A -3.0639
141 K A 0.0000
142 A A -1.4305
143 K A -1.3510
144 G A -1.6640
145 A A -1.9115
146 D A -3.1118
147 G A -2.6270
148 K A -2.6178
149 T A -1.9972
150 K A -1.5334
151 I A 0.6949
152 A A 0.1245
153 T A -0.3009
154 P A -1.2756
155 R A -2.5714
156 G A -1.8935
157 A A -1.1177
158 A A -1.0576
159 P A -1.0210
160 P A -1.3890
161 G A -2.0372
162 Q A -2.7623
163 K A -2.5364
164 G A -2.3360
165 Q A -2.6080
166 A A -2.1892
167 N A -2.4632
168 A A -1.2677
169 T A -1.1005
170 R A -1.4473
171 I A 0.3900
172 P A -0.0938
173 A A -0.9137
174 K A -1.9515
175 T A -1.0294
176 P A -1.0606
177 P A -0.9046
178 A A -0.7331
179 P A -1.4573
180 K A -1.9615
181 T A -1.1516
182 P A -1.2065
183 P A -1.4330
184 S A -1.0036
185 S A -0.6137
186 G A -1.2087
187 E A -1.8814
188 P A -2.1139
189 P A -1.9000
190 K A -2.8318
191 S A -2.4432
192 G A -2.0515
193 D A -3.3601
194 R A -3.4431
195 S A 0.0000
196 G A -1.2886
197 Y A 0.0000
198 S A -0.6325
199 S A 0.0000
200 P A -0.7292
201 G A -0.9417
202 S A -0.4821
203 P A -0.5268
204 G A -1.1601
205 T A -0.9182
206 P A -0.9730
207 G A -0.5620
208 S A 0.0000
209 R A -1.0177
210 S A -1.0822
211 R A -2.0216
212 T A -1.2384
213 P A -1.2271
214 S A -1.1713
215 L A -1.2719
216 P A 0.0000
217 T A -2.0878
218 P A -2.0973
219 P A -1.1927
220 T A -1.4519
221 R A -3.1948
222 E A -3.1605
223 P A -2.8630
224 K A -3.0269
225 K A -2.2454
226 V A -0.5712
227 A A 0.3848
228 V A 1.8638
229 V A 1.7538
230 R A -0.9096
231 T A -1.2209
232 P A -1.2108
233 P A -1.5556
234 K A -2.1107
235 S A 0.0000
236 P A 0.0000
237 S A -0.6730
238 S A 0.0000
239 A A -0.9646
240 K A -1.2642
241 S A -1.8491
242 R A -2.3561
243 L A -0.8385
244 Q A -1.1959
245 T A -0.5579
246 A A -0.1366
247 P A -0.2529
248 V A -0.0088
249 P A 0.0000
250 M A -0.7317
251 P A -1.0618
252 D A -1.6493
253 L A -0.1001
254 K A -1.3346
255 N A -1.5840
256 V A -0.7915
257 K A -1.9885
258 S A -1.6137
259 K A -1.2605
260 I A 0.3076
261 G A -1.1897
262 S A -1.2103
263 T A -1.0593
264 E A -2.0915
265 N A -2.2798
266 L A -1.0680
267 K A -2.3971
268 H A -2.2580
269 Q A -2.0608
270 P A -1.6642
271 G A -1.8368
272 G A -1.0526
273 G A -0.5098
274 K A -0.6696
275 V A -0.6674
276 Q A -1.9820
277 I A -1.0797
278 I A 0.0000
279 N A -2.4510
280 K A -2.7526
281 K A -1.8942
282 L A -1.0277
283 D A 0.0000
284 L A -1.4643
285 S A -1.4889
286 N A -1.8806
287 V A -1.0416
288 Q A -1.8119
289 S A -1.7570
290 K A -2.2146
291 C A -2.0649
292 G A -2.2098
293 S A -2.2072
294 K A -3.0723
295 D A -2.8489
296 N A -1.9230
297 I A -1.3174
298 K A -2.0362
299 H A 0.0000
300 V A 0.0000
301 P A 0.0821
302 G A -0.7838
303 G A -0.8787
304 G A -0.3221
305 S A 0.1363
306 V A 1.4774
307 Q A 0.2745
308 I A 0.0000
309 V A 0.8715
310 Y A 0.7088
311 K A -0.9734
312 P A 0.0253
313 V A 1.1408
314 D A -0.6329
315 L A 0.4092
316 S A -0.5300
317 K A -1.6731
318 V A -0.3110
319 T A -0.2776
320 S A -0.8638
321 K A -1.6186
322 C A -0.8516
323 G A -0.3361
324 S A 0.0000
325 L A -0.1246
326 G A -0.6954
327 N A -0.8432
328 I A -0.3976
329 H A -0.9588
330 H A -1.2900
331 K A -1.0615
332 P A -1.1624
333 G A -1.5109
334 G A -1.5010
335 G A -2.0260
336 Q A -3.0205
337 V A -2.1044
338 E A -2.2072
339 V A -0.5463
340 K A -2.1075
341 S A -2.0365
342 E A -2.7770
343 K A -1.6997
344 L A -0.4420
345 D A -1.3321
346 F A -0.0116
347 K A -1.0640
348 D A -1.7208
349 R A -1.7583
350 V A -0.0780
351 Q A -1.5227
352 S A -0.9850
353 K A -1.0425
354 I A 0.6496
355 G A -0.1206
356 S A -0.0146
357 L A 0.1051
358 D A -1.4432
359 N A -0.7573
360 I A 1.0093
361 T A 0.2244
362 H A 0.1428
363 V A 1.4174
364 P A 0.1938
365 G A -0.8656
366 G A -1.4671
367 G A -1.7737
368 N A -2.2466
369 K A -2.2649
370 K A -1.9936
371 I A -0.4092
372 E A -1.9728
373 T A -1.5483
374 H A -1.7389
375 K A -1.4267
376 L A 0.7267
377 T A 0.5434
378 F A 0.5763
379 R A -1.8940
380 E A -3.0240
381 N A -2.6791
382 A A -2.1303
383 K A -2.8050
384 A A -1.8057
385 K A -2.7102
386 T A -1.9154
387 D A -2.1338
388 H A -2.1375
389 G A -1.0328
390 A A -0.5005
391 E A -0.8762
392 I A 0.1059
393 V A 0.1759
394 Y A -0.8003
395 K A -1.6228
396 S A -0.1932
397 P A 0.5053
398 V A 1.3460
399 V A 1.6939
400 S A 0.2704
401 G A -0.1477
402 D A -0.5478
403 T A -0.6243
404 S A -0.5116
405 P A -0.6760
406 R A -1.5714
407 H A -1.0626
408 L A 0.2333
409 S A -0.4906
410 N A -1.2265
411 V A -0.6348
412 S A -0.7257
413 S A -0.5497
414 T A 0.0972
415 G A 0.0000
416 S A 0.5283
417 I A 1.5581
418 D A -0.2950
419 M A 0.7390
420 V A 0.1344
421 D A -1.1697
422 S A -0.7468
423 P A -0.3297
424 Q A -0.9117
425 L A 0.0000
426 A A 0.4861
427 T A 0.1311
428 L A 0.4884
429 A A -0.4629
430 D A -1.9284
431 E A -1.7479
432 V A 0.2486
433 S A -0.3687
434 A A -0.1877
435 S A -0.2229
436 L A -0.5544
437 A A -0.8385
438 K A -1.9057
439 Q A -1.0379
440 G A -0.5175
441 L A 0.7711
5 K B -2.6279
6 K B -2.7565
7 G B -2.0388
8 P B 0.0000
9 K B -1.5963
10 V B 0.0000
11 T B -1.3097
12 V B -1.3126
13 K B -0.6487
14 V B 0.0000
15 Y B -0.6532
16 F B 0.0000
17 D B -1.8194
18 L B 0.0000
19 R B -3.4645
20 I B 0.0000
21 G B -2.7663
22 D B -3.7169
23 E B -4.1017
24 D B -3.7632
25 V B 0.0000
26 G B -2.2621
27 R B -2.4971
28 V B 0.0000
29 I B -0.6737
30 F B 0.0000
31 G B 0.0000
32 L B 0.0000
33 F B 0.0000
34 G B -1.5853
35 K B -2.0853
36 T B -1.4945
37 V B 0.0000
38 P B -1.6954
39 K B -1.8123
40 T B 0.0000
41 V B 0.0000
42 D B -2.0188
43 N B 0.0000
44 F B 0.0000
45 V B -0.9605
46 A B 0.0000
47 L B 0.0000
48 A B 0.0000
49 T B -1.5519
50 G B -2.0504
51 E B -2.7446
52 K B -2.6737
53 G B -1.6611
54 F B -0.9835
55 G B -1.2401
56 Y B 0.0000
57 K B -2.5413
58 N B -2.2324
59 S B 0.0000
60 K B -1.6545
61 F B 0.0000
62 H B 0.0000
63 R B -0.9879
64 V B 0.0000
65 I B -1.0457
66 K B -2.5202
67 D B -2.4711
68 F B -0.8899
69 M B 0.0000
70 I B 0.0000
71 Q B 0.0000
72 G B 0.0000
73 G B 0.0000
74 D B 0.0000
75 F B -0.9498
76 T B -1.0011
77 R B -1.9578
78 G B -1.2876
79 D B -1.3679
80 G B 0.0000
81 T B -0.8832
82 G B -1.2022
83 G B 0.0000
84 K B -1.5092
85 S B 0.0000
86 I B -0.9102
87 Y B -0.0495
88 G B -1.0653
89 E B -2.4028
90 R B -1.7842
91 F B 0.0000
92 P B -1.2436
93 D B -1.5968
94 E B -1.1569
95 N B -1.1326
96 F B -0.9625
97 K B -1.8019
98 L B 0.0000
99 K B -2.2067
100 H B 0.0000
101 Y B -1.7394
102 G B 0.0000
103 P B -0.9960
104 G B 0.0000
105 W B 0.0000
106 V B 0.0000
107 S B 0.0000
108 M B 0.0000
109 A B 0.0000
110 N B -1.0259
111 A B -1.0055
112 G B -1.6485
113 K B -2.5358
114 D B -2.0295
115 T B -1.5107
116 N B 0.0000
117 G B 0.0000
118 S B 0.0000
119 Q B 0.0000
120 F B 0.0000
121 F B 0.0000
122 I B 0.0000
123 T B 0.0000
124 T B 0.0000
125 V B -1.0302
126 K B -1.8705
127 T B 0.0000
128 A B -0.2032
129 W B 0.4072
130 L B 0.0000
131 D B -1.1235
132 G B -1.5464
133 K B -2.3609
134 H B 0.0000
135 V B 0.0000
136 V B 0.0000
137 F B 0.0000
138 G B 0.0000
139 K B -0.3564
140 V B -0.1425
141 L B -0.2696
142 E B -1.9325
143 G B -1.9717
144 M B -1.6754
145 E B -2.8489
146 V B 0.0000
147 V B 0.0000
148 R B -2.6032
149 K B -2.0714
150 V B 0.0000
151 E B 0.0000
152 S B -1.8110
153 T B -1.6911
154 K B -1.9589
155 T B -1.4258
156 D B -1.4517
157 S B -1.2225
158 R B -2.3009
159 D B -1.8627
160 K B -1.6303
161 P B 0.0000
162 L B -0.2757
163 K B -2.3383
164 D B -1.9217
165 V B 0.0000
166 I B -1.9833
167 I B 0.0000
168 A B -1.9699
169 D B -1.9090
170 C B 0.0000
171 G B 0.0000
172 K B -1.3534
173 I B -0.9200
174 E B -2.4090
175 V B -2.0094
176 E B -2.8420
177 K B -2.6727
178 P B -1.5282
179 F B -0.6282
180 A B -1.3109
181 I B -1.3317
182 A B -2.1099
183 K B -2.7290
184 E B -2.7226

 

Laboratory of Theory of Biopolymers 2015