Project name: 468cefa6882ed7

Chain sequence(s)	A: QKTIKKQVVLEEGTIAFKNWVKTGTEVYRQFWIFDVQNPQEVMMNSSNIQVKQRGPYTYRVRFLAKENVTQDAEDNTVSFLQPNGAIFEPSLSVGTEADNFTVLNLAVAAASHIYQNQFVQMILNSLINKSKSSMFQVRTLRELLWGYRDPFLSLVPYPVTTTVGLFYPYNNTADGVYKVFNGKDNISKVAIIDTYKGKRNLSYWESHCDMINGTDAASFPPFVEKSQVLQFFSSDICRSIYAVFESDVNLKGIPVYRFVLPSKAFASPVENPDNYCFCTEKIISKNCTSYGVLDISKCKEGRPVYISLPHFLYASPDVSEPIDGLNPNEEEHRTYLDIEPITGFTLQFAKRLQVNLLVKPSEKIQVLKNLKRNYIVPILWLNETGTIGDEKANMFRSQV
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.7433
• Maximal score value: 1.622
• Average score: -0.7554
• Total score value: -302.1672

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
35	Q	A	-2.4795
36	K	A	-3.2733
37	T	A	-2.2061
38	I	A	0.0000
39	K	A	-3.6374
40	K	A	-3.5072
41	Q	A	-1.9291
42	V	A	0.0000
43	V	A	0.0000
44	L	A	0.0000
45	E	A	-2.5950
46	E	A	-2.7308
47	G	A	-1.9019
48	T	A	-1.7216
49	I	A	-1.1166
50	A	A	0.0000
51	F	A	0.0000
52	K	A	-2.6912
53	N	A	-1.5812
54	W	A	0.0000
55	V	A	-1.4895
56	K	A	-2.2649
57	T	A	-1.7228
58	G	A	-1.7907
59	T	A	-1.5167
60	E	A	-2.0758
61	V	A	0.0000
62	Y	A	-0.3126
63	R	A	0.0000
64	Q	A	-0.1714
65	F	A	0.0000
66	W	A	-0.3540
67	I	A	0.0000
68	F	A	0.0000
69	D	A	-1.3278
70	V	A	0.0000
71	Q	A	-2.1742
72	N	A	-1.5409
73	P	A	-1.3741
74	Q	A	-1.6982
75	E	A	-1.6960
76	V	A	0.0000
77	M	A	-1.1355
78	M	A	-1.0377
79	N	A	-1.8546
80	S	A	0.0000
81	S	A	-1.3303
82	N	A	-1.3663
83	I	A	0.0000
84	Q	A	-1.9456
85	V	A	0.0000
86	K	A	-2.4202
87	Q	A	-1.7274
88	R	A	-1.0066
89	G	A	-0.1414
90	P	A	0.3096
91	Y	A	0.0000
92	T	A	0.0000
93	Y	A	0.0000
94	R	A	-0.3826
95	V	A	0.0000
96	R	A	-1.0382
97	F	A	-0.4281
98	L	A	-0.1805
99	A	A	-0.9883
100	K	A	-1.3043
101	E	A	-1.8862
102	N	A	-1.6208
103	V	A	-0.5138
104	T	A	-0.7705
105	Q	A	-1.5912
106	D	A	-1.9325
107	A	A	-1.8695
108	E	A	-2.6416
109	D	A	-2.6352
110	N	A	-2.6700
111	T	A	0.0000
112	V	A	0.0000
113	S	A	-0.4006
114	F	A	0.0000
115	L	A	-0.5970
116	Q	A	-0.6922
117	P	A	-1.0504
118	N	A	-1.1347
119	G	A	0.0000
120	A	A	0.2054
121	I	A	1.0204
122	F	A	0.4294
123	E	A	0.3654
124	P	A	0.2887
125	S	A	0.3242
126	L	A	1.0193
127	S	A	0.9781
128	V	A	1.6220
129	G	A	0.3702
130	T	A	-0.4695
131	E	A	-1.1180
132	A	A	-1.1535
133	D	A	-1.2991
134	N	A	-1.4151
135	F	A	0.0000
136	T	A	0.0073
137	V	A	0.0000
138	L	A	0.0000
139	N	A	0.0000
140	L	A	0.0000
141	A	A	0.0000
142	V	A	0.0000
143	A	A	0.0000
144	A	A	0.0000
145	A	A	0.0000
146	S	A	-0.3839
147	H	A	-0.2233
148	I	A	0.0784
149	Y	A	-0.0432
150	Q	A	-1.3325
151	N	A	-1.0462
152	Q	A	-0.5933
153	F	A	1.5962
154	V	A	0.8741
155	Q	A	0.0000
156	M	A	0.8339
157	I	A	1.5695
158	L	A	0.0000
159	N	A	-0.2826
160	S	A	-0.6971
161	L	A	-0.5985
162	I	A	0.0000
163	N	A	-2.2941
164	K	A	-2.5206
165	S	A	-1.8251
166	K	A	-2.5356
167	S	A	-1.3760
168	S	A	-0.8466
169	M	A	0.0000
170	F	A	0.0000
171	Q	A	0.6192
172	V	A	1.1826
173	R	A	-0.3253
174	T	A	-1.2008
175	L	A	0.0000
176	R	A	-2.3364
177	E	A	-1.5010
178	L	A	0.0000
179	L	A	0.0000
180	W	A	-0.3985
181	G	A	-0.6829
182	Y	A	0.0000
183	R	A	-2.0134
184	D	A	0.0000
185	P	A	-0.9622
186	F	A	0.0000
187	L	A	0.0000
188	S	A	-0.2960
189	L	A	0.3329
190	V	A	0.5518
191	P	A	0.2543
192	Y	A	0.3036
193	P	A	0.0480
194	V	A	0.3969
195	T	A	-0.1644
196	T	A	-0.5412
197	T	A	0.0000
198	V	A	0.0000
199	G	A	0.0000
200	L	A	0.4791
201	F	A	0.5400
202	Y	A	0.5476
203	P	A	-0.2183
204	Y	A	-0.6841
205	N	A	-1.6406
206	N	A	-1.9581
207	T	A	-1.1325
208	A	A	-0.7675
209	D	A	-0.4645
210	G	A	0.0000
211	V	A	-0.0246
212	Y	A	0.0000
213	K	A	-0.5691
214	V	A	0.0000
215	F	A	-1.0465
216	N	A	0.0000
217	G	A	0.0000
218	K	A	-3.6977
219	D	A	-3.3732
220	N	A	-2.8533
221	I	A	-2.1130
222	S	A	-1.2906
223	K	A	-1.5522
224	V	A	0.0000
225	A	A	0.0000
226	I	A	-0.2243
227	I	A	0.0000
228	D	A	-1.0298
229	T	A	-1.6226
230	Y	A	-1.4569
231	K	A	-2.1334
232	G	A	-2.0083
233	K	A	-2.6215
234	R	A	-2.8912
235	N	A	-2.2338
236	L	A	0.0000
237	S	A	-0.9850
238	Y	A	-0.5131
239	W	A	0.0000
240	E	A	-1.8625
241	S	A	-1.3666
242	H	A	-1.5930
243	C	A	0.0000
244	D	A	0.0000
245	M	A	-1.0492
246	I	A	0.0000
247	N	A	-0.9469
248	G	A	-0.5719
249	T	A	0.0000
250	D	A	-0.5526
251	A	A	-0.2245
252	A	A	-0.0994
253	S	A	-0.0170
254	F	A	0.0000
255	P	A	-0.2141
256	P	A	0.0000
257	F	A	0.1755
258	V	A	-0.6046
259	E	A	-2.3487
260	K	A	-2.8688
261	S	A	-1.5305
262	Q	A	-1.4011
263	V	A	0.3929
264	L	A	0.0000
265	Q	A	-0.6009
266	F	A	0.0000
267	F	A	0.0000
268	S	A	-0.5233
269	S	A	-0.6680
270	D	A	-1.0966
271	I	A	0.0000
272	C	A	0.0000
273	R	A	0.0000
274	S	A	-0.4020
275	I	A	0.0000
276	Y	A	0.2273
277	A	A	0.0000
278	V	A	0.0328
279	F	A	-1.2439
280	E	A	-2.0586
281	S	A	-1.8034
282	D	A	-2.4827
283	V	A	-1.6749
284	N	A	-2.0396
285	L	A	0.0000
286	K	A	-2.6615
287	G	A	-2.0647
288	I	A	0.0000
289	P	A	-1.3770
290	V	A	0.0000
291	Y	A	-1.4539
292	R	A	-1.3409
293	F	A	0.0000
294	V	A	0.0000
295	L	A	0.0000
296	P	A	-0.4840
297	S	A	-0.7600
298	K	A	-1.5261
299	A	A	0.0000
300	F	A	-0.1203
301	A	A	-0.3856
302	S	A	0.0000
303	P	A	0.1108
304	V	A	1.0502
305	E	A	-0.9396
306	N	A	-0.9981
307	P	A	-0.6712
308	D	A	-1.6523
309	N	A	-0.4695
310	Y	A	0.6433
311	C	A	-0.3409
312	F	A	0.0765
313	C	A	-0.0996
314	T	A	-0.5308
315	E	A	-1.2152
316	K	A	-1.9281
317	I	A	0.1470
318	I	A	0.0000
319	S	A	-1.1157
320	K	A	-1.9715
321	N	A	-2.2396
322	C	A	0.0000
323	T	A	-0.6380
324	S	A	-0.3340
325	Y	A	0.1819
326	G	A	0.0000
327	V	A	0.6006
328	L	A	0.3704
329	D	A	-0.4821
330	I	A	0.0000
331	S	A	-1.6024
332	K	A	-2.4014
333	C	A	-1.6556
334	K	A	-2.0694
335	E	A	-2.6400
336	G	A	-1.7770
337	R	A	-1.4817
338	P	A	0.0000
339	V	A	0.0000
340	Y	A	0.0000
341	I	A	0.0000
342	S	A	0.0000
343	L	A	0.0000
344	P	A	0.0000
345	H	A	0.0000
346	F	A	0.0000
347	L	A	0.0000
348	Y	A	-0.2660
349	A	A	0.0971
350	S	A	0.0000
351	P	A	-1.1522
352	D	A	-1.8377
353	V	A	0.0000
354	S	A	-1.4942
355	E	A	-2.4936
356	P	A	0.0000
357	I	A	0.0000
358	D	A	-2.3102
359	G	A	-1.9628
360	L	A	-1.4395
361	N	A	-1.8364
362	P	A	-2.0208
363	N	A	-2.9546
364	E	A	-3.4786
365	E	A	-3.7433
366	E	A	-3.7006
367	H	A	0.0000
368	R	A	-1.9315
369	T	A	0.0000
370	Y	A	-0.2984
371	L	A	0.0000
372	D	A	0.0000
373	I	A	0.0000
374	E	A	0.0000
375	P	A	0.1617
376	I	A	0.8737
377	T	A	0.0000
378	G	A	0.0000
379	F	A	0.3170
380	T	A	0.0626
381	L	A	0.0000
382	Q	A	-0.0707
383	F	A	0.0581
384	A	A	0.0000
385	K	A	-0.3571
386	R	A	-0.6924
387	L	A	0.0000
388	Q	A	0.0000
389	V	A	0.0000
390	N	A	0.0000
391	L	A	0.0000
392	L	A	0.0000
393	V	A	0.0000
394	K	A	-1.4666
395	P	A	-2.3213
396	S	A	-2.6807
397	E	A	-3.0561
398	K	A	-2.0400
399	I	A	0.0000
400	Q	A	-2.5548
401	V	A	-1.5093
402	L	A	0.0000
403	K	A	-3.3315
404	N	A	-2.6297
405	L	A	0.0000
406	K	A	-2.7425
407	R	A	-1.8666
408	N	A	-1.1465
409	Y	A	0.0000
410	I	A	0.0000
411	V	A	0.0000
412	P	A	0.0000
413	I	A	0.0000
414	L	A	0.0000
415	W	A	0.0000
416	L	A	0.0000
417	N	A	-0.5207
418	E	A	0.0000
419	T	A	-0.3696
420	G	A	0.0000
421	T	A	-0.7078
422	I	A	0.0000
423	G	A	-2.3695
424	D	A	-3.3182
425	E	A	-3.2539
426	K	A	-2.5486
427	A	A	0.0000
428	N	A	-2.9058
429	M	A	-1.8319
430	F	A	0.0000
431	R	A	-2.4473
432	S	A	-1.5418
433	Q	A	-1.4141
434	V	A	-0.2504