Project name: 489c44e190e5de8

Chain sequence(s)	A: DAEFRH; H: VQLLESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASIRSGGGRTYYSDNVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCVRYDHYSGSSDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK; L: YVVMTQSPLSLPVTPGEPASISCKSSQSLLDSDGKTYLNWLLQKPGQSPQRLIYLVSKLDSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCWQGTHFPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.9454
• Maximal score value: 1.8255
• Average score: -0.7237
• Total score value: -321.3074

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	V	H	1.2078
3	Q	H	0.0826
4	L	H	0.0000
5	L	H	0.4760
6	E	H	0.0000
7	S	H	-0.5601
8	G	H	-0.9525
9	G	H	-0.7519
10	G	H	-0.5799
11	L	H	-0.1747
12	V	H	0.0000
13	Q	H	-1.6052
14	P	H	-1.6453
15	G	H	-1.3129
16	G	H	0.0000
17	S	H	-1.2517
18	L	H	-1.1603
19	R	H	-2.0729
20	L	H	0.0000
21	S	H	-0.4821
22	C	H	0.0000
23	A	H	-0.2393
24	A	H	0.0000
25	S	H	-0.0170
26	G	H	0.0780
27	F	H	0.0584
28	T	H	-0.4038
29	F	H	0.0000
30	S	H	-1.1563
31	N	H	-1.5059
32	Y	H	-0.7273
33	G	H	0.0000
34	M	H	0.0000
35	S	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.7921
40	A	H	-1.1540
41	P	H	-1.0017
42	G	H	-1.4706
43	K	H	-2.3432
44	G	H	-1.5330
45	L	H	0.0000
46	E	H	-0.8040
47	W	H	0.0000
48	V	H	0.0000
49	A	H	0.0000
50	S	H	0.0000
51	I	H	0.0000
52	R	H	-1.4357
52A	S	H	-1.3379
53	G	H	-1.4003
54	G	H	-1.5299
55	G	H	-1.8476
56	R	H	-2.3657
57	T	H	-1.0688
58	Y	H	-0.4206
59	Y	H	-0.9611
60	S	H	-1.6178
61	D	H	-2.9340
62	N	H	-2.8869
63	V	H	0.0000
64	K	H	-2.8539
65	G	H	-1.9178
66	R	H	-1.6520
67	F	H	0.0000
68	T	H	-0.7736
69	I	H	0.0000
70	S	H	-0.7032
71	R	H	-1.0812
72	D	H	-1.4935
73	N	H	-1.8352
74	A	H	-1.4069
75	K	H	-2.2802
76	N	H	-1.7063
77	S	H	0.0000
78	L	H	0.0000
79	Y	H	-0.4614
80	L	H	0.0000
81	Q	H	-1.1321
82	M	H	0.0000
82A	N	H	-1.4600
82B	S	H	-1.2213
82C	L	H	0.0000
83	R	H	-2.2117
84	A	H	-1.6770
85	E	H	-2.3337
86	D	H	0.0000
87	T	H	-0.7390
88	A	H	0.0000
89	L	H	0.1306
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	V	H	0.0000
94	R	H	0.0000
95	Y	H	0.0000
96	D	H	0.0000
97	H	H	-0.1498
98	Y	H	1.0115
99	S	H	0.0000
100	G	H	0.0094
100A	S	H	0.0000
100B	S	H	0.0000
101	D	H	0.0000
102	Y	H	0.6547
103	W	H	0.0000
104	G	H	0.0000
105	Q	H	-1.3025
106	G	H	0.0000
107	T	H	-0.1642
108	L	H	-0.0504
109	V	H	0.0000
110	T	H	-0.4866
111	V	H	0.0000
112	S	H	-0.9572
113	S	H	-0.6585
114	A	H	-0.4629
115	S	H	-0.6054
116	T	H	-0.6460
117	K	H	-1.2376
118	G	H	-1.3865
119	P	H	-0.6081
120	S	H	-0.4394
121	V	H	0.0000
122	F	H	0.0000
123	P	H	-1.1134
124	L	H	0.0000
125	A	H	-1.1538
126	P	H	-0.9671
127	S	H	-1.0502
128	S	H	-1.7449
129	K	H	-1.9155
130	S	H	-1.4194
131	T	H	-0.8792
132	S	H	-0.7770
133	G	H	-0.7774
134	G	H	-0.7420
135	T	H	-0.5472
136	A	H	-0.4531
137	A	H	0.0000
138	L	H	0.0000
139	G	H	0.0000
140	C	H	0.0000
141	L	H	0.0000
142	V	H	0.0000
143	K	H	-0.3016
144	D	H	-0.4274
145	Y	H	0.0000
146	F	H	0.0000
147	P	H	0.0000
148	Q	H	-0.3459
149	P	H	-0.5515
150	V	H	-0.5199
151	T	H	-0.4556
152	V	H	-0.1081
153	S	H	-0.3836
154	W	H	0.0000
155	N	H	-0.7990
156	S	H	-0.7003
157	G	H	-0.5324
158	A	H	-0.2477
159	L	H	-0.0217
160	T	H	-0.1787
161	S	H	-0.1908
162	G	H	-0.2281
163	V	H	0.1750
164	H	H	-0.1358
165	T	H	0.0220
166	F	H	0.0000
167	P	H	-0.3523
168	A	H	0.1807
169	V	H	0.3674
170	L	H	1.0471
171	Q	H	0.1976
172	S	H	-0.0956
173	S	H	-0.2208
174	G	H	0.0123
175	L	H	0.0927
176	Y	H	0.4276
177	S	H	0.0000
178	L	H	0.0000
179	S	H	0.0000
180	S	H	0.0000
181	V	H	0.0000
182	V	H	0.0000
183	T	H	-0.1245
184	V	H	0.0000
185	P	H	-0.4340
186	S	H	-0.6638
187	S	H	-0.5232
188	S	H	-0.5971
189	L	H	-0.6204
190	G	H	-0.9560
191	T	H	-0.8035
192	Q	H	-1.2461
193	T	H	-1.1798
194	Y	H	0.0000
195	I	H	-1.4015
196	C	H	0.0000
197	N	H	-1.4187
198	V	H	0.0000
199	N	H	-1.7201
200	H	H	0.0000
201	K	H	-2.7120
202	P	H	-1.5492
203	S	H	-1.8103
204	N	H	-2.4987
205	T	H	-2.0442
206	K	H	-2.5848
207	V	H	-1.4057
208	D	H	-2.4317
209	K	H	-1.9448
210	K	H	-2.5167
211	V	H	0.0000
212	E	H	-2.7213
213	P	H	-2.0553
214	K	H	-2.6966
1	Y	L	1.8255
2	V	L	0.0000
3	V	L	1.7083
4	M	L	0.0000
5	T	L	-0.2622
6	Q	L	0.0000
7	S	L	-0.1448
8	P	L	0.1030
9	L	L	0.4946
10	S	L	-0.2776
11	L	L	-0.4514
12	P	L	-0.9571
13	V	L	0.0000
14	T	L	-1.8066
15	P	L	-2.0583
16	G	L	-2.1847
17	E	L	-2.9835
18	P	L	-2.5474
19	A	L	0.0000
20	S	L	-0.9321
21	I	L	0.0000
22	S	L	-0.8362
23	C	L	0.0000
24	K	L	-1.6269
25	S	L	0.0000
26	S	L	-0.1801
27	Q	L	-0.4776
27A	S	L	-0.3894
27B	L	L	0.0000
27C	L	L	0.4764
27D	D	L	-0.7072
27E	S	L	-1.1852
28	D	L	-2.2791
29	G	L	-1.6349
30	K	L	-1.5334
31	T	L	-0.4002
32	Y	L	0.0000
33	L	L	0.0000
34	N	L	0.0000
35	W	L	0.0000
36	L	L	0.0000
37	L	L	0.0000
38	Q	L	-1.1142
39	K	L	-1.7858
40	P	L	-1.5501
41	G	L	-1.6341
42	Q	L	-1.9976
43	S	L	-1.3843
44	P	L	0.0000
45	Q	L	-1.1402
46	R	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	-0.1500
50	L	L	-0.3237
51	V	L	0.0000
52	S	L	-0.7272
53	K	L	-1.0705
54	L	L	-0.7499
55	D	L	-0.8907
56	S	L	-0.6318
57	G	L	-0.8296
58	V	L	0.0000
59	P	L	-1.2323
60	D	L	-2.0918
61	R	L	-2.3124
62	F	L	0.0000
63	S	L	-1.5496
64	G	L	-0.9203
65	S	L	-1.0668
66	G	L	-1.0488
67	S	L	-0.6578
68	G	L	-0.4942
69	T	L	-1.2100
70	D	L	-2.1377
71	F	L	0.0000
72	T	L	-1.1841
73	L	L	0.0000
74	K	L	-2.2686
75	I	L	0.0000
76	S	L	-2.6550
77	R	L	-3.4373
78	V	L	0.0000
79	E	L	-2.9364
80	A	L	-2.5243
81	E	L	-2.9164
82	D	L	0.0000
83	V	L	0.0000
84	G	L	0.0000
85	V	L	-0.6882
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	W	L	0.0000
90	Q	L	0.0000
91	G	L	0.0000
92	T	L	0.0000
93	H	L	0.4054
94	F	L	0.9697
95	P	L	0.5862
96	R	L	0.0000
97	T	L	0.6085
98	F	L	0.1127
99	G	L	0.0000
100	Q	L	-1.0255
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-1.6079
104	V	L	0.0000
105	E	L	-1.4536
106	I	L	0.0000
107	K	L	-1.4394
108	R	L	-1.0207
109	T	L	-0.0999
110	V	L	0.2347
111	A	L	-0.0973
112	A	L	-0.1458
113	P	L	0.0000
114	S	L	-0.1893
115	V	L	0.0000
116	F	L	0.0028
117	I	L	0.0000
118	F	L	0.0000
119	P	L	-0.7935
120	P	L	0.0000
121	S	L	0.0000
122	D	L	-2.8366
123	E	L	-2.4446
124	Q	L	0.0000
125	L	L	-2.0537
126	K	L	-2.7784
127	S	L	-1.8830
128	G	L	-1.6245
129	T	L	-1.3556
130	A	L	0.0000
131	S	L	0.0000
132	V	L	0.0000
133	V	L	0.0000
134	C	L	0.0000
135	L	L	0.0000
136	L	L	0.0000
137	N	L	0.0000
138	N	L	-0.9788
139	F	L	0.0000
140	Y	L	0.0000
141	P	L	-1.8067
142	R	L	-3.1114
143	E	L	-3.1569
144	A	L	-2.1316
145	K	L	-1.8848
146	V	L	-0.8461
147	Q	L	-0.6222
148	W	L	0.0000
149	K	L	-0.6750
150	V	L	0.0000
151	D	L	-1.6056
152	N	L	-1.2633
153	A	L	-0.3037
154	L	L	0.4800
155	Q	L	-0.5294
156	S	L	-0.8650
157	G	L	-1.3575
158	N	L	-1.7595
159	S	L	-1.6373
160	Q	L	-1.6103
161	E	L	-1.9523
162	S	L	-1.0356
163	V	L	-0.8479
164	T	L	-1.1990
165	E	L	-2.2386
166	Q	L	0.0000
167	D	L	-1.9882
168	S	L	-2.4263
169	K	L	-2.8422
170	D	L	-2.1324
171	S	L	0.0000
172	T	L	0.0000
173	Y	L	0.0000
174	S	L	0.0000
175	L	L	0.0000
176	S	L	0.0000
177	S	L	0.0000
178	T	L	-0.8227
179	L	L	0.0000
180	T	L	-0.6175
181	L	L	-1.0292
182	S	L	-1.7741
183	K	L	-3.1031
184	A	L	-2.4353
185	D	L	-2.7682
186	Y	L	0.0000
187	E	L	-3.9454
188	K	L	-3.6777
189	H	L	-2.9787
190	K	L	-3.0443
191	V	L	-1.6419
192	Y	L	0.0000
193	A	L	0.0000
194	C	L	0.0000
195	E	L	-0.6008
196	V	L	0.0000
197	T	L	-0.9894
198	H	L	0.0000
199	Q	L	-1.6964
200	G	L	-0.4357
201	L	L	-0.1643
202	S	L	-0.4045
203	S	L	-0.3949
204	P	L	-0.4034
205	V	L	0.0166
206	T	L	-0.4986
207	K	L	-0.7615
208	S	L	-0.6077
209	F	L	-1.1598
210	N	L	-2.3614
211	R	L	-2.6185
212	G	L	-2.0810
213	E	L	-2.6140
214	C	L	-1.8338
1	D	A	0.0000
2	A	A	0.0000
3	E	A	0.0000
4	F	A	-0.6169
5	R	A	-1.0083
6	H	A	-1.0536