Project name: m5d2

Chain sequence(s)	H: EVQLQQSGPELVKPGASVKMSCKASGYTFTSFLIHWVKQKPGQGLEWIGFIIPYNDGTKYNEKFKGKATLTSDKSSSTAYMELSSLTSEDSAVYYCARYDGSFEGYFDVWGAGTSVTVSS; L: DVLMTQTPLSLPVSLRDQASISCRSSQSLVHSDGNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHVPWTFGGGTKLEIK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.2149
• Maximal score value: 1.2494
• Average score: -0.6856
• Total score value: -159.0547

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9042
2	V	H	-0.9968
3	Q	H	-1.5197
4	L	H	0.0000
5	Q	H	-1.9014
6	Q	H	-1.2829
7	S	H	-1.2138
8	G	H	-1.0466
9	P	H	-0.6243
11	E	H	-0.7591
12	L	H	0.6198
13	V	H	0.0000
14	K	H	-1.7965
15	P	H	-1.2005
16	G	H	-1.1592
17	A	H	-0.9389
18	S	H	-1.2921
19	V	H	0.0000
20	K	H	-2.3132
21	M	H	0.0000
22	S	H	-1.0916
23	C	H	0.0000
24	K	H	-1.8609
25	A	H	0.0000
26	S	H	-1.1450
27	G	H	-1.0415
28	Y	H	-0.3477
29	T	H	-0.0434
30	F	H	0.0000
35	T	H	-0.0263
36	S	H	0.0246
37	F	H	0.2994
38	L	H	0.0000
39	I	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	K	H	-0.6892
44	Q	H	-1.0188
45	K	H	-1.5071
46	P	H	-1.1636
47	G	H	-1.3982
48	Q	H	-1.8868
49	G	H	-1.2623
50	L	H	0.0000
51	E	H	-1.0583
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	F	H	0.0000
56	I	H	0.0000
57	I	H	-0.0607
58	P	H	0.0000
59	Y	H	0.1702
62	N	H	-1.3430
63	D	H	-1.9852
64	G	H	-1.1678
65	T	H	-0.8996
66	K	H	-0.9551
67	Y	H	-1.3232
68	N	H	0.0000
69	E	H	-3.4422
70	K	H	-3.2105
71	F	H	0.0000
72	K	H	-3.1934
74	G	H	-2.0431
75	K	H	-1.9467
76	A	H	0.0000
77	T	H	-1.0960
78	L	H	0.0000
79	T	H	-0.6954
80	S	H	-0.9540
81	D	H	-1.3852
82	K	H	-1.1850
83	S	H	-0.8547
84	S	H	-0.9058
85	S	H	-0.9677
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.7664
89	M	H	0.0000
90	E	H	-1.9668
91	L	H	0.0000
92	S	H	-1.1321
93	S	H	-0.8945
94	L	H	0.0000
95	T	H	-1.3015
96	S	H	-1.4560
97	E	H	-2.0130
98	D	H	0.0000
99	S	H	-0.7388
100	A	H	0.0000
101	V	H	-0.1006
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	Y	H	0.0000
108	D	H	-0.3425
109	G	H	0.0328
110	S	H	0.3625
111	F	H	1.2394
112	E	H	0.2417
113	G	H	-0.0865
114	Y	H	0.0000
115	F	H	0.0000
116	D	H	-0.5581
117	V	H	-0.2051
118	W	H	-0.3442
119	G	H	0.0000
120	A	H	-0.5136
121	G	H	-0.5224
122	T	H	0.0000
123	S	H	-0.3168
124	V	H	0.0000
125	T	H	-0.2831
126	V	H	0.0000
127	S	H	-0.5683
128	S	H	-0.7309
1	D	L	-1.5473
2	V	L	0.0000
3	L	L	0.5046
4	M	L	0.0000
5	T	L	-0.3707
6	Q	L	0.0000
7	T	L	-0.0530
8	P	L	0.4497
9	L	L	1.2494
10	S	L	0.1213
11	L	L	-0.2741
12	P	L	-1.0553
13	V	L	0.0000
14	S	L	-2.0547
15	L	L	-1.8561
16	R	L	-3.6840
17	D	L	-3.7743
18	Q	L	-3.3479
19	A	L	0.0000
20	S	L	-0.9397
21	I	L	0.0000
22	S	L	-0.8368
23	C	L	0.0000
24	R	L	-2.3472
25	S	L	0.0000
26	S	L	-1.0259
27	Q	L	-1.5745
28	S	L	-0.9408
29	L	L	0.0000
30	V	L	0.0694
31	H	L	-0.8840
32	S	L	-1.2364
34	D	L	-1.9553
35	G	L	-1.4725
36	N	L	-1.1515
37	T	L	-0.4661
38	Y	L	0.0000
39	L	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	L	L	0.0000
44	Q	L	0.0000
45	K	L	-1.5138
46	P	L	-1.1188
47	G	L	-1.4571
48	Q	L	-1.9600
49	S	L	-1.2368
50	P	L	0.0000
51	K	L	-1.5713
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.1374
56	K	L	-0.5129
57	V	L	-0.4967
65	S	L	-0.6172
66	N	L	-0.7016
67	R	L	-0.9687
68	F	L	-0.3974
69	S	L	-0.3607
70	G	L	-0.7776
71	V	L	0.0000
72	P	L	-1.2345
74	D	L	-2.1167
75	R	L	-2.1692
76	F	L	0.0000
77	S	L	-1.3699
78	G	L	0.0000
79	S	L	-0.9580
80	G	L	-1.1443
83	S	L	-0.8651
84	G	L	-0.8117
85	T	L	-1.4567
86	D	L	-2.0826
87	F	L	0.0000
88	T	L	-1.1187
89	L	L	0.0000
90	K	L	-2.0095
91	I	L	0.0000
92	S	L	-3.0190
93	R	L	-4.2149
94	V	L	0.0000
95	E	L	-2.7579
96	A	L	-1.8314
97	E	L	-2.0064
98	D	L	0.0000
99	L	L	-0.6514
100	G	L	0.0000
101	V	L	-0.1266
102	Y	L	0.0000
103	F	L	0.0000
104	C	L	0.0000
105	S	L	0.0000
106	Q	L	0.0000
107	S	L	0.0000
108	T	L	0.1188
109	H	L	-0.1737
114	V	L	0.2929
115	P	L	-0.5522
116	W	L	0.0000
117	T	L	0.0743
118	F	L	0.1384
119	G	L	0.0000
120	G	L	-0.2597
121	G	L	-0.1452
122	T	L	0.0000
123	K	L	-0.3390
124	L	L	0.0000
125	E	L	-1.6937
126	I	L	-1.4583
127	K	L	-1.8761