Project name: 6fxn:D

Chain sequence(s)	D: QVQLQQSGAEVKKPGSSVRVSCKASGGTFNNNAINWVRQAPGQGLEWMGGIIPMFGTAKYSQNFQGRVAITADESTGTASMELSSLRSEDTAVYYCARSRDLLLFPHHALSPWGRGTMVTVSSASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVE
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -2.8181
• Maximal score value: 2.9858
• Average score: -0.5467
• Total score value: -117.5351

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	D	-0.5026
2	V	D	0.9396
3	Q	D	-1.1250
4	L	D	0.0000
5	Q	D	-2.2755
6	Q	D	-1.5861
7	S	D	-1.3266
8	G	D	-1.0007
9	A	D	-0.7889
10	E	D	-1.0216
11	V	D	-0.6956
12	K	D	-1.6138
13	K	D	-2.3825
14	P	D	-2.0896
15	G	D	-1.4721
16	S	D	-1.2410
17	S	D	-1.4040
18	V	D	0.0000
19	R	D	-2.2847
20	V	D	0.0000
21	S	D	-1.1572
22	C	D	0.0000
23	K	D	-1.8672
24	A	D	0.0000
25	S	D	-0.9428
26	G	D	-0.8646
27	G	D	-1.3455
28	T	D	-1.5364
29	F	D	0.0000
30	N	D	-1.9207
31	N	D	-0.7765
32	N	D	0.0000
33	A	D	0.0960
34	I	D	0.0000
35	N	D	0.0000
36	W	D	0.0000
37	V	D	0.0000
38	R	D	-0.3044
39	Q	D	-0.5778
40	A	D	-1.0412
41	P	D	-1.1548
42	G	D	-1.1667
43	Q	D	-1.6476
44	G	D	-0.8011
45	L	D	0.4340
46	E	D	-0.7475
47	W	D	0.0262
48	M	D	0.0000
49	G	D	0.0000
50	G	D	0.0000
51	I	D	0.1615
52	I	D	0.0356
53	P	D	-0.4005
54	M	D	0.3598
55	F	D	0.8775
56	G	D	0.0075
57	T	D	-0.2618
58	A	D	-0.5161
59	K	D	-1.4086
60	Y	D	-0.4999
61	S	D	-1.2405
62	Q	D	-2.1585
63	N	D	-2.2490
64	F	D	0.0000
65	Q	D	-2.0888
66	G	D	-1.4523
67	R	D	-1.1335
68	V	D	-0.6925
69	A	D	-0.5872
70	I	D	0.0000
71	T	D	-0.5235
72	A	D	-0.8862
73	D	D	-2.0405
74	E	D	-2.4075
75	S	D	-1.4342
76	T	D	-1.3428
77	G	D	0.0000
78	T	D	-1.4992
79	A	D	0.0000
80	S	D	0.0000
81	M	D	0.0000
82	E	D	-1.5759
83	L	D	0.0000
84	S	D	-1.0925
85	S	D	-1.1233
86	L	D	0.0000
87	R	D	-2.6932
88	S	D	-2.1824
89	E	D	-2.4308
90	D	D	0.0000
91	T	D	-1.0276
92	A	D	0.0000
93	V	D	0.1879
94	Y	D	0.0000
95	Y	D	0.0792
96	C	D	0.0000
97	A	D	0.0000
98	R	D	-0.1076
99	S	D	-0.1535
100	R	D	-0.0703
101	D	D	0.0000
102	L	D	2.3466
103	L	D	2.9858
104	L	D	2.6036
105	F	D	1.5172
106	P	D	0.6888
107	H	D	-0.8192
108	H	D	-0.9409
109	A	D	-0.6292
110	L	D	-0.0256
111	S	D	-0.1572
112	P	D	-0.0955
113	W	D	-0.2042
114	G	D	-1.3911
115	R	D	-2.0312
116	G	D	0.0000
117	T	D	0.0000
118	M	D	-0.2514
119	V	D	0.0000
120	T	D	-0.8879
121	V	D	0.0000
122	S	D	-1.2762
123	S	D	-1.0240
124	A	D	-0.6186
125	S	D	-0.7510
126	T	D	-0.8233
127	K	D	-1.5545
128	G	D	-1.6650
129	P	D	-0.8420
130	S	D	-0.4245
131	V	D	0.0000
132	F	D	0.6828
133	P	D	-0.0892
134	L	D	0.3701
135	A	D	-0.3363
136	P	D	-0.2956
137	S	D	-0.1813
145	T	D	-0.2474
146	A	D	-0.1690
147	A	D	0.0977
148	L	D	0.0000
149	G	D	0.0000
150	C	D	0.0000
151	L	D	0.5932
152	V	D	0.0000
153	K	D	-0.5929
154	D	D	-0.8915
155	Y	D	0.0000
156	F	D	-0.5905
157	P	D	0.0000
158	E	D	-1.4398
159	P	D	-1.1989
160	V	D	-0.7848
161	T	D	-0.5593
162	V	D	-0.3696
163	S	D	-0.3651
164	W	D	0.0000
165	N	D	-0.6968
166	S	D	-0.6223
167	G	D	-0.4392
168	A	D	-0.1790
169	L	D	0.0504
170	T	D	-0.2518
171	S	D	-0.3686
172	G	D	-0.4586
173	V	D	-0.0999
174	H	D	-0.6142
175	T	D	0.0628
176	F	D	0.7675
177	P	D	0.6303
178	A	D	1.0927
179	V	D	2.3773
180	L	D	2.0938
181	Q	D	0.4745
182	S	D	-0.0460
183	S	D	-0.3306
184	G	D	-0.0412
185	L	D	-0.0079
186	Y	D	0.4417
187	S	D	0.0000
188	L	D	0.7814
189	S	D	0.6034
190	S	D	0.0000
191	V	D	0.3808
192	V	D	0.0000
193	T	D	-0.2602
194	V	D	0.0000
195	P	D	-0.4466
196	S	D	-0.4003
197	S	D	-0.4776
198	S	D	-0.5125
199	L	D	-0.6670
200	G	D	-0.9598
201	T	D	-0.6345
202	Q	D	-1.1680
203	T	D	-1.1804
204	Y	D	0.0000
205	I	D	-1.3319
206	C	D	0.0000
207	N	D	-1.4240
208	V	D	0.0000
209	N	D	-1.6758
210	H	D	0.0000
211	K	D	-2.8181
212	P	D	-1.8127
213	S	D	-1.7910
214	N	D	-2.5833
215	T	D	-2.0690
216	K	D	-2.5916
217	V	D	-1.4436
218	D	D	-2.5570
219	K	D	-2.0261
220	K	D	-2.5748
221	V	D	0.0000
222	E	D	-2.3542